Y chromosome haplotypes reveal prehistorical migrations to the Himalayas - Human Genetics
- ️Jin, Li
- ️Fri Dec 01 2000
Abstract
By using 19 Y chromosome biallelic markers and 3 Y chromosome microsatellite markers, we analyzed the genetic structure of 31 indigenous Sino-Tibetan speaking populations (607 individuals) currently residing in East, Southeast, and South Asia. Our results showed that a T to C mutation at locus M122 is highly prevalent in almost all of the Sino-Tibetan populations, implying a strong genetic affinity among populations in the same language family. Furthermore, the extremely high frequency of H8, a haplotype derived from M122C, in the Sino-Tibetan speaking populations in the Himalayas including Tibet and northeast India indicated a strong bottleneck effect that occurred during a westward and then southward migration of the founding population of Tibeto-Burmans. We, therefore, postulate that the ancient people, who lived in the upper-middle Yellow River basin about 10,000 years ago and developed one of the earliest Neolithic cultures in East Asia, were the ancestors of modern Sino-Tibetan populations.
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Authors and Affiliations
Human Genetics Center, University of Texas-Houston, 6901 Bertner Avenue, 77030, Houston, TX, USA
Bing Su, Chunjie Xiao, Ranajit Chakraborty & Li Jin
Institute of Genetics, School of Life Sciences, Fudan University and Morgan-Tan International Center for Life Sciences, Shanghai, China
Bing Su, Junhua Xiao, Daru Lu & Li Jin
Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
Bing Su
Department of Biology, Yunnan University, Kunming, China
Chunjie Xiao
Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, USA
Ranjan Deka
Program for Population Genetics, Harvard School of Public Health, Boston, Mass., USA
Mark T. Seielstad
Department of Biology, Chiang Mai University, Chiang Mai, Thailand
Daoroong Kangwanpong
Department of Genetics, Stanford University, Stanford, Calif., USA
Peter Underhill & Luca Cavalli-Sforza
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- Bing Su
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- Chunjie Xiao
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- Ranjan Deka
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- Mark T. Seielstad
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- Daoroong Kangwanpong
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- Junhua Xiao
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- Daru Lu
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- Peter Underhill
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- Luca Cavalli-Sforza
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- Ranajit Chakraborty
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- Li Jin
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Correspondence to Li Jin.
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Su, B., Xiao, C., Deka, R. et al. Y chromosome haplotypes reveal prehistorical migrations to the Himalayas. Hum Genet 107, 582–590 (2000). https://doi.org/10.1007/s004390000406
Received: 27 July 2000
Accepted: 21 September 2000
Issue Date: December 2000
DOI: https://doi.org/10.1007/s004390000406