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The promise of a protist: the Dictyostelium genome project - Functional & Integrative Genomics

  • ️Shaulsky, Gad
  • ️Sat Sep 01 2001

Abstract.

The genome of Dictyostelium discoideum is being sequenced by an international consortium and is scheduled for completion in the next few years. The sequence will accelerate research into a number of phenomena carried out by these versatile soil amoebae, providing insight into analogous processes that operate in a wide range of eukaryotes. These include the dynamic regulation of the cytoskeleton during chemotaxis, intercellular communication during multicellular development and the intracellular growth of bacterial pathogens. The current state of the genome project is summarized and the challenges of sequencing a genome with unusually low guanine and cytosine content and with a bimodal base composition distribution are discussed. The prospects for functional analyses at the genomic scale are also considered.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Houston, TX 77030, USA, , , , ,

    Adam Kuspa & Richard Sucgang

  2. Department of Molecular and Human Genetics Baylor College of Medicine, Houston, TX 77030, USA, , , , ,

    Gad Shaulsky

Authors

  1. Adam Kuspa

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  2. Richard Sucgang

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  3. Gad Shaulsky

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Kuspa, A., Sucgang, R. & Shaulsky, G. The promise of a protist: the Dictyostelium genome project. Funct Integr Genomics 1, 279–293 (2001). https://doi.org/10.1007/s101420000033

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  • Received: 23 October 2000

  • Accepted: 24 October 2000

  • Issue Date: September 2001

  • DOI: https://doi.org/10.1007/s101420000033