link.springer.com

Safety of clomiphene citrate: a literature review - Cytotechnology

  • ️Yilmaz, Ebru
  • ️Mon Nov 20 2017

References

  • Althuis MD, Scoccia B, Lamb EJ, Moghissi KS, Westhoff CL, Mabie JE, Brinton LA (2005) Melanoma, thyroid, cervical, and colon cancer risk after use of fertility drugs. Am J Obstet Gynecol 193:668–674

    Article  Google Scholar 

  • Ara C, Asmatullah A (2011) Teratogenic and embryotoxic effects of clomiphene citrate in developing mice. Asian Australas J Anim Sci 24:1053–1059

    Article  CAS  Google Scholar 

  • Athar R, Mehrnoosh M, Masoumeh H, Hooshmand F, Fatemeh A (2015) A clomiphene citrate and letrozol varsus tamoxifen and letrozole as an infertility treatment in women with polycystic ovary syndrome. Pak J Biol Sci 18:300–303

    Article  Google Scholar 

  • Benshushan A, Paltiel O, Brzezinski A, Tanos V, Barchana M, Shoshani O, Gordon L, Schenker JG (2001) Ovulation induction and risk of endometrial cancer: a pilot study. Eur J Obs Gynecol Reprod Biol 98:53–57

    Article  CAS  Google Scholar 

  • Brackett NL, Abae M, Padron OD, Lynne CM (1995) Treatment by assisted conception of severe male factor infertility due to spinal cord injury or other neurologic impairment. J Assist Reprod Genet 12:210–216

    Article  CAS  Google Scholar 

  • Brinton LA, Scoccia B, Moghissi KS, Westhoff CL, Althuis MD, Mabie JE, Lamb EJ (2004) Breast cancer risk associated with ovulation-stimulating drugs. Hum Reprod 19:2005–2013

    Article  CAS  Google Scholar 

  • Brinton LA, Scoccia B, Kamran S, Moghissi KS, Westhoff CL, Niwa S, Ruggieri D, Trabert B, Lamb EJ (2014) Long-term relationship of ovulation-stimulating drugs to breast cancer risk. Cancer Epidemiol Biomark Prev 23:584–593

    Article  CAS  Google Scholar 

  • Brinton LA, Moghissi KS, Scoccia B, Lamb EJ, Trabert B, Niwa S, Ruggieri D, Westhoff CL (2015) Effects of fertility drugs on cancers other than breast and gynecologic malignancies. Fertil Steril 104:980–988

    Article  CAS  Google Scholar 

  • Calderon-Margalit R, Friedlander Y, Yanetz R, Kleinhaus K, Perrin MC, Manor O, Harlap S, Paltiel O (2009) Cancer risk after exposure to treatments for ovulation induction. Am J Epidemiol 169:365–375

    Article  CAS  Google Scholar 

  • Costa F, Dornelles E, Manica-Cattani MF, Algarve TD, de Souza Filho OC, Sagrillo MR, Garcia LF, Cruz IB (2012) Influence of Val16Ala SOD2 polymorphism on the in vitro effect of clomiphene citrate in oxidative metabolism. Reprod BioMed Online 24:474–481

    Article  CAS  Google Scholar 

  • Duran B, Ozdemir I, Demirel Y, Ozdemir O, Çetin A, Güven A (2006) In vivo evaluation of the genotoxic effects of clomiphene citrate on rat reticulocytes: a micronucleus genotoxicity. Gynecol Obs Investig 61:228–231

    Article  CAS  Google Scholar 

  • Elloumi-Mseddi J, Jemel-Oualha I, Beji A, Hakim B, Aifa S (2015) Effect of estradiol and clomiphene citrate on Erk activation in breast cancer cells. J Recept Signal Transduct Res 35:202–206

    Article  CAS  Google Scholar 

  • Fei C, DeRoo LA, Sandler DP, Weinberg CR (2012) Fertility drugs and young-onset breast cancer: results from the two sister study. J Natl Cancer Inst 104:1021–1027

    Article  CAS  Google Scholar 

  • Fiedler K, Ludwig M (2003) Use of clomiphene citrate in in vitro fertilization (IVF) and IVF/intracytoplasmic sperm injection cycles. Fertil Steril 80:1521–1523

    Article  Google Scholar 

  • Hannibal CG, Jensen A, Sharif H, Kjaer SK (2008) Risk of thyroid cancer after exposure to fertility drugs: results from a large Danish cohort study. Hum Reprod 23:451–456

    Article  CAS  Google Scholar 

  • Hughes E, Brown J, Collins JJ, Vanderkerchove P (2000) Clomiphene citrate for unexplained subfertility in women. Cochrance Database Syst Rev 2:CD000057

    Google Scholar 

  • Jensen A, Sharif H, Kjaer SK (2009) Use of fertility drugs and risk of uterine cancer: results from a large danish population-based cohort study. Am J Epidemiol 170:1408–1414

    Article  Google Scholar 

  • Jiann BP, Lub YC, Changa HT, Huanga JK, Janc CR (2002) Effect of clomiphene on Ca2+ movement in human prostate cancer cells. Life Sci 70:3167–3178

    Article  CAS  Google Scholar 

  • Legro RS, Brzyski RG, Diamond MP, Coutifaris C, Schlaff WD, Casson P, Christman GM, Zhang HI (2014) Letrozole versus clomiphene for infertility in the polycystic ovary syndrome. New Eng J Med 371:119–129

    Article  Google Scholar 

  • Moskovic DJ, Katz DJ, Akhavan A, Park K, Mulhall JP (2012) Clomiphene citrate is safe and effective for long-term management of hypogonadism. BJU Int 110:1524–1528

    Article  CAS  Google Scholar 

  • Ohnishi T, Ohashi Y, Amano I, Nozu K (1986) An ovulation inducing agent containing causes DNA-strand breaks without SOS responses in Escherichia coli. Mutat Res 165:57–61

    CAS  Google Scholar 

  • Perri T, Lifshitz D, Sadetzki S, Oberman B, Meirow D, Ben-Baruch G, Friedman E, Korach J (2015) Fertility treatments and invasive epithelial ovarian cancer risk in Jewish Israeli BRCA1 or BRCA2 mutation carriers. Fertil Steril 103:1305–1312

    Article  Google Scholar 

  • Plourde PV, Kulin HE, Santner SJ (1983) Clomiphene in treatment of adolescent gynacomastia: clinical and endocrine studies. Am J Dis Children 137:1080–1082

    Article  CAS  Google Scholar 

  • Practice Committee of the American Society for Reproductive Medicine (2006) Use of clomiphene citrate in women. Fertil Steril 86:187–193

    Google Scholar 

  • Prince A, Ma J, Megli C, Takahashi D, Grove K, Stouffer R, Aagaard K (2016) The intestinal microbiome is regulated by diet in a novel primate model of polycystic ovarian syndrome (PCOS). Am J Obs Gynecol 214:125

    Article  Google Scholar 

  • Rossing MA, Tang MT, Flagg EW, Weiss LK, Wicklund KG (2004) A case-control study of ovarian cancer in relation to infertility and the use of ovulation-inducing drugs. Am J Epidemiol 160:1070–1078

    Article  Google Scholar 

  • Santos Silva ID, Wark PA, McCormack VA, Mayer D, Overton C, Little V, Nieto J, MacLean AB (2009) Ovulation-stimulation drugs and cancer risks: a long-term follow-up of a British cohort. Br J Cancer 100:1824–1831

    Article  Google Scholar 

  • Sönmezer M, Cil AP, Oktem O, Oktay K (2010) Breast cancer diagnosis following ovarian stimulation: are the tumours different? Reprod Biomed Online 21:266–271

    Article  Google Scholar 

  • Trabert B, Lamb EJ, Scoccia B, Moghissi KS, Westhoff CL, Niwa S, Brinton LA (2013) Ovulation-inducing drugs and ovarian cancer risk: results from an extended follow-up of a large United States infertility cohort. Fertil Steril 100:1660–1666

    Article  CAS  Google Scholar 

  • Yilmaz S, Ünal F, Yilmaz E, Yüzbaşıoğlu D, Erkal-Ilhan S (2014) Evaluation of the genotoxicity of clomiphene citrate. Mutat Res 759:21–27

    Article  CAS  Google Scholar 

  • Yilmaz S, Unal F, Yuzbasioğlu D, Gonenc IM (2015) Induction of sister chromatid exchanges and cell division delays by clomiphene citrate in human lymphocytes. Hum Exp Toxicol 34:284–288

    Article  CAS  Google Scholar 

  • Yom-Tov G, Nathan I, Shpilberg O, Polliac A, Levi I (2012) Clomiphene as a novel modality for the treatment of acute myeloid leukaemia: a pilot phase II study. Leuk Res 36:42–45

    Article  CAS  Google Scholar 

Download references