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Risk of Ulcerative Colitis-Associated Colorectal Cancer in China: A Multi-Center Retrospective Study - Digestive Diseases and Sciences

  • ️Jiang, Bo
  • ️Thu Sep 22 2011

Abstract

Background

The number of patients with ulcerative colitis (UC) in China has increased in the past 10 years. Thus, it is anticipated that the incidence of UC-associated colorectal cancer (UC-CRC) will also increase. However, the risk of CRC in UC patients is still unknown in Chinese. The aim of this study was to identify the risk and risk factors of UC-CRC in Chinese.

Methods

A total of 3,922 patients with UC were retrospectively collected from five central teaching hospitals in China, in which high-quality endoscopic and histological diagnoses were available from 1998 to 2009. The database of the UC and UC-associated CRC patients was evaluated.

Results

CRC was diagnosed 34 in patients, and the overall prevalence of CRC in patients with UC was 0.87%. The cumulative risk of developing CRC after a disease duration of 10 years was 1.15% (95% confidence interval [CI] 0.71–1.84%); 20 years, 3.56% (95% CI 2.14–5.89%); and 30 years, 14.36% (95% CI 7.57–26.3%). Longer disease duration, extensive colitis, and dysplasia found in the biopsy specimen were identified as risk factors for developing CRC. 5-ASA use was identified as a protective factor of UC-CRC.

Conclusions

The period prevalence of CRC was lower than that reported from the West. However, the cumulative risk was found to be comparable to that of Western countries, which suggests that the period prevalence of UC-CRC in China may be growing in the future.

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Authors and Affiliations

  1. Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, People’s Republic of China

    Wei Gong, Ye Chen & Bo Jiang

  2. Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, People’s Republic of China

    Nonghua Lv

  3. Department of Gastroenterology, The General Hospital of Tianjin Medical University, Tianjin, 300052, People’s Republic of China

    Bangmao Wang

  4. Department of Gastroenterology, The First Affiliated Hospital of Inner Mongolia Medical Collage, Hohhot, 100050, Inner Mongolia, People’s Republic of China

    Yinglong Huang

  5. Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University, Hangzhou, 310009, Zhejiiang, People’s Republic of China

    Wenshen Pan

Authors

  1. Wei Gong

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  2. Nonghua Lv

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  3. Bangmao Wang

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  4. Ye Chen

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  5. Yinglong Huang

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  6. Wenshen Pan

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  7. Bo Jiang

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Corresponding author

Correspondence to Bo Jiang.

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Gong, W., Lv, N., Wang, B. et al. Risk of Ulcerative Colitis-Associated Colorectal Cancer in China: A Multi-Center Retrospective Study. Dig Dis Sci 57, 503–507 (2012). https://doi.org/10.1007/s10620-011-1890-9

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  • Received: 19 November 2010

  • Accepted: 17 August 2011

  • Published: 22 September 2011

  • Issue Date: February 2012

  • DOI: https://doi.org/10.1007/s10620-011-1890-9

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