Emerging Role of Human Basophil Biology in Health and Disease - Current Allergy and Asthma Reports
- ️Huston, David P.
- ️Wed Dec 18 2013
Papers of particular interest, published recently, have been highlighted as • Of Importance
Chirumbolo S. State-of-the-art review about basophil research in immunology and allergy: is the time right to treat these cells with the respect they deserve? Blood Transfus. 2012;10:148–64.
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Sokol CL, Chu NQ, Yu S, et al. Basophils function as antigen-presenting cells an allergen-induced T helper type 2 response. Nat Immunol. 2009;10:713–20.
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Kim S, Prout M, Ramshaw H, et al. Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3. J Immunol. 2010;184:1143–7.
Galli SJ, Franco CB. Basophils are back! Immunity. 2008;28:495–7.
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Min B. Basophils: what they ‘can do’ versus what they ‘actually do’. Nat Immunol. 2008;9:1333–9.
Min B. Basophils induce Th2 immunity: is this final answer? Virulence. 2010;1:399–401.
Sokol CL, Barton GM, Farr AG, Medzhitov R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol. 2007;9:310–8.
Chen K, Xu W, Wilson M, et al. Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell–stimulating programs in basophils. Nat Immunol. 2009;10:889–98.
Charles N, Hardwick D, Daugas E, et al. Basophils and the T helper 2 environment can promote the development of lupus nephritis. Nat Med. 2010;16(6):701–7. This was the first report potentially linking basophils to the pathogenesis of autoimmune lupus nephritis.
Warde N. Activated basophils exacerbate lupus nephritis by amplifying production of autoreactive IgE. Nat Rev Rheumatol. 2010;6(8):438.
Schuerwegh JM, Ioan-Facsinay A, Dorjee AL, et al. Evidence for a functional role of IgE anticitrullinated protein antibodies in rheumatoid arthritis. PNAS. 2010;107:2586–91. This article provides the first evidence for the potential role of basophils in rheumatoid arthritis.
Anyan WK, Kumagi T, Shimogawara RF, et al. Schistosome eggs have a direct role in the induction of basophils capable of a high level of IL-4 production: comparative study of single- and bisexual infection of Schistosoma mansoni in vivo. Trop Med Health. 2010;38(1):13–22.
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Cerny-Reiterer S, Ghanim V, Hoermann G, et al. Identification of basophils as a major source of hepatocyte growth factor in chronic myeloid leukemia: a novel mechanism of BCR-ABL1 – independent disease progression. Neoplasia. 2012;14(7):572–84.
Yasuda H, Aritaka N, Ando J, et al. Chronic myelogenous leukemia with mild basophilia as the predominant manifestation at presentation. Intern Med. 2011;50:501–2.
Bain BJ, Heller M. Dysplastic basophils in the accelerated phase of chronic myelogenous leukemia. Am J Hematol. 2011;86:949.
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Rudman SM, Josephs DH, Cambrook H, et al. Harnessing engineered antibodies of the IgE class to combat malignancy: initial assessment of FcєRI-mediated basophil activation by a tumour- specific IgE antibody to evaluate the risk of type I hypersensitivity. Clin Exp Allergy. 2011;41:1400–13.
A Study of CSL362 in Patients With CD123+ Acute Myeloid Leukemia Currently in Remission. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000 –Available from: http://www.clinicaltrials.gov/ct2/show/NCT01632852?term=CD123&rank=1 NLM Identifer: NCT01632852. This proposed clinical trial is the first to target CD123, and may establish a future therapy for myeloid leukemia treatment.
Meno KH. Allergen structures and epitopes. Allergy. 2011;66:19–21.
Saini SS, MacGlashan Jr DW. Assessing basophil functional measures during monoclonal anti-IgE therapy. J Immunol Methods. 2012;383:60–4.
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Wakahara K, Baba N, Van VQ, et al. Human basophils interact with memory T cells to augment Th17 responses. Blood. 2012;120:4761–71.
Wada T, Ishiwata K, Koseki H, et al. Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks. J Clin Invest. 2010;120:2867–75.
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Siracusa MC, Tait Wojno ED, Artis D. Functional heterogeneity in the basophil cell lineage. Adv Immunol. 2012;115:141–59. This article provides insight into potential heterogeneity in basophil development.
Stone KD, Prussin C, Metcalfe DD. IgE, mast cells, basophils, and eosinophils. J Allergy Clin Immunol. 2010;125(2):S73–80.
Charles N, Dema B, Rivera J. Reply to: basophils from humans with systemic lupus erythematosus do not express MHC-II. Nat Med. 2012;18:489–90.
Ford LS, Bloom KA, Nowak-Wegrzyn AH, et al. Basophil reactivity, wheal size, and immunoglobulin levels distinguish degrees of cow’s milk tolerance. J Allergy Clin Immunol. 2013;131:180–6.
MacGlashan Jr D. Expression of CD203c and CD63 in human basophils: relationship to differential regulation of piecemeal and anaphylactic degranulation processes. Clin Exp Allergy. 2010;40:1365–77.
Crivellato E, Beatrice N, Ribatti D. The history of the controversial relationship between mast cells and basophils. Immunol Lett. 2011;141(1):10–7.
Kleine-Tebbe J, Erdmann S, Knol EF, et al. Diagnostic tests based on human basophils: potentials, pitfalls and perspectives. Int Arch Allergy Immunol. 2006;141:79–90.
Bieneman AP, Chichester KL, Chen YH, Schroeder JT. Toll-like receptor 2 ligands activate human basophils for both IgE-dependent and IgE-independent secretion. J Allergy Clin Immunol. 2005;115:295–301.
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Tedeschi A, Salmaso C, Di Donato M, et al. Granulocyte-macrophage colony-stimulating factor and interleukin-3 cause basophil histamine release by a common pathway: downregulation by sodium. Immunology. 1999;96:164–70.
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Komiya A, Nagase H, Okugawa S, et al. Expression and function of toll-like receptors in human basophils. Allergy Immunol. 2006;140 suppl 1:23–7.
Smithgall MD, Comeau MR, Yoon B, et al. IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK Cells. Int Immunol. 2008;20(8):1019–30.
Watanabe T, Yamashita K, Sakurai T, et al. Toll-like receptor activation in basophils contributes to the development of IgG4-related disease. J Gastroenterol. 2012;48(2):247–53.
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Lantz CS, Min B, Tsai M, et al. IL-3 is required for increases in blood basophils in nematode infection in mice and can enhance IgE-dependent IL-4 production by basophils in vitro. Lab Investig. 2008;88:1134–42.
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Verweij MM, Sabato V, Nullens S, et al. STAT5 in human basophils: IL-3 is required for its FcεRI-mediated phosphorylation. Clin Cytom. 2012;82B:101–6.
Pecaric-Petkovic T, Didichenko SA, Kaempfer S, et al. Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33. Blood. 2009;113:1526–34.
Cady CT, Powell MS, Harbeck RJ, et al. IgG antibodies produced during subcutaneous allergen immunotherapy mediate inhibition of basophil activation via a mechanism involving both FcγRIIA and FcγRIIB. Immunol Lett. 2010;130:57–65.
Patella V, Florio G, Petraroli, Marone G. HIV-1 gp120 induces IL-4 and IL-13 release from human Fc epsilon RI+ cells through interaction with the VH3 region of IgE. J Immunol. 2000;164:589–95.
Chen K, Cerutti A. The function and regulation of immunoglobulin D. Curr Opin Immunol. 2011;23(3):345–52.
Kroeger KM, Sullivan BM, Locksley RM. IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38alpha-dependent pathway. J Leuko Biol. 2009;86:769–78.
Seok J, Shaw Warren H, Cuenca AG, et al. Genomic responses in mouse models poorly mimic human inflammatory diseases. PNAS. 2013;110:3507–12. Evidence was presented that the current mouse model for inflammatory diseases may not be appropriate for translation to understanding human disease.
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Tsujimura Y, Obata K, Mukai K, et al. Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. Immunity. 2008;2:581–9.
Steiner M, Harrer A, Lang R, et al. Basophil activation test for investigation of IgE-mediated mechanisms in drug hypersensitivity. J Visualized Exp. 2011;55:1–6.
Chirumbolo S. Basophil activation test to optimize the diagnosis of adverse effects following immunization to vaccines. Iran J Asthma Immunol. 2013;12:196–202.
Macglashan Jr DW. Basophil activation testing. J Allergy Immunol. 2013;132(4):777–87. This review discusses the potential of BAT to assess functional changes in basophils.
De Weck AL, Sanz ML, Gamboa PM, et al. Diagnostic tests based on human basophils: more potentials and perspectives than pitfalls. Int Allergy Immunol. 2008;146:177–89.
Khan FM, Ueno-Yamanouchi A, Serushago B, et al. Basophil activation test compared to skin prick test and fluorescence enzyme immunoassay for aeroallergen-specific Immunoglobulin-E. Allergy Clin Immunol. 2012;8:1–13.
Savage JH, Courneya JP, Sterba PM, et al. Kinetics of mast cell, basophil, and oral food challenge responses in omalizumab-treated adults with peanut allergy. J Allergy Clin Immunol. 2012;130:1123–9. Provided here is the application of omalizumab and its effects in modulating immune response to allergy challenge.
Blank S. Components and mechanisms in diagnosis and therapy of hymenoptera venom allergy. University Dissertation - Hamburg. 2009;1–70.
Konstantinou GN, Asero R, Ferrer M, et al. EAACI taskforce position paper: evidence for autoimmune urticaria and proposal for defining diagnostic criteria. Allergy. 2013;68:27–36. Urticaria as an autoimmune disorder involving basophils is discussed.
Gentinetta T, Pecaric-Petkovic T, Wan D, et al. Individual IL-3 priming is crucial for consistent in vitro activation of donor basophils in patients with chronic urticaria. J Allergy Clin Immunol. 2011;128:1227–34.
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Kepley CL, McFeeley PJ, Oliver JM, Lipscomb MF. Immunohistochemical detection of human basophils in postmortem cases of fatal asthma. Am J Resp Crit Care Med. 2011;164:1053–8.
Siracusa MC, Kim BS, Spergel JM, Artis D. Basophils and allergic inflammation. J Allergy Clin Immunol. 2013;132:789–801. This review encapsulates many functions of basophils in allergy but is skewed to mouse biology.
Botturi K, Langelot M, Lair D, et al. Preventing asthma exacerbations: what are the targets? Pharmacol Ther. 2011;131(1):114–29.
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Wong S, McLaughlin J, Cheng D, et al. IL-3 receptor signaling is dispensable for BCR-ABL-induced myeloproliferative disease. Proc Natl Acad Sci U S A. 2003;100(20):11630–5.
Noti M, Tait Wojno ED, Kim BS, et al. Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis. Nat Med. 2013;19:1005–13.
Roan F, Bell BD, Stoklasek TA, et al. The multiple facets of thymic thromal lymphopoietin (TSLP) during allergic inflammation and beyond. J Leukoc Biol. 2012;91(6):1–10.
Bogiatzi SI, Guillot-Delost M, Cappuccio A, et al. Multiple-checkpoint inhibition of thymic stromal lymphopoietin – induced TH2 response by TH17-related cytokines. J Allergy Clin Immunol. 2012;1:233–40.