Cutting-Edge Issues in Celiac Disease and in Gluten Intolerance - Clinical Reviews in Allergy & Immunology
- ️Tonutti, E.
- ️Thu Dec 23 2010
Catassi C, Ratsch IM, Fabiani E et al (1994) Coeliac disease in the year 2000: exploring the iceberg. Lancet 343:200–203
Rostom A, Murray JA, Kagnoff MF (2006) American Gastroenterological Association (AGA) Institute technical review on the diagnosis and management of celiac disease. Gastroenterology 131:1981–2002
Rostom A, Dubè C, Cranney A et al (2005) The diagnostic accuracy of serological test for celiac disease: a systematic review. Gastroenterology 128:S38–S46
Not T, Horvath K, Hill ID et al (1998) Celiac disease risk in the USA: high prevalence of antiendomysium antibodies in healthy blood donors. Scand J Gastroenterol 33:494–498
Dieterich W, Laag E, Schopper H et al (1998) Autoantibodies to tissue transglutaminase as predictors of celiac disease. Gastroenterology 115:1317–1321
Tonutti E, Visentini D, Bizzaro N et al (2003) The role of anti-tissue transglutaminase assay for the diagnosis and monitoring of coeliac disease: a French–Italian multicentre study. J Clin Pathol 56:389–393
Mustalahti K, Catassi C, Reunanen A, Coeliac EU Cluster, Project Epidemiology et al (2010) The prevalence of celiac disease in Europe: results of a centralized, international mass screening project. Ann Med 42:587–595
Catassi C, Kryszak D, Bhatti B et al (2010) Natural history of celiac disease autoimmunity in a USA cohort followed since 1974. Ann Med 42:530–538
Lohi S, Mustalahti K, Kaukinen K et al (2007) Increasing prevalence of coeliac disease over time. Aliment Pharmacol Ther 26:1217–1225
Kurrpa K, Ashorn M, Iltanen S et al (2010) Celiac disease without villous atrophy in children: a prospective study. J Pediatr 157(3):378.e1–380.e1
Hill ID, Dirks MH, Liptak GS et al (2005) Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Ped Gastroenterol Nutr 40:1–19
Sjostrom H, Lundin KEA, Molberg O et al (1998) Identification of a gliadin T cell epitope in coeliac disease: general importance of gliadin deamidation for intestinal T recognition. Scand J Immunol 48:111–115
Molberg O, McAdam SN, Korner R et al (1998) Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease. Nat Med 4:713–717
Aleanzi M, Demonte AM, Esper C, Garcilazo S, Waggener M (2001) Celiac disease: antibody recognition against native and selectively deamidated gliadin peptides. Clin Chem 47:2023–2028
Schwertz E, Kahlenberg F, Sack U et al (2004) Serological assay based on gliadin-related nonapeptides as a highly sensitive and specific diagnostic aid in celiac disease. Clin Chem 50:2370–2375
Sugai E, Vazquez H, Nachman F et al (2006) Accuracy of testing for antibodies to synthetic gliadin-peptides in celiac disease. Clin Gastroenterol Hepatol 4:1112–1117
Kaukinen K, Collin P, Laurila K, Kaartinen T, Partanen J, Maki M (2007) Resurrection of gliadin antibodies in coeliac disease. Deamidated gliadin peptide antibody test provides additional diagnostic benefit. Scand J Gastroenterol 42:1428–1433
Niveloni S, Sugai E, Cabanne A, Vazquez H, Argonz J, Smecuol E et al (2007) Antibodies against synthetic deamidated gliadina peptides as predictors of celiac disease: prospective assessment in an adult population with a high pretest probability of disease. Clin Chem 53:2186–2192
Carlsson AK, Axelsson IE, Borulf SK et al (2001) Serological screening for celiac disease in healthy 2.5-year-old children in Sweden. Pediatrics 107:42–45
Lagerqvist C, Dahlbom I, Hansson T et al (2008) Antigliadin immunoglobulin A best in finding celiac disease in children younger than 18 months of age. J Ped Gastroenterol Nutr 47:428–435
Maglio M, Tosco A, Paparo F et al (2010) Serum and intestinal celiac disease-associated antibodies in children with celiac disease younger than 2 years of age. J Ped Gastroenterol Nutr 50:43–48
Simell S, Kupila A, Hoppu S et al (2005) Natural history of transglutaminase autoantibodies and mucosal changes in children carrying HLA-conferred celiac disease susceptibility. Scand J Gastroenterol 40:1182–1191
Liu E, LI M, Emery L, Taki I, Barriga K, Tiberti C et al (2007) Natural history of antibodies to deamidated gliadin peptides and transglutaminase in early childhood celiac disease. J Ped Gastroenterol Nutr 45:293–300
Agardh D (2007) Antibodies against synthetic deamidated gliadin peptides and tissue transglutaminase for the identification of childhood celiac disease. Clin Gastroenterol Hepatol 5:1276–1281
Basso D, Guariso G, Fogar P et al (2009) Antibodies against synthetic deamidated gliadin peptides for celiac disease diagnosis and follow-up in children. Clin Chem 55:150–157
Naiyer AJ, Hernandez L, Ciaccio EJ et al (2009) Comparison of commercially available serologic kits for the detection of celiac disease. J Clin Gastroenterol 43:225–232
Villalta D, Alessio MG, Tampoia M et al (2007) Testing for IgG class antibodies in celiac disease patients with selective IgA deficiency. A comparison of the diagnostic accuracy of 9 IgG anti-tissue transglutaminase, 1 IgG anti-gliadin and 1 IgG anti-deamidated gliadin peptide antibody assays. Clin Chim Acta 382:95–99
Tozzoli R, Kodermaz G, Tampoia M, Visentini D, Tonutti E, Bizzaro N (2010) [Detection of autoantibodies specific for transglutaminase-gliadin peptides complex: a new way to explore the celiac iceberg?] It. J Lab Med 6:28–35
Clemente MG, Musu MP, Frau F et al (2000) Immune reaction against the cytoskeleton in celiac disease. Gut 47:520–526
Clemente MG, Musu MP, Troncone R et al (2004) Enterocyte actin antibody detection: a new diagnostic tool in celiac disease diagnosis. Results of a multicenter study. Am J Gastroenterol 99:1551–1556
Granito A, Muratori P, Cassani F et al (2004) Anti-actin IgA antibodies in severe coeliac disease. Clin Exp Immunol 137:386–392
Carroccio A, Brusca I, Iacono G et al (2005) Anti-actin antibodies in celiac disease: correlation with intestinal mucosa damage and comparison of ELISA with the immunofluorescence assay. Clin Chem 51:917–920
Carroccio A, Brusca I, Iacono G et al (2007) IgA anti-actin antibodies ELISA in coeliac disease: a multicentre study. Dig Liver Dis 39:818–823
Tonutti E, Visentini D, Picierno A et al (2009) Diagnostic efficacy of the ELISA test for the detection of deamidated anti-gliadin peptide antibodies in the diagnosis and monitoring of celiac disease. J Clin Lab Anal 23:165–171
Villalta D, Tonutti E, Prause C et al (2010) IgG antibodies against deamidated gliadin peptides for diagnosis of celiac disease in patients with IgA deficiency. Clin Chem 56:464–468
Volta U, Fabbri A, Parisi C (2010) Deamidated gliadin peptide antibodies as a routine test for celiac disease: a prospective analysis. J Clin Gastroenterol 44:186–190
Tursi A, Brandimarte G, Giorgietti GM et al (2006) Endoscopic and histological findings in the duodenum of adults with celiac disease before and after changing to a gluten-free diet: a 2-year prospective study. Endoscopy 38:702–707
Biagi F, Pezzimenti D, Campanella J, Vadacca GB, Corazza GR (2001) Endomysial and tissue transglutaminase antibodies in coeliac sera: a comparison not influenced by previous serological testing. Scand J Gastroenterol 36:955–958
Lock RJ, Stevens S, Pitcher MC, Unsworth DJ (2004) Is immunoglobulin A anti-tissue transglutaminase antibody a reliable serological marker of coeliac disease? Eur J Gastroenterol Hepatol 16:467–470
Baudon JJ, Johanet C, Absalon YB, Morgant G, Cabrol S, Mougenot JF (2004) Diagnosing celiac disease: a comparison of human tissue transglutaminase antibodies with antigliadin and antiendomysium antibodies. Arch Pediatr Adolesc Med 158:584–588
Tonutti E, Bizzaro N, Villalta D, Tozzoli R, Tampoia M (2009) Laboratory diagnosis of coeliac disease. Autoimmun Highlights 0:15–21
Visser J, Rozing J, Sapone A, Lammers K, Fasano A (2009) Tight junctions, intestinal permeability, and autoimmunity. Celiac disease and type 1 diabetes paradigms. Ann NY Acad Sci 1165:195–205
Fleckenstein B, Qiao SW, Larsen MR, Jung G, Roepstorff P, Sollid LM (2004) Molecular characterization of covalent complexes between tissue transglutaminase and gliadin peptides. J Biol Chem 79:17607–17616
Ciccocioppo R, Di Sabatino A, Ara C et al (2003) Gliadin and tissue transglutaminase complexes in normal and coeliac duodenal mucosa. Clin Exp Immunol 134:516–524
Mattias T, Pfeiffer S, Selmi C, Gershwin ME (2010) Diagnostic challenges in celiac disease and the role of the tissue transglutaminase-neo-epitope. Clin Rev Allergy Immunol 38:298–301
Pinkas DM, Strop P, Brunger AT, Khosla C (2007) Transglutaminase 2 undergoes a large conformational change upon activation. PLoS Biol 5:2788–2796
Remes-Troche JM, Ramirez-Iglesias MT, Rubio-Tapia A, Alonso-Ramos A, Velazquez A, Uscanga LF (2006) Celiac disease could be a frequent disease in Mexico: prevalence of tissue transglutaminase antibody in healthy blood donors. J Clin Gastroenterol 40:697–700
Remes-Troche JM, Rios-Vaca A, Ramirez-Iglesias MT et al (2008) High prevalence of celiac disease in Mexican Mestizo adults with type 1 diabetes mellitus. J Clin Gastroenterol 42:460–465
Tozzoli R, Kodermaz G, Porcelli B, et al. (2010) Clinical relevance and diagnostic accuracy of a new ELISA method for the detection of autoantibodies to the gliadin-transglutaminase complex. Proceedings of the 7th International Congress on Autoimmunity, Liubljana, 5–9 May 2010
Tonutti E, Visentini D, Fabris M, et al. (2010) Antibodies to the transglutaminase–deamidated gliadin peptides complex: a new serological approach to the diagnosis of celiac disease. Proceedings of the 7th International Congress on Autoimmunity, Ljubljana, 5–9 May 2010
Reeves GEM, Squance ML, Duggan AE et al (2006) Diagnostic accuracy of celiac serological tests: a prospective study. Eur J Gastroenterol Hepatol 18:493–501
Catassi C, Fasano A (2008) Celiac disease. Curr Opin Gastroenterol 24:687–691
Anderson LA, McMillan S, Watson RG et al (2007) Maligancy and mortality in a population-based color of patients with coeliac disease or ‘gluten sensitivity’. World J Gastroenterol 13:146–151
Kaukinen K, Tujanmmaa K, Mäki M et al (2000) Intolerance to cereals is not specific for celiac disease. Scand J Gastroenterol 35:942–946
Clemente MG, De Virgiliis S, Kang JS et al (2003) Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function. Gut 52:218–223
Sapone A, Lammers KM, Mazzarela G et al (2010) Differential mucosal IL-17 expression in two gliadin-induced disorders: gluten sensitivity and the autoimmune enteropathy celiac disease. Int Arch Allergy Immunol 152:75–80
Ferguson A, Gillett H, Humphreys K, Kingstone K (1998) Heterogeneity of celiac disease: clinical, pathological, immunological, and genetic. Ann NY Acad Sci 859:112–120
Catassi C, Fasano A (2008) Is this really celiac disease? Pitfalls in diagnosis. Curr Gastroenterol Rep 10:466–472
Fabris M, Visentini D, Da Re V et al (2007) Elevated B cell-activating factor of the tumor necrosis factor family in coeliac disease. Scand J Gastroenterol 42:1434–1439
Fabris M, De Vita S, Visentini D et al (2009) B-Lymphocyte stimulator and a proliferation-inducing ligand serum levels in IgA-deficient patients with and without celiac disease. Ann NY Acad Sci 1173:268–273
Sapone A, Giuliano MT, Cammarota M et al (2009) Gluten sensitivity is associated to activation of the innate but not adaptive immune response to gluten exposure. Gastroenterology 136(1):5–413
Hadjivassiliou M, Chattopadhyay AK, Grünewald RA et al (2007) Myopathy associated with gluten sensitivity. Muscle Nerve 35:443–450
Ford RPK (2009) The gluten syndrome: a neurological disease. Med Hypotheses 73:438–440
Elder JH (2008) The gluten-free, casein-free diet in autism: an overview with clinical implication. Nutr Clin Pract 23:583–588
Dikerson F, Stallings C, Origoni A et al (2010) Markers of gluten sensitivity and celiac disease in recent-onset psychosis and multi-episode schizophrenia. Biol Psychiatry 68:100–104
Verdu EF, Armstrong D, Murray JA (2009) Between celiac disease and irritable bowel syndrome: the “non man’s land” of gluten sensitivity. Am J Gastroenterol 104:1587–1594
Meresse B, Cerf-Bensussan N (2009) Innate T cell responses in human gut. Semin Immunol 21:121–129
Palmer E (2007) The generation of T cell tolerance. Swiss Med Wkly 137(suppl 155):99S–100S
Maiuri L, Ciacci C, Ricciardelli I et al (2003) Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease. Lancet 362:30–37
Londei M, Ciacci C, Ricciardelli I et al (2005) Gliadin as stimulator of innate responses in celiac disease. Mol Immunol 42:913–918
Schuppan D, Junker Y, Barisani D et al (2009) Celiac disease: from pathogenesis to novel therapies. Gastroenterol 137:912–933
Meresse B, Verdier J, Cerf-Bensussan N (2008) The cytokine interleukin 21: a new player in coeliac disease? Gut 57:879–881
De la Concha EG, Fernandez-Arquero M, Vigil P et al (2000) Celiac disease and TNF promoter polymorphism. Hum Immunol 61:513–517
Maki M, Collin P (1997) Coeliac disease. Lancet 349:200–203
Uibo O, Lambrechts A, Mascart-Lemone F (1995) Human oesophagus: a convenient antigenic substrate for the autoantibodies in the serological diagnosis of coeliac disease. Eur J Gastroenterol Hepatol 7:37–40
Catassi C (2005) Where is celiac disease coming from and why? J Pediatr Gastroenterol Nutr 40:279–282
Schuppan D (2000) Current concepts of celiac disease pathogenesis. Gastroenterology 119:234–242
Salvati VM, Mac Donald TT, Bajaj-Elliott M et al (2002) Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease. Gut 50:186–190
Przemioslo RT, Lundin KEA, Sollid LM, Nelufer J, Ciclitira PJ (1995) Histological changes in small bowel mucosa induced by gliadin sensitive T lymphocytes can be blocked by anti-interferon antibody. Gut 36:874–879
Leon AJ, Garrote JA, Blanco-Quiros A et al (2006) Interleukin 18 maintains a long-standing inflammation in coeliac disease patients. Clin Exp Immunol 146:479–485
De Nitto D, Monteleone I, Franzè E, Pallone F, Monteleone G (2009) Involvement of interleukin-15 and interleukin-21, two gamma-chain-related cytokines, in celiac disease. World J Gastroenterol 15:4609–4614
Garrote JA, Gomez-Gonzales E, Bernardo D, Arranz E, Chirdo F (2008) Celiac disease pathogenesis: the proinflammatory cytokine network. J Pediatr Gastroenterol Nutr 47:27–32
Mackay F, Mackay CR (2002) The role of BAFF in B-cell maturation, T-cell activation and autoimmunity. Trends Immunol 23:113–115
Mackay F, Woodcock SA, Lawton P et al (1999) Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J Exp Med 190:1697–1710
Sthol W (2002) B lymphocyte stimulator protein levels in systemic lupus erythematosus and other diseases. Curr Rheumatol Resp 4:345–350
Seyler TM, Park YW, Takemura S et al (2005) BLyS and APRIL in rheumatoid arthritis. J Clin Invest 115:3083–3092
Mariette X, Roux S, Zhang J et al (2003) The level of BLyS (BAFF) correlates with the titre of autoantibodies in human Sjogren’s syndrome. Ann Rheum Dis 62:168–171
Fabris M, Quartuccio L, Sacco S et al (2007) B-lymphocyte simulator (BLys) up-regulation in mixed cryoglobulinaemia syndrome and hepatitis-C virus infection. Rheumatology 46:37–43
Nardelli B, Belvedere O, Roschke V et al (2001) Synthesis and release of B-lymphocyte stimulator from myeloid cells. Blood 97:198–204
Batten M, Groom J, Cachero TG et al (2000) BAFF mediates survival of peripheral immature B lymphocytes. J Exp Med 192:1453–1466
Daum S, Bauer U, Foss HD et al (1999) Increased expression of mRNA for matrix metalloproteases-1 and -3 and tissue inhibitor of metalloproteases-1 in intestinal biopsy specimens from patients with celiac disease. Gut 44:17–25
Westerholm-Ormio M, Garioch J, Ketola I, Savilahti E (2002) Inflammatory cytokines in small intestinal mucosa of patients with potential celiac disease. Clin Exp Immunol 128:94–101
Penedo-Pita M, Peteiro-Cartelle J (1991) Increased serum levels of interleukin-2 and soluble interleukin-2 receptor in celiac disease. J Pediatr Gastroenterol Nutr 12:50–60
Bianco A, Garrote JA, Arranz E, Alfonso M, Clavo C (2002) Increased serum IL-2R levels in coeliac disease are related to CD4 but not CD8 antigens. J Pediatr Gastroenterol Nutr 15:413–417
Cinova J, Pavlova-Jelinkova L, Smythies LE et al (2007) Gliadin peptides activate blood monocytes from patients with celiac disease. J Clin Immunol 27:201–209
Manavalan JS, Hernandez L, Shah JG et al (2010) Serum cytokine elevations in celiac disease: association with disease presentation. Hum Immunol 71:50–57