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Interaction Between the Antinociceptive Effect of Ketoprofen and Adrenergic Modulatory Systems - Inflammation

  • ️Miranda, H. F.
  • ️Wed Aug 01 2001

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References

  1. Mauleon, D., R. Artigas, M. L García, and G. Carganico. 1996. Preclinical and clinical development of dexketoprofen. Drugs 52(Suppl. 5):24–46.

    Google Scholar 

  2. Ghezzi, P., G. Melillo, C. Meazza, C. Sacco, L. Pellegrini, C. Asti, S. Porzio, A. Marullo, V. Sabbatini, G. Caselli, and R. Bertini. 1998. Differential contribution of R and S isomers in ketoprofen anti-inflammatory activity: role of cytokine modulation. J. Pharmacol. Exp. Ther. 287:969–974.

    Google Scholar 

  3. Handley, D. A., P. Cervoni, J. E. McCray, and J. R. McCullough. 1998. Preclinical enantioselective pharmacology of (R)-and (S)-kerotolac. J. Clin. Pharmacol. 38(Suppl. 2):25S–35S.

    Google Scholar 

  4. Veys, E. M. 1991. 20 years experience with ketoprofen. Scand. J. Rheumatol. 90:1–44.

    Google Scholar 

  5. Papich, M. G. 1997. Principles of analgesic drug therapy. Semin. Vet. Med. Surg. (Small Anim.) 12:80–93.

    Google Scholar 

  6. Herrero, J. F., A. Parrado, and F. Cervero. 1997. Central and peripheral actions of the NSAID ketoprofen on spinal cord nociceptive reflexes. Neuropharmacology 36:1425–1431.

    Google Scholar 

  7. De Beaurepaire, R., C. Suaudeau, A. Chait, and C. Cimetiere. 1990. Anatomical mapping of brain sites involved in the antinociceptive effects of ketoprofen. Brain Res. 536:201–206.

    Google Scholar 

  8. Braga, P. C. Ketoprofen i.c.v. injection and electrophysiological aspects of antinociceptive effect. Eur. J. Pharmacol. 184:273–280.

  9. Bustamante, D., C. Paeile, J. C. Willer, and D. Le Bars. 1997. Effects of intrathecal or intracerebroventricular administration of nonsteroidal anti-inflammatory drugs on a C-fiber reflex in rats. J. Pharmacol. Exp. Ther. 281:1381–1391.

    Google Scholar 

  10. Miranda, H. F., F. Sierralta, and G. Pinardi. 1993. Previous administration of indomethacin or naloxone did not influence ketorolac antinociception in mice. Anesth. Analg. 77:750–753.

    Google Scholar 

  11. Hylden, J. L. K., and G. L. Wilcox. 1980. Intrathecal morphine in mice: a new technique. Eur. J. Pharmacol. 67:313–316.

    Google Scholar 

  12. Tallarida, R. J., F. Porreca, and A. Cowan. 1989. Statistical analysis of drug-drug and site-site interactions with isobolograms. Life Sci. 45:947–961.

    Google Scholar 

  13. Pinardi, G., T. Pelissier, and H. F. Miranda. 1998. Interactions in the antinociceptive effect of tramadol in mice: an isobolographic analysis. Eur. J. Pain 2:343–350.

    Google Scholar 

  14. Tallarida, R. J., and R. B. Murray. 1987. Manual of Pharmacological Calculations With Computer Programs. Springer-Verlag, New York.

    Google Scholar 

  15. Millan, M. J. 1997. The role of descending noradrenergic and serotonergic pathways in the modulation of nociception: focus on receptor multiplicity. In: The Pharmacology of Pain. Dickenson, A., Besson, J. M., Eds. Springer-Verlag, Berlin, 387–446.

    Google Scholar 

  16. Besson, J-M., and A. Chaouch. 1987. Peripheral and spinal mechanisms of antinociception. Pharmacol. Rev. 67:67–186.

    Google Scholar 

  17. Howe, J. R., J-Y. Wang, and P. L. Yaksh. 1983. Selective antagonism of the antinociceptive effect of intrathecally applied alpha adrenergic agonists by intrathecal prazosin and intrathecal yohimbine. J. Pharmacol. Exp. Ther. 224:552–558.

    Google Scholar 

  18. Tasker, R. A., B. J. Connell, and M. J. Yole. 1992. Systemic injections of alpha-1 adrenergic agonists produce antinociception in the formalin test. Pain 49:383–391.

    Google Scholar 

  19. Fürst, S. 1999. Transmitters involved in antinociception in the spinal cord. Brain Res. Bull. 48:129–141.

    Google Scholar 

  20. Buerkle, H., and T. L. Yaksh. 1998. Pharmacological evidence for different alpha 2-adrenoceptor receptor sites mediating analgesia and sedation in the rat. Br. J. Anaesth. 81:208–215.

    Google Scholar 

  21. Galeotti, N., C. Ghelardini, M. C. Vinci, and A. Bartolini. 1999. Role of potassium channel in the antinociception induced by agonists of alpha2-adrenoceptors. Br. J. Pharmacol. 126:1214–1220.

    Google Scholar 

  22. Reimann, W., H. Schultz, and N. Selve. 1999. The antinociceptive effects of morphine, desipramine and serotonin and their combinations after intrathecal injection in the rat. Anesth. Analg. 88:141–145.

    Google Scholar 

  23. Solomon, R. E., and Gebhart, G. F. 1994. Synergistic antinociceptive interactions among drugs administered to the spinal cord. Anesth. Analg. 78:1164–1172.

    Google Scholar 

  24. Tjolsen, A., A. Lund, and K. Hole. 1990. The role of descending noradrenergic systems in regulation of nociception: the effects of intrathecally administered alpha-adrenoceptor antagonists and clonidine. Pain 43:113–120.

    Google Scholar 

  25. Kanui, T. I., A. Tjolsen, A. Lund, N. Mjellem-Joly, and K. Hole. 1993. Antinociceptive effects of intrathecal administration of alpha adrenoceptor antagonists and clonidine in the formalin test in the mouse. Neuropharmacology 32:367–371.

    Google Scholar 

  26. Nicoll, R. A., R. C. Malenka, and J. A. Kauer. 1990. Functional comparison of neurotransmitter receptor subtypes in mammalian central nervous system. Physiol. Rev. 70:513–565.

    Google Scholar 

  27. Zhang, C., S. W. Yang, Y. G. Guo, J. T. Quiao, and N. Dafny, 1997. Locus coeruleus stimulation modeulates the nociceptive response in parafascicular neurons: an analysis of descending and ascending pathways. Brain Res. Bull. 42:273–278.

    Google Scholar 

  28. Hayes, A. G., M. Skingle, and M. B. Tyers. 1986. Antagonism of alpha-adrenoceptor agonist-induced antinociception in the rat. Neuropharmacology 25:397–402.

    Google Scholar 

  29. Aley, K. O., and J. D. Levine. 1997. Multiple receptors involved in peripheral alpha 2, mu and A1 antinociception, tolerance and withdrawal. J. Neurosci. 17:735–744.

    Google Scholar 

Download references