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Triclosan targets lipid synthesis - Nature

  • ️Levy, Stuart B.
  • ️Thu Aug 06 1998
  • Scientific Correspondence
  • Published: 06 August 1998

Nature volume 394, pages 531–532 (1998)Cite this article

Abstract

Triclosan is a broad-spectrum antibacterial and antifungal agent1,2, which acts by previously undetermined mechanisms, that is used in products such as antiseptic soaps, toothpastes, fabrics and plastics. Here we show that triclosan blocks lipid synthesis in Escherichia coli, and that mutations in, or overexpression of, the gene fabI (which encodes enoyl reductase, involved in fatty acid synthesis) prevents this blockage. This is, to our knowledge, the first evidence that triclosan acts on a specific bacterial target, rather than as a nonspecific ‘biocide’.

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Figure 1: Restriction map (partial) and triclosan resistance of pLYT8 and its deletion mutants.

References

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Authors and Affiliations

  1. Center for Adaptation Genetics and Drug Resistance, and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, 02111, Massachusetts, USA

    Laura M. McMurry, Margret Oethinger & Stuart B. Levy

Authors

  1. Laura M. McMurry

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  2. Margret Oethinger

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  3. Stuart B. Levy

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McMurry, L., Oethinger, M. & Levy, S. Triclosan targets lipid synthesis. Nature 394, 531–532 (1998). https://doi.org/10.1038/28970

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  • Issue Date: 06 August 1998

  • DOI: https://doi.org/10.1038/28970