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Detection of human papillomavirus DNA in anogenital neoplasias - Nature

  • ️Faras, Anthony J.
  • ️Thu Dec 23 1982
  • Letter
  • Published: 23 December 1982

Nature volume 300, pages 771–773 (1982)Cite this article

Abstract

The presence of papillomaviruses in epithelial-derived cancers from several animal species1–3 has led to the speculation that these viruses may also have a pathogenic role in the development of certain human carcinomas, particularly those associated with the anogenital tract4. Recently, human papillomavirus (HPV) DNA has been detected in epithelial-derived cancers, both cutaneous1,5 and metastatic5, from patients exhibiting the rare, chronic flat wart disease, epidermodysplasia verruciformis (EV). Except for patients exhibiting this chronic wart syndrome, the association of HPV genomes with human epithelial cancers has not been demonstrated6. In an attempt to delineate the association and possible involvement of papillomaviruses with human anogenital carcinomas, we have begun an analysis of these cancers for the presence of HPV-specific nucleotide sequences by using highly sensitive hybridization procedures capable of detecting distantly related papillomaviruses at low copy number. Here we demonstrate the presence of HPV DNA in several types of anogenital tumours: Bowenoid papulosis, carcinoma in situ, and verrucous carcinoma. These data indicate that HPV can be detected in several types of premalignant and malignant tumours, supporting the contention that this group of viruses may be involved in the development of certain types of human epithelial-derived cancers.

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Author information

Authors and Affiliations

  1. Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota, 55455, USA

    Karen R. Zachow, Ronald S. Ostrow, Susan Watts & Anthony J. Faras

  2. Department of Dermatology, University of Minnesota Medical School, Minneapolis, Minnesota, 55455, USA

    Mitchell Bender

  3. Department of Obstetrics and Gynecology, University of Minnesota Medical School, Minneapolis, Minnesota, 55455, USA

    Takashi Okagaki

  4. Laboratory of Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota, 55455, USA

    Takashi Okagaki

  5. Molecular Genetics, Inc., Minnetonka, Minnesota, 55343, USA

    Franklin Pass

Authors

  1. Karen R. Zachow

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  2. Ronald S. Ostrow

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  3. Mitchell Bender

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  4. Susan Watts

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  5. Takashi Okagaki

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  6. Franklin Pass

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  7. Anthony J. Faras

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Zachow, K., Ostrow, R., Bender, M. et al. Detection of human papillomavirus DNA in anogenital neoplasias. Nature 300, 771–773 (1982). https://doi.org/10.1038/300771a0

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  • Received: 11 August 1982

  • Accepted: 18 October 1982

  • Issue Date: 23 December 1982

  • DOI: https://doi.org/10.1038/300771a0