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Viral myb oncogene encodes a sequence-specific DNA-binding activity - Nature

  • ️Klempnauer, Karl-Heinz
  • ️Thu Oct 27 1988
  • Letter
  • Published: 27 October 1988

Nature volume 335, pages 835–837 (1988)Cite this article

Abstract

The retroviral oncogene v-myb and its cellular progenitor c-myb encode nuclear DNA-binding proteins1–5. Myb genes have been identified in a broad range of species, including vertebrates6–9, the fruit fly Drosophila melanogaster10,11 and the plant Zea mays12. The localization of the DNA-binding domain of the v-MYB protein to the highly conserved amino-terminal region11,13 suggests that the MYB/DNA interaction is important for MYB function. We show here that v-MYB specifically recognizes the nucleotide sequence pyAACG/TG. So like other nuclear transforming proteins, v-MYB seems to be a member of the class of sequence-specific DNA-binding factors presumably involved in gene regulation.

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Author information

Author notes

  1. Uwe Borgmeyer

    Present address: Howard Hughes Medical Institute, Gene Expression Laboratory, The Salk Institute for Biological Studies, PO Box 85800, San Diego, California, 92138, USA

Authors and Affiliations

  1. Zentrum für Molekulare Biologic der Universität Heidelberg, Im Neuenheimer Feld 282, D–6900, Heidelberg, FRG

    Horst Biedenkapp, Uwe Borgmeyer, Albrecht E. Sippel & Karl-Heinz Klempnauer

Authors

  1. Horst Biedenkapp

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  2. Uwe Borgmeyer

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  3. Albrecht E. Sippel

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  4. Karl-Heinz Klempnauer

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Biedenkapp, H., Borgmeyer, U., Sippel, A. et al. Viral myb oncogene encodes a sequence-specific DNA-binding activity. Nature 335, 835–837 (1988). https://doi.org/10.1038/335835a0

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  • Received: 21 July 1988

  • Accepted: 19 September 1988

  • Issue Date: 27 October 1988

  • DOI: https://doi.org/10.1038/335835a0