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RNA editing in wheat mitochondria results in the conservation of protein sequences - Nature

  • ️Grienenberger, Jean-Michel
  • ️Thu Oct 19 1989
  • Letter
  • Published: 19 October 1989

Nature volume 341, pages 660–662 (1989)Cite this article

Abstract

RNA editing is a process that results in the production of a messenger RNA with nucleotide sequences that differ from those of the template DNA1, and provides another mechanism for modulating gene expression. The phenomenon was initially described in the mitochondria of protozoa2, 3. Here we report that RNA editing is also required for the correct expression of plant mitochondria! genes. It has previously been proposed that in plant mitochondria there is a departure from the universal genetic code4, with CGG specifying tryptophan instead of arginine. This was because CGG codons are often found in plant mitochondrial genes at positions corresponding to those encoding conserved tryptophans in other organisms. We have now found, however, wheat mitochondrial gene sequences containing C residues that are edited to U residues in the corresponding mRNA sequences. In this way, CGG codons can be changed to UGG codons in the mRNA so that tryptophan may be encoded according to the universal genetic code. Furthermore, for each codon modification resulting from a C - > U conversion that we studied, we found a corresponding change in the amino acid that was encoded. RNA editing in wheat mitochondria can thus maintain genetic information at the RNA level and as a result contribute to the conservation of mitochondrial protein sequences among plants.

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Author notes

  1. Jean-Michel Grienenberger: To whom correspondence should be addressed

Authors and Affiliations

  1. Institut de Biologie Moléculaire des Plantes du CNRS, Université Louis Pasteur, 12, rue du Général Zimmer, 67084, Strasbourg cedex, France

    José M. Gualberto, Lorenzo Lamattina, Géraldine Bonnard, Jacques-Henry Weil & Jean-Michel Grienenberger

Authors

  1. José M. Gualberto

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  2. Lorenzo Lamattina

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  3. Géraldine Bonnard

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  4. Jacques-Henry Weil

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  5. Jean-Michel Grienenberger

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Gualberto, J., Lamattina, L., Bonnard, G. et al. RNA editing in wheat mitochondria results in the conservation of protein sequences. Nature 341, 660–662 (1989). https://doi.org/10.1038/341660a0

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  • Received: 21 August 1989

  • Accepted: 11 September 1989

  • Issue Date: 19 October 1989

  • DOI: https://doi.org/10.1038/341660a0

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