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The open pore conformation of potassium channels - Nature

  • ️MacKinnon, Roderick
  • ️Thu May 30 2002

References

  1. del Camino, D., Holmgren, M., Liu, Y. & Yellen, G. Blocker protection in the pore of a voltage-gated K+ channel and its structural implications. Nature 403, 321–325 (2000)

    Article  ADS  CAS  Google Scholar 

  2. Liu, Y., Holmgren, M., Jurman, M. E. & Yellen, G. Gated access to the pore of a voltage-dependent K+ channel. Neuron 19, 175–184 (1997)

    Article  Google Scholar 

  3. Doyle, D. A. et al. The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science 280, 69–77 (1998)

    Article  ADS  CAS  Google Scholar 

  4. Zhou, Y., Morais-Cabral, J. H., Kaufman, A. & MacKinnon, R. Chemistry of ion coordination and hydration revealed by a K+ channel–Fab complex at 2.0 Å resolution. Nature 414, 43–48 (2001)

    Article  ADS  CAS  Google Scholar 

  5. del Camino, D. & Yellen, G. Tight steric closure at the intracellular activation gate of a voltage-gated K+ channel. Neuron 32, 649–656 (2001)

    Article  CAS  Google Scholar 

  6. Cuello, L. G., Romero, J. G., Cortes, D. M. & Perozo, E. pH-dependent gating in the Streptomyces lividans K+ channel. Biochemistry 37, 3229–3236 (1998)

    Article  CAS  Google Scholar 

  7. Heginbotham, L., LeMasurier, M., Kolmakova-Partensky, L. & Miller, C. Single streptomyces lividans K+ channels. Functional asymmetries and sidedness of proton activation. J. Gen. Physiol. 114, 551–560 (1999)

    Article  CAS  Google Scholar 

  8. Perozo, E., Cortes, D. M. & Cuello, L. G. Structural rearrangements underlying K+-channel activation gating. Science 285, 73–78 (1999)

    Article  CAS  Google Scholar 

  9. Liu, Y. S., Sompornpisut, P. & Perozo, E. Structure of the KcsA channel intracellular gate in the open state. Nature Struct. Biol. 8, 883–887 (2001)

    Article  CAS  Google Scholar 

  10. Zhou, M., Morais-Cabral, J. H., Mann, S. & MacKinnon, R. Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors. Nature 411, 657–661 (2001)

    Article  ADS  CAS  Google Scholar 

  11. Jiang, Y. et al. Crystal structure and mechanism of a calcium-gated potassium channel. Nature 417, 515–522 (2002)

    Article  ADS  CAS  Google Scholar 

  12. Flynn, G. E., Johnson, J. P. Jr & Zagotta, W. N. Cyclic nucleotide-gated channels: shedding light on the opening of a channel pore. Nature Rev. Neurosci. 2, 643–651 (2001)

    Article  CAS  Google Scholar 

  13. Sigworth, F. J. Voltage gating of ion channels. Q. Rev. Biophys. 27, 1–40 (1994)

    Article  CAS  Google Scholar 

  14. Bezanilla, F. The voltage sensor in voltage-dependent ion channels. Physiol. Rev. 80, 555–592 (2000)

    Article  CAS  Google Scholar 

  15. Jiang, Y., Pico, A., Cadene, M., Chait, B. T. & MacKinnon, R. Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel. Neuron 29, 593–601 (2001)

    Article  CAS  Google Scholar 

  16. Armstrong, C. M. Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons. J. Gen. Physiol. 58, 413–437 (1971)

    Article  CAS  Google Scholar 

  17. Armstrong, C. M. Ionic pores, gates, and gating currents. Q. Rev. Biophys. 7, 179–210 (1974)

    Article  CAS  Google Scholar 

  18. Holmgren, M., Smith, P. L. & Yellen, G. Trapping of organic blockers by closing of voltage-dependent K+ channels: evidence for a trap door mechanism of activation gating. J. Gen. Physiol. 109, 527–535 (1997)

    Article  CAS  Google Scholar 

  19. Mitcheson, J. S., Chen, J., Lin, M., Culberson, C. & Sanguinetti, M. C. A structural basis for drug-induced long QT syndrome. Proc. Natl Acad. Sci. USA 97, 12329–12333 (2000)

    Article  ADS  CAS  Google Scholar 

  20. Roux, B. & MacKinnon, R. The cavity and pore helices in the KcsA K+ channel: electrostatic stabilization of monovalent cations. Science 285, 100–102 (1999)

    Article  CAS  Google Scholar 

  21. Hoshi, T., Zagotta, W. N. & Aldrich, R. W. Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science 250, 533–538 (1990)

    Article  ADS  CAS  Google Scholar 

  22. Zagotta, W. N., Hoshi, T. & Aldrich, R. W. Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB. Science 250, 568–571 (1990)

    Article  ADS  CAS  Google Scholar 

  23. Bezanilla, F. & Armstrong, C. M. Inactivation of the sodium channel. I. Sodium current experiments. J. Gen. Physiol. 70, 549–566 (1977)

    Article  CAS  Google Scholar 

  24. Armstrong, C. M. & Bezanilla, F. Inactivation of the sodium channel. II. Gating current experiments. J. Gen. Physiol. 70, 567–590 (1977)

    Article  CAS  Google Scholar 

  25. Rettig, J. et al. Inactivation properties of voltage-gated K+ channels altered by presence of β-subunit. Nature 369, 289–294 (1994)

    Article  ADS  CAS  Google Scholar 

  26. Warwicker, J. & Watson, H. C. Calculation of the electric potential in the active site cleft due to alpha-helix dipoles. J. Mol. Biol. 157, 671–679 (1982)

    Article  CAS  Google Scholar 

  27. Klapper, I., Hagstrom, R., Fine, R., Sharp, K. & Honig, B. Focusing of electric fields in the active site of Cu-Zn superoxide dismutase: effects of ionic strength and amino-acid modification. Proteins 1, 47–59 (1986)

    Article  CAS  Google Scholar 

  28. Carson, M. Ribbons. Methods Enzymol. 277, 493–505 (1997)

    Article  CAS  Google Scholar 

  29. Esnouf, R. M. An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. J. Mol. Graph. Model. 15, 132–133 (1997)

    Article  CAS  Google Scholar 

  30. Nicholls, A., Sharp, K. A. & Honig, B. Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins 11, 281–296 (1991)

    Article  CAS  Google Scholar 

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