nature.com

Bile acids heat things up - Nature

  • ️Webb, Paul
  • ️Wed Jan 25 2006
  • News & Views
  • Published: 25 January 2006

Metabolism

Nature volume 439, pages 402–403 (2006)Cite this article

Thyroid hormone causes fat loss, but harnessing this action to treat obesity is difficult because it is associated with harmful side effects. However, bile acids generate active thyroid hormone just where it is needed.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 51 print issues and online access

$199.00 per year

only $3.90 per issue

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Figure 1: Bile acids in energy homeostasis.

References

  1. Hedley, A. A. et al. J. Am. Med. Assoc. 291, 2847–2850 (2004).

    Article  CAS  Google Scholar 

  2. Gaede, P. et al. N. Engl. J. Med. 348, 383–393 (2003).

    Article  Google Scholar 

  3. Watanabe, M. et al. Nature 439, 484–489 (2006).

    Article  ADS  CAS  Google Scholar 

  4. Spiegelman, B. M. & Flier, J. S. Cell 104, 531–544 (2001).

    Article  CAS  Google Scholar 

  5. Baxter, J. D. et al. Trends Endocrinol. Metab. 15, 154–157 (2004).

    Article  CAS  Google Scholar 

  6. Kawamata, Y. et al. J. Biol. Chem. 278, 9435–9440 (2003).

    Article  CAS  Google Scholar 

  7. Kalaany, N. Y. & Mangelsdorf, D. J. Annu. Rev. Physiol. doi:10.1146/annurev.physiol.68.033104.152158 (2005).

  8. Ikemoto, S. et al. Am. J. Physiol. 273, 37–45 (1997).

    Article  Google Scholar 

  9. Shoenfield, L. J. & Lachin, J. M. Ann. Intern. Med. 95, 257–282 (1981).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. the Diabetes Center and Department of Medicine, University of California School of Medicine, S1212, 513 Parnassus Avenue, San Francisco, 94143-0540, California, USA

    John D. Baxter & Paul Webb

  2. John D. Baxter & Paul Webb

Authors

  1. John D. Baxter

    You can also search for this author in PubMed Google Scholar

  2. Paul Webb

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Baxter, J., Webb, P. Bile acids heat things up. Nature 439, 402–403 (2006). https://doi.org/10.1038/439402a

Download citation

  • Published: 25 January 2006

  • Issue Date: 26 January 2006

  • DOI: https://doi.org/10.1038/439402a

This article is cited by