nature.com

Conditional telomerase induction causes proliferation of hair follicle stem cells - Nature

  • ️Artandi, Steven E.
  • ️Thu Aug 18 2005

References

  1. Blackburn, E. H. Switching and signalling at the telomere. Cell 106, 661–673 (2001)

    Article  CAS  PubMed  Google Scholar 

  2. Smogorzewska, A. & De Lange, T. Regulation of telomerase by telomeric proteins. Annu. Rev. Biochem. 73, 177–208 (2004)

    Article  CAS  PubMed  Google Scholar 

  3. Morrison, S. J., Prowse, K. R., Ho, P. & Weissman, I. L. Telomerase activity in hematopoietic cells is associated with self-renewal potential. Immunity 5, 207–216 (1996)

    Article  CAS  PubMed  Google Scholar 

  4. Yui, J., Chiu, C. P. & Lansdorp, P. M. Telomerase activity in candidate stem cells from fetal liver and adult bone marrow. Blood 91, 3255–3262 (1998)

    CAS  PubMed  Google Scholar 

  5. Forsyth, N. R., Wright, W. E. & Shay, J. W. Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off again. Differentiation 69, 188–197 (2002)

    Article  CAS  PubMed  Google Scholar 

  6. Blasco, M. A. et al. Telomere shortening and tumour formation by mouse cells lacking telomerase RNA. Cell 91, 25–34 (1997)

    Article  CAS  PubMed  Google Scholar 

  7. Lee, H. W. et al. Essential role of mouse telomerase in highly proliferative organs. Nature 392, 569–574 (1998)

    Article  ADS  CAS  PubMed  Google Scholar 

  8. Rudolph, K. L. et al. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 96, 701–712 (1999)

    Article  CAS  PubMed  Google Scholar 

  9. Gonzalez-Suarez, E. et al. Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. EMBO J. 20, 2619–2630 (2001)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Artandi, S. E. et al. Constitutive telomerase expression promotes mammary carcinomas in aging mice. Proc. Natl Acad. Sci. USA 99, 8191–8196 (2002)

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  11. Stewart, S. A. et al. Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. Proc. Natl Acad. Sci. USA 99, 12606–12611 (2002)

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  12. Chang, S., Khoo, C. M., Naylor, M. L., Maser, R. S. & DePinho, R. A. Telomere-based crisis: functional differences between telomerase activation and ALT in tumour progression. Genes Dev. 17, 88–100 (2003)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Blasco, M. A. & Hahn, W. C. Evolving views of telomerase and cancer. Trends Cell Biol. 13, 289–294 (2003)

    Article  CAS  PubMed  Google Scholar 

  14. Alonso, L. & Fuchs, E. Stem cells in the skin: waste not, Wnt not. Genes Dev. 17, 1189–1200 (2003)

    Article  CAS  PubMed  Google Scholar 

  15. Cotsarelis, G., Sun, T. T. & Lavker, R. M. Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 61, 1329–1337 (1990)

    Article  CAS  PubMed  Google Scholar 

  16. Taylor, G., Lehrer, M. S., Jensen, P. J., Sun, T. T. & Lavker, R. M. Involvement of follicular stem cells in forming not only the follicle but also the epidermis. Cell 102, 451–461 (2000)

    Article  CAS  PubMed  Google Scholar 

  17. Braun, K. M. et al. Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis. Development 130, 5241–5255 (2003)

    Article  CAS  PubMed  Google Scholar 

  18. Tumbar, T. et al. Defining the epithelial stem cell niche in skin. Science 303, 359–363 (2004)

    Article  ADS  CAS  PubMed  Google Scholar 

  19. Morris, R. J. et al. Capturing and profiling adult hair follicle stem cells. Nature Biotechnol. 22, 411–417 (2004)

    Article  CAS  Google Scholar 

  20. Muller-Rover, S. et al. A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. J. Invest. Dermatol. 117, 3–15 (2001)

    Article  CAS  PubMed  Google Scholar 

  21. Ramirez, R. D., Wright, W. E., Shay, J. W. & Taylor, R. S. Telomerase activity concentrates in the mitotically active segments of human hair follicles. J. Invest. Dermatol. 108, 113–117 (1997)

    Article  CAS  PubMed  Google Scholar 

  22. Gossen, M. & Bujard, H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl Acad. Sci. USA 89, 5547–5551 (1992)

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  23. Wright, D. E. et al. Cyclophosphamide/granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycle. Blood 97, 2278–2285 (2001)

    Article  CAS  PubMed  Google Scholar 

  24. Okabe, M., Ikawa, M., Kominami, K., Nakanishi, T. & Nishimune, Y. ‘Green mice’ as a source of ubiquitous green cells. FEBS Lett. 407, 313–319 (1997)

    Article  CAS  PubMed  Google Scholar 

  25. Sawamura, D. et al. Promoter/enhancer cassettes for keratinocyte gene therapy. J. Invest. Dermatol. 112, 828–830 (1999)

    Article  CAS  PubMed  Google Scholar 

  26. Hebert, J. M., Rosenquist, T., Gotz, J. & Martin, G. R. FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations. Cell 78, 1017–1025 (1994)

    Article  CAS  PubMed  Google Scholar 

  27. Gat, U., DasGupta, R., Degenstein, L. & Fuchs, E. De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell 95, 605–614 (1998)

    Article  CAS  PubMed  Google Scholar 

  28. Trempus, C. S. et al. Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34. J. Invest. Dermatol. 120, 501–511 (2003)

    CAS  PubMed  Google Scholar 

  29. Blanpain, C., Lowry, W. E., Geoghegan, A., Polak, L. & Fuchs, E. Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell 118, 635–648 (2004)

    Article  CAS  PubMed  Google Scholar 

  30. Sato, N., Leopold, P. L. & Crystal, R. G. Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog. J. Clin. Invest. 104, 855–864 (1999)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references