Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice - Nature

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We thank D. Kioussis for providing the Vav1-Cre mice and A. Rudensky for providing the GFP–Foxp3 mice. This work was supported by grants from the National Heart, Lung and Blood Institute (to D.S.), the National Institute of Allergy and Infectious Diseases (to J.A.B and B.R.) and funds from the Sandler Program for Asthma Research (to B.R.). M.A.T. was the recipient of an American Lung Association Research Fellowship.

Author Contributions M.A.T. performed all of the experiments described and wrote most of the manuscript; B.R. generated the CD11c-Cre mice and contributed to the design and interpretation of studies using those mice; A.C.M. contributed to the studies of colonic inflammation, colonic T_R cells and designed and performed all of the qPCR studies described; E.M. helped design, perform and interpret the in vitro T_R cell induction assays; Q.T. helped to design, perform and interpret the studies analysing the nature of the immunological defects described; J.M.P. generated the conditional Itgb8 knockout mice and helped in the design and interpretation of genotyping assays and crosses to Cre-expressing lines; Y.W., X.B. and X.H. helped in the design, performance and interpretation of all of the studies of tissue morphology; L.F.R. oversaw the generation of the conditional Itgb8 knockout mice and contributed to the design and interpretation of studies using these animals; J.A.B. contributed to the design and interpretation of the studies characterizing the immunological abnormalities seen and analysing the contribution of T_R cells; D.S. oversaw the design and interpretation of all studies described and oversaw writing of the manuscript.

Author notes

1. Mark A. Travis

   Present address: Present address: Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, A3051 Smith Building, Oxford Road, Manchester M13 9PT, UK.,

Authors and Affiliations

1. Department of Medicine, Lung Biology Center, University of California San Francisco, 1550 4th Street, Room 545, San Francisco, California 94158, USA,

   Mark A. Travis, Andrew C. Melton, Yanli Wang, Xin Bernstein, Xiaozhu Huang & Dean Sheppard

2. Department of Microbiology, Columbia University, 701 West 168th Street, Room 609, New York, New York 10032, USA,

   Boris Reizis

3. Department of Medicine, Diabetes Center, 513 Parnassus Avenue, University of San Francisco, San Francisco, California 94143, USA,

   Emma Masteller, Qizhi Tang & Jeffrey A. Bluestone

4. Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, California 94158, USA,

   John M. Proctor & Louis F. Reichardt

Corresponding author

Correspondence to Dean Sheppard.

Competing interests

Reprints and permissions information is available at www.nature.com/reprints. The authors declare no competing financial interests.

Cite this article

Travis, M., Reizis, B., Melton, A. et al. Loss of integrin α_vβ₈ on dendritic cells causes autoimmunity and colitis in mice. Nature 449, 361–365 (2007). https://doi.org/10.1038/nature06110

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• Received: 09 April 2007

• Accepted: 23 July 2007

• Published: 12 August 2007

• Issue Date: 20 September 2007

• DOI: https://doi.org/10.1038/nature06110