Dual epithelial origin of vertebrate oral teeth - Nature

1. Romer, A. S. The Vertebrate Body (Saunders, 1962)

   Google Scholar 

2. Kardong, K. V. Vertebrates. Comparative Anatomy, Function, Evolution (Brown, 1995)

   Google Scholar 

3. Chai, Y. et al. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development 127, 1671–1679 (2000)

   CAS  PubMed  Google Scholar 

4. Tucker, A. & Sharpe, P. The cutting-edge of mammalian development: how the embryo makes teeth. Nature Rev. Genet. 5, 499–508 (2004)

   Article  CAS  Google Scholar 

5. Pispa, J. & Thesleff, I. Mechanisms of ectodermal organogenesis. Dev. Biol. 262, 195–205 (2003)

   Article  CAS  Google Scholar 

6. Stock, D. W. The genetic basis of modularity in the development and evolution of the vertebrate dentition. Phil. Trans. R. Soc. Lond. B 356, 1633–1653 (2001)

   Article  CAS  Google Scholar 

7. Janvier, P. Early Vertebrates (Oxford Univ. Press, 1996)

   Google Scholar 

8. Huysseune, A., Van der Heyden, C., Verreijdt, L., Wautier, K. & Van Damme, N. Fish dentitions as paradigms for odontogenic questions. Connect. Tissue Res. 43, 98–102 (2002)

   Article  CAS  Google Scholar 

9. Sire, J. Y., Davit-Beal, T., Delgado, S., Van Der Heyden, C. & Huysseune, A. First-generation teeth in nonmammalian lineages: evidence for a conserved ancestral character? Microsc. Res. Tech. 59, 408–434 (2002)

   Article  Google Scholar 

10. Dickinson, A. J. & Sive, H. Development of the primary mouth in Xenopus laevis . Dev. Biol. 295, 700–713 (2006)

    Article  CAS  Google Scholar 

11. Reif, W.-E. Evolution of dermal skeleton and dentition in vertebrates: the odontode-regulation theory. Evol. Biol. 15, 287–368 (1982)

    Article  Google Scholar 

12. Smith, M. M. & Coates, M. I. in Major Events in Early Vertebrate Evolution (ed. Ahlberg, P. E.) 223–240 (Taylor and Francis, 2001)

    Google Scholar 

13. Smith, M. M. & Johanson, Z. Separate evolutionary origins of teeth from evidence in fossil jawed vertebrates. Science 299, 1235–1236 (2003)

    Article  ADS  CAS  Google Scholar 

14. Chibon, P. Analyse expérimentale de la régionalisation et des capacités morphogénétiques de la crete neurale chez l'Amphibien Urodéle Pleurodeles waltlii Michah. Mem. Soc. Zool. Fr. 36, 1–107 (1966)

    Google Scholar 

15. Jackman, W. R., Draper, B. W. & Stock, D. W. Fgf signaling is required for zebrafish tooth development. Dev. Biol. 274, 139–157 (2004)

    Article  CAS  Google Scholar 

16. Hall, B. K. The Neural Crest in Development and Evolution (Springer, 1999)

    Book  Google Scholar 

17. de Beer, G. R. The differentiation of neural crest cells into visceral cartilages and odontoblasts in Amblystoma, and re-examination of the germ-layer theory. Proc. R. Soc. Lond. B 134, 377–398 (1947)

    Article  ADS  CAS  Google Scholar 

18. Adams, A. E. An experimental study of the development of the mouth in the amphibian embryo. J. Exp. Zool. 40, 311–379 (1924)

    Article  Google Scholar 

19. Imai, H., Osumi, N. & Eto, K. Contribution of foregut endoderm to tooth initiation of mandibular incisor in rat embryos. Eur. J. Oral Sci. 106 (Suppl. 1). 19–23 (1998)

    Article  Google Scholar 

20. Sharpe, P. T. Homeobox genes and orofacial development. Connect. Tissue Res. 32, 17–25 (1995)

    Article  CAS  Google Scholar 

21. Barlow, L. A. & Northcutt, R. G. Embryonic origin of amphibian taste buds. Dev. Biol. 169, 273–285 (1995)

    Article  CAS  Google Scholar 

22. Sobkow, L., Epperlein, H. H., Herklotz, S., Straube, W. L. & Tanaka, E. M. A germline GFP transgenic axolotl and its use to track cell fate: dual origin of the fin mesenchyme during development and the fate of blood cells during regeneration. Dev. Biol. 290, 386–397 (2006)

    Article  CAS  Google Scholar 

23. Barlow, L. A. & Northcutt, R. G. Taste buds develop autonomously from endoderm without induction by cephalic neural crest or paraxial mesoderm. Development 124, 949–957 (1997)

    CAS  PubMed  Google Scholar 

24. Smith, M. M. & Coates, M. I. Evolutionary origins of the vertebrate dentition: phylogenetic patterns and developmental evolution. Eur. J. Oral Sci. 106 (Suppl. 1). 482–500 (1998)

    Article  Google Scholar 

25. Reiss, J. O. Early development of chondrocranium in the tailed frog Ascaphus truei (Amphibia: Anura): implications for anuran palatoquadrate homologies. J. Morphol. 231, 63–100 (1997)

    Article  CAS  Google Scholar 

26. Debiais-Thibaud, M. et al. Development of oral and pharyngeal teeth in the medaka (Oryzias latipes): comparison of morphology and expression of eve1 gene. J. Exp. Zool. B Mol. Dev. Evol. 308, 693–708 (2007)

    Article  Google Scholar 

27. Fraser, G. J., Graham, A. & Smith, M. M. Conserved deployment of genes during odontogenesis across osteichthyans. Proc. R. Soc. Lond. B 271, 2311–2317 (2004)

    Article  Google Scholar 

28. Smith, M. M. Vertebrate dentitions at the origin of jaws: when and how pattern evolved. Evol. Dev. 5, 394–413 (2003)

    Article  Google Scholar 

29. Mitsiadis, T. A., Caton, J. & Cobourne, M. Waking-up the sleeping beauty: recovery of the ancestral bird odontogenic program. J. Exp. Zool. B Mol. Dev. Evol. 306, 227–233 (2006)

    Article  Google Scholar 

30. Cerny, R. et al. Combined intrinsic and extrinsic influences pattern cranial neural crest migration and pharyngeal arch morphogenesis in axolotl. Dev. Biol. 266, 252–269 (2004)

    Article  CAS  Google Scholar 

31. Epperlein, H. H., Meulemans, D., Bronner-Fraser, M., Steinbeisser, H. & Selleck, M. A. Analysis of cranial neural crest migratory pathways in axolotl using cell markers and transplantation. Development 127, 2751–2761 (2000)

    CAS  PubMed  Google Scholar 

32. Cerny, R. et al. Developmental origins and evolution of jaws: new interpretation of “maxillary” and “mandibular”. Dev. Biol. 276, 225–236 (2004)

    Article  CAS  Google Scholar 

Download references

We wish to thank E. Tanaka and H. Andreas for supplying us with GFP axolotl embryos, L. Mchedlishvili for technical advice and O. Sebesta for help with confocal microscopy. We are grateful to M. Bronner–Fraser, R. Ericsson, D. Meulemans Medeiros, L. Olsson, P. D. Polly, D. W. Stock and A. Tucker for comments on the manuscript. Grants from the Ministry of Youth, Education and Sport of the Czech Republic (MSMT 0021620828), SMWK (Dresden) and COST Action B23 ‘Oral facial development and regeneration’ are gratefully acknowledged.

Author Contributions Tissue grafting was carried out in the laboratory of H.-H.E., who also helped with initial experiments. V.S. made transplantations and performed sectioning and image analyses as his Master’s thesis under the supervision of R.C., who also designed the initial experiments and wrote the manuscript. R.C. and I.H. planned the study and interpreted the results, I.H. made statistical analyses and helped in writing the manuscript, and all authors discussed the results and commented on the manuscript.

Authors and Affiliations

1. Department of Zoology, Charles University in Prague, Vinicna 7, 128 44 Prague, Czech Republic,

   Vladimír Soukup, Ivan Horácek & Robert Cerny

2. Department of Anatomy, TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany,

   Hans-Henning Epperlein

Corresponding author

Correspondence to Robert Cerny.

Cite this article

Soukup, V., Epperlein, HH., Horácek, I. et al. Dual epithelial origin of vertebrate oral teeth. Nature 455, 795–798 (2008). https://doi.org/10.1038/nature07304

Download citation

• Received: 09 January 2008

• Accepted: 29 July 2008

• Published: 14 September 2008

• Issue Date: 09 October 2008

• DOI: https://doi.org/10.1038/nature07304