The cells and peripheral representation of sodium taste in mice - Nature

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We thank W. Guo and A. Becker for generation and maintenance of mouse lines, and K. Scott and members of our laboratories for valuable comments. This research was supported in part by the intramural research program of the NIH, NIDCR (N.J.P.R.). C.S.Z. is an investigator of the Howard Hughes Medical Institute.

Author Contributions J.C. designed the study, carried out electrophysiological and expression studies, analysed data and wrote the paper; C.K. designed and carried out behavioural experiments and analysed expression in engineered and knockout mice; Y.O. designed and carried out calcium imaging experiments and analysed data; D.A.Y. carried out molecular studies and helped write the paper; E.H. provided essential reagents; N.J.P.R. and C.S.Z. designed the study, analysed data and wrote the paper.

Author notes

1. Jayaram Chandrashekar, Yuki Oka, David A. Yarmolinsky & Charles S. Zuker

   Present address: Present addresses: Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA (J.C.); Departments of Biochemistry and Molecular Biophysics and of Neuroscience, Howard Hughes Medical Institute, Columbia College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA (Y.O., D.A.Y., C.S.Z.).,

2. Christina Kuhn and Yuki Oka: These authors contributed equally to this work.

Authors and Affiliations

1. Howard Hughes Medical Institute and Departments of Neurobiology and Neurosciences, University of California at San Diego, La Jolla, California 92093-0649, USA,

   Jayaram Chandrashekar, Yuki Oka, David A. Yarmolinsky & Charles S. Zuker

2. National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA ,

   Christina Kuhn & Nicholas J. P. Ryba

3. Pharmacology and Toxicology Department, Faculty of Biology and Medicine, University of Lausanne, CH-1005 Lausanne, Switzerland

   Edith Hummler

Corresponding author

Correspondence to Charles S. Zuker.

Competing interests

C.S.Z. is a scientific founder and scientific advisory board member of Senomyx.

Supplementary Information

This file contains Supplementary Figures S1-S6 with Legends and Supplementary References. (PDF 2975 kb)

Cite this article

Chandrashekar, J., Kuhn, C., Oka, Y. et al. The cells and peripheral representation of sodium taste in mice. Nature 464, 297–301 (2010). https://doi.org/10.1038/nature08783

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• Received: 04 November 2009

• Accepted: 05 January 2010

• Published: 27 January 2010

• Issue Date: 11 March 2010

• DOI: https://doi.org/10.1038/nature08783