SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis - Nature
- ️Dikic, Ivan
- ️Wed Mar 30 2011
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Acknowledgements
We thank E. Kim, K. Rajalingham and H.-J. Kreienkampfor reagents used in this study, I. Matic for initial MS analysis of HOIP/HOIL-1L samples, S. Wahl for sample preparation, and V. Dötsch and members of the Dikic lab for discussions and comments. This work was supported by grants from the Deutsche Forschungsgemeinschaft (DI 931/3-1), the Cluster of Excellence “Macromolecular Complexes” of the Goethe University Frankfurt (EXC115) to I.D., Landesstiftung Baden-Württemberg to B.M., the Medical Research Council UK to K.R. and B.S., JSPS Postdoctoral Fellowships for Research Abroad to F.I., EMBO long-term fellowship to S.S.S. and The National Institutes of Health (AR049288 to J.P.S.). V.N. was supported by the Unity Through Knowledge Fund, 3B Grant. C.G. acknowledges support from The International Human Frontier Science Program Organization.
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Author notes
Yonathan Lissanu Deribe and Sigrid S. Skånland: These authors contributed equally to this work.
Authors and Affiliations
Frankfurt Institute for Molecular Life Sciences and Institute of Biochemistry II, Goethe University School of Medicine, Theodor-Stern-Kai 7, D-60590 Frankfurt (Main), Germany,
Fumiyo Ikeda, Yonathan Lissanu Deribe, Sigrid S. Skånland, Caroline Grabbe, Sjoerd J. L. van Wijk, Panchali Goswami & Ivan Dikic
MRC-National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK,
Benjamin Stieglitz & Katrin Rittinger
Department of Molecular Biology, Umeå University, Building 6L, 901 87 Umeå, Sweden,
Caroline Grabbe
Proteome Center Tübingen, Interfaculty Institute for Cell Biology, University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany,
Mirita Franz-Wachtel & Boris Macek
IMBA-Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr. Bohrgasse 3, 1030 Vienna, Austria,
Vanja Nagy
School of Medicine, University of Split, Soltanska 2, Split, HR-21000, Croatia,
Janos Terzic & Ivan Dikic
Department of Biophysics and Biochemistry, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan,
Fuminori Tokunaga, Tomoko Nakagawa & Kazuhiro Iwai
Institute for Genetics, Centre for Molecular Medicine (CMMC), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Zülpicher Str. 47a, 50674 Cologne, Germany,
Ariadne Androulidaki & Manolis Pasparakis
Cell Biology and Metabolism Group, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan,
Kazuhiro Iwai
The Jackson Laboratory, Bar Harbor, 04609, Maine, USA
John P. Sundberg
Division Nephropharmakologie, Allgemeine Pharmakologie und Toxikologie, Klinikum der Goethe Universität, Theodor-Stern Kai 7, 60590 Frankfurt, Germany,
Liliana Schaefer
Authors
- Fumiyo Ikeda
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- Yonathan Lissanu Deribe
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- Sigrid S. Skånland
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- Benjamin Stieglitz
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- Caroline Grabbe
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- Mirita Franz-Wachtel
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- Sjoerd J. L. van Wijk
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- Panchali Goswami
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- Vanja Nagy
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- Janos Terzic
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- Fuminori Tokunaga
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- Ariadne Androulidaki
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- Tomoko Nakagawa
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- Manolis Pasparakis
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- Kazuhiro Iwai
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- John P. Sundberg
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- Liliana Schaefer
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- Katrin Rittinger
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- Boris Macek
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- Ivan Dikic
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Contributions
F.I., Y.L.D., S.S.S., B.S., C.G., S.J.L.v.W., B.M., V.N., M.F.-W. and P.G. performed the experiments. F.T., A.A. and T.N. contributed with reagents used throughout the study. F.I., Y.L.D., S.S.S., C.G., M.P., J.T., K.I., J.P.S., L.F., B.M. and K.R. contributed to the project by co-ordination of experimental work and writing the manuscript. I.D. provided ideas, co-ordinated the entire project and wrote the manuscript.
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Correspondence to Ivan Dikic.
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Ikeda, F., Deribe, Y., Skånland, S. et al. SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature 471, 637–641 (2011). https://doi.org/10.1038/nature09814
Received: 06 April 2010
Accepted: 11 January 2011
Published: 30 March 2011
Issue Date: 31 March 2011
DOI: https://doi.org/10.1038/nature09814