SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis - Nature

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Author notes

1. Yonathan Lissanu Deribe and Sigrid S. Skånland: These authors contributed equally to this work.

Authors and Affiliations

1. Frankfurt Institute for Molecular Life Sciences and Institute of Biochemistry II, Goethe University School of Medicine, Theodor-Stern-Kai 7, D-60590 Frankfurt (Main), Germany,

   Fumiyo Ikeda, Yonathan Lissanu Deribe, Sigrid S. Skånland, Caroline Grabbe, Sjoerd J. L. van Wijk, Panchali Goswami & Ivan Dikic

2. MRC-National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK,

   Benjamin Stieglitz & Katrin Rittinger

3. Department of Molecular Biology, Umeå University, Building 6L, 901 87 Umeå, Sweden,

   Caroline Grabbe

4. Proteome Center Tübingen, Interfaculty Institute for Cell Biology, University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany,

   Mirita Franz-Wachtel & Boris Macek

5. IMBA-Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr. Bohrgasse 3, 1030 Vienna, Austria,

   Vanja Nagy

6. School of Medicine, University of Split, Soltanska 2, Split, HR-21000, Croatia,

   Janos Terzic & Ivan Dikic

7. Department of Biophysics and Biochemistry, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan,

   Fuminori Tokunaga, Tomoko Nakagawa & Kazuhiro Iwai

8. Institute for Genetics, Centre for Molecular Medicine (CMMC), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Zülpicher Str. 47a, 50674 Cologne, Germany,

   Ariadne Androulidaki & Manolis Pasparakis

9. Cell Biology and Metabolism Group, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan,

   Kazuhiro Iwai

10. The Jackson Laboratory, Bar Harbor, 04609, Maine, USA

    John P. Sundberg

11. Division Nephropharmakologie, Allgemeine Pharmakologie und Toxikologie, Klinikum der Goethe Universität, Theodor-Stern Kai 7, 60590 Frankfurt, Germany,

    Liliana Schaefer

Contributions

F.I., Y.L.D., S.S.S., B.S., C.G., S.J.L.v.W., B.M., V.N., M.F.-W. and P.G. performed the experiments. F.T., A.A. and T.N. contributed with reagents used throughout the study. F.I., Y.L.D., S.S.S., C.G., M.P., J.T., K.I., J.P.S., L.F., B.M. and K.R. contributed to the project by co-ordination of experimental work and writing the manuscript. I.D. provided ideas, co-ordinated the entire project and wrote the manuscript.

Corresponding author

Correspondence to Ivan Dikic.

Competing interests

The authors declare no competing financial interests.

Cite this article

Ikeda, F., Deribe, Y., Skånland, S. et al. SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature 471, 637–641 (2011). https://doi.org/10.1038/nature09814

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• Received: 06 April 2010

• Accepted: 11 January 2011

• Published: 30 March 2011

• Issue Date: 31 March 2011

• DOI: https://doi.org/10.1038/nature09814