Spatio-temporal transcriptome of the human brain - Nature
- ️Šestan, Nenad
- ️Wed Oct 26 2011
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Primary accessions
Gene Expression Omnibus
Data deposits
Exon array have been deposited in the NCBI Gene Expression Omnibus under accession number GSE25219 and genotyping data have been deposited in the NCBI database of Genotypes and Phenotypes under accession number phs000406.v1.p1.
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Acknowledgements
We thank A. Belanger, V. Imamovic, R. Johnson, P. Larton, S. Lindsay, B. Poulos, J. Rajan, D. Rimm and R. Zielke for assistance with tissue acquisition, D. Singh for technical assistance, I. Kostovic and Z. Petanjek for dendrite measurements, P. Levitt for suggesting the inclusion of ITC in the study, and D. Karolchik and A. Zweig for help in creating tracks for the UCSC Genome Browser. We also thank A. Beckel-Mitchener, M. Freund, M. Gerstein, D. Geschwind, T. Insel, M. Judas, J. Knowles, E. Lein, P. Levitt, N. Parikshak and members of the Sestan laboratory for discussions and criticism. Tissue was obtained from several sources including the Human Fetal Tissue Repository at the Albert Einstein College of Medicine, the NICHD Brain and Tissue Bank for Developmental Disorders at the University of Maryland, the Laboratory of Developmental Biology at the University of Washington (supported by grant HD000836 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development) and the Joint MRC/Wellcome Trust Human Developmental Biology Resource (http://hdbr.org) at the IHG, Newcastle Upon Tyne (UK funding awards G0700089 and GR082557). Support for predoctoral fellowships was provided by the China Scholarship Council (Y.Z.), the Portuguese Foundation for Science and Technology (A.M.M.S.), the Samsung Scholarship Foundation (Y.S.), a Fellowship of the German Academic Exchange Service – DAAD (S. Mayer) and NIDA grant DA026119 (T.G.). This work was supported by grants from the US National Institutes of Health (MH081896, MH089929, NS054273), the Kavli Foundation and NARSAD, and by a James S. McDonnell Foundation Scholar Award (N.S.).
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Author notes
Hyo Jung Kang, Yuka Imamura Kawasawa, Feng Cheng, Ying Zhu, Xuming Xu and Mingfeng Li: These authors contributed equally to this work.
Authors and Affiliations
Department of Neurobiology and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, 06510, Connecticut, USA
Hyo Jung Kang, Yuka Imamura Kawasawa, Feng Cheng, Ying Zhu, Xuming Xu, Mingfeng Li, André M. M. Sousa, Mihovil Pletikos, Kyle A. Meyer, Goran Sedmak, Yurae Shin, Matthew B. Johnson, Željka Krsnik, Simone Mayer, Sofia Fertuzinhos & Nenad Šestan
Graduate Program in Areas of Basic and Applied Biology, Abel Salazar Biomedical Sciences Institute, University of Porto, 4099-003 Porto, Portugal,
André M. M. Sousa
Graduate Program in Neuroscience, Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10000 Zagreb, Croatia,
Mihovil Pletikos & Goran Sedmak
Department of Biostatistics, Virginia Commonwealth University, Richmond, 23298, Virginia, USA
Tobias Guennel & Mark Reimers
MSc/PhD Molecular Biology Program, International Max Planck Research School for Molecular Biology, 37077 Göttingen, Germany,
Simone Mayer
Yale Center for Genome Analysis, Yale University School of Medicine, New Haven, 06510, Connecticut, USA
Sheila Umlauf & Shrikant Mane
Institute of Genetic Medicine, Newcastle University, International Centre for Life, Newcastle upon Tyne NE1 3BZ, UK,
Steven N. Lisgo
Department of Pathology, Yale University School of Medicine, New Haven, 06510, Connecticut, USA
Alexander Vortmeyer & Anita Huttner
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, 20892, Maryland, USA
Daniel R. Weinberger, Thomas M. Hyde & Joel E. Kleinman
The Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, 21205, Maryland, USA
Thomas M. Hyde
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- Hyo Jung Kang
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- Yuka Imamura Kawasawa
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- Feng Cheng
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- Ying Zhu
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- Xuming Xu
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- Mingfeng Li
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- André M. M. Sousa
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- Mihovil Pletikos
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- Kyle A. Meyer
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- Goran Sedmak
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- Tobias Guennel
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- Yurae Shin
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- Matthew B. Johnson
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- Željka Krsnik
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- Simone Mayer
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- Sofia Fertuzinhos
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- Sheila Umlauf
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- Steven N. Lisgo
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- Alexander Vortmeyer
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- Daniel R. Weinberger
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- Shrikant Mane
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- Thomas M. Hyde
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- Anita Huttner
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- Mark Reimers
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- Joel E. Kleinman
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- Nenad Šestan
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Contributions
H.J.K., Y.I.K., A.M.M.S., M.P., K.A.M., G.S., Y.S., M.B.J., Z.K., S. Mayer, S.F., S.U., S. Mane and N.S. performed and analysed the experiments. F.C., Y.Z., X.X., M.L., T.G. and M.R. analysed the data. Z.K., A.M.M.S., M.P., G.S., S.N.L, A.V., D.R.W., T.M.H., A.H., J.E.K. and N.S. participated in tissue procurement and examination. N.S. designed the study and wrote the manuscript, which all authors commented and edited.
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Correspondence to Nenad Šestan.
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Supplementary Information
This file contains Supplementary Text, Data and Methods (1-9 ) - see Contents for full details, (10 ) Supplementary References, (11) Legends for Supplementary Tables 1-17 (see separate excel file for tables), and (12) Supplementary Figures 1-25 with legends. (PDF 7421 kb)
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Kang, H., Kawasawa, Y., Cheng, F. et al. Spatio-temporal transcriptome of the human brain. Nature 478, 483–489 (2011). https://doi.org/10.1038/nature10523
Received: 11 December 2010
Accepted: 30 August 2011
Published: 26 October 2011
Issue Date: 27 October 2011
DOI: https://doi.org/10.1038/nature10523