Genetic recombination is directed away from functional genomic elements in mice - Nature
- ️Petukhova, Galina V.
- ️Sun May 13 2012
Parvanov, E. D., Petkov, P. M. & Paigen, K. Prdm9 controls activation of mammalian recombination hotspots. Science 327, 835 (2010)
Myers, S. et al. Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination. Science 327, 876–879 (2010)
Baudat, F. et al. PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice. Science 327, 836–840 (2010)
Berg, I. L. et al. PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans. Nature Genet. 42, 859–863 (2010)
Berg, I. L. et al. Variants of the protein PRDM9 differentially regulate a set of human meiotic recombination hotspots highly active in African populations. Proc. Natl Acad. Sci. USA 108, 12378–12383 (2011)
Hinch, A. G. et al. The landscape of recombination in African–Americans. Nature 476, 170–175 (2011)
Mihola, O., Trachtulec, Z., Vlcek, C., Schimenti, J. C. & Forejt, J. A mouse speciation gene encodes a meiotic histone H3 methyltransferase. Science 323, 373–375 (2009)
Grey, C. et al. Mouse PRDM9 DNA-binding specificity determines sites of histone H3 lysine 4 trimethylation for initiation of meiotic recombination. PLoS Biol. 9, e1001176 (2011)
Hayashi, K., Yoshida, K. & Matsui, Y. A histone H3 methyltransferase controls epigenetic events required for meiotic prophase. Nature 438, 374–378 (2005)
Burgoyne, P. S. Genetic homology and crossing over in the X and Y chromosomes of mammals. Hum. Genet. 61, 85–90 (1982)
Neale, M. J. & Keeney, S. Clarifying the mechanics of DNA strand exchange in meiotic recombination. Nature 442, 153–158 (2006)
Smagulova, F. et al. Genome-wide analysis reveals novel molecular features of mouse recombination hotspots. Nature 472, 375–378 (2011)
Khil, P. P., Smagulova, F., Brick, K. M., Camerini-Otero, R. D. & Petukhova, G. V. Sensitive mapping of recombination hotspots using sequencing-based detection of ssDNA. Genome Res. http://dx.doi.org/10.1101/gr.130583.111 (2012)
Borde, V. et al. Histone H3 lysine 4 trimethylation marks meiotic recombination initiation sites. EMBO J. 28, 99–111 (2009)
Buard, J., Barthès, P., Grey, C. & de Massy, B. Distinct histone modifications define initiation and repair of meiotic recombination in the mouse. EMBO J. 28, 2616–2624 (2009)
Guenther, M. G., Levine, S. S., Boyer, L. A., Jaenisch, R. & Young, R. A. A chromatin landmark and transcription initiation at most promoters in human cells. Cell 130, 77–88 (2007)
Ernst, J. et al. Mapping and analysis of chromatin state dynamics in nine human cell types. Nature 473, 43–49 (2011)
Pekowska, A. et al. H3K4 tri-methylation provides an epigenetic signature of active enhancers. EMBO J. 30, 4198–4210 (2011)
Tan, M. et al. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell 146, 1016–1028 (2011)
Pan, J. et al. A hierarchical combination of factors shapes the genome-wide topography of yeast meiotic recombination initiation. Cell 144, 719–731 (2011)
Wu, T. C. & Lichten, M. Meiosis-induced double-strand break sites determined by yeast chromatin structure. Science 263, 515–518 (1994)
Kauppi, L. et al. Distinct properties of the XY pseudoautosomal region crucial for male meiosis. Science 331, 916–920 (2011)
Oliver, P. L. et al. Accelerated evolution of the Prdm9 speciation gene across diverse metazoan taxa. PLoS Genet. 5, e1000753 (2009)
Bellott, D. W. & Page, D. C. Reconstructing the evolution of vertebrate sex chromosomes. Cold Spring Harb. Symp. Quant. Biol. 74, 345–353 (2009)
Lim, F. L., Soulez, M., Koczan, D., Thiesen, H. J. & Knight, J. C. A KRAB-related domain and a novel transcription repression domain in proteins encoded by SSX genes that are disrupted in human sarcomas. Oncogene 17, 2013–2018 (1998)
Margolin, J. F. et al. Krüppel-associated boxes are potent transcriptional repression domains. Proc. Natl Acad. Sci. USA 91, 4509–4513 (1994)
Axelsson, E. et al. Death of PRDM9 coincides with stabilization of the recombination landscape in the dog genome. Genome Res. 22, 51–63 (2012)
Muñoz-Fuentes, V., Di Rienzo, A. & Vilà, C. Prdm9, a major determinant of meiotic recombination hotspots, is not functional in dogs and their wild relatives, wolves and coyotes. PLoS ONE 6, e25498 (2011)
Jothi, R., Cuddapah, S., Barski, A., Cui, K. & Zhao, K. Genome-wide identification of in vivo protein–DNA binding sites from ChIP-Seq data. Nucleic Acids Res. 36, 5221–5231 (2008)
Zhang, Y. et al. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 9, R137 (2008)