nature.com

Common variants of FUT2 are associated with plasma vitamin B12 levels - Nature Genetics

  • ️Hunter, David J
  • ️Sun Sep 07 2008

This is a preview of subscription content, access via your institution

References

  1. Siva, A. et al. QJM 100, 495–499 (2007).

    Article  CAS  Google Scholar 

  2. Watanabe, F. Exp. Biol. Med. (Maywood) 232, 1266–1274 (2007).

    Article  CAS  Google Scholar 

  3. Kang, J.H. et al. Epidemiology 17, 650–657 (2006).

    Article  Google Scholar 

  4. Dahlin, A.M. et al. Int. J. Cancer 122, 2057–2061 (2008).

    Article  CAS  Google Scholar 

  5. Tanner, S.M. et al. Hum. Mutat. 23, 327–333 (2004).

    Article  CAS  Google Scholar 

  6. Hunter, D.J. et al. Nat. Genet. 39, 870–874 (2007).

    Article  CAS  Google Scholar 

  7. Kelly, R.J. et al. J. Biol. Chem. 270, 4640–4649 (1995).

    Article  CAS  Google Scholar 

  8. Koda, Y. et al. Genetics 158, 747–756 (2001).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Lindesmith, L.C. et al. PLoS Med. 5, e31 (2008).

    Article  Google Scholar 

  10. Carmel, R. et al. J. Lab. Clin. Med. 109, 454–463 (1987).

    CAS  PubMed  Google Scholar 

  11. Azevedo, M. et al. J. Pathol. 215, 308–316 (2008).

    Article  CAS  Google Scholar 

  12. van Oijen, M.G. et al. J. Nutr. Sci. Vitaminol. (Tokyo) 50, 305–308 (2004).

    Article  CAS  Google Scholar 

  13. Dholakia, K.R. et al. World J. Gastroenterol. 11, 7078–7083 (2005).

    Article  CAS  Google Scholar 

  14. Annibale, B. et al. Dig. Liver Dis. 34 (Suppl. 2), S72–S77 (2002).

    Article  CAS  Google Scholar 

  15. Tamura, A. et al. Am. J. Gastroenterol. 97, 861–866 (2002).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank H. Ranu, C. Chen and the staff at the Core Genotyping Facility at the National Cancer Institute for their expertise. This research is supported by the National Institutes of Health Research Grants U54 CA100971, P01 CA87969, P01 CA55075, U01 CA098233, R01 CA 065725 and CA070817. A.H. is supported in part by training grant NIH T-32 CA 09001-30.

Author information

Authors and Affiliations

  1. Department of Epidemiology, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, 02115, Massachusetts, USA

    Aditi Hazra, Peter Kraft & David J Hunter

  2. Department of Medicine, Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, 02115, Massachusetts, USA

    Aditi Hazra, Edward L Giovannucci & David J Hunter

  3. Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Vitamin Metabolism and Aging Laboratory, Tufts University, Boston, Massachusetts, 02111, USA

    Jacob Selhub

  4. Department of Nutrition, Harvard School of Public Health, 677 Huntington Avenue, Boston, 02115, Massachusetts, USA

    Edward L Giovannucci & David J Hunter

  5. Division of Cancer Epidemiology and Genetics, Department of Health and Human Services (DHHS), National Cancer Institute(NCI), US National Institutes of Health (NIH), Bethesda, 20892, Maryland, USA

    Gilles Thomas, Robert N Hoover, Stephen J Chanock & David J Hunter

  6. Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, 02142, Massachusetts, USA

    David J Hunter

Authors

  1. Aditi Hazra

    You can also search for this author in PubMed Google Scholar

  2. Peter Kraft

    You can also search for this author in PubMed Google Scholar

  3. Jacob Selhub

    You can also search for this author in PubMed Google Scholar

  4. Edward L Giovannucci

    You can also search for this author in PubMed Google Scholar

  5. Gilles Thomas

    You can also search for this author in PubMed Google Scholar

  6. Robert N Hoover

    You can also search for this author in PubMed Google Scholar

  7. Stephen J Chanock

    You can also search for this author in PubMed Google Scholar

  8. David J Hunter

    You can also search for this author in PubMed Google Scholar

Contributions

This study is a joint effort of the Nurses' Health Study investigators (A.H., P.K., E.L.G. and D.J.H.) and Cancer Genetics Markers of Susceptibility study investigators (G.T., R.N.H., S.J.C. and D.J.H.). A.H. and D.J.H. designed the study; J.S. measured the plasma vitamin B12 and homocysteine levels; A.H. performed the analyses; P.K. supervised the statistical analyses; A.H. wrote the manuscript and prepared the tables, figures and supplementary material, with input from all co-authors.

Corresponding author

Correspondence to David J Hunter.

Supplementary information

About this article

Cite this article

Hazra, A., Kraft, P., Selhub, J. et al. Common variants of FUT2 are associated with plasma vitamin B12 levels. Nat Genet 40, 1160–1162 (2008). https://doi.org/10.1038/ng.210

Download citation

  • Received: 18 March 2008

  • Accepted: 26 June 2008

  • Published: 07 September 2008

  • Issue Date: October 2008

  • DOI: https://doi.org/10.1038/ng.210