nature.com

Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis - Nature Genetics

  • ️Cucca, Francesco
  • ️Sun May 09 2010

References

  1. The Australia and New Zealand Multiple Sclerosis Genetics Consortium. Nat. Genet. 41, 824–828 (2009).

  2. De Jager, P.L. et al. Nat. Genet. 41, 776–782 (2009).

    Google Scholar 

  3. Hafler, D.A. et al. N. Engl. J. Med. 357, 851–862 (2007).

    Google Scholar 

  4. Pugliatti, M. et al. Eur. J. Neurol. 13, 700–722 (2006).

    Google Scholar 

  5. Marrosu, M.G. et al. Hum. Mol. Genet. 10, 2907–2916 (2001).

    Google Scholar 

  6. Li, Y., Willer, C., Sanna, S. & Abecasis, G. Annu. Rev. Genomics Hum. Genet. 10, 387–406 (2009).

    Google Scholar 

  7. Schmitz, M.L. Sci. Signal. 2, pe38 (2009).

    Google Scholar 

  8. Qiao, G. et al. J. Immunol. 179, 4473–4479 (2007).

    Google Scholar 

  9. Kojo, S. et al. Proc. Natl. Acad. Sci. USA 106, 17847–17851 (2009).

    Google Scholar 

  10. Chiang, Y.J. et al. Nature 403, 216–220 (2000).

    Google Scholar 

  11. Bachmaier, K. et al. Nature 403, 211–216 (2000).

    Google Scholar 

  12. Yokoi, N. et al. Nat. Genet. 31, 391–394 (2002).

    Google Scholar 

  13. Jeon, M.S. et al. Immunity 21, 167–177 (2004).

    Google Scholar 

  14. Loeser, S. & Penninger, J.M. Semin. Immunol. 19, 206–214 (2007).

    Google Scholar 

Download references

Acknowledgements

This study was supported by the Fondazione Italiana Sclerosi Multipla (FISM) Cod. 2008/R/7 to F.C., by the Italian Ministry of Scientific Research (MIUR grant 2007KXNKNP) and by US National Institutes of Health contract NO1-AG-1-2109 from National Institute of Aging (NIA) to the SardiNIA ('ProgeNIA') team. The contributions of G.R.A., Y.L. and L.L. were supported in part by NIH grants HG002651, HG005214 and MH084698.

We thank all the cases and controls who made this research possible; J. Todd for a critical revision of the manuscript and helpful suggestions; A. Cao for his continuous help and support; D. Longo, D. Taub, S. Naitza, L. Crisponi, M. Congia, C. Jones, P. Zanella, R. Tirler, L. Leoni, R. Cusano, R. Lampis, V. Orrù, F. Coraddu, J. Foster, M. Luiu, L. Davolio Marani, S. Solveig Fois and M. Arru for help and advice; J. Frau, L. Lorefice, G. Coghe, G. Fenu, L. Mannu, P. Cossu, W. Satta, I. Pirastru, S. Leoni and C. Buscarinu for collaboration in the collection of MS cases; and W. Garau and F. Virdis, along with the personnel of the blood donor centers of Cagliari and Sassari, for their help in the collection of the controls. We are grateful for the important computing resources made available for the imputation and analysis by the CRS4 Computing Cluster in Pula (Cagliari, Italy).

Author information

Author notes

  1. Serena Sanna, Maristella Pitzalis and Magdalena Zoledziewska: These authors contributed equally to this work.

Authors and Affiliations

  1. Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy

    Serena Sanna, Carlo Sidore, Fabio Busonero, Andrea Maschio, Mariano Dei, Sandra Lai, Antonella Mulas, Gianmauro Cuccuru, Eleonora Porcu, Manuela Uda & Francesco Cucca

  2. Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy

    Maristella Pitzalis, Magdalena Zoledziewska, Francesca Deidda, Fausto Poddie, Laura Morelli, Elisa Deriu & Francesco Cucca

  3. Center for Advanced Studies, Research and Development in Sardinia (CRS4), Laboratorio di Bioinformatica, Parco tecnologico della Sardegna, Pula, Italy

    Ilenia Zara

  4. CRS4, Laboratorio di Genomica, Parco tecnologico della Sardegna, Pula, Italy

    Carlo Sidore, Michael B Whalen, M Francesca Urru & Andrea Angius

  5. Dipartimento di Scienze Neurologiche e Cardiovascolari, Centro Sclerosi Multipla, Università di Cagliari, Cagliari, Italy

    Raffaele Murru, Gianna Costa, Maria Cristina Melis, Loredana Moi, Eleonora Cocco & Maria Giovanna Marrosu

  6. Istituto di Neurologia Clinica, Università di Sassari, Sassari, Italy

    Gabriele Farina, Stefano Sotgiu, Maura Pugliatti & Giulio Rosati

  7. Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA

    Yun Li, Liming Liang & Gonçalo R Abecasis

  8. Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA

    Yun Li

  9. Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, USA

    Yun Li

  10. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA

    Liming Liang

  11. Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA

    Liming Liang

  12. Dipartimento di Scienze Biomediche e biotecnologie, Università di Cagliari, Cagliari, Italy

    Patrizia Zavattari

  13. Azienda Ospedaliera Brotzu, Centro Trasfusionale, Cagliari, Italy

    Michele Bajorek

  14. Azienda Sanitaria Locale 1, Sassari, Italy

    Maria Anna Satta

  15. Divisione di Neurologia, Azienda Ospedaliera Brotzu, Cagliari, Italy

    Paola Ferrigno & Maurizio Melis

  16. Divisione Neurologia, Presidio Ospedaliero, Ozieri, Italy

    Sebastiano Traccis

  17. Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA

    David Schlessinger

Authors

  1. Serena Sanna

    You can also search for this author inPubMed Google Scholar

  2. Maristella Pitzalis

    You can also search for this author inPubMed Google Scholar

  3. Magdalena Zoledziewska

    You can also search for this author inPubMed Google Scholar

  4. Ilenia Zara

    You can also search for this author inPubMed Google Scholar

  5. Carlo Sidore

    You can also search for this author inPubMed Google Scholar

  6. Raffaele Murru

    You can also search for this author inPubMed Google Scholar

  7. Michael B Whalen

    You can also search for this author inPubMed Google Scholar

  8. Fabio Busonero

    You can also search for this author inPubMed Google Scholar

  9. Andrea Maschio

    You can also search for this author inPubMed Google Scholar

  10. Gianna Costa

    You can also search for this author inPubMed Google Scholar

  11. Maria Cristina Melis

    You can also search for this author inPubMed Google Scholar

  12. Francesca Deidda

    You can also search for this author inPubMed Google Scholar

  13. Fausto Poddie

    You can also search for this author inPubMed Google Scholar

  14. Laura Morelli

    You can also search for this author inPubMed Google Scholar

  15. Gabriele Farina

    You can also search for this author inPubMed Google Scholar

  16. Yun Li

    You can also search for this author inPubMed Google Scholar

  17. Mariano Dei

    You can also search for this author inPubMed Google Scholar

  18. Sandra Lai

    You can also search for this author inPubMed Google Scholar

  19. Antonella Mulas

    You can also search for this author inPubMed Google Scholar

  20. Gianmauro Cuccuru

    You can also search for this author inPubMed Google Scholar

  21. Eleonora Porcu

    You can also search for this author inPubMed Google Scholar

  22. Liming Liang

    You can also search for this author inPubMed Google Scholar

  23. Patrizia Zavattari

    You can also search for this author inPubMed Google Scholar

  24. Loredana Moi

    You can also search for this author inPubMed Google Scholar

  25. Elisa Deriu

    You can also search for this author inPubMed Google Scholar

  26. M Francesca Urru

    You can also search for this author inPubMed Google Scholar

  27. Michele Bajorek

    You can also search for this author inPubMed Google Scholar

  28. Maria Anna Satta

    You can also search for this author inPubMed Google Scholar

  29. Eleonora Cocco

    You can also search for this author inPubMed Google Scholar

  30. Paola Ferrigno

    You can also search for this author inPubMed Google Scholar

  31. Stefano Sotgiu

    You can also search for this author inPubMed Google Scholar

  32. Maura Pugliatti

    You can also search for this author inPubMed Google Scholar

  33. Sebastiano Traccis

    You can also search for this author inPubMed Google Scholar

  34. Andrea Angius

    You can also search for this author inPubMed Google Scholar

  35. Maurizio Melis

    You can also search for this author inPubMed Google Scholar

  36. Giulio Rosati

    You can also search for this author inPubMed Google Scholar

  37. Gonçalo R Abecasis

    You can also search for this author inPubMed Google Scholar

  38. Manuela Uda

    You can also search for this author inPubMed Google Scholar

  39. Maria Giovanna Marrosu

    You can also search for this author inPubMed Google Scholar

  40. David Schlessinger

    You can also search for this author inPubMed Google Scholar

  41. Francesco Cucca

    You can also search for this author inPubMed Google Scholar

Corresponding author

Correspondence to Francesco Cucca.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

About this article

Cite this article

Sanna, S., Pitzalis, M., Zoledziewska, M. et al. Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis. Nat Genet 42, 495–497 (2010). https://doi.org/10.1038/ng.584

Download citation

  • Received: 21 December 2009

  • Accepted: 13 April 2010

  • Published: 09 May 2010

  • Issue Date: June 2010

  • DOI: https://doi.org/10.1038/ng.584