Chfr is required for tumor suppression and Aurora A regulation - Nature Genetics
- ️Chen, Junjie
- ️Sun Mar 27 2005
Carmena, M. & Earnshaw, W.C. The cellular geography of aurora kinases. Nat. Rev. Mol. Cell. Biol. 4, 842–854 (2003).
Katayama, H., Brinkley, W.R. & Sen, S. The Aurora kinases: role in cell transformation and tumorigenesis. Cancer Metastasis Rev. 22, 451–464 (2003).
Bischoff, J.R. et al. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J. 17, 3052–3065 (1998).
Zhou, H. et al. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat. Genet. 20, 189–193 (1998).
Littlepage, L.E. et al. Identification of phosphorylated residues that affect the activity of the mitotic kinase Aurora A. Proc. Natl. Acad. Sci. USA 99, 15440–15445 (2002).
Cleveland, D.W., Mao, Y. & Sullivan, K.F. Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling. Cell 112, 407–421 (2003).
Chan, G.K. & Yen, T.J. The mitotic checkpoint: a signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit. Prog. Cell Cycle Res. 5, 431–439 (2003).
Lew, D.J. & Burke, D.J. The spindle assembly and spindle position checkpoints. Annu. Rev. Genet. 37, 251–282 (2003).
Cahill, D.P. et al. Mutations of mitotic checkpoint genes in human cancers. Nature 392, 300–303 (1998).
Imai, Y., Shiratori, Y., Kato, N., Inoue, T. & Omata, M. Mutational inactivation of mitotic checkpoint genes, hsMAD2 and hBUB1, is rare in sporadic digestive tract cancers. Jpn. J. Cancer Res. 90, 837–840 (1999).
Scolnick, D.M. & Halazonetis, T.D. Chfr defines a mitotic stress checkpoint that delays entry into metaphase. Nature 406, 430–435 (2000).
Matsusaka, T. & Pines, J. Chfr acts with the p38 stress kinases to block entry to mitosis in mammalian cells. J. Cell Biol. 166, 507–516 (2004).
Stavridi, E.S. et al. Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate. Structure (Camb) 10, 891–899 (2002).
Murone, M. & Simanis, V. The fission yeast dma1 gene is a component of the spindle assembly checkpoint, required to prevent septum formation and premature exit from mitosis if spindle function is compromised. EMBO J. 15, 6605–6616 (1996).
Guertin, D.A., Venkatram, S., Gould, K.L. & McCollum, D. Dma1 prevents mitotic exit and cytokinesis by inhibiting the septation initiation network (SIN). Dev. Cell 3, 779–790 (2002).
Kang, D., Chen, J., Wong, J. & Fang, G. The checkpoint protein Chfr is a ligase that ubiquitinates PLK1 and inhibits Cdc2 at the G2 to M transition. J. Cell Biol. 156, 249–259 (2002).
Chaturvedi, P. et al. Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity. Cancer Res. 62, 1797–1801 (2002).
Bothos, J., Summers, M.K., Venere, M., Scolnick, D.M. & Halazonetis, T.D. The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains. Oncogene 22, 7101–7107 (2003).
Erson, A.E. & Petty, E.M. CHFR-associated early G2/M checkpoint defects in breast cancer cells. Mol. Carcinog. 39, 26–33 (2004).
Mizuno, K. et al. Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancers. Oncogene 21, 2328–3233 (2002).
Shibata, Y. et al. Chfr expression is downregulated by CpG island hypermethylation in esophageal cancer. Carcinogenesis 23, 1695–1699 (2002).
Corn, P.G. et al. Frequent hypermethylation of the 5′ CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer. Carcinogenesis 24, 47–51 (2003).
Toyota, M. et al. Epigenetic inactivation of CHFR in human tumors. Proc. Natl. Acad. Sci. USA 100, 7818–7823 (2003).
Mariatos, G. et al. Inactivating mutations targeting the chfr mitotic checkpoint gene in human lung cancer. Cancer Res. 63, 7185–7189 (2003).
Satoh, A. et al. Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer. Cancer Res. 63, 8606–8613 (2003).
Ewart-Toland, A. et al. Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nat. Genet. 34, 403–412 (2003).
Sen, S., Zhou, H. & White, R.A. A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines. Oncogene 14, 2195–2200 (1997).
Tanner, M.M. et al. Frequent amplification of chromosomal region 20q12-q13 in ovarian cancer. Clin. Cancer Res. 6, 1833–1839 (2000).
Meraldi, P., Honda, R. & Nigg, E.A. Aurora A overexpression reveals tetraploidization as a major route to centrosome amplification in p53−/− cells. EMBO J. 21, 483–492 (2002).
Anand, S., Penrhyn-Lowe, S. & Venkitaraman, A.R. AURORA A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol. Cancer Cell 3, 51–62 (2003).