The composition and signaling of the IL-35 receptor are unconventional - Nature Immunology
- ️Vignali, Dario A A
- ️Sun Feb 05 2012
Vignali, D.A., Collison, L.W. & Workman, C.J. How regulatory T cells work. Nat. Rev. Immunol. 8, 523–532 (2008).
Zou, W. Regulatory T cells, tumour immunity and immunotherapy. Nat. Rev. Immunol. 6, 295–307 (2006).
O'Shea, J.J. & Paul, W.E. Regulation of TH1 differentiation–controlling the controllers. Nat. Immunol. 3, 506–508 (2002).
Artis, D. et al. The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity. J. Immunol. 173, 5626–5634 (2004).
Awasthi, A. et al. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat. Immunol. 8, 1380–1389 (2007).
Fitzgerald, D.C. et al. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat. Immunol. 8, 1372–1379 (2007).
Stumhofer, J.S. et al. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat. Immunol. 8, 1363–1371 (2007).
Collison, L.W. et al. IL-35-mediated induction of a potent regulatory T cell population. Nat. Immunol. 11, 1093–1101 (2010).
Collison, L.W., Pillai, M.R., Chaturvedi, V. & Vignali, D.A. Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner. J. Immunol. 182, 6121–6128 (2009).
Collison, L.W. et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 450, 566–569 (2007).
Chua, A.O., Wilkinson, V.L., Presky, D.H. & Gubler, U. Cloning and characterization of a mouse IL-12 receptor-β component. J. Immunol. 155, 4286–4294 (1995).
Parham, C. et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R. J. Immunol. 168, 5699–5708 (2002).
Pflanz, S. et al. WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. J. Immunol. 172, 2225–2231 (2004).
Silver, J.S. & Hunter, C.A. gp130 at the nexus of inflammation, autoimmunity, and cancer. J. Leukoc. Biol. 88, 1145–1156 (2010).
Bacon, C.M. et al. Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. Proc. Natl. Acad. Sci. USA 92, 7307–7311 (1995).
Delgoffe, G.M., Murray, P.J. & Vignali, D.A. Interpreting mixed signals: the cell's cytokine conundrum. Curr. Opin. Immunol. 23, 1–7 (2011).
Thierfelder, W.E. et al. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382, 171–174 (1996).
Huber, M. et al. IL-27 inhibits the development of regulatory T cells via STAT3. Int. Immunol. 20, 223–234 (2008).
Owaki, T. et al. STAT3 is indispensable to IL-27-mediated cell proliferation but not to IL-27-induced Th1 differentiation and suppression of proinflammatory cytokine production. J. Immunol. 180, 2903–2911 (2008).
Wu, C. et al. IL-12 receptor β 2 (IL-12Rβ2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites. J. Immunol. 165, 6221–6228 (2000).
Presky, D.H. et al. A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits. Proc. Natl. Acad. Sci. USA 93, 14002–14007 (1996).
Villarino, A. et al. The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. Immunity 19, 645–655 (2003).
Schroers, A. et al. Dynamics of the gp130 cytokine complex: a model for assembly on the cellular membrane. Protein Sci. 14, 783–790 (2005).
Skiniotis, G., Lupardus, P.J., Martick, M., Walz, T. & Garcia, K.C. Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex. Mol. Cell 31, 737–748 (2008).
Betz, U.A. & Muller, W. Regulated expression of gp130 and IL-6 receptor α chain in T cell maturation and activation. Int. Immunol. 10, 1175–1184 (1998).
Charlot-Rabiega, P., Bardel, E., Dietrich, C., Kastelein, R. & Devergne, O. Signaling events involved in interleukin 27 (IL-27)-induced proliferation of human naive CD4+ T cells and B cells. J. Biol. Chem. 286, 27350–27362 (2011).
Hibbert, L., Pflanz, S., De Waal Malefyt, R. & Kastelein, R.A. IL-27 and IFN-α signal via Stat1 and Stat3 and induce T-bet and IL-12Rβ2 in naive T cells. J. Interferon Cytokine Res. 23, 513–522 (2003).
Takeda, A. et al. Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. J. Immunol. 170, 4886–4890 (2003).
Liao, W., Lin, J.X., Wang, L., Li, P. & Leonard, W.J. Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages. Nat. Immunol. 12, 551–559 (2011).
O'Shea, J.J. & Murray, P.J. Cytokine signaling modules in inflammatory responses. Immunity 28, 477–487 (2008).
Ho, H.H. & Ivashkiv, L.B. Role of STAT3 in type I interferon responses. Negative regulation of STAT1-dependent inflammatory gene activation. J. Biol. Chem. 281, 14111–14118 (2006).
Yamamoto, K., Miura, O., Hirosawa, S. & Miyasaka, N. Binding sequence of STAT4: STAT4 complex recognizes the IFN-γ activation site (GAS)-like sequence (T/A)TTCC(C/G)GGAA(T/A). Biochem. Biophys. Res. Commun. 233, 126–132 (1997).
Ehret, G.B. et al. DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites. J. Biol. Chem. 276, 6675–6688 (2001).
Yu, Q., Thieu, V.T. & Kaplan, M.H. Stat4 limits DNA methyltransferase recruitment and DNA methylation of the IL-18Rα gene during Th1 differentiation. EMBO J. 26, 2052–2060 (2007).
Ramsauer, K. et al. Distinct modes of action applied by transcription factors STAT1 and IRF1 to initiate transcription of the IFN-γ-inducible gbp2 gene. Proc. Natl. Acad. Sci. USA 104, 2849–2854 (2007).
Boulanger, M.J., Chow, D.C., Brevnova, E.E. & Garcia, K.C. Hexameric structure and assembly of the interleukin-6/IL-6 α-receptor/gp130 complex. Science 300, 2101–2104 (2003).
Stern, A.S., Gubler, U., Presky, D.H. & Magram, J. Structural and functional aspects of the IL-12 receptor complex. Chem. Immunol. 68, 23–37 (1997).
Huyton, T. et al. An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor. Proc. Natl. Acad. Sci. USA 104, 12737–12742 (2007).
Lucas, S., Ghilardi, N., Li, J. & de Sauvage, F.J. IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms. Proc. Natl. Acad. Sci. USA 100, 15047–15052 (2003).
Canda-Sánchez, A. et al. Differential distribution of both IL-12Rβ chains in the plasma membrane of human T cells. J. Membr. Biol. 227, 1–12 (2009).
Maldonado, R.A., Irvine, D.J., Schreiber, R. & Glimcher, L.H. A role for the immunological synapse in lineage commitment of CD4 lymphocytes. Nature 431, 527–532 (2004).
Szabo, S.J., Dighe, A.S., Gubler, U. & Murphy, K.M. Regulation of the interleukin (IL)-12Rβ2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185, 817–824 (1997).
Grohmann, U. et al. IL-12 acts directly on DC to promote nuclear localization of NF-κB and primes DC for IL-12 production. Immunity 9, 315–323 (1998).
Andersson, J. et al. CD4+FoxP3+ regulatory T cells confer infectious tolerance in a TGF-β-dependent manner. J. Exp. Med. 205, 1975–1981 (2008).
Pot, C. et al. Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J. Immunol. 183, 797–801 (2009).
Pistoia, V., Cocco, C. & Airoldi, I. Interleukin-12 receptor β2: from cytokine receptor to gatekeeper gene in human B-cell malignancies. J. Clin. Oncol. 27, 4809–4816 (2009).
Hirschfield, G.M. et al. Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. N. Engl. J. Med. 360, 2544–2555 (2009).
Matsui, E. et al. Mutations of the IL-12 receptor β2 chain gene in atopic subjects. Biochem. Biophys. Res. Commun. 266, 551–555 (1999).
Remmers, E.F. et al. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R–IL12RB2 regions associated with Behçet's disease. Nat. Genet. 42, 698–702 (2010).
Xu, Y. et al. Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes. J. Biol. Chem. 285, 21214–21218 (2010).