Thymic microenvironments for T cell differentiation and selection - Nature Immunology
- ️Robey, Ellen A
- ️Mon Mar 20 2006
Gray, D.H. et al. Controlling the thymic microenvironment. Curr. Opin. Immunol. 17, 137–143 (2005).
Blackburn, C.C. & Manley, N.R. Developing a new paradigm for thymus organogenesis. Nat. Rev. Immunol. 4, 278–289 (2004).
Lind, E., Prockop, S., Porritt, H. & Petrie, H. Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development. J. Exp. Med. 194, 127–134 (2001).
Foss, D.L., Donskoy, E. & Goldschneider, I. The importation of hematogenous precursors by the thymus is a gated phenomenon in normal adult mice. J. Exp. Med. 193, 365–374 (2001).
Prockop, S.E. & Petrie, H.T. Regulation of thymus size by competition for stromal niches among early T cell progenitors. J. Immunol. 173, 1604–1611 (2004).
Rossi, F.M. et al. Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1. Nat. Immunol. 6, 626–634 (2005).
Campbell, D.J., Kim, C.H. & Butcher, E.C. Chemokines in the systemic organization of immunity. Immunol. Rev. 195, 58–71 (2003).
Petrie, H.T. Cell migration and the control of post-natal T-cell lymphopoiesis in the thymus. Nat. Rev. Immunol. 3, 859–866 (2003).
Bleul, C.C. & Boehm, T. Chemokines define distinct microenvironments in the developing thymus. Eur. J. Immunol. 30, 3371–3379 (2000).
Liu, C. et al. The role of CCL21 in recruitment of T-precursor cells to fetal thymi. Blood 105, 31–39 (2005).
Zubkova, I., Mostowski, H. & Zaitseva, M. Up-regulation of IL-7, stromal-derived factor-1α, thymus-expressed chemokine, and secondary lymphoid tissue chemokine gene expression in the stromal cells in response to thymocyte depletion: implication for thymus reconstitution. J. Immunol. 175, 2321–2330 (2005).
Cyster, J.G. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu. Rev. Immunol. 23, 127–159 (2005).
Matloubian, M. et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427, 355–360 (2004).
Allende, M.L., Dreier, J.L., Mandala, S. & Proia, R.L. Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration. J. Biol. Chem. 279, 15396–15401 (2004).
Wei, S.H. et al. Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat. Immunol. 6, 1228–1235 (2005).
Mandala, S. et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296, 346–349 (2002).
Schwab, S.R. et al. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science 309, 1735–1739 (2005).
Feng, C. et al. A potential role for CD69 in thymocyte emigration. Int. Immunol. 14, 535–544 (2002).
Cotta-de-Almeida, V. et al. Impaired migration of NOD mouse thymocytes: a fibronectin receptor-related defect. Eur. J. Immunol. 34, 1578–1587 (2004).
Poznansky, M.C. et al. Thymocyte emigration is mediated by active movement away from stroma-derived factors. J. Clin. Invest. 109, 1101–1110 (2002).
Ueno, T. et al. Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus. Immunity 16, 205–218 (2002).
Barbee, S.D. & Alberola-Ila, J. Phosphatidylinositol 3-kinase regulates thymic exit. J. Immunol. 174, 1230–1238 (2005).
Boehm, T., Scheu, S., Pfeffer, K. & Bleul, C.C. Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTβR. J. Exp. Med. 198, 757–769 (2003).
Campbell, J.J. & Butcher, E.C. Chemokines in tissue-specific and microenvironment-specific lymphocyte homing. Curr. Opin. Immunol. 12, 336–341 (2000).
Ara, T. et al. A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo. J. Immunol. 170, 4649–4655 (2003).
Plotkin, J., Prockop, S.E., Lepique, A. & Petrie, H.T. Critical role for CXCR4 signaling in progenitor localization and T cell differentiation in the postnatal thymus. J. Immunol. 171, 4521–4527 (2003).
Misslitz, A. et al. Thymic T cell development and progenitor localization depend on CCR7. J. Exp. Med. 200, 481–491 (2004).
Benz, C., Heinzel, K. & Bleul, C.C. Homing of immature thymocytes to the subcapsular microenvironment within the thymus is not an absolute requirement for T cell development. Eur. J. Immunol. 34, 3652–3663 (2004).
Ueno, T. et al. CCR7 signals are essential for cortex-medulla migration of developing thymocytes. J. Exp. Med. 200, 493–505 (2004).
Kwan, J. & Killeen, N. CCR7 directs the migration of thymocytes into the thymic medulla. J. Immunol. 172, 3999–4007 (2004).
Uehara, S., Grinberg, A., Farber, J.M. & Love, P.E. A role for CCR9 in T lymphocyte development and migration. J. Immunol. 168, 2811–2819 (2002).
Wurbel, M.A. et al. Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor γδ+ gut intraepithelial lymphocytes. Blood 98, 2626–2632 (2001).
Bousso, P., Bhakta, N.R., Lewis, R.S. & Robey, E. Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy. Science 296, 1876–1880 (2002).
Bhakta, N.R., Oh, D.Y. & Lewis, R.S. Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environment. Nat. Immunol. 6, 143–151 (2005).
Witt, C.M., Raychaudhuri, S., Schaefer, B., Chakraborty, A.K. & Robey, E.A. Directed migration of positively selected thymocytes visualized in real time. PLoS Biol. 3, 1062–1069 (2005).
Bousso, P. & Robey, E. Dynamic behavior of T cells and thymocytes in lymphoid organs as revealed by 2-photon microscopy. Immunity 21, 349–355 (2004).
Kyewski, B. & Derbinski, J. Self-representation in the thymus: an extended view. Nat. Rev. Immunol. 4, 688–698 (2004).
Ramsey, C. et al. Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum. Mol. Genet. 11, 397–409 (2002).
Anderson, M.S. et al. Projection of an immunological self shadow within the thymus by the aire protein. Science 298, 1395–1401 (2002).
Ramsey, C., Bukrinsky, A. & Peltonen, L. Systematic mutagenesis of the functional domains of AIRE reveals their role in intracellular targeting. Hum. Mol. Genet. 11, 3299–3308 (2002).
Burkly, L. et al. Expression of relB is required for the development of thymic medulla and dendritic cells. Nature 373, 531–536 (1995).
Kajiura, F. et al. NF-κB-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner. J. Immunol. 172, 2067–2075 (2004).
Derbinski, J. & Kyewski, B. Linking signalling pathways, thymic stroma integrity and autoimmunity. Trends Immunol. 26, 503–506 (2005).
Akiyama, T. et al. Dependence of self-tolerance on TRAF6-directed development of thymic stroma. Science 308, 248–251 (2005).
Derbinski, J. et al. Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J. Exp. Med. 202, 33–45 (2005).
Chin, R.K. et al. Lymphotoxin pathway directs thymic Aire expression. Nat. Immunol. 4, 1121–1127 (2003).
Liston, A., Lesage, S., Wilson, J., Peltonen, L. & Goodnow, C.C. Aire regulates negative selection of organ-specific T cells. Nat. Immunol. 4, 350–354 (2003).
Anderson, M.S. et al. The cellular mechanism of Aire control of T cell tolerance. Immunity 23, 227–239 (2005).
Derbinski, J., Schulte, A., Kyewski, B. & Klein, L. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2, 1032–1039 (2001).
Gallegos, A.M. & Bevan, M.J. Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J. Exp. Med. 200, 1039–1049 (2004).
Dooley, J., Erickson, M. & Farr, A.G. An organized medullary epithelial structure in the normal thymus expresses molecules of respiratory epithelium and resembles the epithelial thymic rudiment of nude mice. J. Immunol. 175, 4331–4337 (2005).
Watanabe, N. et al. Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus. Nature 436, 1181–1185 (2005).
Shortman, K., Egerton, M., Spangrude, G.J. & Scollay, R. The generation and fate of thymocytes. Semin. Immunol. 2, 3–12 (1990).
Sakaguchi, S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 6, 345–352 (2005).
Paust, S. & Cantor, H. Regulatory T cells and autoimmune disease. Immunol. Rev. 204, 195–207 (2005).
Khattri, R., Cox, T., Yasayko, S.A. & Ramsdell, F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat. Immunol. 4, 337–342 (2003).
Fontenot, J.D., Gavin, M.A. & Rudensky, A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4, 330–336 (2003).
Fontenot, J.D. & Rudensky, A.Y. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat. Immunol. 6, 331–337 (2005).
Farr, A.G., Dooley, J.L. & Erickson, M. Organization of thymic medullary epithelial heterogeneity: implications for mechanisms of epithelial differentiation. Immunol. Rev. 189, 20–27 (2002).
Leonard, W.J. TSLP: finally in the limelight. Nat. Immunol. 3, 605–607 (2002).
Kronenberg, M. Toward an understanding of NKT cell biology: progress and paradoxes. Annu. Rev. Immunol. 23, 877–900 (2005).
Bendelac, A. Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes. J. Exp. Med. 182, 2091–2096 (1995).
Coles, M.C. & Raulet, D.H. NK1.1+ T cells in the liver arise in the thymus and are selected by interactions with class I molecules on CD4+CD8+ cells. J. Immunol. 164, 2412–2418 (2000).
Wei, D.G. et al. Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes. J. Exp. Med. 202, 239–248 (2005).
Forestier, C. et al. T cell development in mice expressing CD1d directed by a classical MHC class II promoter. J. Immunol. 171, 4096–4104 (2003).
Pasquier, B. et al. Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product. J. Exp. Med. 201, 695–701 (2005).
Nichols, K.E. et al. Regulation of NKT cell development by SAP, the protein defective in XLP. Nat. Med. 11, 340–345 (2005).
Chung, B., Aoukaty, A., Dutz, J., Terhorst, C. & Tan, R. Signaling lymphocytic activation molecule-associated protein controls NKT cell functions. J. Immunol. 174, 3153–3157 (2005).
Borowski, C. & Bendelac, A. Signaling for NKT cell development: the SAP-FynT connection. J. Exp. Med. 201, 833–836 (2005).
Hayes, S.M., Li, L. & Love, P.E. TCR signal strength influences αβ/γδ lineage fate. Immunity 22, 583–593 (2005).
Haks, M.C. et al. Attenuation of γδTCR signaling efficiently diverts thymocytes to the αβ lineage. Immunity 22, 595–606 (2005).
Robey, E. The αβ versus γδ T cell fate decision: when less is more. Immunity 22, 533–534 (2005).
Pennington, D.J. et al. The inter-relatedness and interdependence of mouse T cell receptor γδ+ and αβ+ cells. Nat. Immunol. 4, 991–998 (2003).
Silva-Santos, B., Pennington, D.J. & Hayday, A.C. Lymphotoxin-mediated regulation of γδ cell differentiation by αβ T cell progenitors. Science 307, 925–928 (2005).
Ikuta, K. et al. A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells. Cell 62, 863–874 (1990).
Havran, W.L., Carbone, A. & Allison, J.P. Murine T cells with invariant γδ antigen receptors: origin, repertoire, and specificity. Semin. Immunol. 3, 89–97 (1991).
Zerrahn, J. et al. Class I MHC molecules on hematopoietic cells can support intrathymic positive selection of T cell receptor transgenic T cells. Proc. Natl. Acad. Sci. USA 96, 11470–11475 (1999).
Choi, E.Y. et al. Thymocyte-thymocyte interaction for efficient positive selection and maturation of CD4 T cells. Immunity 23, 387–396 (2005).
Li, W. et al. An alternate pathway for CD4 T cell development: thymocyte-expressed MHC class II selects a distinct T cell population. Immunity 23, 375–386 (2005).
Choi, E.Y. et al. Thymocytes positively select thymocytes in human system. Hum. Immunol. 54, 15–20 (1997).
Traggiai, E. et al. Development of a human adaptive immune system in cord blood cell-transplanted mice. Science 304, 104–107 (2004).
Yahata, T. et al. Functional human T lymphocyte development from cord blood CD34+ cells in nonobese diabetic/Shi-scid, IL-2 receptor γ null mice. J. Immunol. 169, 204–209 (2002).
Anderson, G. & Jenkinson, E.J. Lymphostromal interactions in thymic development and function. Nat. Rev. Immunol. 1, 31–40 (2001).
Clegg, C.H., Rulffes, J.T., Wallace, P.M. & Haugen, H.S. Regulation of an extrathymic T-cell development pathway by oncostatin M. Nature 384, 261–263 (1996).
Terra, R. et al. T-cell generation by lymph node resident progenitor cells. Blood 106, 193–200 (2005).
Schmitt, T.M. & Zuniga-Pflucker, J.C. Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity 17, 749–756 (2002).
Poznansky, M.C. et al. Efficient generation of human T cells from a tissue-engineered thymic organoid. Nat. Biotechnol. 18, 729–734 (2000).
Zuniga-Pflucker, J.C. T-cell development made simple. Nat. Rev. Immunol. 4, 67–72 (2004).
Clark, R., Yamanaka, K., Bai, M., Dowgiert, R. & Kupper, T. Human skin cells support thymus-independent T cell development. J. Clin. Invest. 115, 3239–3249 (2005).
Robey, E.A. & Bluestone, J.A. Notch signaling in lymphocyte development and function. Curr. Opin. Immunol. 16, 360–366 (2004).