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Tempering antigen-presenting cells in multiple sclerosis - Nature Medicine

  • ️Zamvil, Scott S
  • ️Sun Jun 01 2008
  • News & Views
  • Published: June 2008

Bench to Bedside

Nature Medicine volume 14, pages 614–615 (2008)Cite this article

A variety of immune cell types contribute to disease in individuals with multiple sclerosis, an autoimmune condition of the central nervous system. Thomas Prod'homme and Scott Zamvil comment on the 'Bench to Bedside' approach, examining how recent basic research implicates the antigen-presenting cell in this disease. In our 'Bedside to Bench' column, Hans Link explores how recent clinical trials may bolster a mechanistic role for the B cell.

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Figure 1: Signaling via IFN-β regulates differentiation of TH17 cells, a proinflammatory cell type that is thought to contribute to multiple sclerosis.

References

  1. Tourbah, A. & Lyon-Caen, O. Biochimie 89, 899–902 (2007).

    Article  CAS  Google Scholar 

  2. Guo, B., Chang, E.Y. & Cheng, G. J. Clin. Invest. 118, 1680–1690 (2008).

    Article  CAS  Google Scholar 

  3. Prinz, M. et al. Immunity 28, 675–686 (2008).

    Article  CAS  Google Scholar 

  4. Teige, I. et al. J. Immunol. 170, 4776–4784 (2003).

    Article  CAS  Google Scholar 

  5. Zamvil, S.S. & Steinman, L. Neuron 38, 685–688 (2003).

    Article  CAS  Google Scholar 

  6. Steinman, L. Nat. Med. 13, 139–145 (2007).

    Article  CAS  Google Scholar 

  7. Fitzgerald, D.C. et al. J. Immunol. 179, 3268–3275 (2007).

    Article  CAS  Google Scholar 

  8. Rudick, R.A. et al. Ann. Neurol. 40, 618–627 (1996).

    Article  CAS  Google Scholar 

  9. Bielekova, B. et al. Nat. Med. 6, 1167–1175 (2000).

    Article  CAS  Google Scholar 

  10. Kappos, L. et al. Nat. Med. 6, 1176–1182 (2000).

    Article  CAS  Google Scholar 

  11. Krieg, A.M. & Vollmer, J. Immunol. Rev. 220, 251–269 (2007).

    Article  CAS  Google Scholar 

  12. Weber, M.S. et al. Nat. Med. 13, 935–943 (2007).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Thomas Prod'homme and Scott S. Zamvil are in the Department of Neurology and Program in Immunology, University of California San Francisco, 513 Parnassus Avenue S-268, San Francisco, California 94143-0114, USA. zamvil@ucsf.neuroimmunol.org,

    Thomas Prod'homme & Scott S Zamvil

Authors

  1. Thomas Prod'homme

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  2. Scott S Zamvil

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Prod'homme, T., Zamvil, S. Tempering antigen-presenting cells in multiple sclerosis. Nat Med 14, 614–615 (2008). https://doi.org/10.1038/nm0608-614

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  • Issue Date: June 2008

  • DOI: https://doi.org/10.1038/nm0608-614

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