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Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer - Nature Medicine

  • ️Jain, Rakesh K
  • ️Sun Jan 25 2004

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Acknowledgements

This study was supported by two National Cancer Institute grants (R21 CA099237 to C.G.W. and PO1 CA80124 to R.K.J.). D.G.D. is a Cancer Research Institute fellow. R.T.T. is a fellow of the Susan G. Komen Breast Cancer Foundation. We thank T. Lee for his contribution to the CT analysis, M. Ancukiewicz, T.P. Padera and W. Strauss for helpful comments, and J. Tooredman for the ELISAs.

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Author notes

  1. Yves Boucher, Emmanuelle di Tomaso, Dan G Duda, Lance L Munn and Ricky T Tong: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, Massachusetts, USA

    Christopher G Willett, Yves Boucher, Emmanuelle di Tomaso, Dan G Duda, Lance L Munn, Ricky T Tong, Sergey V Kozin, Alan C Hartford & Rakesh K Jain

  2. Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, Massachusetts, USA

    Daniel C Chung

  3. Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, Massachusetts, USA

    Dushyant V Sahani & Sanjeeva P Kalva

  4. Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, Massachusetts, USA

    Mari Mino & Gregory Y Lauwers

  5. AIDS Research Center/Experimental Hematology, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, Massachusetts, USA

    Kenneth S Cohen & David T Scadden

  6. Department of Nuclear Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, Massachusetts, USA

    Alan J Fischman

  7. Division of Hematology/Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, Massachusetts, USA

    Jeffrey W Clark, David P Ryan, Andrew X Zhu & Lawrence S Blaszkowsky

  8. Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, Massachusetts, USA

    Paul C Shellito

  9. Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, 20852, Maryland, USA

    Helen X Chen

Authors

  1. Christopher G Willett

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  2. Yves Boucher

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  3. Emmanuelle di Tomaso

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  4. Dan G Duda

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  5. Lance L Munn

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  6. Ricky T Tong

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  7. Daniel C Chung

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  8. Dushyant V Sahani

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  9. Sanjeeva P Kalva

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  10. Sergey V Kozin

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  11. Mari Mino

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  12. Kenneth S Cohen

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  13. David T Scadden

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  14. Alan C Hartford

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  15. Alan J Fischman

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  16. Jeffrey W Clark

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  17. David P Ryan

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  18. Andrew X Zhu

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  19. Lawrence S Blaszkowsky

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  20. Helen X Chen

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  21. Paul C Shellito

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  22. Gregory Y Lauwers

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  23. Rakesh K Jain

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Corresponding authors

Correspondence to Christopher G Willett or Rakesh K Jain.

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Competing interests

The authors declare no competing financial interests.

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Willett, C., Boucher, Y., di Tomaso, E. et al. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med 10, 145–147 (2004). https://doi.org/10.1038/nm988

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  • Received: 18 November 2003

  • Accepted: 05 January 2004

  • Published: 25 January 2004

  • Issue Date: 01 February 2004

  • DOI: https://doi.org/10.1038/nm988