nature.com

Nax channel involved in CNS sodium-level sensing - Nature Neuroscience

  • ️Noda, Masaharu
  • ️Mon May 06 2002
  • Brief Communication
  • Published: 06 May 2002

Nature Neuroscience volume 5, pages 511–512 (2002)Cite this article

Abstract

Mammals feel thirsty or an appetite for salt when the correct balance between water and sodium in the body fluid has been disrupted, but little is known about the mechanism in the brain that controls salt homeostasis. It has been postulated that the existence of both an osmoreceptor and a specific sodium receptor is essential if the experimental data are to be encompassed1,2. Several candidate osmoreceptors have been identified3,4,5, and here we show that the Nax channel in the circumventricular organs (CVO) is a probable candidate for the specific sodium receptor.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 12 print issues and online access

$209.00 per year

only $17.42 per issue

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Similar content being viewed by others

References

  1. Johnson, A.K. & Edwards, G.L. Curr. Top. Neuroendocrinol. 10, 149– 190 (1990).

    Article  Google Scholar 

  2. Denton, D.A., McKinley, M.J. & Weisinger, R.S. Proc. Natl. Acad. Sci. USA 93, 7397– 7404 (1996).

    Article  CAS  Google Scholar 

  3. Oliet, S.H.R. & Bourque, C.W. Nature 364, 341– 343 (1993).

    Article  CAS  Google Scholar 

  4. Liedtke, W. et al. Cell 103, 525– 535 (2000).

    Article  CAS  Google Scholar 

  5. Wells, T. Mol. Cell. Endocrinol. 136, 103– 107 (1998).

    Article  CAS  Google Scholar 

  6. Goldin, A.L. et al. Neuron 28, 365– 368 (2000).

    Article  CAS  Google Scholar 

  7. Goldin, A.L. Annu. Rev. Physiol. 63, 871– 894 (2001).

    Article  CAS  Google Scholar 

  8. Watanabe, E. et al. J. Neurosci. 20, 7743– 7751 (2000).

    Article  CAS  Google Scholar 

  9. Minta, A. & Tsien, R.Y. J. Biol. Chem. 264, 19449– 19457 (1989).

    CAS  PubMed  Google Scholar 

  10. Wakerley, J.B., Poulain, D.A. & Brown, D. Brain Res. 148, 425– 440 (1978).

    Article  CAS  Google Scholar 

  11. Nose, H. et al. J. Appl. Physiol. 73, 1419– 1424 (1992).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank T. Mohri for technical advice and comments on the manuscript; M. Yasuda, A. Tozaki and C. Egusa for technical assistance; and A. Kodama for secretarial assistance. This study was supported by grants-in-aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and from the Japan Science and Technology Corporation (CREST).

Author information

Authors and Affiliations

  1. Division of Molecular Neurobiology and Center for Transgenic Animals and Plants, and Department of Molecular Biomechanics, National Institute for Basic Biology, Graduate University for Advanced Studies, Myodaiji-cho, Okazaki, 444-8585, Japan

    Takeshi Y. Hiyama, Eiji Watanabe & Masaharu Noda

  2. Department of Physiology, Kyushu Dental College, Manazuru, Kokurakitaku, Kitakyushu, 803-8580, Japan

    Kentaro Ono & Kiyotoshi Inenaga

  3. Department of Physiology, Colorado State University, Fort Collins, 80523, Colorado, USA

    Michael M. Tamkun

  4. Laboratory of Intracellular Metabolism, National Institute for Physiological Sciences, Myodaiji-cho, Okazaki, 444-8585, Japan

    Shigeru Yoshida

  5. Department of Physiology, Nagasaki University School of Medicine, Nagasaki, 852-8523, Japan

    Shigeru Yoshida

Authors

  1. Takeshi Y. Hiyama

    You can also search for this author in PubMed Google Scholar

  2. Eiji Watanabe

    You can also search for this author in PubMed Google Scholar

  3. Kentaro Ono

    You can also search for this author in PubMed Google Scholar

  4. Kiyotoshi Inenaga

    You can also search for this author in PubMed Google Scholar

  5. Michael M. Tamkun

    You can also search for this author in PubMed Google Scholar

  6. Shigeru Yoshida

    You can also search for this author in PubMed Google Scholar

  7. Masaharu Noda

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Masaharu Noda.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

About this article

Cite this article

Hiyama, T., Watanabe, E., Ono, K. et al. Nax channel involved in CNS sodium-level sensing. Nat Neurosci 5, 511–512 (2002). https://doi.org/10.1038/nn0602-856

Download citation

  • Received: 11 January 2002

  • Accepted: 25 March 2002

  • Published: 06 May 2002

  • Issue Date: 01 June 2002

  • DOI: https://doi.org/10.1038/nn0602-856