Bluetongue virus VP4 is an RNA-capping assembly line - Nature Structural & Molecular Biology
- ️Roy, Polly
- ️Sun Apr 08 2007
- Brief Communication
- Published: 08 April 2007
Nature Structural & Molecular Biology volume 14, pages 449–451 (2007)Cite this article
Abstract
Eukaryotic organisms cap the 5′ ends of their messenger RNAs by a series of four chemical reactions. Some viruses achieve this using a single molecule; the crystal structure of such an enzyme from bluetongue virus reveals an elongated modular architecture that provides a scaffold for an assemblage of active sites, two contributed by a domain of novel structure.
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References
Furuichi, Y. & Miura, K. Nature 253, 374–375 (1975).
Shatkin, A.J. Cell 9, 645–653 (1976).
Furuichi, Y., LaFiandra, A. & Shatkin, A.J. Nature 266, 235–239 (1977).
Muthukrishnan, S., Both, G.W., Furuichi, Y. & Shatkin, A.J. Nature 255, 33–37 (1975).
Mertens, P. Virus Res. 101, 3–13 (2004).
Ramadevi, N., Burroughs, N.J., Mertens, P.P., Jones, I.M. & Roy, P. Proc. Natl. Acad. Sci. USA 95, 13537–13542 (1998).
Ramadevi, N. & Roy, P. J. Gen. Virol. 79, 2475–2480 (1998).
Ramadevi, N., Rodriguez, J. & Roy, P. J. Virol. 72, 2983–2990 (1998).
Bujnicki, J.M. & Rychlewski, L. Genome Biol. 2, RESEARCH0038 (2001).
Li, C., Xia, Y., Gao, X. & Gershon, P.D. Biochemistry 43, 5680–5687 (2004).
Fabrega, C., Hausmann, S., Shen, V., Shuman, S. & Lima, C.D. Mol. Cell 13, 77–89 (2004).
Funke, L., Dakoji, S. & Bredt, D.S. Annu. Rev. Biochem. 74, 219–245 (2005).
Nason, E.L. et al. J. Virol. 78, 8059–8067 (2004).
Takagi, T., Moore, C.R., Diehn, F. & Buratowski, S. Cell 89, 867–873 (1997).
Gouet, P. et al. Cell 97, 481–490 (1999).
Reinisch, K.M., Nibert, M.L. & Harrison, S.C. Nature 404, 960–967 (2000).
Lawton, J.A., Estes, M.K. & Prasad, B.V. J. Virol. 75, 1632–1642 (2001).
Acknowledgements
We thank L. Lyne, W. Lu and the staff of BM14 and ID14 beamlines at the European Synchrotron Radiation Facility for technical support. This work was supported by the Medical Research Council, UK, EC SPINE grant QLG2-CT-2002-00988 (D.I.S.), and by the Royal Society, UK (J.M.G.).
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Authors and Affiliations
Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, OX3 7BN, Oxford, UK
Geoff Sutton, Jonathan M Grimes & David I Stuart
London School of Hygiene and Tropical Medicine, University of London, Keppel Street, London, WC1E 7HT, UK
Polly Roy
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- Geoff Sutton
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- Jonathan M Grimes
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- David I Stuart
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- Polly Roy
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Correspondence to David I Stuart or Polly Roy.
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Sutton, G., Grimes, J., Stuart, D. et al. Bluetongue virus VP4 is an RNA-capping assembly line. Nat Struct Mol Biol 14, 449–451 (2007). https://doi.org/10.1038/nsmb1225
Received: 17 July 2006
Accepted: 05 March 2007
Published: 08 April 2007
Issue Date: May 2007
DOI: https://doi.org/10.1038/nsmb1225