nature.com

Cancer-associated fibroblasts and M2-polarized macrophages synergize during prostate carcinoma progression - Oncogene

  • ️Chiarugi, P
  • ️Mon Jun 03 2013
  • Cirri P, Chiarugi P . Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression. Cancer Metastasis Rev 2012; 31: 195–208.

    Article  PubMed  Google Scholar 

  • Kalluri R, Zeisberg M . Fibroblasts in cancer. Nat Rev Cancer 2006; 6: 392–401.

    Article  CAS  PubMed  Google Scholar 

  • Fiaschi T, Marini A, Giannoni E, Taddei ML, Gandellini P, De DA et al. Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay. Cancer Res 2012; 72: 5130–5140.

    Article  CAS  PubMed  Google Scholar 

  • Giannoni E, Bianchini F, Masieri L, Serni S, Torre E, Calorini L et al. Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness. Cancer Res 2010; 70: 6945–6956.

    Article  CAS  PubMed  Google Scholar 

  • Giannoni E, Bianchini F, Calorini L, Chiarugi P . Cancer associated fibroblasts exploit reactive oxygen species through a proinflammatory signature leading to epithelial mesenchymal transition and stemness. Antioxid Redox Signal 2011; 14: 2361–2371.

    Article  CAS  PubMed  Google Scholar 

  • Friedl P, Hegerfeldt Y, Tusch M . Collective cell migration in morphogenesis and cancer. Int J Dev Biol 2004; 48: 441–449.

    Article  CAS  PubMed  Google Scholar 

  • Kalluri R . EMT: when epithelial cells decide to become mesenchymal-like cells. J Clin Invest 2009; 119: 1417–1419.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mantovani A, Sica A, Locati M . New vistas on macrophage differentiation and activation. Eur J Immunol 2007; 37: 14–16.

    Article  CAS  PubMed  Google Scholar 

  • Martinez FO, Helming L, Gordon S . Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol 2009; 27: 451–483.

    Article  CAS  PubMed  Google Scholar 

  • Allavena P, Sica A, Solinas G, Porta C, Mantovani A . The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages. Crit Rev Oncol Hematol 2008; 66: 1–9.

    Article  PubMed  Google Scholar 

  • Geldhof AB, van Ginderachter JA, Liu Y, Noel W, de BP . Ablation of NK cell function during tumor growth favors Type 2-associated macrophages, leading to suppressed CTL generation. Clin Dev Immunol 2003; 10: 71–81.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Solinas G, Germano G, Mantovani A, Allavena P . Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. J Leukoc Biol 2009; 86: 1065–1073.

    Article  CAS  PubMed  Google Scholar 

  • Mantovani A, Allavena P, Sica A, Balkwill F . Cancer-related inflammation. Nature 2008; 454: 436–444.

    Article  CAS  PubMed  Google Scholar 

  • Sica A, Schioppa T, Mantovani A, Allavena P . Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy. Eur J Cancer 2006; 42: 717–727.

    Article  CAS  PubMed  Google Scholar 

  • Talmadge JE, Donkor M, Scholar E . Inflammatory cell infiltration of tumors: Jekyll or Hyde. Cancer Metastasis Rev 2007; 26: 373–400.

    Article  PubMed  Google Scholar 

  • Wu Y, Deng J, Rychahou PG, Qiu S, Evers BM, Zhou BP . Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion. Cancer Cell 2009; 15: 416–428.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Erez N, Truitt M, Olson P, Arron ST, Hanahan D . Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner. Cancer Cell 2010; 17: 135–147.

    Article  CAS  PubMed  Google Scholar 

  • Cat B, Stuhlmann D, Steinbrenner H, Alili L, Holtkotter O, Sies H et al. Enhancement of tumor invasion depends on transdifferentiation of skin fibroblasts mediated by reactive oxygen species. J Cell Sci 2006; 119 (Pt 13): 2727–2738.

    Article  CAS  PubMed  Google Scholar 

  • Comito G, Giannoni E, Di GP, Segura CP, Gerlini G, Chiarugi P . Stromal fibroblasts synergize with hypoxic oxidative stress to enhance melanoma aggressiveness. Cancer Lett 2012; 324: 31–41.

    Article  CAS  PubMed  Google Scholar 

  • Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005; 121: 335–348.

    Article  CAS  PubMed  Google Scholar 

  • Toullec A, Gerald D, Despouy G, Bourachot B, Cardon M, Lefort S et al. Oxidative stress promotes myofibroblast differentiation and tumour spreading. EMBO Mol Med 2010; 2: 211–230.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mantovani A, Sica A . Macrophages, innate immunity and cancer: balance, tolerance, and diversity. Curr Opin Immunol 2010; 22: 231–237.

    Article  CAS  PubMed  Google Scholar 

  • Giannoni E, Taddei ML, Parri M, Bianchini F, Santosuosso M, Grifantini R et al. EphA2-mediated mesenchymal-amoeboid transition induced by endothelial progenitor cells enhances metastatic spread due to cancer-associated fibroblasts. J Mol Med 2013; 91: 103–115.

    Article  CAS  PubMed  Google Scholar 

  • Nolan DJ, Ciarrocchi A, Mellick AS, Jaggi JS, Bambino K, Gupta S et al. Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization. Genes Dev 2007; 21: 1546–1558.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Giannoni E, Parri M, Chiarugi P . EMT and oxidative stress: a bidirectional interplay affecting tumor malignancy. Antioxid Redox Signal 2012; 16: 1248–1263.

    Article  CAS  PubMed  Google Scholar 

  • Duda DG, Duyverman AM, Kohno M, Snuderl M, Steller EJ, Fukumura D et al. Malignant cells facilitate lung metastasis by bringing their own soil. Proc Natl Acad Sci USA 2010; 107: 21677–21682.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Muerkoster SS, Werbing V, Koch D, Sipos B, Ammerpohl O, Kalthoff H et al. Role of myofibroblasts in innate chemoresistance of pancreatic carcinoma–;epigenetic downregulation of caspases. Int J Cancer 2008; 123: 1751–1760.

    Article  PubMed  Google Scholar 

  • Roodhart JM, Daenen LG, Stigter EC, Prins HJ, Gerrits J, Houthuijzen JM et al. Mesenchymal stem cells induce resistance to chemotherapy through the release of platinum-induced fatty acids. Cancer Cell 2011; 20: 370–383.

    Article  CAS  PubMed  Google Scholar 

  • Guido C, Whitaker-Menezes D, Capparelli C, Balliet R, Lin Z, Pestell RG et al. Metabolic reprogramming of cancer-associated fibroblasts by TGF-beta drives tumor growth: connecting TGF-beta signaling with ‘Warburg-like’ cancer metabolism and L-lactate production. Cell Cycle 2012; 11: 3019–3035.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Servais C, Erez N . From sentinel cells to inflammatory culprits: cancer-associated fibroblasts in tumour-related inflammation. J Pathol 2013; 229: 198–207.

    Article  CAS  PubMed  Google Scholar 

  • Hao NB, Lu MH, Fan YH, Cao YL, Zhang ZR, Yang SM . Macrophages in tumor microenvironments and the progression of tumors. Clin Dev Immunol 2012; 2012: 948098.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sica A, Porta C, Morlacchi S, Banfi S, Strauss L, Rimoldi M et al. Origin and functions of tumor-associated myeloid cells (TAMCs). Cancer Microenviron 2012; 5: 133–149.

    Article  CAS  PubMed  Google Scholar 

  • Balkwill FR, Mantovani A . Cancer-related inflammation: common themes and therapeutic opportunities. Semin Cancer Biol 2012; 22: 33–40.

    Article  CAS  PubMed  Google Scholar 

  • Qian BZ, Li J, Zhang H, Kitamura T, Zhang J, Campion LR et al. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature 2011; 475: 222–225.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Teicher BA, Fricker SP . CXCL12 (SDF-1)/CXCR4 pathway in cancer. Clin Cancer Res 2010; 16: 2927–2931.

    Article  CAS  PubMed  Google Scholar 

  • Hembruff SL, Jokar I, Yang L, Cheng N . Loss of transforming growth factor-beta signaling in mammary fibroblasts enhances CCL2 secretion to promote mammary tumor progression through macrophage-dependent and -independent mechanisms. Neoplasia 2010; 12: 425–433.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ksiazkiewicz M, Gottfried E, Kreutz M, Mack M, Hofstaedter F, Kunz-Schughart LA . Importance of CCL2-CCR2A/2B signaling for monocyte migration into spheroids of breast cancer-derived fibroblasts. Immunobiology 2010; 215: 737–747.

    Article  CAS  PubMed  Google Scholar 

  • Silzle T, Kreutz M, Dobler MA, Brockhoff G, Knuechel R, Kunz-Schughart LA . Tumor-associated fibroblasts recruit blood monocytes into tumor tissue. Eur J Immunol 2003; 33: 1311–1320.

    Article  CAS  PubMed  Google Scholar 

  • Inoue H, Nishimura K, Oka D, Nakai Y, Shiba M, Tokizane T et al. Prostate cancer mediates osteoclastogenesis through two different pathways. Cancer Lett 2005; 223: 121–128.

    Article  CAS  PubMed  Google Scholar 

  • de WO, Mareel M . Role of tissue stroma in cancer cell invasion. J Pathol 2003; 200: 429–447.

    Article  Google Scholar 

  • Zumsteg A, Christofori G . Corrupt policemen: inflammatory cells promote tumor angiogenesis. Curr Opin Oncol 2009; 21: 60–70.

    Article  PubMed  Google Scholar 

  • Whiteside TL . The tumor microenvironment and its role in promoting tumor growth. Oncogene 2008; 27: 5904–5912.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jinushi M, Baghdadi M, Chiba S, Yoshiyama H . Regulation of cancer stem cell activities by tumor-associated macrophages. Am J Cancer Res 2012; 2: 529–539.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Margheri F, Chilla A, Laurenzana A, Serrati S, Mazzanti B, Saccardi R et al. Endothelial progenitor cell-dependent angiogenesis requires localization of the full-length form of uPAR in caveolae. Blood 2011; 118: 3743–3755.

    Article  CAS  PubMed  Google Scholar 

  • Yoder MC . Developing reagents and conditions to induce mesoderm subsets from ES cells. Cell Stem Cell 2007; 1: 603–604.

    Article  CAS  PubMed  Google Scholar