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Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells - British Journal of Cancer

  • ️Okamoto, T
  • ️Fri Feb 08 2002

References

  • Adams WJ, Lawson J, Morris DL (1994) Cimetidine inhibits in vivo growth of human colon cancer and reverses histamine stimulated in vitro and in vivo growth. Gut 35: 1632–1636

    Article  CAS  Google Scholar 

  • Adams WJ, Morris DL (1994) Short-course cimetidine and survival with colorectal cancer. Lancet 344: 8939–9840 1768–1769

    Article  CAS  Google Scholar 

  • Charpin C, Bhan AK, Zurawski Jr VR, Scully RE (1982) Carcinoembryonic antigen (CEA) and carbohydrate determinant 19-9 (CA 19-9) localization in 121 primary and metastatic ovarian tumors: an immunohistochemical study with the use of monoclonal antibodies. Int J Gynecol Pathol 1: 231–245

    Article  CAS  Google Scholar 

  • Creagan ET, Ahmans DL, Green SJ, Long HJ, Frytak S, Itri M (1985) Phase II study of recombinant leukocyte A interferon (IFN-RA) plus cimetidine in disseminated malignant melanoma. J Clin Oncol 3: 977–981

    Article  CAS  Google Scholar 

  • Dohi T, Nemoto T, Ohta S, Shirata K, Hanai N, Nudelman E, Hakomori S, Ohsima M (1993) Different binding properties of three monoclonal antibodies to sialyl Le(x) glyciolipids in a gastric cancer cell line and normal stomach tissue. Anticancer Res 13: 1277–1282

    CAS  PubMed  Google Scholar 

  • Fukushi Y, Nudelman E, Levery SB, Hakomori S, Rauvala H (1984) Novel fucolipids accumulating in human adenocarcinoma. III. A hybridoma antibody (FH6) defining a human cancer-associated difucoganglioside (VI3NeuAcV3III3Fuc2nLc6). Biol Chem 259: 10511–10517

    CAS  Google Scholar 

  • Fukushima K, Hirota M, Terasaki PI, Wakisaka A, Togashi H, Chia D, Suyama Y, Nudelman E, Hakomori S (1984) Characterization sialosylated Lewisx as a new tumor-associated antigen. Cancer Res 44: 5279–5285

    CAS  PubMed  Google Scholar 

  • Garcia-Caballero M, Neugebauer E, Rodriguez F, Castro N, Vera-Thorbeck C (1994) Histamine synthesis and content in benign and malignant breast tumors. Its effects on other host tissues. Surg Oncol 3: 167–173

    Article  CAS  Google Scholar 

  • Hansbrough JF, Zapata-Sirvent RL, Bender EM (1986) Prevention of alterations in postoperative lymphocyte subpopulations by cimetidine and ibuprofen. Am J Surg 151: 249–255.7

    Article  CAS  Google Scholar 

  • Hellstrand K, Naredi P, Lindner P, Lundholm K, Rudenstam CM, Hermodsson S, Asztely M, Hafstrom L (1994) Histamine in immunotherapy of advanced melanoma: a pilot study. Cancer Immunol Immunother 9: 416–419

    Article  Google Scholar 

  • Hoff SD, Matsushita Y, Ota DM, Cleary KR, Yamori T, Hakomori S, Irimura T (1989) Increased expression of sialyl-dimeric Lex antigen in liver metastasis of human colorectal carcinoma. Cancer Res 49: 6883–6888

    CAS  PubMed  Google Scholar 

  • Hoff SD, Irimura T, Matsushita Y, Ota DM, Cleary KR, Hakomori S (1990) Metastatic potential of colon carcinoma: Expression of ABO/ Lewis-related antigens. Arch Surg 125: 206–209

    Article  CAS  Google Scholar 

  • Katoh J, Tsuchiya K, Sato W, Nakajima M, Iida Y (1996) Cimetidine and immunoreactivity. Lancet 348: 404–405

    Article  CAS  Google Scholar 

  • Kimura E, Koike T, Shimizu Y, Kodama M (1986) Complexes of the histamine H2-antagonist cimetidine with divalent and monovalent copper ions. Inorg Chem 25: 2242–2246

    Article  CAS  Google Scholar 

  • Kobayashi K, Matsumoto S, Morishima T, Kawabe T, Okamoto T (2000) Cimetidine inhibits cancer cell adhesion to endothelial cells and prevents metastasis by blocking E-selectin expression. Cancer Res 60: 3978–3984

    CAS  PubMed  Google Scholar 

  • Kumar A (1990) Cimetidine: an immunomodulator. Ann Pharmacother 24: 289–295

    CAS  Google Scholar 

  • Matsumoto S (1995) Cimetidine and survival with colorectal cancer. Lancet 346: 115

    Article  CAS  Google Scholar 

  • Nakamori S, Kameyama M, Imaoka S, Furukawa H, Ishikawa O, Sasaki Y, Kabuto T, Imanaga T, Matsushita Y, Irimura T (1993) Increased expression of sialyl Lewisx antigen correlates with poor survival in patients with colorectal carcinoma: clinicopathological and immunohistochemical study. Cancer Res 53: 3632–3637

    CAS  PubMed  Google Scholar 

  • Phillips ML, Nudelman E, Gaeta FCA, Perez M, Singhal AK, Hakomori S, Paulson JC (1990) ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl- Lex. Science 250: 1130–1132

    Article  CAS  Google Scholar 

  • Reynolds JL, Ahkter J, Morris DL (1996) In vitro effect of histamine and histamine H1 and H2 receptor antagonists on cellular proliferation of human malignant melanoma cell lines. Melanoma Res 6: 95–99

    Article  CAS  Google Scholar 

  • Sagaster P, Mikcksche M, Flamm J, Ludiwig H (1995) Randomized study using IFN-alpha versus IFN-alpha plus coumarin and cimetidine for treatment of advanced renal cell cancer. Ann Oncol 6: 999–1003

    Article  CAS  Google Scholar 

  • Shirata K, Hanai N, Yoshida H (1987) Distribution of lung adenocarcinoma-associated antigens in human tissues and sera defined by monoclonal antibodies KM-52 and KM-93. Cancer Res 47: 1267–1272

    Google Scholar 

  • Srinivas U, Pahlsson P, Lundblad A (1996) E-selectin: sialyl Lewis a dependent adhesion of colon cancer cells is inhibited differently by antibodies against E-selectin ligands. Scand J Immunol 44: 197–203

    Article  CAS  Google Scholar 

  • Svendsen LB, Ross C, Knigge U, Frederiksen HJ, Graverse P, Kjaergard J, Luke M, Stimpel H, Sparso BH (1995) Cimetidine as an adjuvant treatment in colorectal cancer. Dis Colon Rectum 38: 514–518

    Article  CAS  Google Scholar 

  • Takada A, Ohmori K, Takahashi N, Tsuyuoka K, Yago A, Zenita K, Hasegawa A, Kannagi R (1991) Adhesion of human cancer cells to vascular endothelium mediated by carbohydrate antigen, sialyl Lewis A. Biochem Biophs Res Commun 179: 713–719

    Article  CAS  Google Scholar 

  • Takada A, Ohmori K, Yoneda T, Tsuyuoka K, Hasegawa A, Kiso M, Kannagi R (1993) Contribution of carbohydrate antigens sialyl Lewis-A and sialyl Lewis-X to adhesion of human cancer cells to vascular endothelium. Cancer Res 53: 354–361

    CAS  PubMed  Google Scholar 

  • Tonnesen H, Knigge U, Bulow S, Damm P, Fisherman K, Hasselfeldt P, Hjortrup A, Pedersen VM, Siemsson CJ, Svendsen LB, Christiansen PM (1988) Effect of cimetidine on survival after gastric cancer. Lancet 2: 990–992

    Article  CAS  Google Scholar 

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