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The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes - Molecular Psychiatry

  • ️Johansson, L
  • ️Tue Aug 08 2006
  • Asherson P . IMAGE consortium. Attention-deficit hyperactivity disorder in the post-genomic era. Eur Child Adolesc Psychiatry 2004; 13 (Suppl 1): 150–170.

    Google Scholar 

  • Burd L, Klug MG, Coumbe MJ, Kerbeshian J . Children adolescents with attention deficit-hyperactivity disorder: 1. Prevalence cost of care. J Child Neurol 2003; 18: 555–561.

    Article  PubMed  Google Scholar 

  • Kessler RC, Adler L, Ames M, Barkley RA, Birnbaum H, Greenberg P et al. The prevalence effects of adult attention deficit/hyperactivity disorder on work performance in a nationally representative sample of workers. J Occup Environ Med 2005; 47: 565–572.

    Article  PubMed  Google Scholar 

  • Biederman J, Faraone SV . Attention-deficit hyperactivity disorder. Lancet 2005; 366: 237–248.

    Article  PubMed  Google Scholar 

  • Taylor E, Dopfner M, Sergeant J, Asherson P, Banaschewski T, Buitelaar J et al. European clinical guidelines for hyperkinetic disorder – first upgrade. Eur Child Adolesc Psychiatry 2004; 13 (Suppl 1): 17–30.

    Google Scholar 

  • Asherson P . Clinical assessment and treatment of attention deficit hyperactivity disorder in adults. Expert Rev Neurotherapeutics 2005; 5: 525–539.

    Article  Google Scholar 

  • Todd RD, Lobos EA, Sun LW, Neuman RJ . Mutational analysis of the nicotinic acetylcholine receptor alpha 4 subunit gene in attention deficit/hyperactivity disorder: evidence for association of an intronic polymorphism with attention problems. 2003; 8: 103–108.

  • Faraone SV, Perlis RH, Doyle AE, Smoller JH, Goralnick JJ, Holmergen MA et al. Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry 2005; 57: 1313–1323.

    Article  CAS  PubMed  Google Scholar 

  • Willcutt EG, Pennington BF, DeFries JC . Twin study of the etiology of comorbidity between reading disability and attention-deficit/hyperactivity disorder. Am J Med Genet 2000; 96: 293–301.

    Article  CAS  PubMed  Google Scholar 

  • Gilger JW, Pennington BF, DeFries JC . A twin study of the etiology of comorbidity: attention-deficit hyperactivity disorder and dyslexia. J Am Acad Child Adolesc Psychiatry 1992; 31: 343–348.

    Article  CAS  PubMed  Google Scholar 

  • Kuntsi J, Eley TC, Taylor A, Hughes C, Asherson P, Caspi A et al. Co-occurrence of ADHD and low IQ has genetic origins. Am J Med Genet B Neuropsychiatr Genet 2004; 124: 41–47.

    Article  Google Scholar 

  • Arcos-Burgos M, Castellanos X, Pineda D, Lopera F, Palcio JD, Palacio LJ et al. Attention-deficit/hyperactivity disorder in a population isolate: linkage to loci at 4q13.2, 5q33.3, 11q22, and 17p11. Am J Hum Genet 2004; 75: 998–1014.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bakker SC, van der Meulen EM, Buitelaar JK, Sandkuijl LA, Pauls DL, Monsuur AJ et al. A whole-genome scan in 164 Dutch sib pairs with attention-deficit/hyperactivity disorder: suggestive evidence for linkage on chromosomes 7p and 15q. Am J Hum Genet 2003; 72: 1251–1260.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fisher SE, Francks C, McCracken JT, McGough JJ, Marlow AJ, MacPhie IL et al. A genomewide scan for loci involved in attention-deficit/hyperactivity disorder. Am J Hum Genet 2002; 70: 1183–1196.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Smalley SL, Kustanovich V, Minassian SL, Stone JL, Ogdie MN, McGough JJ et al. Genetic linkage of attention-deficit/hyperactivity disorder on chromosome 16p13, in a region implicated in autism. Am J Hum Genet 2002; 71: 959–963.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ogdie MN, Macphie IL, Minassian SL, Yang M, Fisher SE, Francks C et al. A genomewide scan for attention-deficit/hyperactivity disorder in an extended sample: suggestive linkage on 17p11. Am J Hum Genet 2003; 72: 1268–1279.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ogdie MN, Fisher SE, Yang M, Ishii J, Francks C, Loo SK et al. Attention deficit hyperactivity disorder: fine mapping supports linkage to 5p13, 6q12, 16p13, and 17p11. Am J Hum Genet 2004; 75: 661–668.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hebebrand J, Dempfle A, Saar K, Thiele H, Herpetz-Dahlmann B, Linder M et al. A genome-wide scan for attention-deficit/hyperactivity disorder in 155 German sib-pairs. Mol Psychiatry 2005; 11: 196–205.

    Article  CAS  Google Scholar 

  • Winstanley CA, Theobald DE, Dalley JW, Robbins TW . Interactions between serotonin and dopamine in the control of impulsive choice in rats: therapeutic implications for impulse control disorders. Neuropsychopharmacology 2005; 30: 669–682.

    Article  CAS  PubMed  Google Scholar 

  • Gainetdinov RR, Wetsel WC, Jones SR, Levin ED, Jaber M, Caron MG . Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. Science 1999; 283: 397–401.

    Article  CAS  PubMed  Google Scholar 

  • Brookes KJ, Knight J, Xu X, Asherson P . DNA pooling analysis of ADHD and genes regulating vesicle release of neurotransmitters. Am J Med Genet B Neuropsychiatr Genet 2005; 139: 33–37.

    Article  CAS  Google Scholar 

  • Hallahan B, Garland MR . Essential fatty acids and mental health. Br J Psychiatry 2005; 186: 275–277.

    Article  PubMed  Google Scholar 

  • Tjon Pian Gi CV, Broeren JP, Starreveld JS, Versteegh FG . Melatonin for treatment of sleeping disorders in children with attention deficit/hyperactivity disorder: a preliminary open label study. Eur J Pediatr 2003; 162: 554–555.

    Article  PubMed  Google Scholar 

  • Sei H et al. Increase of hippocampal acetylcholine release at the onset of dark phase is suppressed in a mutant mice model of evening-type individuals. Neuroscience 2003; 117: 785–789.

    Article  CAS  PubMed  Google Scholar 

  • Castellanos FX, Tannock R . Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes. Nat Rev Neurosci 2002; 3: 617–628.

    Article  CAS  PubMed  Google Scholar 

  • Altshuler D, Brooks LD, Chakravarti A, Collins FS, Daly MJ, Donnelly P . A haplotype map of the human genome. Nature 2005; 437: 1299–1320.

    Article  CAS  Google Scholar 

  • Ford T, Goodman R, Meltzer H . The British Child and Adolescent Mental Health Survey 1999: the prevalence of DSM-IV disorders. J Am Acad Child Adolesc Psychiatry 2003; 42: 1203–1211.

    Article  PubMed  Google Scholar 

  • Taylor E, Schachar R, Thorley G, Wieselberg M . Conduct disorder and hyperactivity: I. Separation of hyperactivity and antisocial conduct in British child psychiatric patients. Br J Psychiatry 1986; 149: 760–767.

    Article  CAS  PubMed  Google Scholar 

  • Conners CK . Conners’ Rating Scales-Revised: Technical Manual. 2003 Sixth Printing MHS.

  • Goodman R . The strengths and difficulties questionnaire: a research note. J Child Psychol Psychiatry 1997; 38: 581–586.

    Article  CAS  PubMed  Google Scholar 

  • Brookes K, Mill J, Guindalini C, Curran S, Xu X, Knight J et al. A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol. Arch Gen Psychiatry 2006; 63: 74–81.

    Article  CAS  PubMed  Google Scholar 

  • Brookes KJ, Xu X, Chen CK, Huang YS, Wu YY, Asherson P . No evidence for the association of DRD4 with ADHD in a Taiwanese population within-family study. BMC Med Genet 2005; 6: 31.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Xu X, Mill J, Chen CK, Brookes K, Taylor E, Asherson P . Family-based association study of serotonin transporter gene polymorphisms in attention deficit hyperactivity disorder: no evidence for association in UK and Taiwanese samples. Am J Med Genet B Neuropsychiatr Genet 2005; 139: 11–13.

    Article  CAS  Google Scholar 

  • Ao SI, Yip K, Cheung D, Fong PY, Melhado I, Sham PC . CLUSTAG: hierarchical clustering and graph methods for selecting tag SNPs. Bioinformatics 2005; 21: 1735–1736.

    Article  CAS  PubMed  Google Scholar 

  • Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B et al. The structure of haplotype blocks in the human genome. Science 2002; 296: 2225–2229.

    Article  CAS  PubMed  Google Scholar 

  • Neale BM, Sham PC . The future of association studies: gene-based analysis and replication. Am J Hum Genet 2004; 75: 353–362.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Feng Y, Wigg KG, Makkar R, Ickowicz A, Pathare T, Tannock R et al. Sequence variation in the 3′-untranslated region of the dopamine transporter gene and attention-deficit hyperactivity disorder (ADHD). Am J Med Genet B Neuropsychiatr Genet 2005; 139: 1–6.

    Article  CAS  Google Scholar 

  • Bobb AJ, Addington AM, Sidransky E, Gornick EM, lerch JP, Greenstein JK et al. Support for association between ADHD and two candidate genes: NET1 and DRD1. Am J Med Genet B Neuropsychiatr Genet 2005; 134: 67–72.

    Article  Google Scholar 

  • Hawi Z, Lowe N, Kirley A, Gruenhage F, Nothen M, Greenwood T et al. Linkage disequilibrium mapping at DAT1, DRD5 and DBH narrows the search for ADHD susceptibility alleles at these loci. Mol Psychiatry 2003; 8: 299–308.

    Article  CAS  PubMed  Google Scholar 

  • Lowe N, Kirley A, Mullins C, Fitzgerald M, Gill M, Hawi Z . Multiple marker analysis at the promoter region of the DRD4 gene and ADHD: evidence of linkage and association with the SNP -616. Am J Med Genet B Neuropsychiatr Genet 2004; 131: 33–37.

    Article  Google Scholar 

  • Bellgrove MA, Hawi Z, Lowe N, Kirley A, Robertson IH, Gill M . DRD4 gene variants and sustained attention in attention deficit hyperactivity disorder (ADHD): effects of associated alleles at the VNTR and −521 SNP. Am J Med Genet B Neuropsychiatr Genet 2005; 136: 81–86.

    Article  Google Scholar 

  • Xu X, Knight J, Brookes K, Mill J, Sham P, Craig I et al. DNA pooling analysis of 21 norepinephrine transporter gene SNPs with attention deficit hyperactivity disorder: no evidence for association. Am J Med Genet B Neuropsychiatr Genet 2005; 134: 115–118.

    Article  Google Scholar 

  • Jiang S, Xin R, Lin S, Qian Y, Tang G, Wang D et al. Linkage studies between attention-deficit hyperactivity disorder and the monoamine oxidase genes. Am J Med Genet 2001; 105: 783–788.

    Article  CAS  PubMed  Google Scholar 

  • Domschke K, Sheehan K, Lowe N, Kirley A, Mullins C, O'Sullivan R et al. Association analysis of the monoamine oxidase A and B genes with attention deficit hyperactivity disorder (ADHD) in an Irish sample: preferential transmission of the MAO-A 941G allele to affected children. Am J Med Genet B Neuropsychiatr Genet 2005; 134: 110–114.

    Article  Google Scholar 

  • Manor I, Tyano S, Mel E, Eisenberg J, Bachner-Melman R, Kotler M et al. Family-based and association studies of monoamine oxidase A and attention deficit hyperactivity disorder (ADHD): preferential transmission of the long promoter-region repeat and its association with impaired performance on a continuous performance test (TOVA). Mol Psychiatry 2002; 7: 626–632.

    Article  CAS  PubMed  Google Scholar 

  • Lawson DC, Turic D, Langely K, Pay KM, Govan CF Norton N et al. Association analysis of monoamine oxidase A and attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 2003; 116: 84–89.

    Article  Google Scholar 

  • Brophy K, Hawi Z, Kirley A, Fitzgerald M, Gill M . Synaptosomal-associated protein 25 (SNAP-25) and attention deficit hyperactivity disorder (ADHD): evidence of linkage and association in the Irish population. Mol Psychiatry 2002; 7: 913–917.

    Article  CAS  PubMed  Google Scholar 

  • Barr CL, Feng Y, Wigg K, Bloom S, Roberts W, Malone M et al. Identification of DNA variants in the SNAP-25 gene and linkage study of these polymorphisms and attention-deficit hyperactivity disorder. Mol Psychiatry 2000; 5: 405–409.

    Article  CAS  PubMed  Google Scholar 

  • Kustanovich V, Merriman B, McGough J, McCracken JT, Smalley SL, Nelson SF . Biased paternal transmission of SNAP-25 risk alleles in attention-deficit hyperactivity disorder. Mol Psychiatry 2003; 8: 309–315.

    Article  CAS  PubMed  Google Scholar 

  • Mill J, Richards S, Knight S, Curran S, Taylor E, Asherson P . Haplotype analysis of SNAP-25 suggests a role in the aetiology of ADHD. Mol Psychiatry 2004; 9: 801–810.

    Article  CAS  PubMed  Google Scholar 

  • Mill J, Curran S, Kent L, Gould A, Huckett L, Richards S et al. Association study of a SNAP-25 microsatellite and attention deficit hyperactivity disorder. Am J Med Genet 2002; 114: 269–271.

    Article  PubMed  Google Scholar 

  • Todd RD, Lobos EA, Sun LW, Neuman RJ . Mutational analysis of the nicotinic acetylcholine receptor alpha 4 subunit gene in attention deficit/hyperactivity disorder: evidence for association of an intronic polymorphism with attention problems. Mol Psychiatry 2003; 8: 103–108.

    Article  CAS  PubMed  Google Scholar 

  • Sheehan K, Lowe N, Kirley A, Mullins C, Fitzgerald M, Gill M et al. Tryptophan hydroxylase 2 (TPH2) gene variants associated with ADHD. Mol Psychiatry 2005; 10: 944–949.

    Article  CAS  PubMed  Google Scholar 

  • Walitza S, Renner TJ, Dempfle A, Konrad K, Wewetzer Ch, Halbach A et al. Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder. Mol Psychiatry 2005; 10: 1126–1132.

    Article  CAS  PubMed  Google Scholar 

  • Brookes K, Chen W, Xu X, Taylor E, Asherson P . Association of fatty acid desaturase genes with Attention Deficit Hyperactivity disorder. Biol Psychiatry 2006, in press.

  • Payton A, Holmes J, Barrett JH, Hever T, Fitzpatrick H, Trumper AL et al. Examining for association between candidate gene polymorphisms in the dopamine pathway and attention-deficit hyperactivity disorder: a family-based study. Am J Med Genet 2001; 105: 464–470.

    Article  CAS  PubMed  Google Scholar 

  • Hawi Z, Foley D, Kirley A, McCarron M, Fitzgerald M, Gill M . Dopa decarboxylase gene polymorphisms and attention deficit hyperactivity disorder (ADHD): no evidence for association in the Irish population. Mol Psychiatry 2001; 6: 420–424.

    Article  CAS  PubMed  Google Scholar 

  • Kruglyak L . Power tools for human genetics. Nat Genet 2005; 37: 1299–1300.

    Article  CAS  PubMed  Google Scholar 

  • Taylor E, Everitt B, Thorley G, Schacher R, Rutter M, Wieselberg M . Conduct disorder and hyperactivity: II. A cluster analytic approach to the identification of a behavioural syndrome. Br J Psychol 1986; 149: 768–777.

    Article  CAS  Google Scholar 

  • Ho TP, Luk ES, Leung PW, Taylor E, Lieh-Mak F, Bcaon-Shone J . Situational versus pervasive hyperactivity in a community sample. Psychol Med 1996; 26: 309–321.

    Article  CAS  PubMed  Google Scholar 

  • West A, Langley K, Hamshere ML, Kent L, Craddock N, Owen MJ et al. Evidence to suggest biased phenotypes in children with attention deficit. Mol Psychiatry 2002; 7: 962–966.

    Article  CAS  PubMed  Google Scholar 

  • Barr CL, Feng Y, Wigg KG, Schachar R, Tannock R, Roberts W et al. 5′-untranslated region of the dopamine D4 receptor gene and attention-deficit hyperactivity disorder. Am J Med Genet 2001; 105: 84–90.

    Article  CAS  PubMed  Google Scholar 

  • Feng Y, Crosbie J, Wigg K, Pathare T, Ickowicz A, Schachar R et al. The SNAP25 gene as a susceptibility gene contributing to attention-deficit hyperactivity disorder. MolPsychiatry 2005; 10: 998–1005.

    CAS  Google Scholar 

  • Barr CL, Kroft J, Feng Y, Wigg K, Roberts W, Malone M et al. The norepinephrine transporter gene attention-deficit hyperactivity disorder. Am J Med Genet 2002; 114: 255–259.

    Article  PubMed  Google Scholar 

  • McEvoy B, Hawi Z, Fitzgerald M, Gill M . No evidence of linkage or association between the norepinephrine transporter (NET) gene polymorphisms and ADHD in the Irish population. Am J Med Genet 2002; 114: 665–666.

    Article  PubMed  Google Scholar 

  • Comings DE, Gade-Andavolu R, Gonzalez N, Wu S, Muhleman D, Blake H et al. Multivariate analysis of associations of 42 genes in ADHD, ODD and conduct disorder. Clin Genet 2000; 58: 31–40.

    Article  CAS  PubMed  Google Scholar 

  • De Luca V, Muglia P, Jain U, Kennedy JL . No evidence of linkage or association between the norepinephrine transporter (NET) gene MnlI polymorphism and adult ADHD. Am J Med Genet B Neuropsychiatr Genet 2004; 124: 38–40.

    Article  Google Scholar 

  • Kent L, Middle F, Hawi Z, Fitzgerald M, Gill M, Feehan C et al. Nicotinic acetylcholine receptor alpha4 subunit gene polymorphism and attention deficit hyperactivity disorder. Psychiatr Genet 2001; 11: 37–40.

    Article  CAS  PubMed  Google Scholar 

  • Comings DE, Gade-Andavolu R, Gonzalez N, Wu S, Muhleman D, Blake H et al. Comparison of the role of dopamine, serotonin, and noradrenaline genes in ADHD, ODD and conduct disorder: multivariate regression analysis of 20 genes. Clin Genet 2000; 57: 178–196.

    Article  CAS  PubMed  Google Scholar 

  • Todd RD, Lobos EA, Sun LW, Neuman RJ . Mutational analysis of the nicotinic acetylcholine receptor alpha 4 subunit gene in attention deficit/hyperactivity disorder: evidence for association of an intronic polymorphism with attention problems. Mol Psychiatry 2003; 8: 103–108.

    Article  CAS  PubMed  Google Scholar 

  • Rowe DC, Van den Oord EJ, Stever C, Giedinghagen LN, Gard JM, Cleveland HH et al. The DRD2 TaqI polymorphism and symptoms of attention deficit hyperactivity disorder. Mol Psychiatry 1999; 4: 580–586.

    Article  CAS  PubMed  Google Scholar 

  • Comings DE, Comings BG, Muhleman D, Dietz G, Shahbahrami B, Tast D et al. dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders. JAMA 1991; 266: 1793–1800.

    Article  CAS  PubMed  Google Scholar 

  • Comings DE . Clinical and molecular genetics of ADHD and Tourette syndrome. Two related polygenic disorders. Ann NY Acad Sci 2001; 931: 50–83.

    Article  CAS  PubMed  Google Scholar 

  • Todd RD, Lobos EA . Mutation screening of the dopamine D2 receptor gene in attention-deficit hyperactivity disorder subtypes: preliminary report of a research strategy. Am J Med Genet 2002; 114: 34–41.

    Article  PubMed  Google Scholar 

  • Huang YS, Lin SK, Wu YY, Chao CC, Chen CK . A family-based association study of attention-deficit hyperactivity disorder and dopamine D2 receptor TaqI A alleles. Chang Gung Med J 2003; 26: 897–903.

    PubMed  Google Scholar 

  • Muglia P, Jain U, Kennedy JL . A transmission disequilibrium test of the Ser9/Gly dopamine D3 receptor gene polymorphism in adult attention-deficit hyperactivity disorder. Behav Brain Res 2002; 130: 91–95.

    Article  CAS  PubMed  Google Scholar 

  • Barr CL, Wigg KG, Bloom S, Schachar R, Tannock R, Roberts W et al. Further evidence from haplotype analysis for linkage of the dopamine D4 receptor gene and attention-deficit hyperactivity disorder. Am J Med Genet 2000; 96: 262–267.

    Article  CAS  PubMed  Google Scholar 

  • Comings DE, Gade-Andavolu R, Gonzalez N, Blake H, Wu S, MacMurray JP . Additive effect of three noradrenergic genes (ADRA2a, ADRA2C, DBH) on attention-deficit hyperactivity disorder and learning disabilities in Tourette syndrome subjects. Clin Genet 1999; 55: 160–172.

    Article  CAS  PubMed  Google Scholar 

  • Daly G, Hawi Z, Fitzgerald M, Gill M . Mapping susceptibility loci in attention deficit hyperactivity disorder: preferential transmission of parental alleles at DAT1, DBH and DRD5 to affected children. MolPsychiatry 1999; 4: 192–196.

    CAS  Google Scholar 

  • Wigg K, Zai G, Schachar R, Tannock R, Roberts W, Malone M et al. Attention deficit hyperactivity disorder and the gene for dopamine Beta-hydroxylase. Am J Psychiatry 2002; 159: 1046–1048.

    Article  PubMed  Google Scholar 

  • Roman T, Schmitz M, Polanczyk GV, Eizirik M, Rohde LA, Hutz MH . Further evidence for the association between attention-deficit/hyperactivity disorder and the dopamine-beta-hydroxylase gene. Am J Med Genet 2002; 114: 154–158.

    Article  PubMed  Google Scholar 

  • Inkster B, Muglia P, Jain U, Kennedy JL . Linkage disequilibrium analysis of the dopamine beta-hydroxylase gene in persistent attention deficit hyperactivity disorder. Psychiatr Genet 2004; 14: 117–120.

    Article  PubMed  Google Scholar 

  • Smith KM, Daly M, Fischer M, Yiannoutsos CT, Bauer L, Barkley R et al. Association of the dopamine beta hydroxylase gene with attention deficit hyperactivity disorder: genetic analysis of the Milwaukee longitudinal study. Am J Med Genet B Neuropsychiatr Genet 2003; 119: 77–85.

    Article  Google Scholar 

  • Zhang HB, Wang YF, Li J, Wang B, Yang L . Association of dopamine beta-hydroxylase polymorphism with attention deficit hyperactivity disorder in children. Beijing Da Xue Xue Bao 2004; 36: 290–293.

    CAS  PubMed  Google Scholar 

  • Zhang HB, Wang YF, Li J, Wang B, Yang L . Association between dopamine beta hydroxylase gene and attention deficit hyperactivity disorder complicated with disruptive behavior disorder. Zhonghua ErKeZa Zhi 2005; 43: 26–30.

    Google Scholar 

  • Eisenberg J, Mei-Tal G, Steinberg A, Tartakovsky E, Zohar A, Gritsenko I, Nemanov L, Ebstein RP . Haplotype relative risk study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD): association of the high-enzyme activity Val allele with ADHD impulsive-hyperactive phenotype. Am J Med Genet 1999; 88: 497–502.

    Article  CAS  PubMed  Google Scholar 

  • Qian Q, Wang Y, Zhou R, Li J, Wang B, Glatt S, Faraone SV . Family-based and case-control association studies of catechol-O-methyltransferase in attention deficit hyperactivity disorder suggest genetic sexual dimorphism. Am J Med Genet B Neuropsychiatr Genet 2003; 118: 103–109.

    Article  Google Scholar 

  • Thapar A, Langley K, Fowler T, Rice F, Turic D, Whittinger N et al. Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 2005; 62: 1275–1278.

    Article  CAS  PubMed  Google Scholar 

  • Curran S, Purcell S, Craig I, Asherson P, Sham P . The serotonin transporter gene as a QTL for ADHD. Am J Med Genet B Neuropsychiatr Genet 2005; 134: 42–47.

    Article  Google Scholar 

  • Kent L, Doerry U, Hardy E, Parmar R, Gingell K, Hawi Z et al. Evidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD): analysis and pooled analysis. MolPsychiatry 2002; 7: 908–912.

    CAS  Google Scholar 

  • Li J, Wang Y, Qian Q, Wang B, Zhou R . Association of 5-HT(2A) receptor polymorphism and attention deficit hyperactivity disorder in children. Zhonghua Yi Xue Za Zhi 2002; 82: 1173–1176.

    CAS  PubMed  Google Scholar 

  • Hawi Z, Dring M, Kirley A, Foley D, Kent L, Craddock N et al. Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sample. MolPsychiatry 2002; 7: 718–725.

    CAS  Google Scholar 

  • Quist JF, Barr CL, Schachar R, Roberts W, Malone M, Tannock R et al. The serotonin 5-HT1B receptor gene and attention deficit hyperactivity disorder. MolPsychiatry 2003; 8: 98–102.

    CAS  Google Scholar 

  • Li J, Wang Y, Zhou R, Zhang H, Yang L, Wang B et al. Serotonin 5-HT1B receptor gene and attention deficit hyperactivity disorder in Chinese Han subjects. Am J Med Genet B Neuropsychiatr Genet 2005; 132: 59–63.

    Article  Google Scholar 

  • Li J, Wang YF, Zhou RL, Zhang HB, Wang B, Yang L . Association between serotonin 2C gene polymorphisms and attention deficit hyperactivity disorder comorbid or not comorbid with learning disorder. Beijing Da Xue Xue Bao 2004; 36: 366–369.

    CAS  PubMed  Google Scholar 

  • Li D, Sham PC, Owen MJ, He L . Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD). Hum Mol Genet 2006; 15: 2276–2284.

    Article  CAS  PubMed  Google Scholar