Structural characterization of zinc bicarbonate compounds relevant to the mechanism of action of carbonic anhydrase
- ️Gerard Parkin
* Corresponding authors
a Department of Chemistry, Columbia University, New York, New York 10027, USA
Abstract
The tris(3-t-butyl-5-methylpyrazolyl)hydroborato and tris(2-pyridylthio)methyl derivatives, [TpBut,Me]ZnOCO2H and [κ4-Tptm]ZnOCO2H, are the first pair of terminal zinc bicarbonate complexes to be structurally characterized by using X-ray diffraction. In both cases, the bicarbonate ligand coordinates in a unidentate manner, comparable to that in human carbonic anhydrase I. While the bicarbonate complex [κ4-Tptm]ZnOCO2H is obtained by treatment of {[κ3-Tptm]Zn(μ–OH)}2 with CO2 in the presence of water, the bridging carbonate complex [Tptm]Zn(μ-CO3)Zn[Tptm] is obtained in the absence of water. The reactivity of {[κ3-Tptm]Zn(μ–OH)}2 towards CO2 is sufficiently high that the carbonate complex is obtained upon exposure to air.
Supplementary files
Article information
- https://doi.org/10.1039/C2SC20167D
- Edge Article
- 09 Feb 2012
- 01 Mar 2012
- 29 Mar 2012
DOI
Article type
Submitted
Accepted
First published
Chem. Sci., 2012,3, 2015-2019
Permissions
Structural characterization of zinc bicarbonate compounds relevant to the mechanism of action of carbonic anhydrase
W. Sattler and G. Parkin, Chem. Sci., 2012, 3, 2015 DOI: 10.1039/C2SC20167D
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