doi.org

Genome-Scale Compositional Comparisons in Eukaryotes

  • ️Sun Apr 01 2001
  1. Andrew J. Gentles and
  2. Samuel Karlin1
  1. Mathematics Department, Stanford University, Stanford, California 94305, USA

Abstract

We examined dinucleotide relative abundances and their biases in recent sequences of eukaryotic genomes and chromosomes, including human chromosomes 21 and 22, Saccharomyces cerevisiae, Arabidopsis thaliana, and Drosophila melanogaster. We found that dinucleotide relative abundances are remarkably constant across human chromosomes and within the DNA of a particular species. The dinucleotide biases differ between species, providing a genome signature that is characteristic of the bulk properties of an organism's DNA. We detail the relations between species genome signatures and suggest possible mechanisms for their origin and maintenance.

Footnotes

  • ↵1 E-MAIL ; FAX (650) 725-2040.

  • Article and publication are at www.genome.org/cgi/doi/10.1101/gr.163101.

    • Received August 30, 2000.
    • Accepted February 5, 2001.
  • Cold Spring Harbor Laboratory Press
  • AACR Annual Meeting