Trading translation with RNA-binding proteins

1. Irina Abaza and
2. Fátima Gebauer

1. Centre de Regulació Genòmica (CRG), Gene Regulation Programme, 08003 Barcelona, Spain

Abstract

RNA-binding proteins regulate every aspect of RNA metabolism, including pre-mRNA splicing, mRNA trafficking, stability, and translation. This review summarizes the available information on molecular mechanisms of translational repression by RNA-binding proteins. By using a specific set of well-defined examples, we also describe how regulation can be reversed.

• translation
• RNA-binding proteins
• hnRNP K
• SXL
• Maskin
• Cup
• IRP
• GAIT
• CPEB
• Smaug

Footnotes

• Reprint requests to: Fátima Gebauer, Centre de Regulació Genòmica (CRG), Gene Regulation Programme, Dr Aiguader 88, Planta 6, 08003 Barcelona, Spain; e-mail: fatima.gebauer{at}crg.es; fax: 0034-93-3969983.

• Article published online ahead of print. Article and publication date are at http://www.rnajournal.org/cgi/doi/10.1261/rna.848208.

• Copyright © 2008 RNA Society