Evaluation of the Ergogenic Properties of Ginseng - Sports Medicine
- ️Morgan, William P.
- ️Fri Oct 19 2012
Goldstein B. Ginseng: its history, dispersion, and folk tradition. Am J Chin Med 1975; 3(3): 223–34
Hu SY. A contribution to our knowledge of ginseng. Am J Chin Med 1977; 5(1): 1–23
Liu C-X, Xiao P-G. Recent advances on ginseng research in China. J Ethnopharmacol 1992; 36: 27–38
Brekhman II, Dardymov IV. New substances of plant origin which increase nonspecific resistance. Annu Rev Pharmacol 1969; 9: 419–30
Cartwright L. Ginseng in pharmacies. Aust J Pharm 1979; 60: 346–9
Hu S. Y. The genus Panax (ginseng) in Chinese medicine. Econ Botany 1976; 30: 11–28
Li CP, Li RC. An introductory note to ginseng. Am J Chin Med 1973; 1(2): 249–61
Perry LM, Metzger J. Medicinal plants of East and Southeast Asia: attributed properties and uses. Cambridge: MIT Press, 1980
Baranov A. Recent advances in our knowledge of the morphology, cultivation and uses of ginseng (Panax ginseng C.A. Meyer). Economic Botany 1966; 20: 403–6
Bitties AH, Fulder SJ, Grant EC, et al. The effect of ginseng on lifespan and stress responses in mice. Gerontology 1979; 25: 125–31
Popov IM, Goldwag WJ. A review of the properties and clinical effects of ginseng. Am J Chin Med 1973; 1(2): 263–70
Liberti LE, Der Marderosian A. Evaluation of commercial ginseng products. J Pharm Sci 1978; 67(10): 1487–9
Wood HC, La Wall CH, Youngken HW, et al. The dispensatory of the United States of America. Centennial (22nd) ed. Philadelphia: JB Lippincott Co, 1937: 1393
Siegel RK. Ginseng abuse syndrome: problems with the panacea. JAMA 1979; 241(15): 1614–5
Phillipson JD, Anderson LA. Ginseng — quality, safety, and efficacy? Pharmaceut J 1984; 232: 161–5
Chong SKF, Oberholzer VG. Ginseng — is there a use in clinical medicine? Postgrad Med J 1988; 64: 841–6
Editorial. Weekly Pharmacy Report 1977; 35: 1
Yamaguchi H, Matsuura H, Kasai R, et al. Analysis of saponins of wild Panax ginseng. Chem Pharm Bull 1988; 36(10): 4177–81
Dorling E, Kirchdorfer AM, Ruckert KH. Do ginsenosides influence the performance? Notabene Med 1980; 10(5): 241–6
Forgo I. Doping control of top-ranking athletes after a 14-day treatment with Ginsana. Report dated February 13. Delray Beach: Ginsana USA Corporation; 1980
Forgo I. Effect of drugs on physical performance and hormone system of sportsmen. Meunchener Med Wochenschrift 1983; 125(38): 822–4
Forgo I, Kirchdorfer AM. On the question of influencing the performance of top sportsmen by means of biologically active substances. Ärtl Praxis 1981; 33(44): 1784–6
Forgo I, Kirchdorfer AM. The effect of different ginsenoside concentrations on physical work capacity. Notabene Med 1982; 12(9): 721–7
Forgo I, Schimert G. The duration of effect of the standardized ginseng extract G115 in healthy competitive athletes. Notabene Med 1985; 15(9): 636–40
Pietta P, Mauri P, Rava A. Improved high-performance liquid chromatographic method for the analysis of ginsenosides in Panax ginseng extracts and products. J Chromatogr 1986; 356: 212–9
Soldati F, Sticher O. HPLC separation and quantitative determination of ginsenosides from Panax ginseng, Panax quinquefolium and from ginseng drug preparations. Planta Med 1980; 38: 348–57
Barna P. Food or drug? The case of ginseng [letter]. Lancet 1985; 2: 548
Court WE. Ginseng — a Chinese folk medicine of current interest. Pharm J 1975; 214: 180–1
Williams LO. Ginseng. Econ Botany 1957; 11: 344–8
Baranov AI. Medicinal uses of ginseng and related plants in the Soviet Union: recent trends in the Soviet literature. J Ethnopharmacol 1982; 6: 339–53
Brekhman II. Eleutherococcus senticosus — a new medicinal herb of the araliaceae family. In: Chen KK, Mukerji B, editors. Pharmacology of oriental plants. New York: Macmillan Company, 1965
Hou JP. The chemical constituents of ginseng plants. Comparat Med East West 1977; 5(2): 123–45
Iwabuchi H, Yoshikura M, Ikawa Y, et al. Studies on the sesquiterpenoids of Panax ginseng C.A. Meyer. Isolation and structure determination of sesquiterpene alcohols, panasinsanols A and B. Chem Pharm Bull 1987; 35(5): 1975–81
Iwabuchi H, Yoshikura M, Kamisako W. Studies on the sesquiterpenoids of Panax ginseng C.A. Meyer. II: isolation and structure determination of ginsenol, a novel sesquiterpene alcohol. Chem Pharm Bull 1988; 36(7): 2447–51
Kasai R, Yamaguchi H, Tanaka O. High-performance liquid chromatography of glycosides on a new type of hydroxyapatite column. J Chromatogr 1987; 407: 205–10
Shibata S, Fujita M, Itokawa H, et al. Studies on the constituents of Japanese and Chinese crude drugs. XI: panaxadiol, a sapogenin of ginseng roots. Chem Pharm Bull 1963; 11(6): 759–761
Tanaka O, Nagai M, Shibata S. Chemical studies on the Oriental plant drugs. XVI: the stereochemistry of protopanaxadiol, a genuine sapogenin of ginseng. Chem Pharm Bull 1966; 14(10): 1150–6
Yamaguchi H, Kasai R, Matsuura H, et al. High-performance liquid chromatographic analysis of acidic saponins of ginseng and related plants. Chem Pharm Bull 1988; 36(9): 3468–73
Iida Y, Tanaka O, Shibata S. Studies on saponins of ginseng: the structure of ginsenoside-Rg1. Tetrahedron Lett 1968; 52: 5449–53
Shibata S, Tanaka O, Soma K, et al. Studies on saponins and sapogenins of ginseng: the structure of panaxatriol. Tetrahedron Lett 3: 207–13
Besso H, Kasai R, Wei J, et al. Further studies on dammarane-saponins of American ginseng, roots of Panax quinquefolium L. Chem Pharm Bull 1982; 30(12): 4534–8
Elyakov GB, Strigina LI, Uvarova NI, et al. Glycosides from ginseng roots. Tetrahedron Lett 1964; 48: 3591–7
Petkov VD, Yinglin C, Todorov I, et al. Behavioral effects of stem-leaves extract from Panax ginseng C.A. Meyer. Acta Physiol Pharmacol Bulg 1992; 18(2): 41–8
Matsuda H, Namba K, Fukuda S, et al. Pharmacological study on Panax Ginseng C.A. Meyer. III: effects of red ginseng on experimental disseminated intravascular coagulation. (2). Effects of ginsenosides on blood coagulative and fibrinolytic systems. Chem Pharm Bull 1986; 34(3): 1153–7
Staba EJ. Ginseng [letter]. Lancet 1985; 2(8467): 1309–10
Odani T, Tanizawa H, Takino Y. Studies on the absorption, distribution, excretion and metabolism of ginseng saponins. II: the absorption, distribution and excretion of ginsenoside Rg1 in the rat. Chem Pharm Bull 1983; 31(1): 292–8
Takino Y, Tanizawa H, Odani T. Studies of the absorption, distribution, excretion and metabolism of genoside Rg1 and Rb1in rats. In: Proceedings of the 4th International Ginseng Symposium. Seoul: Korean Ginseng Research Institute, 1984
Karikura M, Tanizawa H, Hirata T, et al. Studies on absorption, distribution, excretion and metabolism of ginseng saponins, VIII: isotope labeling of ginsenoside Rb2. Chem Pharmaceut Bull 1992; 40(9): 2458–60
Cui J, Garle M, Eneroth P, et al. What do commercial ginseng preparations contain? [letter]. Lancet 1994; 344(8915): 134
Fulder SJ. Ginseng and the hypothalamic-pituitary control of stress. Am J Chin Med 1981; 9(2): 112–8
Nabata H, Saito H, Takagi K. Pharmacological studies of neutral saponins (GNS) of Panax ginseng root. Jpn J Pharmacol 1973; 23: 29–41
Petkov V. Über den Wirkungsmechanimus der Panax Ginseng C.A. Meyer. Arzneim Forsch 1961; 11(3): 288–96
Takagi K, Saito H, Nabata H. Pharmacological studies of Panax ginseng root: estimation of pharmacological actions of Panax ginseng root. Jpn J Pharmacol 1972; 22: 245–59
Takagi K, Saito H, Tsuchiya M. Pharmacological studies of Panax ginseng root: pharmacological properties of a crude saponin fraction. Jpn J Pharmacol 1972; 22: 339–46
Takagi K, Saito H, Tsuchiya M. Effect of Panax ginseng root on spontaneous movement and exercise in mice. Jpn J Pharmacol 1974; 24: 41–8
Petkov V. Effect of ginseng on the brain biogenic monoamines and 3′,5′-AMP system. Arzneim Forsch 1978; 28(1): 388–93
Hiai G, Sasaki S, Oura H. Effect of ginseng saponin on rat adrenal cyclic AMP. Planta Med 1979; 37: 15–9
Brekhman II, Dardymov IV. Proceedings of the Pacific Scientific Congress 1966; 8: 11
Brekhman II, Dardymov IV. Pharmacological investigation of glycosides from ginseng and eleutherococcus. Lloydia 1969; 32: 46–51
Kim C, Kim CC, Kim MS, et al. Influence of ginseng on the stress mechanism. Lloydia 1970; 33: 43–8
Petkov V, Staneva-Stoicheva D. The effect of an extract of ginseng on the adrenal cortex. In: Chen KK, Mukerji B, editors. Pharmacology of oriential plants. New York: Macmillan Company, 1965
Hiai S, Sasayama Y, Oguro C. Chronic effects of ginseng saponin, glycyrrhizin and flavin adenine dinucleotide on adrenal and thymus weight in normal and dexamethasone-treated rats. Chem Pharm Bull 1097; 35(1): 241–8
Sugaya A, Yuzurihara M, Tsuda T, et al. Proliferative effect of ginseng saponin on neurite extension of primary cultured neurons of the rat cerebral cortex. J Ethnopharmacol 1988; 22: 173–81
Himi T, Saito H, Nishiyama N. Effect of ginseng saponins on the survival of cerebral cortex neurons in cell cultures. Chem Pharm Bull 1989; 37(2): 481–4
Takeda A, Yonezawa M, Katoh N. Restoration of radiation injury by ginseng. I: responses of X-irradiated mice to ginseng extract. J Radiat Res 1981; 22: 323–35
Takeda A, Katoh N, Yonezawa M. Restoration of radiation injury by ginseng. III: radioprotective effect of thermostable fraction of ginseng extract on mice, rats and guinea pigs. J Radiat Res 1982; 23: 150–67
Yonezawa M. Restoration of radiation injury by intraperitoneal injection of ginseng extract in mice. J Radiat Res 1976; 17: 111–3
Yonezawa M, Katoh N, Takeda A. Restoration of radiation injury by ginseng. II: some properties of the radioprotective substances. J Radiat Res 1981; 22: 336–43
Yonezawa M, Katoh N, Takeda A. Restoration of radiation injury by ginseng. IV: stimulation of recoveries in CFUs and megakaryocyte counts related to the prevention of occult blood appearance in X-irradiated mice. J Radiat Res 1985; 26: 436–42
Zhang J-S, Sigdestad CP, Gemmell MA, et al. Modification of radiation response in mice by fractionated extracts of Panax ginseng. Radiat Res 1987; 112: 156–63
Hallstrom C, Fulder S, Carruthers M. Effects of ginseng on the performance of nurses on night duty. Comparat Med East West 1982; 6(4): 277–82
Forgo I, Kayasseh L, Staub JJ. Einfluss eines standardisierten Ginseng-Extraktes auf das Allgemeinbefinden, die Reaktionsfähigkeit, Lungenfunktion und die gonadalen Hormone. Med Welt 1981; 32(19): 751–6
von Ardenne M, Klemm W. Measurements of the increase in the difference between the arterial and venous Hb-O2 saturation obtained with daily administration of 200mg standardized ginseng extract Gl 15 for four weeks. Panminerva Med 1987; 29: 143–50
Wiklund I, Karlberg J, Lund B. A double-blind comparison of the effect on quality of life of a combination of vital substances including standardized ginseng G115 and placebo. Curr Ther Res 1994; 55(1): 32–42
Jenny E. On the cardiovascular action of the standardized ginseng extract G115 and pure ginsenosides. Report dated September 29. Delray Beach: Ginsana USA Corporation, 1982
Lee DC, Lee MO, Kim CY, et al. Effect of ether, ethanol and aqueous extracts of ginseng on cardiovascular functions in dogs. Can J Comparat Med 1981; 45: 182–7
Lei X-L, Chiou GCY. Cardiovascular pharmacology of Panax Notoginseng (Burk) F.H. Chen and Salvia miltiorrhiza. Am J Chin Med 1986; 14(3 & 4): 145–52
Wood WB, Roh BL, White RP. Cardiovascular actions of Panax ginseng in dogs. Jpn J Pharmacol 1964; 14: 284–94
Kimura Y, Okuda H, Arichi S. Effects of various ginseng saponins on 5-hydroxytryptamine release and aggregation in human platelets. J Pharm Pharmacol 1988; 40: 838–43
Matsuda H, Namba K, Fukuda S, et al. Pharmacological study on Panax Ginseng C.A. Meyer. IV. Effects of red ginseng on experimental disseminated intravascular coagulation. (3). Effect of ginsenoside-Ro on the blood coagulative and fibrinolytic system. Chem Pharm Bull 1986; 34(5): 2100–4
Matsuda H, Samukawa K, Fukuda S, et al. Studies on Panax japonicus fibrinolysis. Planta Med 1989; 55: 18–21
Teng C-M, Kuo S-C, Ko F-N, et al. Antiplatelet actions of panaxynol and ginsenosides isolated from ginseng. Biochim Biophys Acta 1989; 990: 315–20
Lasarova MB, Mosharrof AH, Petkov VD, et al. Effect of Piracetam and of standardized ginseng extract on the electroconvulsive shock-induced memory disturbances in ‘step-down’ passive avoidance. Acta Physiol Pharmacol Bulg 1987; 13(2): 11–7
Petkov VD, Mosharrof AH. Effects of standardized ginseng extract on learning, memory and physical capabilities. Am J Chin Med 1987; 15(1 and 2): 19–29
Petlov VD, Kehayov R, Belcheva S, et al. Memory effects of standardized extracts of Panax ginseng (G115), Ginkgo biloba(GK501) and their combination (PHL-00701). Planta Med 1993; 59: 106–14
Saito H, Tsuchiya M, Naka S, et al. Effects of Panax ginseng root on conditioned avoidance response in rats. Jpn J Pharmacol 1977; 27: 509–16
Yoshimura H, Watanabe K, Ogawa N. Psychotropic effects of ginseng saponins on agonistic behaviour between resident and intruder mice. Eur J Pharmacol 1988; 146: 291–7
Yoshimura H, Watanabe K, Ogawa N. Acute and chronic effects of ginseng saponins on maternal aggression in mice. Eur J Pharmacol 1988; 150: 319–24
Bhattacharya SK, Mitra SK. Anxiolytic activity of Panax ginseng roots: an experimental study. J Ethnopharmacol 1991; 34: 87–92
D’Angelo L, Grimaldi R, Caravaggi M, et al. A double-blind, placebo controlled clinical study on the effect of a standardized ginseng extract on psychomotor performance in healthy volunteers. J Ethnopharmacol 1986; 16: 15–22
Sandberg F. Vitalitet och senilitet — effekten av ginsengglykosi-der pa prestationsformagan. Svensk Farmaceut Tidskrift 1980; 84(13): 499–502
Filaretov AA, Bogdanova TS, Podvigina TT, et al. Role of pi-tuitary-adrenocortical system in body adaptation abilities. Exper Clin Endocrinol 1988; 92: 129–36
Savel J. Pharmacological investigation of the standardized ginseng extract G115. Delray Beach: Ginsana USA Corporation, 1971
Petkov VD, Getova D, Mosharrof AH. A study of nootropic drugs for anti-anxiety action. Acta Physiol Pharmacol Bulg 1987; 13(4): 25–30
Sterner VW, Kirchdorfer AM. Vergleichende Leistungs-prufungen an Mausen mit standardisierten Ginseng-Extrakt und einem ginsenghaltingen Gerotherapeutikum. Zeitschr Gerontol 1970; 3: 307–12
Saito H, Yoshida Y, Takagi K. Effect of Panax ginseng root on exhaustive exercise in mice. Jpn J Pharmacol 1974; 24: 119–27
Avakian EV, Evonuk E. Effect of Panax ginseng extract on tissue glycogen and adrenal cholesterol depletion during prolonged exercise. Planta Med 1979; 36: 43–8
Martinez B, Staba EJ. The physiological effects of Aralia, Panax, and Eleutherococcus on exercised rats. Jpn J Pharmacol 1984; 35: 79–85
Avakian EV, Sugimoto RB, Taguchi S, et al. Effect of Panax ginseng extract on energy metabolism during exercise in rats. Planta Med 1984; 50: 151–4
Fahim MS, Fahim Z, Harman JM, et al. Effect of Panax ginseng on testosterone level and prostate in male rats. Arch Androl 1982; 8: 261–3
Lewis WH, Zenger VE, Lynch RG. No adaptogen response of mice to ginseng and eleutherococcus infusions. J Ethnopharmacol 1983; 8: 209–14
Knapik JJ, Wright JE, Welch MJ, et al. The influence of Panax ginseng on indices of substrate utilization during repeated, exhaustive exercise in man [abstract]. Fed Proc 1983; 42: 336
Pieralisi G, Ripari P, Vecchiet L. Effects of a standardized ginseng extract combined with dimethylaminoethanol bitartrate, vitamins, minerals, and trace elements on physical performance during exercise. Clin Ther 1991; 13(3): 373–82
Van Schepdael P. Les effects du ginseng G115 sur la capacité physique de sportifs d’endurance. Acta Ther 1993; 19: 337–47
Morris AC, Jacobs I, Klugerman TM. No ergogenic effect of ginseng extract ingestion [abstract]. Med Sci Sports Exerc 1994; 26(5): S6
Hess FG, Parent RA, Stevens KR, et al. Effects of subchronic feeding of ginseng extract G115 in beagle dogs. Food Chem Toxicol 1983; 21(1): 95–7
Brunner J. Nasty medicine. New Scientist 1983; 97(1339): 44
Dukes MNG. Ginseng and mastalgia [letter]. Br Med J 1978; 1: 1621
Subiza J, Subiza JL, Escribano PM, et al. Occupational asthma caused by Brazil ginseng dust. J Allergy Clin Immunol 1991; 88: 731–6
Siegel RK. Ginseng and high blood pressure. JAMA 1980; 243(1): 32
Koriech OM. Ginseng and mastalgia [letter]. Br Med J 1978; 1: 1556
Palmer BV, Montgomery ACV, Monteiro JCMP. Ginseng and mastalgia [letter]. Br Med J 1978; 1: 1284
Greenspan EM. Ginseng and vaginal bleeding. JAMA 1983; 249(15): 2018
Hopkins MP, Androff L, Benninghoff AS. Ginseng face cream and unexplained vaginal bleeding. Am J Obstet Gynaecol 1988; 150(5): 1121–2
Punnonen R, Lukola A. Oestrogen-like effect of ginseng. Br Med J 1980; 281: 1110
Kim C, Choi H, Kim CC, et al. Influence of ginseng on mating behaviour of male rats. Am J Chin Med 1976; 4(2): 163–8
Hikino H, Takahashi M, Otake K, et al. Isolation and hypoglycemic activity of eleutherans A, B, C, D, E, F, and G: glycans of Eleutherococcus senticosus roots. J Nat Prod 1986; 49(2): 293–7
Oshima Y, Sato K, Hikino H. Isolation and hypoglycemic activity of quinquefolans A, B, and C, glycans of Panax quinquefolium roots. J Nat Prod 1987; 50(2): 188–90
Shader RI, Greenblatt DJ. Phenelzine and the dream machine-ramblings and reflections. J Clin Psychopharmacol 1985; 5(2): 65
Shader RI, Greenblatt DJ. Bees, ginseng and MAOIs revisited. J Clin Psychopharmacol 1988; 8(4): 235
Jones BD, Runikis AM. Interaction of ginseng with phenelzine. J Psychopharmacol 1987; 7(3): 201–2
Nikaido T, Ohmoto T, Sankawa U, et al. Inhibitors of cyclic AMP phosphodiesterase in Panax ginseng C.A. Meyer and Panax japonicus C.A. Meyer. Chem Pharm Bull 1984; 32(4): 1477–83
Tsang D, Yeung HW, Tso WW, et al. Ginseng saponins: influence on neurotransmitter uptake in rat brain synaptosomes. Planta Med 1985; 51(3): 221–4
US Olympic Committee. US Olympic Committee Drug Education Handbook 1989–92 (80909–5760). Colorado Springs: USOC Drug Education Program, 1989
Watt J, Bottomley MB, Read MTF. Olympic athletics medical experience, Seoul — personal views. Br J Sports Med 1989; 23(2): 76–9