link.springer.com

Effect of Endurance Exercise on Autonomic Control of Heart Rate - Sports Medicine

  • ️Blaber, Andrew P.
  • ️Tue Oct 23 2012
  • Amano M, Kanda T, Ue H, et al. Exercise training and autonomic nervous system activity in obese individuals. Med Sci Sports Exerc 2001; 33: 1287–91

    Article  PubMed  CAS  Google Scholar 

  • Dixon EM, Kamath MV, McCartney N, et al. Neural regulation of heart rate variability in endurance athletes and sedentary controls. Cardiovasc Res 1992; 26: 713–9

    Article  PubMed  CAS  Google Scholar 

  • Goldsmith RL, Bloomfeld DM, Rosenwinkel ET. Exercise and autonomic function. Coronary Artery Dis 2000; 11: 129–35

    Article  CAS  Google Scholar 

  • Gregoire J, Tuck S, Yamamoto Y, et al. Heart rate variability at rest and exercise: influence of age, gender and physical training. Can J Appl Physiol 1996; 21 (6): 455–70

    Article  PubMed  CAS  Google Scholar 

  • Shi X, Stevens G, Foresman B, et al. Autonomic nervous system control of the heart: endurance exercise training. Med Sci Sports Exerc 1995; 27 (10): 1406–13

    PubMed  CAS  Google Scholar 

  • Shin K, Minamitani H, Onishi S, et al. The power spectral analysis of heart rate variability in athletes during dynamic exercise: part 1. Clin Cardiol 1995; 18: 583–6

    Article  PubMed  CAS  Google Scholar 

  • Smith ML, Hudson D, Graitzer H, et al. Exercise training bradycardia: the role of autonomic balance. Med Sci Sports Exerc 1989; 21 (1): 40–4

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto K, Miyachi M, Saitoh T, et al. Effects of endurance training on resting and post-exercise cardiac autonomic control. Med Sci Sports Exerc 2001; 33: 1496–502

    Article  PubMed  CAS  Google Scholar 

  • Areskog N. Effects and adverse effects of autonomic blockade in physical exercise. Am J Cardiol 1985; 55: 132–134D

    Article  Google Scholar 

  • Chen C, DiCarlo SE. Endurance exercise training-induces resting bradycardia: a brief review. Sports Med Training Rehab 1997; 8 (1): 37–77

    Article  Google Scholar 

  • Wilmore JH, Stanforth P, Gagnon J, et al. Endurance exercise training has a minimal effect on resting heart rate: the HERITAGE study. Med Sci Sports Exerc 1996; 28 (7): 829–35

    Article  PubMed  CAS  Google Scholar 

  • Brenner IK, Thomas S, Shephard RJ. Spectral analysis of heart rate variability during heat exposure and repeated exercise. Eur J Appl Physiol 1997; 76: 145–56

    Article  CAS  Google Scholar 

  • Lucini D, Trabucchi V, Malliani A, et al. Analysis of initial autonomic adjustments to moderate exercise in humans. J Hypertens 1995; 13: 1660–3

    Article  PubMed  CAS  Google Scholar 

  • Nakamura Y, Yamamoto Y, Muraoka I. Autonomic control of heart rate during physical exercise and fractal dimension of heart rate variability. J Appl Physiol 1993; 74 (2): 875–81

    PubMed  CAS  Google Scholar 

  • Robinson BF, Epstein SE, Beiser GD, et al. Control of heart rate by the autonomic nervous system. Circ Res 1966; 19: 400–11

    Article  PubMed  CAS  Google Scholar 

  • Breuer HM, Skyschally A, Schulz R, et al. Heart rate variability and circulating catecholamine concentrations during steady state exercise in healthy volunteers. Br Heart J 1993; 70: 144–9

    Article  PubMed  CAS  Google Scholar 

  • Clausen JP. Effect of physical training on cardiovascular adjustments to exercise in man. Physiol Rev 1977; 57 (4): 779–813

    PubMed  CAS  Google Scholar 

  • Norton KH, Boushel R, Strange S, et al. Resetting of the carotid arterial baroreflex during dynamic exercise in humans. J Appl Physiol 1999; 87 (1): 332–8

    PubMed  CAS  Google Scholar 

  • Sleight P, Casadei B. Relationships between heart rate, respiration and blood pressure variabilities. In: Malik M, Camm AJ, editors. Heart rate variability. Armonk (NY): Futura Publishing Company, Inc., 1995: 311–27

    Google Scholar 

  • Smith SA, Querry RG, Fadel PJ, et al. Differential baroreflex control of heart rate in sedentary and aerobically fit individuals. Med Sci Sports Exerc 2000; 32: 1419–30

    Article  PubMed  CAS  Google Scholar 

  • Arai Y, Saul JP, Albrecht P, et al. Modulation of cardiac autonomic activity during and immediately after exercise. Am J Physiol (Heart Circ Physiol) 1989; 213: H1322–41

    Google Scholar 

  • Yamamoto Y, Hughson RL. Coarse-graining spectral analysis: new method for studying heart rate variability. J Appl Physiol 1991; 71 (3): 1143–50

    PubMed  CAS  Google Scholar 

  • Polanczyk CA, Rohde LE, Moraes RS, et al. Sympathetic nervous system representation in time and frequency domain indices of heart rate variability. Eur J Appl Physiol 1998; 79: 69–73

    Article  CAS  Google Scholar 

  • Challapalli S, Kadish AH, Horvath G, et al. Differential effects of parasympathetic blockade and parasympathetic withdrawal on heart rate variability. J Cardiovasc Electrophysiol 1999; 10: 1192–9

    Article  PubMed  CAS  Google Scholar 

  • Ekblom B, Kilbom A, Soltysiak J. Physical training, bradycardia and autonomic nervous system. Scan J Clin Lab Invest 1973; 32: 251–6

    Article  CAS  Google Scholar 

  • Maciel B, Gallo L, Neto J, et al. Parasympathetic contribution to bradycardia induced by endurance training in man. Cardiovasc Res 1985; 19: 642–8

    Article  PubMed  CAS  Google Scholar 

  • Katona PG, McLean M, Dighton D, et al. Sympathetic and parasympathetic cardiac control in athletes and nonathletes at rest. J Appl Physiol 1982; 52 (6): 1652–7

    PubMed  CAS  Google Scholar 

  • Shin K, Minamitani H, Onishi S, et al. Autonomic differences between athletes and nonathletes: spectral analysis approach. Med Sci Sports Exerc 1997; 29 (11): 1482–90

    Article  PubMed  CAS  Google Scholar 

  • Bouchard C, Rankinen T. Individual differences in response to regular physical activity. Med Sci Sports Exerc 2001; 33: S446–51

    Article  Google Scholar 

  • Blomqvist CG, Saltin S. Cardiovascular adaptations to physical training. Ann Rev Physiol 1983; 45: 169–89

    Article  CAS  Google Scholar 

  • Crawford MH. Physiologic consequences of systemic training. Cardiol Clin 1992; 10 (2): 209–18

    PubMed  CAS  Google Scholar 

  • Evans JM, Ziegler M, Patwardhan AR, et al. Gender differences in autonomic cardiovascular regulation: spectral, hormonal, and hemodynamic indexes. J Appl Physiol 2001; 91: 2611–8

    PubMed  CAS  Google Scholar 

  • Meredith C, Frontera W, Fisher E, et al. Peripheral effects of endurance training in young and old subjects. J Appl Physiol 1989; 66: 2844–9

    PubMed  CAS  Google Scholar 

  • Tanaka H, Dinenno FA, Monahan KD, et al. Aging, habitual exercise, and dynamic arterial compliance. Circulation 2000; 102: 1270–5

    Article  PubMed  CAS  Google Scholar 

  • Vaitkevicius PV, Fleg JL, Engel JH, et al. Effects of age and aerobic capacity on arterial stiffness in healthy adults. Circulation 1993; 88: 1456–62

    Article  PubMed  CAS  Google Scholar 

  • Banhegyi A, Pavlik G, Olexo Z. The effect of detraining on echocardiographic parameters due to injury. Acta Physiol Hung 1999; 86 (3–4): 223–7

    PubMed  CAS  Google Scholar 

  • Hughson RL, Yamamoto Y, Blaber AP, et al. Effect of 28- day head down bed rest with counter measures on heart rate variability during LBNP. Aviat Space Environ Med 1994; 65: 293–300

    PubMed  CAS  Google Scholar 

  • Lipsitz LA, Mietus J, Moody GB, et al. Spectral characteristics of heart rate variability before and during postural tilt: relations to aging and risk of syncope. Circulation 1990; 81: 1803–10

    Article  PubMed  CAS  Google Scholar 

  • Goldsmith RL, Bigger JT, Bloomfeld DM, et al. Physical fitness as a determinant of vagal modulation. Med Sci Sports Exerc 1997; 29 (6): 812–7

    Article  PubMed  CAS  Google Scholar 

  • Cerutti S, Bianchi AM, Mainardi LT. Spectral analysis of the heart rate variability signal. In: Malik M, Camm AJ, editors. Heart rate variability. Armonk (NY): Futura Publishing Company, Inc., 1995: 63–74

    Google Scholar 

  • Lipsitz LA, Goldberger AL. Loss of ’complexity’ and aging. JAMA 1992; 267: 1806–9

    Article  PubMed  CAS  Google Scholar 

  • Task Force of the European Society of Cardiology, North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurement, physiological interpretation, and clinical use. Circulation 1996; 93: 1043–65

    Article  Google Scholar 

  • Brenner IK, Thomas S, Shephard RJ. Autonomic regulation of circulation during exercise and heat exposure: inferences from heart rate variability. Sports Med 1998; 26: 85–99

    Article  PubMed  CAS  Google Scholar 

  • Eckberg DL. Sympathovagal balance: a critical appraisal. Circulation 1997; 96: 3224–32

    Article  PubMed  CAS  Google Scholar 

  • Kleiger RE, Bigger JT, Bosner MS, et al. Stability over time measuring heart rate variability in normal subjects. Am J Cardiol 1991; 68: 626–30

    Article  PubMed  CAS  Google Scholar 

  • Malik M. Heart rate variability. Curr Opin Cardiol 1998; 13: 36–44

    Article  PubMed  CAS  Google Scholar 

  • Saul JP. Beat-to-beat variations of heart rate reflect modulation of cardiac autonomic outflow. News Physiol Sci 1990; 5: 32–7

    Google Scholar 

  • Sinnreich R, Kark JD, Friedlander Y, et al. Five minute recordings of heart rate variability for population studies: repeatability and age-sex characteristics. Heart 1998; 80: 156–62

    PubMed  CAS  Google Scholar 

  • Blaber AP, Bondar RL, Freeman R. Coarse graining spectral analysis of HR and BP variability in patientswith autonomic failure. Am J Physiol (Heart Circ Physiol) 1996; 271: H1555–64

    Google Scholar 

  • Butler GC, Yamamoto Y, Hughson R. Fractal nature of short term systolic blood pressure and heart rate variability during lower body negative pressure. Am J Physiol 1994; 267: R26–33

    Google Scholar 

  • Huikuri HV, Makikallio TH, Peng CK, et al. Fractal properties of R-R interval dynamics and mortality in patients with depressed left ventricular function after acute myocardial infarction. Circulation 2000; 101: 47–53

    Article  PubMed  CAS  Google Scholar 

  • Iyengar N, Peng CK, Morin RJ, et al. Age-related alterations in the fractal scaling of cardiac interbeat dynamics. Am J Physiol 1996; 271: R1078–84

    Google Scholar 

  • Makikallio TH, Hoiber S, Kober L, et al. Fractal analysis of heart rate dynamics as a predictor of mortality in patients with depresses left ventricular function after acute myocardial infarction. Am J Cardiol 1999; 83: 836–9

    Article  PubMed  CAS  Google Scholar 

  • Pikkujamsa SM, Makikallio TH, Sourander LB, et al. Cardiac interbeat interval dynamics from childhood to senescence: comparison of conventional and new measures based on fractals and chaos theory. Circulation 1999; 100: 393–9

    Article  PubMed  CAS  Google Scholar 

  • Peng CK, Mietus J, Hausdorff JM, et al. Long-range anticorrelations and non-gaussian behaviour of the heart beat. Physical Rev Lett 1993; 70: 1343–6

    Article  Google Scholar 

  • Yamamoto Y, Hughson R. Extracting fractal components from time series. Physica D 1993; 68: 250–64

    Article  Google Scholar 

  • Yamamoto Y, Hughson RL, Peterson JC. Autonomic control of heart rate during exercise studied by heart rate variability spectral analysis. J Appl Physiol 1991; 71: 1136–42

    PubMed  CAS  Google Scholar 

  • Berger R, Saul JP, Cohen RJ. Transfer function analysis of autonomic regulation I: canine atrial rate response. Am J Physiol (Heart Circ Physiol) 1989; 256: H142–52

    Google Scholar 

  • Sayers BM. Analysis of heart rate variability. Ergonomics 1973; 16: 17–32

    Article  PubMed  CAS  Google Scholar 

  • Singh JP, Larson MG, O’Donnell CJ, et al. Heritability of heart rate variability: the Framingham study. Circulation 1999; 99: 2251–4

    Article  PubMed  CAS  Google Scholar 

  • Kreutz R, Struk B, Stock P, et al. Evidence for primary genetic determination of heart rate regulation. Circulation 1997; 96: 1078–81

    Article  PubMed  CAS  Google Scholar 

  • Chess GF, Tam MK, Calaresu FR. Influence of cardiac neural inputs on rhythmic variations of heart period in cats. Am J Physiol 1975; 228: 775–80

    PubMed  CAS  Google Scholar 

  • Akselrod S, Gordon D, Madwed JB, et al. Hemodynamic regulation: investigation by spectral analysis. Am J Physiol 1985; 249: H867–75

    Google Scholar 

  • Bootsma M, Swenne CA, Van Bolhuis HH, et al. Heart rate variability as indexes of sympathovagal balance. Am J Physiol (Heart Circ Physiol) 1996; 266: H1565–71

    Google Scholar 

  • Malik M, Camm AJ. Components of heart rate variability: what they really mean and what we really measure. Am J Cardiol 1993; 72: 821–2

    Article  PubMed  CAS  Google Scholar 

  • Malliani A, Lombardi F, Pagani M, et al. The neural regulation of circulation explored in the frequency domain. J Autonom Nerv Sys 1990; 30: S103–8

    Article  Google Scholar 

  • Malliani A, Pagani M, Lombardi F, et al. Cardiovascular neural regulation explored in the frequency domain. Circulation 1991; 84: 482–92

    Article  PubMed  CAS  Google Scholar 

  • Pagani M, Lombardi F, Gussetti S, et al. Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interactions in man and conscious dog. Circ Res 1986; 59: 178–93

    Article  PubMed  CAS  Google Scholar 

  • Pomeranz B, Macaulay JB, Caudill MA, et al. Assessment of autonomic function in humans by heart rate spectral analysis. Am J Physiol (Heart Circ Physiol) 1985; 266: H151–3

    Google Scholar 

  • Thomaseth K, Cobelli C, Bellavere F, et al. Heart rate spectral analysis for assessing autonomic regulation in diabetic patients. J Autonom Nerv Sys 1990; 30: S169–72

    Article  Google Scholar 

  • Saul JP, Albrecht P, Berger R, et al. Analysis of long heart rate variability: methods of 1/f scaling and implications. Comp Cardiol 1988; 14: 419–22

    CAS  Google Scholar 

  • Peng CK, Havlin S, Stanley HE, et al. Quantification of scaling exponents and crossover phenomena in nonstationary heartbeat time series. Chaos 1995; 5: 82–6

    Article  PubMed  CAS  Google Scholar 

  • Pichot V, Gaspoz JM, Molliex S, et al. Wavelet transform to quantify heart rate variability and to assess its instantaneous changes. J Appl Physiol 1999; 86: 1081–91

    PubMed  CAS  Google Scholar 

  • Yeragani VK, Sobolewski E, Jampala VC, et al. Fractal dimension and approximate entropy of heart period and heart rate: awake versus sleep differences and methodological issues. Clin Sci 1998; 95: 295–301

    Article  PubMed  CAS  Google Scholar 

  • Goldberger JJ. Sympathovagal balance: how should we measure it? Am J Physiol (Heart Circ Physiol) 1999; 276: H1273–80

    Google Scholar 

  • Hojgaard MV, Holstein-Rathlou NH, Agner E, et al. Dynamics of spectral components of heart rate variability during changes in autonomic balance. Am J Physiol (Heart Circ Physiol) 1998; 275: H213–9

    Google Scholar 

  • Houle MS, Billman GE. Low-frequency component of the heart rate variability spectrum: a poor marker of sympathetic activity. Am J Physiol (Heart Circ Physiol) 1999; 276: H215–23

    Google Scholar 

  • Katz A, Liberty IF, Porath A, et al. A simple bedside test of 1-minute heart rate variability during deep breathing as a prognostic index after myocardial infarction. Am Heart J 1999; 138: 32–8

    Article  PubMed  CAS  Google Scholar 

  • Nolan J, Batin PD, Andrews R, et al. Prospective study of heart rate variability and mortality in chronic heart failure. Circulation 1998; 98: 1510–6

    Article  PubMed  CAS  Google Scholar 

  • Keteyian SJ, Brawner CA, Schairer JR, et al. Effects of exercise training on chronotropic incompetence in patients with heart failure. Am Heart J 1999; 138: 233–40

    Article  PubMed  CAS  Google Scholar 

  • Davy KP, Miniclier NL, Taylor JA, et al. Elevated heart rate variability in physically active postmenopausal women: a cardioprotective effect. Am J Physiol (Heart Circ Physiol) 1996; 271: H455–60

    Google Scholar 

  • Furlan R, Piazza S, Dell’Orto S, et al. Early and late effects of exercise and athletic training on neural mechanisms controlling heart rate. Cardiovasc Res 1993; 27: 482–8

    Article  PubMed  CAS  Google Scholar 

  • Reiling MJ, Seals DR. Resiratory sinus arrhythmia and carotid baroreflex control of heart rate in endurance athletes and untrained controls. Clin Phys 1988; 8: 511–9

    Article  CAS  Google Scholar 

  • Butler GC, Yamamoto Y, Hughson R. Heart rate variability to monitor autonomic nervous system activity during orthostatic stress. J Clin Pharmacol 1994; 34: 558–62

    PubMed  CAS  Google Scholar 

  • Casadei B, Cochrane S, Johnston J, et al. Pitfalls in the interpretation of spectral analysis of the heart rate variability during exercise in humans. Acta Physiol Scand 1995; 153: 125–31

    Article  PubMed  CAS  Google Scholar 

  • Kamath MV, Fallen EL, McKelvie R. Effects of steady state exercise on the power spectrum of heart rate variability. Med Sci Sports Exerc 1991; 23 (4): 428–34

    PubMed  CAS  Google Scholar 

  • Pagani M, Somers V, Furlan R, et al. Changes in autonomic regulation induced by physical training in mild hypertension. Hypertension 1988; 12: 600–10

    Article  PubMed  CAS  Google Scholar 

  • Perini R, Orizio C, Baselli G, et al. The influence of exercise intensity on the power spectrum of heart rate variability. Eur J Appl Physiol 1990; 61: 143–8

    Article  CAS  Google Scholar 

  • Yamamoto Y, Hughson R, Nakamura Y. Autonomic nervous system responses to exercise in relation to ventilatory threshold. Chest 1992; 101 (5): 206S-10S

    Article  Google Scholar 

  • Gerstenblith G, Lakatta EG, Weisfeldt ML. Age changes in myocardial function and exercise response. Prog Card Dis 1976; 19: 1–21

    Article  CAS  Google Scholar 

  • Ogawa T, Spina RJ, Martin WH, et al. Effects of aging, sex, and physical training on cardiovascular responses to exercise. Circulation 1992; 86: 494–503

    Article  PubMed  CAS  Google Scholar 

  • Spina RJ. Cardiovascular adaptations to endurance exercise training in older men and women. Ex Sport Sci Rev 1999; 27: 317–32

    CAS  Google Scholar 

  • Stratton JR, Levy WC, Cerqueira MD, et al. Cardiovascular responses to exercise: effects of aging and exercise training in healthy men. Circulation 1994; 89: 1648–55

    Article  PubMed  CAS  Google Scholar 

  • Fagard R, Thijs L, Amery A. Age and hemodynamic response to posture and to exercise. Am J Geriatr Cardiol 1993; 2: 23–40

    PubMed  Google Scholar 

  • Hossack KF, Bruce RA. Maximal cardiac function in sedentary normal men and women: comparison of age-related changes. J Appl Physiol 1982; 53: 799–804

    PubMed  CAS  Google Scholar 

  • Rodeheffer RJ, Gerstenblith G, Becker LC, et al. Exercise cardiac output is maintained with advancing age in healthy human subjects: cardiac dilation and increasing stroke volume compensate for a diminished heart rate. Circulation 1984; 69: 203–13

    Article  PubMed  CAS  Google Scholar 

  • Hagberg JM, Allen WK, Seals DR, et al. A hemodynamic comparison of young and older endurance athletes during exercise. J Appl Physiol 1985; 53: 2041–6

    Google Scholar 

  • Heath GW, Hagberg JM, Ehsani AA, et al. A physiological comparison of young and older endurance athletes. J Appl Physiol 1981; 51: 634–40

    PubMed  CAS  Google Scholar 

  • Korkushko OV, Shatilo VB, Plachinda YI, et al. Autonomic control of cardiac chronotropic function in man as a function of age: assessment by power spectral analysis of heart rate variability. J Autonom Nerv Sys 1991; 32: 191–8

    Article  CAS  Google Scholar 

  • O’Brien IA, O’Hare P, Corrall RJ. Heart rate variability in healthy subjects: effect of age and the derivation of normal ranges for tests of autonomic function. Br Heart J 1986; 55: 348–54

    Article  PubMed  Google Scholar 

  • Odemuyiwa O. Effect of age on heart rate variability. In: Malik M, Camm AJ, editors. Heart rate variability. Armonk (NY): Futura Publishing Company, Inc., 1995: 235–9

    Google Scholar 

  • DeMeersman RE. Heart rate variability and aerobic fitness. Am Heart J 1993; 125 (3): 726–31

    Article  CAS  Google Scholar 

  • Ryan SM, Goldberger AL, Pincus SM, et al. Gender- and agerelated differences in heart rate dynamics: are women more complex than men? J Am Coll Cardiol 1994; 24 (7): 1700–7

    Article  PubMed  CAS  Google Scholar 

  • Tulppo MP, Makikallio TH, Seppanen T, et al. Vagal modulation of heart rate during exercise: effects of age and physical fitness. Am J Physiol (Heart Circ Physiol) 1998; 274 (43): H424–9

    Google Scholar 

  • Ingram DK. Age-related decline in physical activity: generalization to nonhumans. Med Sci Sports Exerc 2000; 32 (9): 1623–9

    PubMed  CAS  Google Scholar 

  • Schuit AJ, Van Amelsvoort LG, Verheij TC, et al. Exercise training and heart rate variability in older people. Med Sci Sports Exerc 1999; 31 (6): 816–21

    Article  PubMed  CAS  Google Scholar 

  • Stein PK, Ehsani AA, Domitrovich PP, et al. Effect of exercise training on heart rate variability in healthy older adults. Am Heart J 1999; 138: 567–76

    Article  PubMed  CAS  Google Scholar 

  • Kaplan DT, Furman MI, Pincus SM, et al. Aging and complexity of cardiovascular dynamics. Biophys J 1991; 59: 945–9

    Article  PubMed  CAS  Google Scholar 

  • Seals D, Taylor JA, Ng AV, et al. Exercise and aging: autonomic control of the circulation. Med Sci Sports Exerc 1994; 26 (5): 568–76

    PubMed  CAS  Google Scholar 

  • Parati G, Saul JP, DiRienzo M, et al. Spectral analysis of blood pressure and heart rate variability in evaluating cardiovascular regulation: a critical appraisal. Hypertension 1995; 25: 1276–86

    Article  PubMed  CAS  Google Scholar 

  • Davy KP, Desouza CA, Jones PP, et al. Elevated heart rate variability in physically active young and older adult women. Clin Sci 1998; 94: 579–84

    PubMed  CAS  Google Scholar 

  • Seals DR, Hagberg JM, Spina RJ, et al. Enhanced left ventricular performance in endurance trained older men. Circulation 1994; 89: 198–205

    Article  PubMed  CAS  Google Scholar 

  • Rowell LB. Central circulatory adjustments to dynamic exercise. In: Rowell LB, editor. Human cardiovascular control. New York: Oxford University Press, 1993: 162–203

    Google Scholar 

  • Kohrt WM, Malley MT, Coggan AR, et al. Effects of gender, age, and fitness level on response of VO2max to training in 60–71 yr olds. J Appl Physiol 1991; 71: 2004–11

    PubMed  CAS  Google Scholar 

  • Raven PB, Drinkwater BL, Horvath SM. Cardiovascular responses of young female track athletes during exercise. Med Sci Sports 1972; 4: 205–9

    PubMed  CAS  Google Scholar 

  • Saltin B, Astrand PO. Maximal oxygen uptake in athletes. J Appl Physiol 1967; 23: 353–8

    PubMed  CAS  Google Scholar 

  • Tanaka H, Seals D. Age and gender interactions in physiological functional capacity: insight from swimming performance. J Appl Physiol 1997; 82: 846–51

    PubMed  CAS  Google Scholar 

  • Wiebe CG, Gledhill N, Jamnik VK, et al. Exercise cardiac function in young through elderly endurance trained women. Med Sci Sports Exerc 1999; 31: 684–91

    Article  PubMed  CAS  Google Scholar 

  • Mitchell JE, Tate C, Raven P, et al. Acute response and chronic adaptation to exercise in women. Med Sci Sports Exerc 1992; 24: S258–65

    Google Scholar 

  • Barnett SR, Morin RJ, Kiely DK, et al. Effect of age and gender on autonomic control of blood pressure dynamics. Hypertension 1999; 33: 1195–200

    Article  PubMed  CAS  Google Scholar 

  • Huikuri HV, Pikkujamsa SM, Airaksinen J, et al. Sex-related differences in autonomic modulation of heart rate in middle aged subjects. Circulation 1996; 94: 122–5

    Article  PubMed  CAS  Google Scholar 

  • Kuo TB, Lin T, Yang CC, et al. Effect of aging on gender differences in neural control of heart rate. Am J Physiol (Heart Circ Physiol) 1999; 277 (46): H2233–9

    Google Scholar 

  • Laitinen T, Hartikainen J, Vanninen E, et al. Age and gender dependency of baroreflex sensitivity in healthy subjects. J Appl Physiol 1998; 84 (2): 576–83

    PubMed  CAS  Google Scholar 

  • Singer DH, Ori Z. Changes in heart rate variability associated with sudden cardiac death. In: Malik M, Camm AJ, editors. Heart rate variability. Armonk (NY): Futura Publishing Company, Inc., 1995: 429–48

    Google Scholar 

  • Bigger JT, Fleiss JL, Steinman RC, et al. Frequency domain measures of heart period variability and mortality after myocardial infarction. Circulation 1992; 85 (1): 164–71

    Article  PubMed  Google Scholar 

  • Shusterman V, Aysin B, Weiss R, et al. Dynamics of low-frequency R-R interval oscillations preceding spontaneous ventricular tachycardia. Am Heart J 2000; 139 (1): 126–33

    Article  PubMed  CAS  Google Scholar 

  • Tsuji H, Larson MG, Venditti FJ, et al. Impact of reduced heart rate variability on risk for cardiac events. Circulation 1996; 94: 2850–5

    Article  PubMed  CAS  Google Scholar 

  • van de Borne P, Montano N, Pagani M, et al. Absence of low frequency variability of sympathetic nerve activity in severe heart failure. Circulation 1994; 95: 1449–54

    Article  Google Scholar 

  • Adamopoulos S, Ponikowski P, Cerquetani E, et al. Circadian pattern of heart rate variability in chronic heart failure patients: effects of physical training. Eur Heart J 1995; 16: 1380–6

    PubMed  CAS  Google Scholar 

  • Kohl HW. Physical activity and cardiovascular disease evidence for a dose response. Med Sci Sports Exerc 2001; 33: S472–83

    Article  Google Scholar 

  • Williams PT. Physical fitness and activity as separate heart disease risk factors: a meta-analysis. Med Sci Sports Exerc 2001; 33: 754–61

    PubMed  CAS  Google Scholar 

  • Malfatto G, Facchini M, Bragato R, et al. Short and long term effects of exercise training on the tonic autonomic modulation of heart rate variability after myocardial infarction. Eur Heart J 1996; 17: 532–8

    Article  PubMed  CAS  Google Scholar 

  • Pagani M, Lucini D, Rimoldi O, et al. Effects of physical and mental exercise on heart rate variability. In: Malik M, Camm AJ, editors. Heart rate variability. Armonk (NY): Futura Publishing Company, Inc., 1995: 245–66

    Google Scholar