Medical management of Lennox-Gastaut syndrome - CNS Drugs
- ️Farrell, Kevin
- ️Wed Aug 29 2012
Karbowski K. Developments in epileptology in the 18th and 19th century prior to the delineation of the Lennox-Gastaut syndrome. In: Niedermeyer E, Degen R, editors. The Lennox-Gastaut syndrome. Nrw York: Alan R. Liss, 1988:1–8
Gibbs FA, Gibbs EL, Lennox WG. Influence of the blood sugar level on the wave and spike formation in petit mal epilepsy. Arch Neurol Psychiatr 1939; 41: 1111–6
Lennox WG, Davis JP. Clinical correlates of the fast and the slow spike-wave electroencephalogram. Pediatrics 1950 Apr; 5(4): 626–44
Gastaut H, Roger J, Soulayrol R, et al. Childhood epileptic encephalopathy with diffuse slow spikes and waves (otherwise known as “petit mal variant”) or Lennox syndrome. Epilepsia 1966; 7: 139–79
Markand ON. Lennox-Gastaut syndrome (childhood epileptic encephalopathy). J Clin Neurophysiol 2003 Nov–Dec; 20(6): 426–41
Niedermeyer E. The Lennox-Gastaut syndrome: a severe type of childhood epilepsy. Dtsch Z Nervenheilkd 1969; 195(4): 263–82
Hancock E, Cross H. Treatment of Lennox-Gastaut syndrome. Cochrane Database Syst Rev 2003; (3): CD003277
Beaumanoir A, Blume W. The Lennox-Gastaut syndrome. In: Roger J, Bureau M, Dravet C, et al., editors. Epileptic syndromes in infancy, childhood and adolescence. 4th ed. Montrouge: John Libbey Eurotext Ltd, 2005: 125–48
Dulac O, N’Guyen T. The Lennox-Gastaut syndrome. Epilepsia 1993; 34 Suppl. 7: S7–17
Arzimanoglou A, French J, Blume WT, et al. Lennox-Gastaut syndrome: a consensus approach on diagnosis, assessment, management, and trial methodology. Lancet Neurol 2009 Jan; 8(1): 82–93
Ikeno T, Shigematsu H, Miyakoshi M, et al. An analytic study of epileptic falls. Epilepsia 1985 Nov–Dec; 26(6): 612–21
Engel Jr J. International League Against Epilepsy (ILAE): a proposed diagnostic scheme for people with epileptic seizures and with epilepsy. Report of the ILAE Task Force on Classification and Terminology. Epilepsia 2001 Jun; 42(6): 796–803
Oguni H. Myoclonic-astatic epilepsy. Ryoikibetsu Shokogun Shirizu 2002; (37 Pt 6): 99–103
Guerrini R, Belmonte A, Genton P. Antiepileptic drug-induced worsening of seizures in children. Epilepsia 1998; 39 Suppl. 3: S2–10
Caraballo RH, Cersosimo RO, Sakr D, et al. Ketogenic diet in patients with Dravet syndrome. Epilepsia 2005 Sep; 46(9): 1539–44
Chiron C, Marchand MC, Tran A, et al. Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndrome-dedicated trial. STICLO study group. Lancet 2000 Nov 11; 356(9242): 1638–42
Arzimanoglou A, Guerrini R, Aicardi J. Lennox-Gastaut syndrome. In: Aicardi’s epilepsy in children. 3rd ed. Philadelphia (PA): Lippincott Williams and Wilkins, 2004: 38–50
Aicardi J, Chevrie JJ. Atypical benign partial epilepsy of childhood. Dev Med Child Neurol 1982; 24: 281–92
Dravet C, Bureau M, Oguni H, et al. Severe myoclonic epilepsy in infancy: Dravet syndrome. Adv Neurol 2005; 95: 71–102
Nickels K, Wirrell E. Electrical status epilepticus in sleep. Semin Pediatr Neurol 2008 Jun; 15(2): 50–60
Genton P, Guerrini R, Dravet C. The Lennox-Gastaut syndrome. In: Meinardi H, editor. Handbook of clinical neurology: the epilepsies, part II. Amsterdam: Elsevier, 2000:211–22
Dulac O, Engel Jr J. Lennox-Gastaut syndrome [online]. Available from URL: http://www.ilae.org/Visitors/Centre/ctf/lennox_gastaut.html [Accessed 2008 Sep 10]
Marini C, Harvey AS, Pelekanos JT, et al. Epilepsy in offspring of whom both parents have idiopathic generalized epilepsy: biparental inheritance. Epilepsia 2003 Sep; 44(9): 1250–4
Singh R, Andermann E, Whitehouse WP, et al. Severe myoclonic epilepsy of infancy: extended spectrum of GEFS+? Epilepsia 2001 Jul; 42(7): 837–44
Doose H, Sitepu B. Childhood epilepsy in a German city. Neuropediatrics 1983 Nov; 14(4): 220–4
Binnie CD. Cognitive impairment during epileptiform discharges: is it ever justifiable to treat the EEG? Lancet Neurol 2003 Dec; 2(12): 725–30
Lux AL, Osborne JP. A proposal for case definitions and outcome measures in studies of infantile spasms and West syndrome: consensus statement of the West Delphi group. Epilepsia 2004 Nov; 45(11): 1416–28
Felbamate Study Group. Efficacy of felbamate in childhood epileptic encephalopathy (Lennox-Gastaut syndrome). N Engl J Med 1993; 328: 29–33
Motte J, Trevathan E, Arvidsson JF, et al. Lamotrigine for generalized seizures associated with Lennox-Gastaut syndrome. N Engl J Med 1997; 337: 1807–12
Sachdeo RC, Glauser TA, Ritter F, et al. A double-blind, randomized trial of topiramate in Lennox-Gastaut syndrome. Neurology 1999; 52: 1882–7
Glauser T, Kluger G, Sachdeo R, et al. Rufinamide for generalized seizures associated with Lennox-Gastaut syndrome. Neurology 2008 May 20; 70(21): 1950–8
Wheless JW, Clarke DF, Carpenter D. Treatment of pediatric epilepsy: expert opinion. J Child Neurol 2005 Dec; 20 Suppl. 1: S1–56; quiz S59-60
Wheless JW, Clarke DF, Arzimanoglou A, et al. Treatment of pediatric epilepsy: European expert opinion, 2007. Epileptic Disord 2007 Dec; 9(4): 353–412
Lombroso CT. A prospective study of infantile spasms: clinical and therapeutic correlations. Epilepsia 1983; 24: 135–58
Chiron C, Dumas C, Jambaque I, et al. Randomized trial comparing vigabatrin and hydrocortisone in infantile spasms due to tuberous sclerosis. Epilepsy Res 1997 Jan; 26(2): 389–95
Vigevano F, Fusco L, Cusmai R, et al. The idiopathic form of West syndrome. Epilepsia 1993; 34: 743–6
Culy CR, Goa KL. Lamotrigine: a review of its use in childhood epilepsy. Pediatr Drugs 2000 Jul–Aug; 2(4): 299–330
Farrell K, Connolly MB, Munn R, et al. Prospective, open-label, add-on study of lamotrigine in 56 children with intractable generalized epilepsy. Pediatr Neurol 1997; 16: 201–5
Timmings PL, Richens A. Lamotrigine as an add-on drug in the management of Lennox-Gastaut syndrome. Eur Neurol 1992; 32(6): 305–7
Donaldson JA, Glauser TA, Olberding LS. Lamotrigine adjunctive therapy in childhood epileptic encephalopathy (the Lennox Gastaut syndrome). Epilepsia 1997 Jan; 38(1): 68–73
Messenheimer JA. Rash in adult and pediatric patients treated with lamotrigine. Can J Neurol Sci 1998 Nov; 25(4): S14–8
Mockenhaupt M, Messenheimer J, Tennis P, et al. Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics. Neurology 2005 Apr 12; 64(7): 1134–8
Kanner AM, Frey M. Adding valproate to lamotrigine: a study of their pharmacokinetic interaction. Neurology 2000 Aug 22; 55(4): 588–91
White HS. Topiramate: mechanisms of action. In: Levy RH, Mattson RH, Meldrum BS, editors. Antiepileptic drugs. 5th ed. Philadelphia (PA): Lippincott Williams Wilkins, 2002:719–26
Guerreiro MM, Manreza ML, Scotoni AE, et al. A pilot study of topiramate in children with Lennox-Gastaut syn-drome. Arq Neuropsiquiatr 1999 Jun; 57(2A): 167–75
Lamb EJ, Stevens PE, Nashef L. Topiramate increases biochemical risk of nephrolithiasis. Ann Clin Biochem 2004 Mar; 41 (Pt 2): 166–9
O’Donohoe NV. Use of antiepileptic drugs in childhood epilepsy. Arch Dis Child 1991 Oct; 66(10): 1173–5
Jeavons PM, Clark JE, Maheshwari MC. Treatment of generalized epilepsies of childhood and adolescence with sodium valproate (“epilim”). Dev Med Child Neurol 1977 Feb; 19(1): 9–25
Dreifuss FE, Santilli N, Langer DH, et al. Valproic acid hepatic fatalities: a retrospective review. Neurology 1987; 37: 379–85
Johannessen CU, Johannessen SI. Valproate: past, present, and future. CNS Drug Rev 2003; 9(2): 199–216
Dodson WE. Felbamate in the treatment of Lennox-Gastaut syndrome: results of a 12-month open-label study following a randomized clinical trial. Epilepsia 1993; 34 Suppl. 7: S18–24
Pellock JM, Faught E, Leppik IE, et al. Felbamate: consensus of current clinical experience. Epilepsy Res 2006 Oct;71(2–3): 89–101
Arroyo S. Rufinamide. Neurotherapeutics 2007 Jan; 4(1): 155–62
MacDonald RL, Olsen RW. GABAA receptor channels. Annu Rev Neurosci 1994; 17: 569–602
MacDonald RL. Benzodiazepines: mechanisms of action. In: Levy RH, Mattson RH, Meldrum BS, editors. Antiepileptic drugs. 4th ed. New York: Raven Press,Ltd, 1995: 695–703
Schmidt D, Bourgeois B. A risk-benefit assessment of therapies for Lennox-Gastaut syndrome. Drug Saf 2000; 22(6): 467–77
Chamberlain MC. Nitrazepam for refractory infantile spasms and the Lennox-Gastaut syndrome. J Child Neurol 1996; 11(1): 31–4
Munn R, Farrell K. Open study of clobazam in refractory epilepsy. Pediatr Neurol 1993; 9: 465–9
Bittencourt PR, Richens A. Anticonvulsant-induced status epilepticus in Lennox-Gastaut syndrome. Epilepsia 1981 Feb; 22(1): 129–34
Tassinari CA, Dravet C, Roger J, et al. Tonic status epilepticus precipitated by intravenous benzodiazepine in five patients with Lennox-Gastaut syndrome. Epilepsia 1972 Jul; 13(3): 421–35
Crest C, Dupont S, Leguern E, et al. Levetiracetam in progressive myoclonic epilepsy: an exploratory study in 9 patients. Neurology 2004 Feb 24; 62(4): 640–3
De Los Reyes EC, Sharp GB, Williams JP, et al. Levetiracetam in the treatment of Lennox-Gastaut syndrome. Pediatr Neurol 2004 Apr; 30(4): 254–6
Labate A, Colosimo E, Gambardella A, et al. Levetiracetam in patients with generalised epilepsy and myoclonic seizures: an open label study. Seizure 2006 Apr; 15(3): 214–8
Huber B, Bommel W, Hauser I, et al. Efficacy and tolerability of levetiracetam in patients with therapy-resistant epilepsy and learning disabilities. Seizure 2004 Apr; 13(3): 168–75
Weber S, Beran RG. A pilot study of compassionate use of levetiracetam in patients with generalised epilepsy. J Clin Neurosci 2004 Sep; 11(7): 728–31
Bayerlein K, Frieling H, Beyer B, et al. Drug-induced psychosis after long-term treatment with levetiracetam [letter]. Can J Psychiatry 2004; 49(12): 868
Czapinski P, Blaszczyk B, Czuczwar SJ. Mechanisms of action of antiepileptic drugs. Curr Top Med Chem 2005; 5(1): 3–14
Feucht M, Brantner-Inthaler S. Gamma-vinyl-GABA (vigabatrin) in the therapy of Lennox-Gastaut syndrome: an open study. Epilepsia 1994 Sep–Oct; 35(5): 993–8
Herranz JL, Arteaga R, Farr IN, et al. Dose-response study of vigabatrin in children with refractory epilepsy. J Child Neurol 1991; Suppl. 2: S45–51
Zareba G. Zonisamide: review of its use in epilepsy therapy. Drugs Today (Barc) 2005 Sep; 41(9): 589–97
You SJ, Kang HC, Kim HD, et al. Clinical efficacy of zonisamide in Lennox-Gastaut syndrome: Korean multicentric experience. Brain Dev 2008 Apr; 30(4): 287–90
Yagi K, Seino M. Methodological requirements for clinical trials in refractory epilepsies: our experience with zonisamide. Prog Neuropsychopharmacol Biol Psychiatry 1992 Jan; 16(1): 79–85
Ohtahara S. Zonisamide in the management of epilepsy: Japanese experience. Epilepsy Res 2006 Feb; 68 Suppl. 2: S25–33
Perucca E, Gram L, Avanzini G, et al. Antiepileptic drugs as a cause of worsening seizures. Epilepsia 1998 Jan; 39(1): 5–17
Crespel A, Genton P, Berramdane M, et al. Lamotrigine associated with exacerbation or de novo myoclonus in idiopathic generalized epilepsies. Neurology 2005 Sep 13; 65(5): 762–4
Gelisse P, Genton P, Kuate C, et al. Worsening of seizures by oxcarbazepine in juvenile idiopathic generalized epilepsies. Epilepsia 2004 Oct; 45(10): 1282–6
Kim DY, Rho JM. The ketogenic diet and epilepsy. Curr Opin Clin Nutr Metab Care 2008 Mar; 11(2): 113–20
Seo JH, Lee YM, Lee JS, et al. Efficacy and tolerability of the ketogenic diet according to lipid: nonlipid ratios: comparison of 3:1 with 4:1 diet. Epilepsia 2007 Apr; 48(4): 801–5
Freeman JM, Vining EPG, Pillas DJ, et al. The efficacy of the ketogenic diet-1998: a prospective evaluation of intervention in 150 children. Pediatrics 1998; 102: 1358–63
Vining EPG, Freeman JM, Balaban-Gil K, et al. A multicenter study of the efficacy of the ketogenic diet. Arch Neurol 1998; 55: 1433–7
Arts WF, Geerts AT. When to start drug treatment for childhood epilepsy: the clinical-epidemiological evidence. Eur J Paediatr Neurol 2009 Mar; 13(2): 93–101
Freeman JM, Vining EP. Seizures decrease rapidly after fasting: preliminary studies of the ketogenic diet. Arch Pediatr Adolesc Med 1999 Sep; 153(9): 946–9
Yamatogi Y, Ohtsuka Y, Ishida T, et al. Treatment of the Lennox syndrome with ACTH: a clinical and electroencephalographic study. Brain Dev 1979; 1(4): 267–76
Snead OC 3rd, Benton JW, Myers GJ. ACTH and pred-nisone in childhood seizure disorders. Neurology 1983 Aug; 33(8): 966–70
Sinclair DB. Prednisone therapy in pediatric epilepsy. Pediatr Neurol 2003 Mar; 28(3): 194–8
Dravet C, Natale O, Magaudda A, et al. Status epilepticus in the Lennox-Gastaut syndrome. Rev Electroencephalogr Neurophysiol Clin 1986 Feb; 15(4): 361–8
Rychlicki F, Zamponi N, Trignani R, et al. Vagus nerve stimulation: clinical experience in drug-resistant pediatric epileptic patients. Seizure 2006 Oct; 15(7): 483–90
Rossignol E, Lortie A, Thomas T, et al. Vagus nerve stimulation in pediatric epileptic syndromes. Seizure 2009 Jan; 18(1): 34–7
You SJ, Kang HC, Ko TS, et al. Comparison of corpus callosotomy and vagus nerve stimulation in children with Lennox-Gastaut syndrome. Brain Dev 2008 Mar; 30(3): 195–9
Majoie HJ, Berfelo MW, Aldenkamp AP, et al. Vagus nerve stimulation in patients with catastrophic childhood epilepsy, a 2-year follow-up study. Seizure 2005 Jan; 14(1): 10–8
Oguni H, Andermann F, Gotman J, et al. Effect of anterior callosotomy on bilaterally synchronous spike and wave and other EEG discharges. Epilepsia 1994 May–Jun; 35(3): 505–13
Cukiert A, Burattini JA, Mariani PP, et al. Extended, one-stage callosal section for treatment of refractory secondarily generalized epilepsy in patients with Lennox-Gastaut and Lennox-like syndromes. Epilepsia 2006 Feb; 47(2): 371–4
Pinard JM, Delande OJ, Plouin P, et al. Results of callosotomy in children according to etiology and epileptic syndrome [abstract]. Epilepsia 1992; 33 Suppl. 3: 27
Nei M, O’Connor M, Liporace J, et al. Refractory generalized seizures: response to corpus callosotomy and vagal nerve stimulation. Epilepsia 2006 Jan; 47(1): 115–22
Velasco AL, Velasco F, Jimenez F, et al. Neuromodulation of the centromedian thalamic nuclei in the treatment of generalized seizures and the improvement of the quality of life in patients with Lennox-Gastaut syndrome. Epilepsia 2006 Jul; 47(7): 1203–12