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Serglycin – Structure and biology - Cellular and Molecular Life Sciences

  • ️Tveit, H.
  • ️Sat Dec 08 2007

Abstract.

Serglycin is a proteoglycan found in hematopoietic cells and endothelial cells. It has important functions related to formation of several types of storage granules. In connective tissue mast cells the covalently attached glycosaminoglycan is heparin, whereas mucosal mast cells and activated macrophages contain oversulfated chondroitin sulfate (type E). In mast cells, serglycin interact with histamine, chymase, tryptase and carboxypeptidase, in neutrophils with elastase, in cytotoxic T cells with granzyme B, in endothelial cells with tissue-type plasminogen activator and in macrophages with tumor necrosis factor-α. Serglycin is important for the retention of key inflammatory mediators inside storage granules and secretory vesicles. Serglycin can further modulate the activities of partner molecules in different ways after secretion from activated immune cells, through protection, transport, activation and interactions with substrates or target cells. Serglycin is a proteoglycan with important roles in inflammatory reactions.

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Authors and Affiliations

  1. Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Box 1046, Blindern, 0316, Oslo, Norway

    S. O. Kolset

  2. Institute of Molecular Bioscience, Faculty of Mathematics and Natural Sciences, University of Oslo, Box 1041, Blindern, 0316, Oslo, Norway

    H. Tveit

Authors

  1. S. O. Kolset

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  2. H. Tveit

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Corresponding author

Correspondence to S. O. Kolset.

Additional information

Received 2 October 2007; received after revision 7 November 2007; accepted 12 November 2007

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Cite this article

Kolset, S.O., Tveit, H. Serglycin – Structure and biology. Cell. Mol. Life Sci. 65, 1073–1085 (2008). https://doi.org/10.1007/s00018-007-7455-6

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  • Published: 08 December 2007

  • Issue Date: April 2008

  • DOI: https://doi.org/10.1007/s00018-007-7455-6

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