Managing Alcohol Withdrawal in the Elderly - Drugs & Aging
- ️Saitz, Richard
- ️Sat Sep 22 2012
Reid MC, Anderson PA. Geriatric substance use disorders. Med Clin North Am 1997; 81(4): 999–1016
Fink A, Hays RD, Moore AA, et al. Alcohol-related problems in older persons. Determinants, consequences, and screening. Arch Intern Med 1996; 156(11): 1150–6
Council on Scientific Affairs. Alcoholism in the elderly: council report. JAMA 1996; 275(10): 797–801
Schuckit MA. Clinical review of alcohol, alcoholism, and the elderly patient. J Clin Psychiatry 1982; 43: 396–9
Atkinson RM. Aging and alcohol use disorders: diagnostic issues in the elderly. Int Psychogeriatr 1990; 2: 55–72
Finlayson RE, Hurt RD, Davis Jr LJ, et al. Alcoholism in elderly persons: a study of the psychiatric and psychosocial features of 216 inpatients. Mayo Clin Proc 1988; 63(8): 761–8
Beresford TP, Beresford T, Gomberg E, editors. Alcohol and aging. New York: Oxford University Press, 1995
Hurt RD, Finlayson RE, Morse RM, et al. Alcoholism in elderly persons: medical aspects and prognosis of 216 inpatients. Mayo Clin Proc 1988; 63(8): 753–60
Grant BE. Alcohol consumption, alcohol abuse and alcohol dependence: the United States as an example. Addiction 1994; 89(11): 1357–65
Williams GD, DeBakey SF. Changes in levels of alcohol consumption: United States, 1983–1988. Br J Addict 1992; 87: 643–8
Adams WL, Magruder-Habib K, Trued S, et al. Alcohol abuse in elderly emergency department patients. J Am Geriatr Soc 1992; 40(12): 1236–40
Buchsbaum DG, Buchanan RG, Lawton MJ, et al. Alcohol consumption patterns in a primary care population. Alcohol Alcohol 1991; 26(2): 215–20
Curtis JR, Geller G, Stokes EJ, et al. Characteristics, diagnosis, and treatment of alcoholism in elderly patients. J Am Geriatr Soc 1989; 37(4): 310–6
Liberto JG, Oslin DW, Ruskin PE. Alcoholism in older persons: a review of the literature. Hosp Community Psychiatry 1992; 43(10): 975–84
Magruder-Habib K, Saltz CC, Barron PM. Age-related patterns of alcoholism among veterans in ambulatory care. Hosp Community Psychiatry 1986; 37(12): 1251–5
Mangion DM, Platt JS, Syam V. Alcohol and acute medical admission of elderly people. Age Ageing 1992; 21(5): 362–7
Schuckit MA, Miller PL. Alcoholism in elderly men: a survey of a general medical ward. Ann N Y Acad Sci 1975; 275: 558–71
Simon A, Epstein LJ, Reynolds L. Alcoholism in the geriatric mentally ill. Geriatrics 1968; 23(10): 125–31
Gaitz CM, Baer PE. Characteristics of elderly persons with alcoholism. Arch Gen Psychiatry 1971; 24: 372–8
Tabisz E, Badger M, Meatherall R, et al. Identification of chemical abuse in the elderly admitted to emergency rooms. Clin Gerontol 1991; 11: 27–38
Adams WL, Yuan Z, Barboriak JJ, et al. Alcohol-related hospitalizations of elderly people: prevalence and geographic variation in the United States [published erratum appears in JAMA 1993 Nov 3; 270 (17): 2055]. JAMA 1993; 270(10): 1222–5
Kraemer KL, Mayo-Smith MF, Calkins DR. Impact of age on the severity, course, and complications of alcohol withdrawal. Arch Intern Med 1997; 157(19): 2234–41
American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: American Psychiatric Association, 1994
Whitfield CL, Thompson G, Lamb A, et al. Detoxification of 1,024 alcoholic patients without psychoactive drugs. JAMA 1978; 239: 1409–10
Benzer DG. Quantification of the alcohol withdrawal syndrome in 487 alcoholic patients. J Subst Abuse Treat 1990; 7(2): 117–23
Liskow BI, Rinck C, Campbell J, et al. Alcohol withdrawal in the elderly. J Stud Alcohol 1989; 50(5): 414–21
Brower KJ, Mudd S, Blow FC, et al. Severity and treatment of alcohol withdrawal in elderly versus younger patients. Alcohol Clin Exp Res 1994; 18(1): 196–201
Linnoila M. Alcohol withdrawal and noradrenergic function. Ann Intern Med 1987; 107: 875–89
Sellers EM, Zilm DH, Degani NC. Comparative efficacy of propranolol and chlordiazepoxide in alcohol withdrawal. J Stud Alcohol 1977; 38(11): 2096–108
Worner TM. Propranolol versus diazepam in the management of the alcohol withdrawal syndrome: double-blind controlled trial. Am J Drug Alcohol Abuse 1994; 20(1): 115–24
Kraus ML, Gottlieb LD, Horwitz RI, et al. Randomized clinical trial of atenolol in patients with alcohol withdrawal. N Engl J Med 1985; 313(15): 905–9
Zilm DH, Jacob MS, MacLeod SM, et al. Propranolol and chlordiazepoxide effects on cardiac arrhythmias during alcohol withdrawal. Alcohol Clin Exp Res 1980; 4(4): 400–5
Bjorkqvist SE. Clonidine in alcohol withdrawal. Acta Psychiatr Scand 1975; 52(4): 256–63
Wilkins AJ, Jenkins WJ, Steiner JA. Efficacy of clonidine in treatment of the alcohol withdrawal state. Psychopharmacology 1983; 81(1): 78–80
Manhem P, Nilsson LH, Moberg AL, et al. Alcohol withdrawal: effects of clonidine treatment on sympathetic activity, the renin-aldosterone system, and clinical symptoms. Alcohol Clin Exp Res 1985; 9(3): 238–43
Baumgartner GR, Rowen RC. Clonidine vs chlordiazepoxide in the management of acute alcohol withdrawal syndrome. Arch Intern Med 1987; 147(7): 1223–6
Cushman Jr P, Sowers JR. Alcohol withdrawal syndrome: clinical and hormonal responses to alpha 2-adrenergic agonist treatment. Alcohol Clin Exp Res 1989; 13(3): 361–4
Robinson BJ, Robinson GM, Maling TJ, et al. Is clonidine useful in the treatment of alcohol withdrawal? Alcohol Clin Exp Res 1989; 13(1): 95–8
Baumgartner GR, Rowen RC. Transdermal clonidine versus chlordiazepoxide in alcohol withdrawal: a randomized, controlled clinical trial. South Med J 1991; 84(3): 312–21
Ticku MK. Alcohol and GAB A-benzodiazepine receptor function. Ann Med 1990; 22: 241–6
Gorelick DA. Recent developments in alcoholism: pharmacological treatment. Recent Dev Alcohol 1993; 11: 413–27
Tsai G, Gastfriend DR, Coyle JT. The glutamatergic basis of human alcoholism. Am J Psychiatry 1995; 152(3): 332–40
Freund G, Anderson KJ. Glutamate receptors in the frontal cortex of alcoholics. Alcohol Clin Exp Res 1996; 20: 1165–72
Ballenger JC, Post RM. Kindling as a model for alcohol withdrawal syndromes. Br J Psychiatry 1978; 133: 1–14
Lechtenberg R, Worner TM. Seizure risk with recurrent alcohol detoxification. Arch Neurol 1990; 47: 535–8
Brown ME, Anton RF, Malcolm R, et al. Alcohol detoxification and withdrawal seizures: clinical support for a kindling hypothesis. Biol Psychiatry 1988; 23(5): 507–14
Booth BM, Blow FC. The kindling hypothesis: further evidence from a US national study of alcoholic men. Alcohol Alcohol 1993; 28(5): 593–8
Lechtenberg R, Worner TM. Relative kindling effect of detoxification and non-detoxification admissions in alcoholics. Alcohol Alcohol 1991; 26(2): 221–5
Foy A, Kay J, Taylor A. The course of alcohol withdrawal in a general hospital. Q J Med 1997; 90(4): 253–61
Isbell H, Fraser HF, Wikler A, et al. An experimental study of the etiology of ‘rum fits’ and delirium tremens. Q J Stud Alcohol 1955; 16: 1–33
Pristach CA, Smith CM, Whitney RB. Alcohol withdrawal syndromes: prediction from detailed medical and drinking histories. Drug Alcohol Depend 1983; 11(2): 177–99
Ferguson JA, Suelzer CJ, Eckert GJ, et al. Risk factors for delirium tremens development. J Gen Intern Med 1996; 11(7): 410–4
Schuckit MA, Tipp JE, Reich T, et al. The histories of withdrawal convulsions and delirium tremens in 1648 alcohol dependent subjects. Addiction 1995; 90: 1335–47
Wetterling T, Kanitz RD, Veltrup C, et al. Clinical predictors of alcohol withdrawal delirium. Alcohol Clin Exp Res 1994; 18(5): 1100–2
Vinson DC, Menezes M. Admission alcohol level: a predictor of the course of alcohol withdrawal. J Fam Pract 1991; 33(2): 161–7
Foy A, March S, Drinkwater V. Use of an objective clinical scale in the assessment and management of alcohol withdrawal in a large general hospital. Alcohol Clin Exp Res 1988; 12(3): 360–4
Victor M, Adams RD. The effect of alcohol on the nervous system. Res Publ Assoc Res Nerv Ment Dis 1953; 32: 526–73
Morton AW, Laird LK, Crane DF, et al. A prediction model for identifying alcohol withdrawal seizures. Am J Drug Alcohol Abuse 1994; 20: 75–86
Metcalfe P, Sobers M, Dewey M. The Windsor clinic alcohol withdrawal assessment scale (WCAWAS): investigation of factors associated with complicated withdrawals. Alcohol Alcohol 1995; 30(3): 367–72
Fiellin DA, Samet JH, O’Connor PG. Reducing bias in observational research on alcohol withdrawal syndrome. Subst Abuse 1998; 19: 23–31
Shaw JM, Kolesar GS, Sellers EM, et al. Development of optimal treatment tactics for alcohol withdrawal: I. Assessment and effectiveness of supportive care. J Clin Psychopharmacol 1981; 1(6): 382–7
Sullivan JT, Sykora K, Schneiderman J, et al. Assessment of alcohol withdrawal: the revised clinical institute withdrawal assessment for alcohol scale (CIWA-Ar). Br J Addict 1989; 84(11): 1353–7
Sullivan JT, Swift RM, Lewis DC. Benzodiazepine requirements during alcohol withdrawal syndrome: clinical implications of using a standardized withdrawal scale. J Clin Psychopharmacol 1991; 11(5): 291–5
Salloum IM, Cornelius JR, Daley DC, et al. The utility of diazepam loading in the treatment of alcohol withdrawal among psychiatric inpatients. Psychopharmacol Bull 1995; 31(2): 305–10
Wartenberg AA, Nirenberg TD, Liepman MR, et al. Detoxification of alcoholics: improving care by symptom-triggered sedation. Alcohol Clin Exp Res 1990; 14(1): 71–5
Saitz R, Mayo-Smith MF, Roberts MS, et al. Individualized treatment for alcohol withdrawal: a randomized double-blind controlled trial. JAMA 1994; 272(7): 519–23
Hayashida M, Alterman AI, McLellan AT, et al. Comparative effectiveness and costs of inpatient and outpatient detoxification of patients with mild-to-moderate alcohol withdrawal syndrome. N Engl J Med 1989; 320(6): 358–65
Sparadeo FR, Zwick WR, Ruggiero SD, et al. Evaluation of a social-setting detoxication program. J Stud Alcohol 1982; 43(11): 1124–36
O’Connor PG, Gottlieb LD, Kraus ML, et al. Social and clinical features as predictors of outcome in outpatient alcohol withdrawal. J Gen Intern Med 1991; 6(4): 312–6
Feldman DJ, Pattison EM, Sobell LC, et al. Outpatient alcohol detoxification: initial findings on 564 patients. Am J Psychiatry 1975; 132: 407–12
Stockwell T, Bolt L, Milner I, et al. Home detoxification from alcohol: its safety and efficacy in comparison with inpatient care. Alcohol Alcohol 1991; 26(5–6): 645–50
Evans DJ, Street SD, Lynch DJ. Alcohol withdrawal at home: pilot project for frail elderly people. Can Fam Physician 1996; 42: 937–45
Naranjo CA, Sellers EM, Chater K, et al. Nonpharmacologic intervention in acute alcohol withdrawal. Clin Pharmacol Ther 1983; 34(2): 214–9
Sellers EM, Naranjo CA, Harrison M, et al. Diazepam loading: simplified treatment of alcohol withdrawal. Clin Pharmacol Ther 1983; 34(6): 822–6
Levkoff SE, Marcantonio ER. Delirium: a major diagnostic and therapeutic challenge for clinicians caring for the elderly. Compr Ther 1994; 20: 550–7
Mayo-Smith MF. Pharmacological management of alcohol withdrawal: a meta-analysis and evidence-based practice guideline. JAMA 1997; 278(2): 144–51
Saitz R, O’Malley SS. Pharmacotherapies for alcohol abuse: withdrawal and treatment. Med Clin North Am 1997; 81(4): 881–907
Sellers EM, Kalant H. Alcohol intoxication and withdrawal. N Eng J Med 1976; 294: 757–62
Turner RC, Lichstein PR, Peden Jr JG, et al. Alcohol withdrawal syndromes: a review of pathophysiology, clinical presentation, and treatment. J Gen Intern Med 1989; 4(5): 432–44
Saitz R, Friedman LS, Mayo-Smith ME. Alcohol withdrawal: a nationwide survey of inpatient treatment practices. J Gen Intern Med 1995; 10(9): 479–87
Institute of Medicine. Prevention and treatment of alcohol problems. Washington, DC: National Academy Press, 1990: 268
Rosenfeld JE, Bizzoco DH. A controlled study of alcohol withdrawal. Q J Stud Alcohol 1961; 1: 77–84
Sereny G, Kalant H. Comparative clinical evaluation of chlordiazepoxide and promazine in treatment of alcohol withdrawal syndrome. BMJ 1965; 1: 92–7
Kaim SC, Klett CJ, Rothfeld B. Treatment of the acute alcohol withdrawal state: a comparison of four drugs. Am J Psychiatry 1969; 125(12): 1640–6
Greenblatt DJ, Shader RI, Abernethy DR. Drugtherapy: current status of benzodiazepines. N Engl J Med 1983; 309(7): 410–6
Peppers MP. Benzodiazepines for alcohol withdrawal in the elderly and in patients with liver disease. Pharmacotherapy 1996; 16(1): 49–57
Meyer BR. Benzodiazepines in the elderly. Med Clin North Am 1982; 66(5): 1017–35
American Psychiatric Association. Task force on benzodiazepine dependency: benzodiazepine dependence, toxicity and abuse. Washington, DC: American Psychiatric Association, 1990
Shader RI, Greenblatt DJ, Harmatz JS, et al. Absorption and disposition of chlordiazepoxide in young and elderly male volunteers. J Clin Pharmacol 1977; 17: 709–18
MacLeod SM, Giles HG, Bengert B, et al. Age and gender related differences in diazepam pharmacokinetics. J Clin Pharmacol 1979; 19: 15–9
Greenblatt DJ, Allen MD, Harmatz JS, et al. Diazepam disposition determinants. Clin Pharmacol Ther 1980; 27: 301–12
Roberts RK, Wilkinson GR, Branch RA, et al. Effects of age and parenchymal liver disease on the disposition of chlordiazepoxide (librium). Gastroenterology 1978; 75: 479–85
Macklon AF, Barton M, James O, et al. The effect of age on the pharmacokinetics of diazepam. Clin Sci 1980; 59: 479–83
Allen MD, Greenblatt DJ, Harmatz JS, et al. Desmethyldiazepam kinetics in the elderly after prazepam. Clin Pharmacol Ther 1980; 28: 196–202
Klotz U, Muller-Seydlitz P. Altered elimination of desmethyldiazepam in the elderly. Br J Clin Pharmacol 1979; 7: 119–20
Greenblatt DJ, Allen MD, Locniskar A, et al. Lorazepam kinetics in the elderly. Clin Pharmacol Ther 1979; 26: 103–13
Kraus JW, Desmond PU, Marshall JP, et al. Effects of aging and liver disease on disposition of lorazepam. Clin Pharmacol Ther 1978; 24: 411–9
Murray TG, Chiang ST, Koepke HH, et al. Renal disease, age, and oxazepam kinetics. Clin Pharmacol Ther 1981; 30: 805–9
Greenblatt DJ, Divoll M, Harmatz JS, et al. Oxazepam kinetics: effects of age and sex. J Pharmacol Exp Ther 1980; 215: 86–91
Salzman C, Shader RI, Greenblatt DJ, et al. Long versus short half-life benzodiazepines in the elderly: kinetics and clinical effects of diazepam and oxazepam. Arch Gen Psychiatry 1983; 40: 293–7
Castledon CM, George CF, Marcer D, et al. Increased sensitivity to nitrazepam in old age. BMJ 1977; 1: 10–2
Healy M, Pickens R, Meisch R, et al. Effects of clorazapate, diazepam, lorazepam, and placebo on human memory. J Clin Psychiatry 1983; 44: 436–9
Gottshalk L. Affective and cognitive problems with benzodiazepines. J Clin Psychopharmacol 1988; 8: 223–5
Reidenberg MM, Levy M, Warner H, et al. Relationship between diazepam dose, plasma level, age, and central nervous system depression. Clin Pharmacol Ther 1978; 23: 371–4
Giles HG, MacLeod SM, Wright JR, et al. Influence of age and previous use on diazepam dosage required for endoscopy. Can Med Assoc J 1978; 118: 513–4
Ritson B, Chick J. Comparison of two benzodiazepines in the treatment of alcohol withdrawal: effects on symptoms and cognitive recovery. Drug Alcohol Depend 1986; 18(4): 329–34
Shader RI, Greenblatt DJ. Use of benzodiazepines in anxiety disorders. N Engl J Med 1993; 328(19): 1398–405
Wilson A, Vulcano BA. Double-blind trial of alprazolam and chlordiazepoxide in the management of the acute ethanol withdrawal syndrome. Alcohol Clin Exp Res 1985; 9(1): 23–7
Mayo-Smith MF, Bernard D. Late-onset seizures in alcohol withdrawal. Alcohol Clin Exp Res 1995; 19(3): 656–9
Solomon K, Manepalli J, Ireland GA, et al. Alcoholism and prescription drug abuse in the elderly: St Louis University grand rounds [clinical conference]. J Am Geriatric Soc 1993; 41(1): 57–69
Hill A, Williams D. Hazards associated with the use of benzodiazepines in alcohol detoxification. J Subst Abuse Treat 1993; 10(5): 449–51
Bird RD, Makela EH. Alcohol withdrawal: what is the benzodiazepine of choice? Ann Pharmacother 1994; 28(1): 67–71
Ayd FJ. Oxazepam: update 1989. Int Clin Psychopharmacol 1991; 5: 1–15
Heinala P, Piepponen T, Heikkinen H. Diazepam loading in alcohol withdrawal: clinical pharmacokinetics. Int J Clin Pharmacol Ther Toxicol 1990; 28(5): 211–7
Wadstein J, Manhem P, Nilsson LH, et al. Clonidine versus chlormethiazole in alcohol withdrawal. Acta Psychiatr Scand 1986; 327 Suppl.: 144–8
Jacob MS, Zilm DH, MacLeod SM, et al. Propranolol-associated confused states during alcohol withdrawal. J Clin Psychopharmacol 1983; 3(3): 185–7
Kuhr BM. Prolonged delirium with propanolol. J Clin Psychiatry 1979; 40(4): 198–9
Zechnich RJ. Beta blockers can obscure diagnosis of delirium tremens [letter]. Lancet 1982; I(8280): 1071–2
Kramp P, Rafaelsen OJ. Delirium tremens: a double-blind comparison of diazepam and barbital treatment. Acta Psychiatr Scand 1978; 58(2): 174–90
Bernus I, Dickinson RG, Hooper WD, et al. Anticonvulsant therapy in aged patients: clinical pharmacokinetic considerations. Drugs Aging 1997; 10: 278–89
Mendelson JH, Ogata M, Mello NK. Effects of alcohol ingestion and withdrawal on magnesium states of alcoholics: clinical and experimental findings. Ann N Y Acad Sci 1969; 162: 918–33
Wacker WEC, Parisi AF. Magnesium metabolism. N Eng J Med 1968; 278: 658–63
Dirks JH. The kidney and magnesium regulation. Kidney Int 1983; 23: 771–7
Kramp P, Hemmingsen R, Rafaelsen OJ. Magnesium concentrations in blood and cerebrospinal fluid during delirium tremens. Psychiatry Res 1979; 1(2): 161–71
Ragland G. Electrolyte abnormalities in the alcoholic patient. Emerg Med Clin North Am 1990; 8(4): 761–73
Wilson A, Vulcano BA. A double-blind, placebo-controlled trial of magnesium sulfate in the ethanol withdrawal syndrome. Alcohol Clin Exp Res 1984; 8: 542–5
Denison H, Jern S, Jagenburg R, et al. Influence of increased adrenergic activity and magnesium depletion on cardiac rhythm in alcohol withdrawal. Br Heart J 1994; 72(6): 554–60
Victor M, Adams RC, Collins GH. The Wernicke-Korsakoff syndrome and related neurological disorders due to alcoholism and malnutrition. Philadelphia: FA Davis, 1989
Harper C. Wernicke’s encephalopathy: a more common disease than realised: a neuropathological study of 51 cases. J Neurol Neurosurg Psychiatry 1979; 42(3): 226–31
Bjorkqvist SE, Isohanni M, Makela R, et al. Ambulant treatment of alcohol withdrawal symptoms with carbamazepine: a formal multicentre double-blind comparison with placebo. Acta Psychiatr Scand 1976; 53(5): 333–42
Flygenring J, Hansen J, Holst B, et al. Treatment of alcohol withdrawal symptoms in hospitalized patients: a randomized, double-blind comparison of carbamazepine (Tegretol) and barbital (Diemal). Acta Psychiatr Scand 1984; 69(5): 398–408
Malcolm R, Ballenger JC, Sturgis ET, et al. Double-blind controlled trial comparing carbamazepine to oxazepam treatment of alcohol withdrawal. Am J Psychiatry 1989; 146(5): 617–21
Stuppaeck CH, Pycha R, Miller C, et al. Carbamazepine versus oxazepam in the treatment of alcohol withdrawal: a double-blind study. Alcohol Alcohol 1992; 27(2): 153–8
Chu NS. Carbamazepine: prevention of alcohol withdrawal seizures. Neurology 1979; 29(10): 1397–401
Racine R. Kindling: the first decade. Neurosurgery 1978; 3(2): 234–52
Bowman EH, Thimann J. Treatment of alcoholism in the sub-acute stage: a study of three active agents. Dis Nerv Syst 1966; 27(5): 342–6
Palestine ML, Alatorre E. Control of acute alcoholic withdrawal symptoms: a comparative study of haloperidol and chlordiazepoxide. Curr Ther Res Clin Exp 1976; 20(3): 289–99
Thomas DW, Freedman DX. Treatment of the alcohol withdrawal syndrome: comparison of promazine and paraldehyde. JAMA 1964; 188: 244–6
Chambers JF, Schultz JD. Double-blind study of three drugs in the treatment of acute alcoholic states. Q J Stud Alcohol 1965; 26: 10–18
Blum K, Eubanks JD, Wallace JE, et al. Enhancement of alcohol withdrawal convulsions in mice by haloperidol. Clin Toxicol 1976; 9: 427–34
Thompson WL, Johnson AD, Maddrey WL. Diazepam and par-aldehyde for treatment of severe delirium tremens: a controlled trial. Ann Intern Med 1975; 82(2): 175–80
Golbert TM, Sanz CJ, Rose HD, et al. Comparative evaluation of treatments of alcohol withdrawal syndromes. JAMA 1967; 201(2): 99–102
Morgan MY. The management of alcohol withdrawal using chlormethiazole. Alcohol Alcohol 1995; 30(6): 771–4
Fulton B, Park GR. Intravenous chlormethiazole. Br J Hosp Med 1992; 48(11): 742–7
Spies CD, Dubisz N, Funk W, et al. Prophylaxis of alcohol withdrawal syndrome in alcohol-dependent patients admitted to the intensive care unit after tumour resection. Br J Anaesth 1995; 75(6): 734–9
Gillman MA, Lichtigfeld FJ. The drug management of severe alcohol withdrawal syndrome. Postgrad Med J 1991; 66: 1005–9
Tubridy P. Alprazolam versus chlormethiazole in acute alcohol withdrawal. Br J Addict 1988; 83(5): 581–5
Palsson A. The efficacy of early chlormethiazole medication in the prevention of delirium tremens. Acta Psychiatr Scand 1986; 329 Suppl.: 140–5
Burroughs AK, Morgan MY, Sherlock S. Double-blind controlled trial of bromocriptine, chlordiazepoxide and chlormethiazole for alcohol withdrawal symptoms. Alcohol Alcohol 1985; 20(3): 263–71
Lapierre YD, Buhner DR, Oyewumi LK, et al. Comparison of chlormethiazole and chlordiazepoxide in the treatment of acute alcohol withdrawal. Neuropsychobiology 1983; 10: 127–30
Frecker RC, Shaw JM, Zilm DH, et al. Nonpharmacological supportive care compared to chlormethiazole infusion in the management of severe acute alcohol withdrawal. J Clin Psychopharmacol 1982; 2(4): 277–80
Ritola E, Malinen L. A double-blind comparison of carbamazepine and chlormethiazole in the treatment of alcohol withdrawal syndrome. Acta Psychiatr Scand 1981; 64: 254–9
Madden JS, Jones D, Frisch ER. Chlormethiazole and trifluoperazine in alcohol withdrawal. Br J Psychiatry 1969; 115: 1191–2
Harfst MJ, Greene JG, Lassae FG. Controlled trial comparing amobarbital and chlormethiazole in alcohol withdrawal symptoms. Q J Stud Alcohol 1967; 28: 641–8
Glatt MM, George HR, Frisch EP. Evaluation of chlormethiazole in treatment for alcohol withdrawal syndrome. Acta Psychiatr Scand 1966; 192 Suppl.: 121–37
Marcantonio ER, Goldman L, Mangione CM, et al. A clinical prediction rule for delirium after elective noncardiac surgery. JAMA 1994; 271(2): 134–9
Inouye SK, Viscoli CM, Horwitz RI, et al. A predictive model for delirium in hospitalized elderly medical patients based on admission characteristics. Ann InternMed 1993; 119(6): 474–81
Jacobson SA. Delirium in the elderly. Psychiatr Clin North Am 1997; 20(1): 91–110
Hoey LL, Nahum A, Vance-Bryan K. A prospective evaluation of benzodiazepine guidelines in the management of patients hospitalized for alcohol withdrawal. Pharmacotherapy 1994; 14(5): 579–85
Cavanaugh SV. Psychiatric emergencies. Med Clin North Am 1986; 70(5): 1185–202
D’Onofrio G, Rathlev NK, Ulrich AS, et al. Lorazepam prevents recurrent alcohol-related seizures [abstract]. Acad Emerg Med 1995; 2: 368
Chance JF. Emergency department treatment of alcohol withdrawal seizures with phenytoin. Ann Emerg Med 1991; 20(5): 520–2
Alldredge BK, Lowenstein DH. Status epilepticus related to alcohol abuse. Epilepsia 1993; 34(6): 1033–7
Alldredge BK, Lowenstein DH, Simon RP. Placebo-controlled trial of intravenous diphenylhydantoin for short-term treatment of alcohol withdrawal seizures. Am J Med 1989; 87(6): 645–8
Sampliner R, Iber FL. Diphenylhydantoin control of alcohol withdrawal seizures: results of a controlled study. JAMA 1974; 230(10): 1430–2
Rathlev NK, D’Onofrio G, Fish SS, et al. The lack of efficacy of phenytoin in the prevention of recurrent alcohol-related seizures. Ann Emerg Med 1994; 23(3): 513–8
Tavani CA. Perioperative psychiatric considerations in the elderly. Clin Geriatr Med 1990; 6(3): 543–56
Gower WE, Kersten H. Prevention of alcohol withdrawal symptoms in surgical patients. Surg Gynecol Obstet 1980; 151(3): 382–4
Craft PP, Foil MB, Cunningham PR, et al. Intravenous ethanol for alcohol detoxification in trauma patients. South Med J 1994; 87(1): 47–54
Hansbrough JF, Zapata-Sirvent RL, Carroll WJ, et al. Administration of intravenous alcohol for prevention of withdrawal in alcoholic burn patients. Am J Surg 1984; 148(2): 266–9
Carlen PL, McAndrews MP, Weiss RT, et al. Alcohol-related dementia in the institutionalized elderly. Alcohol Clin Exp Res 1994; 18(6): 1330–4
Smith DM, Atkinson RM. Alcoholism and dementia. Int J Addict 1995; 30(13–14): 1843–69
Whitcup SM, Miller F. Unrecognized drug dependence in psychiatrically hospitalized elderly patients. J Am Geriatr Soc 1987; 35(4): 297–301
Kashner TM, Rodell DE, Ogden SR, et al. Outcomes and costs of two VA inpatient treatment programs for older alcoholic patients. Hosp Community Psychiatry 1992; 43(10): 985–9
Kofoed LL, Toison RL, Atkinson RM, et al. Treatment compliance of older alcoholics: an elder-specific approach is superiorto ‘mainstreaming’. J Stud Alcohol 1987; 48(1): 47–51
Bien TH, Miller WR. Brief interventions for alcohol problems: a review. Addiction 1993; 88: 315–36
Samet JH, Rollnick S, Barnes H. Beyond CAGE: abrief clinical approach after detection of substance abuse. Arch Intern Med 1996; 156: 2287–93