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Plasmin

Plasmin

) present in blood that degrades many blood plasma proteins, most notable, fibrin clots. The degradation of fibrin is termed fibrinolysis.

Functions

It is a serine protease that is released as plasminogen from the liver into the circulation and activated by tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), thrombin, fibrin, and factor XII (Hageman factor). It is inactivated by alpha 2-antiplasmin, a serine protease inhibitor (serpin).

Apart from fibrinolysis, plasmin proteolyses proteins in various other systems: It activates collagenases, some mediators of the complement system and weakens the wall of the Graafian follicle (leading to ovulation). It cleaves fibrin, fibronectin, thrombospondin, laminin, and von Willebrand factor.

Pathology

Deficiency in plasmin may lead to thrombosis, as clots are not degraded adequately.

Further reading

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citations =
*cite journal | author=Anglés-Cano E, Rojas G |title=Apolipoprotein(a): structure-function relationship at the lysine-binding site and plasminogen activator cleavage site |journal=Biol. Chem. |volume=383 |issue= 1 |pages= 93–9 |year= 2003 |pmid= 11928826 |doi=
*cite journal | author=Ranson M, Andronicos NM |title=Plasminogen binding and cancer: promises and pitfalls |journal=Front. Biosci. |volume=8 |issue= |pages= s294–304 |year= 2004 |pmid= 12700073 |doi=

External links

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Look at other dictionaries:

  • Plasmin — Masse/Länge Primärstruktur 791 = 561+230 Aminosäuren …   Deutsch Wikipedia

  • Plasmin — Plas min, n. (Physiol. Chem.) A proteid body, separated by some physiologists from blood plasma. It is probably identical with fibrinogen. [1913 Webster] …   The Collaborative International Dictionary of English

  • plasmin — plasmin. См. плазмин. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Plasmin — ⇒ Fibrinolyse …   Deutsch wörterbuch der biologie

  • plasmin — [plaz′min] n. [ PLASM(A) + IN1] a proteolytic enzyme, derived from substances in the blood plasma, that slowly dissolves blood clots …   English World dictionary

  • plasmin — A serine proteinase hydrolyzing peptides and esters of l arginine and l lysine and converting fibrin to soluble products; occurs in plasma as the precursor plasminogen (profibrinolysin) and is activated to p. by organic solvents, which remove an… …   Medical dictionary

  • plasmin — fibrinolysin; n. an enzyme that digests the protein fibrin. Its function is the dissolution of blood clots (see fibrinolysis). Plasmin is not normally present in the blood but exists as an inactive precursor, plasminogen …   The new mediacal dictionary

  • plasmin — plazminas statusas T sritis chemija apibrėžtis Kraujo fibriną skaidantis proteolitinis fermentas. atitikmenys: angl. fibrinolysin; plasmin rus. плазмин; фибринолизин ryšiai: sinonimas – fibrinolizinas …   Chemijos terminų aiškinamasis žodynas

  • plasmin — noun Date: circa 1866 a proteolytic enzyme that dissolves the fibrin of blood clots …   New Collegiate Dictionary

  • plasmin — (= fibrinolysin) Trypsin like serine protease that is responsible for digesting fibrin in blood clots. Generated from plasminogen by the action of another protease, plasminogen activator. Also acts on activated Hagemann factor and on complement …   Dictionary of molecular biology