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Suprofen


Systematic (IUPAC) name
(RS)-2-[4-(2-thienylcarbonyl)phenyl]propanoic acid
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy cat.	?
Legal status	?
Pharmacokinetic data
Protein binding	20%
Identifiers
CAS number	40828-46-4
ATC code	M01AE07
PubChem	CID 5359
DrugBank	APRD00230
ChemSpider	5166
UNII	988GU2F9PE
KEGG	D00452
ChEBI	CHEBI:9362
ChEMBL	CHEMBL956
Chemical data
Formula	C₁₄H₁₂O₃S
Mol. mass	260.309 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17) Key:MDKGKXOCJGEUJW-UHFFFAOYSA-N
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Suprofen is an NSAID marketed in a 1% solution under the trade name Profenal.

Uses

Suprofen was originally used as a tablet but has since been discontinued in that form.^[1] It is now used exclusively as a topical ophthalmic solution, typically to prevent miosis during and after ophthalmic surgery.

References

^ http://www.fda.gov/ora/compliance_ref/cpg/cpgdrg/cpg460-200.html Guidance for FDA Staff and Industry Compliance Policy Guides Manual Sec. 460.200

v · d · eNon-steroidal anti-inflammatory drug (NSAID) products (primarily M01A and M02A, also N02BA)

Salicylates	Aspirin (acetylsalicylic acid) • Aloxiprin • Benorylate • Diflunisal • Ethenzamide • Magnesium salicylate • Methyl salicylate • Salsalate • Salicin • Salicylamide • Sodium salicylate

Arylalkanoic acids	Diclofenac • Aceclofenac • Acemetacin • Alclofenac • Bromfenac • Etodolac • Indometacin • Indometacin farnesil • Nabumetone • Oxametacin • Proglumetacin • Sulindac • Tolmetin

2-Arylpropionic acids (profens)	Ibuprofen • Alminoprofen • Benoxaprofen • Carprofen • Dexibuprofen • Dexketoprofen • Fenbufen • Fenoprofen • Flunoxaprofen • Flurbiprofen • Ibuproxam • Indoprofen^† • Ketoprofen • Ketorolac • Loxoprofen • Miroprofen • Naproxen • Oxaprozin • Pirprofen • Suprofen • Tarenflurbil • Tiaprofenic acid

N-Arylanthranilic acids (fenamic acids)	Mefenamic acid • Flufenamic acid • Meclofenamic acid • Tolfenamic acid

Pyrazolidine derivatives	Phenylbutazone • Ampyrone • Azapropazone • Clofezone • Kebuzone • Metamizole • Mofebutazone • Oxyphenbutazone • Phenazone • Sulfinpyrazone

Oxicams	Piroxicam • Droxicam • Lornoxicam • Meloxicam • Tenoxicam • Ampiroxicam

COX -2 inhibitors	Celecoxib • Deracoxib^‡ • Etoricoxib • Firocoxib^‡ • Lumiracoxib^† • Parecoxib • Rofecoxib^† • Valdecoxib^†

Sulfonanilides	Nimesulide

Topically used products	Bendazac • Diclofenac • Etofenamate • Felbinac • Flurbiprofen • Ibuprofen • Indometacin • Ketoprofen • Naproxen • Piroxicam • Suprofen

COX-inhibiting nitric oxide donators	Naproxcinod

Others	Fluproquazone

Items listed in bold indicate initially developed compounds of specific groups. ^†Withdrawn drugs. ^‡Veterinary use medications.