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Colestipol

Wikipedia

Colestipol


Systematic (IUPAC) name
Copolymer of N'-(2-aminoethyl)-N-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine and 2-(chloromethyl)oxirane
Clinical data
Trade names	Colestid
AHFS/Drugs.com	monograph
MedlinePlus	a682157
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	50925-79-6
ATC code	C10AC02
PubChem	CID 62816
DrugBank	DB00375
ChemSpider	56550
UNII	K50N755924
KEGG	C06925
ChEMBL	CHEMBL1201678
Chemical data
Formula	C₁₁H₂₈Cl N₅O
Mol. mass	281.8260 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C8H23N5.C3H5ClO/c9-1-3-11-5-7-13-8-6-12-4-2-10;4-1-3-2-5-3/h11-13H,1-10H2;3H,1-2H2 Key:GMRWGQCZJGVHKL-UHFFFAOYSA-N
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Colestipol is a bile acid sequestrant. It works in the gut trapping bile salts, and preventing them from being reabsorbed.

This leads to decreased enterohepatic recirculation of bile salts, increased synthesis of new bile salts by the liver, decreased liver cholesterol, increased LDL receptor expression, and decreasing LDL in blood.

Side effects

Increases in VLDL and TAG synthesis
Gastrointestinal tract disturbances
Malabsorption of lipid soluble vitamins (A,D,E,K) and lipid soluble drugs

Contrandications

Colestipol is contraindicated in hypotriglyceridemia.

v · d · eLipid modifying agents (C10)

GI tract

Cholesterol absorption inhibitors, NPC1L1	Ezetimibe • SCH-48461

Bile acid sequestrants/resins (LDL)	Cholestyramine • Colestipol • Colestilan • Colextran • Colesevelam

Liver

Statins (HMG-CoA reductase, LDL)	Simvastatin^# • Atorvastatin • Fluvastatin • Lovastatin • Mevastatin • Pitavastatin • Pravastatin • Rosuvastatin • Cerivastatin^‡

Niacin and derivatives (HDL and LDL)	Niceritrol • Niacin • Nicofuranose • Aluminium nicotinate • Nicotinyl alcohol • Acipimox

Blood vessels

Fibrates (PPAR)	Clofibrate^‡ • Bezafibrate • Aluminium clofibrate • Gemfibrozil • Fenofibrate • Simfibrate • Ronifibrate • Ciprofibrate • Etofibrate • Clofibride • Clinofibrate

CETP inhibitors (HDL)	Anacetrapib^† • Dalcetrapib • Evacetrapib • Torcetrapib^§

Combinations

Niacin/lovastatin • Niacin/simvastatin • Ezetimibe/simvastatin • Niacin/laropiprant

Other

Dextrothyroxine • Probucol • Tiadenol • Benfluorex • Meglutol • Omega-3-triglycerides • Magnesium pyridoxal 5-phosphate glutamate • Policosanol • Lapaquistat^§ • Alipogene tiparvovec

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

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