5α-Reductase, the Glossary
5α-Reductases, also known as 3-oxo-5α-steroid 4-dehydrogenases, are enzymes involved in steroid metabolism.[1]
Table of Contents
114 relations: Acne, Aldosterone, Alfatradiol, Allopregnanolone, American Journal of Medical Genetics, Androgen, Androstanedione, Androstenedione, Anxiety disorder, Aqueous humour, Asparagine, Benign prostatic hyperplasia, Bile acid, Catalysis, Cerebral cortex, Chemical reaction, Cholestenone 5alpha-reductase, Chronic stress, Conserved sequence, Constipation, Corticosterone, Cortisol, Crystal structure, Cushing's syndrome, Cytosol, Deoxycorticosterone, Depression (mood), Dihydrodeoxycorticosterone, Dihydrotestosterone, Dopaminergic pathways, Dutasteride, Endoplasmic reticulum, Enzyme, Epididymis, Epitestosterone, Epithelium, Erectile dysfunction, Estradiol, Estrogen, Fatigue, Feminizing hormone therapy, Finasteride, GABA, Ganoderic acid, Green tea, Gynecomastia, Hirsutism, Hypoglycemia, Immortalised cell line, In vitro, ... Expand index (64 more) »
- Steroid hormone biosynthesis
Acne
Acne, also known as acne vulgaris, is a long-term skin condition that occurs when dead skin cells and oil from the skin clog hair follicles.
Aldosterone
Aldosterone is the main mineralocorticoid steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland.
See 5α-Reductase and Aldosterone
Alfatradiol
Alfatradiol, also known as 17α-estradiol and sold under the brand names Avicis, Avixis, Ell-Cranell Alpha, and Pantostin, is a weak estrogen and 5α-reductase inhibitor medication which is used topically in the treatment of pattern hair loss (androgenic alopecia or pattern baldness) in men and women.
See 5α-Reductase and Alfatradiol
Allopregnanolone
Allopregnanolone is a naturally occurring neurosteroid which is made in the body from the hormone progesterone.
See 5α-Reductase and Allopregnanolone
American Journal of Medical Genetics
American Journal of Medical Genetics is a peer-reviewed medical journal dealing with human genetics published in three separate sections (parts) by Wiley-Liss.
See 5α-Reductase and American Journal of Medical Genetics
Androgen
An androgen (from Greek andr-, the stem of the word meaning "man") is any natural or synthetic steroid hormone that regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors.
Androstanedione
Androstanedione, also known as 5α-androstanedione or as 5α-androstane-3,17-dione, is a naturally occurring androstane (5α-androstane) steroid and an endogenous metabolite of androgens like testosterone, dihydrotestosterone (DHT), dehydroepiandrosterone (DHEA), and androstenedione.
See 5α-Reductase and Androstanedione
Androstenedione
Androstenedione, or 4-androstenedione (abbreviated as A4 or Δ4-dione), also known as androst-4-ene-3,17-dione, is an endogenous weak androgen steroid hormone and intermediate in the biosynthesis of estrone and of testosterone from dehydroepiandrosterone (DHEA).
See 5α-Reductase and Androstenedione
Anxiety disorder
Anxiety disorders are a group of mental disorders characterized by significant and uncontrollable feelings of anxiety and fear such that a person's social, occupational, and personal functions are significantly impaired.
See 5α-Reductase and Anxiety disorder
Aqueous humour
The aqueous humour is a transparent water-like fluid similar to blood plasma, but containing low protein concentrations.
See 5α-Reductase and Aqueous humour
Asparagine
Asparagine (symbol Asn or N) is an α-amino acid that is used in the biosynthesis of proteins.
See 5α-Reductase and Asparagine
Benign prostatic hyperplasia
Benign prostatic hyperplasia (BPH), also called prostate enlargement, is a noncancerous increase in size of the prostate gland.
See 5α-Reductase and Benign prostatic hyperplasia
Bile acid
Bile acids are steroid acids found predominantly in the bile of mammals and other vertebrates.
See 5α-Reductase and Bile acid
Catalysis
Catalysis is the increase in rate of a chemical reaction due to an added substance known as a catalyst.
See 5α-Reductase and Catalysis
Cerebral cortex
The cerebral cortex, also known as the cerebral mantle, is the outer layer of neural tissue of the cerebrum of the brain in humans and other mammals.
See 5α-Reductase and Cerebral cortex
Chemical reaction
A chemical reaction is a process that leads to the chemical transformation of one set of chemical substances to another.
See 5α-Reductase and Chemical reaction
Cholestenone 5alpha-reductase
In enzymology, a cholestenone 5alpha-reductase is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are 5alpha-cholestan-3-one and NADP+, whereas its 3 products are cholest-4-en-3-one, NADPH, and H+. 5α-Reductase and cholestenone 5alpha-reductase are eC 1.3.1.
See 5α-Reductase and Cholestenone 5alpha-reductase
Chronic stress
Chronic stress is the physiological or psychological response induced by a long-term internal or external stressor.
See 5α-Reductase and Chronic stress
Conserved sequence
In evolutionary biology, conserved sequences are identical or similar sequences in nucleic acids (DNA and RNA) or proteins across species (orthologous sequences), or within a genome (paralogous sequences), or between donor and receptor taxa (xenologous sequences).
See 5α-Reductase and Conserved sequence
Constipation
Constipation is a bowel dysfunction that makes bowel movements infrequent or hard to pass.
See 5α-Reductase and Constipation
Corticosterone
Corticosterone, also known as 17-deoxycortisol and 11β,21-dihydroxyprogesterone, is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.
See 5α-Reductase and Corticosterone
Cortisol
Cortisol is a steroid hormone in the glucocorticoid class of hormones and a stress hormone.
Crystal structure
In crystallography, crystal structure is a description of ordered arrangement of atoms, ions, or molecules in a crystalline material.
See 5α-Reductase and Crystal structure
Cushing's syndrome
Cushing's syndrome is a collection of signs and symptoms due to prolonged exposure to glucocorticoids such as cortisol.
See 5α-Reductase and Cushing's syndrome
Cytosol
The cytosol, also known as cytoplasmic matrix or groundplasm, is one of the liquids found inside cells (intracellular fluid (ICF)).
Deoxycorticosterone
Deoxycorticosterone (DOC), or desoxycorticosterone, may refer to.
See 5α-Reductase and Deoxycorticosterone
Depression (mood)
Depression is a mental state of low mood and aversion to activity.
See 5α-Reductase and Depression (mood)
Dihydrodeoxycorticosterone
5α-Dihydrodeoxycorticosterone (abbreviated as DHDOC), also known as 21-hydroxy-5α-pregnan-20-one, is an endogenous progestogen and neurosteroid.
See 5α-Reductase and Dihydrodeoxycorticosterone
Dihydrotestosterone
Dihydrotestosterone (DHT, 5α-dihydrotestosterone, 5α-DHT, androstanolone or stanolone) is an endogenous androgen sex steroid and hormone primarily involved in the growth and repair of the prostate and the penis, as well as the production of sebum and body hair composition.
See 5α-Reductase and Dihydrotestosterone
Dopaminergic pathways
Dopaminergic pathways (dopamine pathways, dopaminergic projections) in the human brain are involved in both physiological and behavioral processes including movement, cognition, executive functions, reward, motivation, and neuroendocrine control.
See 5α-Reductase and Dopaminergic pathways
Dutasteride
Dutasteride, sold under the brand name Avodart among others, is a medication primarily used to treat the symptoms of a benign prostatic hyperplasia (BPH), an enlarged prostate not associated with cancer.
See 5α-Reductase and Dutasteride
Endoplasmic reticulum
The endoplasmic reticulum (ER) is a part of a transportation system of the eukaryotic cell, and has many other important functions such as protein folding.
See 5α-Reductase and Endoplasmic reticulum
Enzyme
Enzymes are proteins that act as biological catalysts by accelerating chemical reactions.
Epididymis
The epididymis (epididymides or) is an elongated tubular structure attached to the posterior side of each one of the two male reproductive glands, the testicles.
See 5α-Reductase and Epididymis
Epitestosterone
Epitestosterone, or isotestosterone, also known as 17α-testosterone or as androst-4-en-17α-ol-3-one, is an endogenous steroid and an epimer of the androgen sex hormone testosterone.
See 5α-Reductase and Epitestosterone
Epithelium
Epithelium or epithelial tissue is a thin, continuous, protective layer of compactly packed cells with little extracellular matrix.
See 5α-Reductase and Epithelium
Erectile dysfunction
Erectile dysfunction (ED), also referred to as impotence, is a form of sexual dysfunction in males characterized by the persistent or recurring inability to achieve or maintain a penile erection with sufficient rigidity and duration for satisfactory sexual activity.
See 5α-Reductase and Erectile dysfunction
Estradiol
Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone.
See 5α-Reductase and Estradiol
Estrogen
Estrogen (oestrogen; see spelling differences) is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics.
Fatigue
Fatigue describes a state of tiredness (which is not sleepiness), exhaustion or loss of energy.
Feminizing hormone therapy
Feminizing hormone therapy, also known as transfeminine hormone therapy, is hormone therapy and sex reassignment therapy to change the secondary sex characteristics of transgender people from masculine or androgynous to feminine.
See 5α-Reductase and Feminizing hormone therapy
Finasteride
Finasteride, sold under the brand names Proscar and Propecia among others, is a medication used to treat pattern hair loss and benign prostatic hyperplasia (BPH) in men.
See 5α-Reductase and Finasteride
GABA
GABA (gamma Aminobutyric acid, γ-Aminobutyric acid) is the chief inhibitory neurotransmitter in the developmentally mature mammalian central nervous system.
Ganoderic acid
Ganoderic acids are a class of closely related triterpenoids (derivatives from lanosterol) found in Ganoderma mushrooms.
See 5α-Reductase and Ganoderic acid
Green tea
Green tea is a type of tea that is made from Camellia sinensis leaves and buds that have not undergone the same withering and oxidation process which is used to make oolong teas and black teas.
See 5α-Reductase and Green tea
Gynecomastia
Gynecomastia (also spelled gynaecomastia) is the abnormal non-cancerous enlargement of one or both breasts in males due to the growth of breast tissue as a result of a hormone imbalance between estrogens and androgens.
See 5α-Reductase and Gynecomastia
Hirsutism
Hirsutism is excessive body hair on parts of the body where hair is normally absent or minimal.
See 5α-Reductase and Hirsutism
Hypoglycemia
Hypoglycemia, also called low blood sugar, is a fall in blood sugar to levels below normal, typically below 70 mg/dL (3.9 mmol/L).
See 5α-Reductase and Hypoglycemia
Immortalised cell line
An immortalised cell line is a population of cells from a multicellular organism that would normally not proliferate indefinitely but, due to mutation, have evaded normal cellular senescence and instead can keep undergoing division.
See 5α-Reductase and Immortalised cell line
In vitro
In vitro (meaning in glass, or in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context.
Isopregnanolone
Isopregnanolone, also known as isoallopregnanolone and epiallopregnanolone, as well as sepranolone, and as 3β-hydroxy-5α-pregnan-20-one or 3β,5α-tetrahydroprogesterone (3β,5α-THP), is an endogenous neurosteroid and a natural 3β-epimer of allopregnanolone.
See 5α-Reductase and Isopregnanolone
Isozyme
In biochemistry, isozymes (also known as isoenzymes or more generally as multiple forms of enzymes) are enzymes that differ in amino acid sequence but catalyze the same chemical reaction.
Lens (vertebrate anatomy)
The lens, or crystalline lens, is a transparent biconvex structure in most land vertebrate eyes.
See 5α-Reductase and Lens (vertebrate anatomy)
Lingzhi (mushroom)
Lingzhi, Ganoderma sichuanense, also known as reishi or Ganoderma lingzhi is a polypore fungus ("bracket fungus") native to East Asia belonging to the genus Ganoderma.
See 5α-Reductase and Lingzhi (mushroom)
Linolenic acid
Linolenic acid is a type of naturally-occurring fatty acid.
See 5α-Reductase and Linolenic acid
Lipogenesis
In biochemistry, lipogenesis is the conversion of fatty acids and glycerol into fats, or a metabolic process through which acetyl-CoA is converted to triglyceride for storage in fat.
See 5α-Reductase and Lipogenesis
List of enzymes
Enzymes are listed here by their classification in the International Union of Biochemistry and Molecular Biology's Enzyme Commission (EC) numbering system.
See 5α-Reductase and List of enzymes
Liver
The liver is a major metabolic organ exclusively found in vertebrate animals, which performs many essential biological functions such as detoxification of the organism, and the synthesis of proteins and various other biochemicals necessary for digestion and growth.
Lower urinary tract symptoms
Lower urinary tract symptoms (LUTS) refer to a group of clinical symptoms involving the bladder, urinary sphincter, urethra and, in men, the prostate.
See 5α-Reductase and Lower urinary tract symptoms
Mania
Mania, also known as manic syndrome, is a mental and behavioral disorder defined as a state of abnormally elevated arousal, affect, and energy level, or "a state of heightened overall activation with enhanced affective expression together with lability of affect." During a manic episode, an individual will experience rapidly changing emotions and moods, highly influenced by surrounding stimuli.
Metabolic dysfunction–associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), is a type of chronic liver disease.
See 5α-Reductase and Metabolic dysfunction–associated steatotic liver disease
Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical reactions in organisms.
See 5α-Reductase and Metabolism
In biochemistry, a metabolite is an intermediate or end product of metabolism.
See 5α-Reductase and Metabolite
Monomer
A monomer (mono-, "one" + -mer, "part") is a molecule that can react together with other monomer molecules to form a larger polymer chain or three-dimensional network in a process called polymerization.
Nandrolone
Nandrolone, also known as 19-nortestosterone, is an endogenous androgen which exists in the male body at a ratio of 1:50 compared to testosterone.
See 5α-Reductase and Nandrolone
Natriuresis
Natriuresis is the process of sodium excretion in the urine through the action of the kidneys.
See 5α-Reductase and Natriuresis
Nervous system
In biology, the nervous system is the highly complex part of an animal that coordinates its actions and sensory information by transmitting signals to and from different parts of its body.
See 5α-Reductase and Nervous system
Neurosteroid
Neurosteroids, also known as neuroactive steroids, are endogenous or exogenous steroids that rapidly alter neuronal excitability through interaction with ligand-gated ion channels and other cell surface receptors.
See 5α-Reductase and Neurosteroid
Nicotinamide adenine dinucleotide phosphate
Nicotinamide adenine dinucleotide phosphate, abbreviated NADP or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require NADPH as a reducing agent ('hydrogen source').
See 5α-Reductase and Nicotinamide adenine dinucleotide phosphate
Oxidoreductase
In biochemistry, an oxidoreductase is an enzyme that catalyzes the transfer of electrons from one molecule, the reductant, also called the electron donor, to another, the oxidant, also called the electron acceptor.
See 5α-Reductase and Oxidoreductase
Pattern hair loss
Pattern hair loss (also known as androgenetic alopecia (AGA)) is a hair loss condition that primarily affects the top and front of the scalp.
See 5α-Reductase and Pattern hair loss
Polycystic ovary syndrome
Polycystic ovary syndrome, or polycystic ovarian syndrome (PCOS), is the most common endocrine disorder in women of reproductive age.
See 5α-Reductase and Polycystic ovary syndrome
Polyunsaturated fat
In biochemistry and nutrition, a polyunsaturated fat is a fat that contains a polyunsaturated fatty acid (abbreviated PUFA), which is a subclass of fatty acid characterized by a backbone with two or more carbon–carbon double bonds.
See 5α-Reductase and Polyunsaturated fat
Prefrontal cortex
In mammalian brain anatomy, the prefrontal cortex (PFC) covers the front part of the frontal lobe of the cerebral cortex.
See 5α-Reductase and Prefrontal cortex
Product (chemistry)
Products are the species formed from chemical reactions.
See 5α-Reductase and Product (chemistry)
Progesterone
Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species.
See 5α-Reductase and Progesterone
Prostate
The prostate is both an accessory gland of the male reproductive system and a muscle-driven mechanical switch between urination and ejaculation.
Prostate cancer
Prostate cancer is the uncontrolled growth of cells in the prostate, a gland in the male reproductive system below the bladder.
See 5α-Reductase and Prostate cancer
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues.
Pseudomonadota
Pseudomonadota (synonym Proteobacteria) is a major phylum of Gram-negative bacteria.
See 5α-Reductase and Pseudomonadota
Pyramidal cell
Pyramidal cells, or pyramidal neurons, are a type of multipolar neuron found in areas of the brain including the cerebral cortex, the hippocampus, and the amygdala.
See 5α-Reductase and Pyramidal cell
Riboflavin
Riboflavin, also known as vitamin B2, is a vitamin found in food and sold as a dietary supplement.
See 5α-Reductase and Riboflavin
Schizophrenia
Schizophrenia is a mental disorder characterized by reoccurring episodes of psychosis that are correlated with a general misperception of reality.
See 5α-Reductase and Schizophrenia
Selective serotonin reuptake inhibitor
Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions.
See 5α-Reductase and Selective serotonin reuptake inhibitor
Seminal vesicles
The seminal vesicles (also called vesicular glands or seminal glands) are a pair of convoluted tubular accessory glands that lie behind the urinary bladder of male mammals.
See 5α-Reductase and Seminal vesicles
Serenoa
Serenoa repens, commonly known as saw palmetto, is a small palm, growing to a maximum height around.
Sex hormone
Sex hormones, also known as sex steroids, gonadocorticoids and gonadal steroids, are steroid hormones that interact with vertebrate steroid hormone receptors.
See 5α-Reductase and Sex hormone
Sexual dysfunction
Sexual dysfunction is difficulty experienced by an individual or partners during any stage of normal sexual activity, including physical pleasure, desire, preference, arousal, or orgasm.
See 5α-Reductase and Sexual dysfunction
Skin
Skin is the layer of usually soft, flexible outer tissue covering the body of a vertebrate animal, with three main functions: protection, regulation, and sensation.
Sleep deprivation
Sleep deprivation, also known as sleep insufficiency or sleeplessness, is the condition of not having adequate duration and/or quality of sleep to support decent alertness, performance, and health.
See 5α-Reductase and Sleep deprivation
Small interfering RNA
Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA at first non-coding RNA molecules, typically 20–24 (normally 21) base pairs in length, similar to miRNA, and operating within the RNA interference (RNAi) pathway.
See 5α-Reductase and Small interfering RNA
SRD5A1
3-Oxo-5α-steroid 4-dehydrogenase 1 is an enzyme that in humans is encoded by the SRD5A1 gene. 5α-Reductase and SRD5A1 are genes on human chromosome 5.
SRD5A2
The human gene SRD5A2 encodes the 3-oxo-5α-steroid 4-dehydrogenase 2 enzyme, also known as 5α-reductase type 2 (5αR2), one of three isozymes of 5α-reductase. 5α-Reductase and SRD5A2 are genes on human chromosome 2.
SRD5A3
Steroid 5-alpha-reductase 3, also known as 3-oxo-5-alpha-steroid 4-dehydrogenase 3, is an enzyme that in humans is encoded by the SRD5A3 gene.
Steroidogenesis inhibitor
A steroidogenesis inhibitor, also known as a steroid biosynthesis inhibitor, is a type of drug which inhibits one or more of the enzymes that are involved in the process of steroidogenesis, the biosynthesis of endogenous steroids and steroid hormones.
See 5α-Reductase and Steroidogenesis inhibitor
Steroidogenic enzyme
Steroidogenic enzymes are enzymes that are involved in steroidogenesis and steroid biosynthesis.
See 5α-Reductase and Steroidogenic enzyme
Substrate (chemistry)
In chemistry, the term substrate is highly context-dependent.
See 5α-Reductase and Substrate (chemistry)
Suicidal ideation
Suicidal ideation, or suicidal thoughts, is the thought process of having ideas, or ruminations about the possibility of completing suicide.
See 5α-Reductase and Suicidal ideation
Testosterone
Testosterone is the primary male sex hormone and androgen in males.
See 5α-Reductase and Testosterone
Tetrahydrodeoxycorticosterone
Tetrahydrodeoxycorticosterone (abbreviated as THDOC; 3α,21-dihydroxy-5α-pregnan-20-one), also referred to as allotetrahydrocorticosterone, is an endogenous neurosteroid.
See 5α-Reductase and Tetrahydrodeoxycorticosterone
Trans woman
A trans woman (short for transgender woman) is a woman who was assigned male at birth.
See 5α-Reductase and Trans woman
Zinc
Zinc is a chemical element with the symbol Zn and atomic number 30.
11β-Hydroxysteroid dehydrogenase type 1
11β-Hydroxysteroid dehydrogenase type 1, also known as cortisone reductase, is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system.
See 5α-Reductase and 11β-Hydroxysteroid dehydrogenase type 1
17β-Hydroxysteroid dehydrogenase
17β-Hydroxysteroid dehydrogenases (17β-HSD, HSD17B), also 17-ketosteroid reductases (17-KSR), are a group of alcohol oxidoreductases which catalyze the reduction of 17-ketosteroids and the dehydrogenation of 17β-hydroxysteroids in steroidogenesis and steroid metabolism. 5α-Reductase and 17β-Hydroxysteroid dehydrogenase are steroid hormone biosynthesis.
See 5α-Reductase and 17β-Hydroxysteroid dehydrogenase
3α-Dihydroprogesterone
3α-Dihydroprogesterone (3α-DHP), also known as 3α-hydroxyprogesterone, as well as pregn-4-en-3α-ol-20-one, is an endogenous neurosteroid.
See 5α-Reductase and 3α-Dihydroprogesterone
3α-Hydroxysteroid dehydrogenase
3α-Hydroxysteroid dehydrogenase (3α-HSD) is an enzyme (1.1.1.50) that plays a role in the metabolism of steroids and non-steroidal compounds in humans and other species, such as bacteria, fungi, plants, and so on.
See 5α-Reductase and 3α-Hydroxysteroid dehydrogenase
3β-Dihydroprogesterone
3β-Dihydroprogesterone (3β-DHP), also known as 3β-hydroxyprogesterone, or pregn-4-en-3β-ol-20-one (4-pregnenolone, δ4-pregnenolone), is an endogenous steroid.
See 5α-Reductase and 3β-Dihydroprogesterone
3β-Hydroxysteroid dehydrogenase
3β-Hydroxysteroid dehydrogenase/Δ5-4 isomerase (3β-HSD) is an enzyme that catalyzes the biosynthesis of the steroid progesterone from pregnenolone, 17α-hydroxyprogesterone from 17α-hydroxypregnenolone, and androstenedione from dehydroepiandrosterone (DHEA) in the adrenal gland. 5α-Reductase and 3β-Hydroxysteroid dehydrogenase are steroid hormone biosynthesis.
See 5α-Reductase and 3β-Hydroxysteroid dehydrogenase
5α-Dihydroaldosterone
5α-Dihydroaldosterone is a metabolite of aldosterone that is formed by 5α-reductase.
See 5α-Reductase and 5α-Dihydroaldosterone
5α-Dihydrocorticosterone
5α-Dihydrocorticosterone (5α-DHC, 5α-DHB), also known as 11β,21-dihydroxy-5α-pregnane-3,20-dione, is a naturally occurring, endogenous glucocorticoid steroid hormone and neurosteroid.
See 5α-Reductase and 5α-Dihydrocorticosterone
5α-Dihydronandrolone
5α-Dihydronandrolone (also known as 5α-DHN, dihydronandrolone, DHN, 5α-dihydro-19-nortestosterone, or 5α-estran-17β-ol-3-one) is a naturally occurring anabolic–androgenic steroid (AAS) and a 5α-reduced derivative of nandrolone (19-nortestosterone).
See 5α-Reductase and 5α-Dihydronandrolone
5α-Dihydroprogesterone
5α-Dihydroprogesterone (5α-DHP, allopregnanedione, or 5α-pregnane-3,20-dione) is an endogenous progestogen and neurosteroid that is synthesized from progesterone.
See 5α-Reductase and 5α-Dihydroprogesterone
5α-Reductase 2 deficiency
5α-Reductase 2 deficiency (5αR2D) is an autosomal recessive condition caused by a mutation in SRD5A2, a gene encoding the enzyme 5α-reductase type 2 (5αR2).
See 5α-Reductase and 5α-Reductase 2 deficiency
5α-Reductase inhibitor
5α-Reductase inhibitors (5-ARIs), also known as dihydrotestosterone (DHT) blockers, are a class of medications with antiandrogenic effects which are used primarily in the treatment of enlarged prostate and scalp hair loss.
See 5α-Reductase and 5α-Reductase inhibitor
See also
Steroid hormone biosynthesis
- 17β-Hydroxysteroid dehydrogenase
- 21-Hydroxylase
- 3β-Hydroxysteroid dehydrogenase
- 5α-Reductase
- CYP17A1
- Cholesterol side-chain cleavage enzyme
- Cytochrome P450 reductase
- Estradiol 17beta-dehydrogenase
- Ferredoxin
- Lanosterol synthase
- Squalene
- Steroid 11β-hydroxylase
- Steroidogenic acute regulatory protein
- Testosterone 17b-dehydrogenase (NADP+)
References
[1] https://en.wikipedia.org/wiki/5α-Reductase
Also known as 3-oxo-5a-steroid 4-dehydrogenase, 3-oxo-5alpha-steroid 4-dehydrogenase, 3-oxo-5alpha-steroid:acceptor Delta4-oxidoreductase, 5 a Reductase, 5 alpha reductase, 5 alpha-reductase, 5-Alpha reductase, 5-alpha-reductase, 5A-Reductase, 5AR, 5aReductase, 5α-reductase type 2, EC 1.3.99.5, Testosterone 5-alpha-Reductase.
, Isopregnanolone, Isozyme, Lens (vertebrate anatomy), Lingzhi (mushroom), Linolenic acid, Lipogenesis, List of enzymes, Liver, Lower urinary tract symptoms, Mania, Metabolic dysfunction–associated steatotic liver disease, Metabolism, Metabolite, Monomer, Nandrolone, Natriuresis, Nervous system, Neurosteroid, Nicotinamide adenine dinucleotide phosphate, Oxidoreductase, Pattern hair loss, Polycystic ovary syndrome, Polyunsaturated fat, Prefrontal cortex, Product (chemistry), Progesterone, Prostate, Prostate cancer, Protein, Pseudomonadota, Pyramidal cell, Riboflavin, Schizophrenia, Selective serotonin reuptake inhibitor, Seminal vesicles, Serenoa, Sex hormone, Sexual dysfunction, Skin, Sleep deprivation, Small interfering RNA, SRD5A1, SRD5A2, SRD5A3, Steroidogenesis inhibitor, Steroidogenic enzyme, Substrate (chemistry), Suicidal ideation, Testosterone, Tetrahydrodeoxycorticosterone, Trans woman, Zinc, 11β-Hydroxysteroid dehydrogenase type 1, 17β-Hydroxysteroid dehydrogenase, 3α-Dihydroprogesterone, 3α-Hydroxysteroid dehydrogenase, 3β-Dihydroprogesterone, 3β-Hydroxysteroid dehydrogenase, 5α-Dihydroaldosterone, 5α-Dihydrocorticosterone, 5α-Dihydronandrolone, 5α-Dihydroprogesterone, 5α-Reductase 2 deficiency, 5α-Reductase inhibitor.