Alirocumab, the Glossary
Alirocumab, sold under the brand name Praluent, is a medication used as a second-line treatment for high cholesterol for adults whose cholesterol is not controlled by diet and statin treatment.[1]
Table of Contents
46 relations: Amgen, Apheresis, Atherosclerosis, Biological target, BioMarin Pharmaceutical, Biopharmaceutical, Cardiovascular disease, Chinese hamster ovary cell, Clinical trial, CVS Caremark, Disulfide, Drug discovery, European Medicines Agency, Express Scripts, Familial hypercholesterolemia, Fetus, Food and Drug Administration, Forbes, Health Canada, Hypercholesterolemia, Immunoglobulin heavy chain, Immunoglobulin light chain, Indication (medicine), Industrial fermentation, Injection site reaction, Injunction, International nonproprietary name, Investigational New Drug, Kidney dialysis, LDL receptor, Low-density lipoprotein, Medication, Monoclonal antibody, Patent infringement under United States law, PCSK9, Pharmacy benefit management, Placebo, Priority review, Proteolysis, Recombinant DNA, Regeneron Pharmaceuticals, Sanofi, Statin, Subcutaneous administration, The New England Journal of Medicine, Therapy.
- PCSK9 inhibitors
Amgen
Amgen Inc. (formerly Applied Molecular Genetics Inc.) is an American multinational biopharmaceutical company headquartered in Thousand Oaks, California.
Apheresis
Apheresis (ἀφαίρεσις (aphairesis, "a taking away")) is a medical technology in which the blood of a person is passed through an apparatus that separates out one particular constituent and returns the remainder to the circulation.
Atherosclerosis
Atherosclerosis is a pattern of the disease arteriosclerosis, characterized by development of abnormalities called lesions in walls of arteries.
See Alirocumab and Atherosclerosis
Biological target
A biological target is anything within a living organism to which some other entity (like an endogenous ligand or a drug) is directed and/or binds, resulting in a change in its behavior or function.
See Alirocumab and Biological target
BioMarin Pharmaceutical
BioMarin Pharmaceutical Inc. is an American biotechnology company headquartered in San Rafael, California.
See Alirocumab and BioMarin Pharmaceutical
Biopharmaceutical
A biopharmaceutical, also known as a biological medical product, or biologic, is any pharmaceutical drug product manufactured in, extracted from, or semisynthesized from biological sources.
See Alirocumab and Biopharmaceutical
Cardiovascular disease
Cardiovascular disease (CVD) is any disease involving the heart or blood vessels.
See Alirocumab and Cardiovascular disease
Chinese hamster ovary cell
Chinese hamster ovary (CHO) cells are a family of immortalized cell lines derived from epithelial cells of the ovary of the Chinese hamster, often used in biological and medical research and commercially in the production of recombinant therapeutic proteins.
See Alirocumab and Chinese hamster ovary cell
Clinical trial
Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison.
See Alirocumab and Clinical trial
CVS Caremark (formerly Caremark Rx) (stylized as, previously CVS/caremark) is the pharmacy benefit management subsidiary of CVS Health, headquartered in Woonsocket, Rhode Island.
See Alirocumab and CVS Caremark
Disulfide
In chemistry, a disulfide (or disulphide in British English) is a compound containing a functional group or the anion.
Drug discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered.
See Alirocumab and Drug discovery
European Medicines Agency
The European Medicines Agency (EMA) is an agency of the European Union (EU) in charge of the evaluation and supervision of pharmaceutical products.
See Alirocumab and European Medicines Agency
Express Scripts
Express Scripts Holding Company is a pharmacy benefit management (PBM) organization.
See Alirocumab and Express Scripts
Familial hypercholesterolemia
Familial hypercholesterolemia (FH) is a genetic disorder characterized by high cholesterol levels, specifically very high levels of low-density lipoprotein cholesterol (LDL cholesterol), in the blood and early cardiovascular diseases.
See Alirocumab and Familial hypercholesterolemia
Fetus
A fetus or foetus (fetuses, foetuses, rarely feti or foeti) is the unborn offspring that develops from a mammal embryo.
Food and Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services.
See Alirocumab and Food and Drug Administration
Forbes
Forbes is an American business magazine founded by B. C. Forbes in 1917 and owned by Hong Kong-based investment group Integrated Whale Media Investments since 2014.
Health Canada
Health Canada (HC; Santé Canada, SC)Health Canada is the applied title under the Federal Identity Program; the legal title is Department of Health.
See Alirocumab and Health Canada
Hypercholesterolemia
Hypercholesterolemia, also called high cholesterol, is the presence of high levels of cholesterol in the blood.
See Alirocumab and Hypercholesterolemia
Immunoglobulin heavy chain
The immunoglobulin heavy chain (IgH) is the large polypeptide subunit of an antibody (immunoglobulin).
See Alirocumab and Immunoglobulin heavy chain
Immunoglobulin light chain
The immunoglobulin light chain is the small polypeptide subunit of an antibody (immunoglobulin).
See Alirocumab and Immunoglobulin light chain
Indication (medicine)
In medicine, an indication is a valid reason to use a certain test, medication, procedure, or surgery.
See Alirocumab and Indication (medicine)
Industrial fermentation
Industrial fermentation is the intentional use of fermentation in manufacturing processes.
See Alirocumab and Industrial fermentation
Injection site reaction
Injection site reactions (ISRs) are reactions that occur at the site of injection of a drug.
See Alirocumab and Injection site reaction
Injunction
An injunction is an equitable remedy in the form of a special court order that compels a party to do or refrain from specific acts.
International nonproprietary name
An international nonproprietary name (INN) is an official generic and nonproprietary name given to a pharmaceutical drug or an active ingredient.
See Alirocumab and International nonproprietary name
Investigational New Drug
The United States Food and Drug Administration's Investigational New Drug (IND) program is the means by which a pharmaceutical company obtains permission to start human clinical trials and to ship an experimental drug across state lines (usually to clinical investigators) before a marketing application for the drug has been approved.
See Alirocumab and Investigational New Drug
Kidney dialysis
Kidney dialysis (from Greek,, 'dissolution'; from,, 'through', and,, 'loosening or splitting') is the process of removing excess water, solutes, and toxins from the blood in people whose kidneys can no longer perform these functions naturally.
See Alirocumab and Kidney dialysis
LDL receptor
The low-density lipoprotein receptor (LDL-R) is a mosaic protein of 839 amino acids (after removal of 21-amino acid signal peptide) that mediates the endocytosis of cholesterol-rich low-density lipoprotein (LDL).
See Alirocumab and LDL receptor
Low-density lipoprotein
Low-density lipoprotein (LDL) is one of the five major groups of lipoprotein that transport all fat molecules around the body in extracellular water.
See Alirocumab and Low-density lipoprotein
Medication
A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease.
Monoclonal antibody
A monoclonal antibody (mAb, more rarely called moAb) is an antibody produced from a cell lineage made by cloning a unique white blood cell. Alirocumab and monoclonal antibody are monoclonal antibodies.
See Alirocumab and Monoclonal antibody
Patent infringement under United States law
In the United States, a valid patent provides its proprietor with the right to exclude others from practicing the invention claimed in that patent.
See Alirocumab and Patent infringement under United States law
PCSK9
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene in humans on chromosome 1.
Pharmacy benefit management
In the United States, a pharmacy benefit manager (PBM) is a third-party administrator of prescription drug programs for commercial health plans, self-insured employer plans, Medicare Part D plans, the Federal Employees Health Benefits Program, and state government employee plans.
See Alirocumab and Pharmacy benefit management
Placebo
A placebo is a substance or treatment which is designed to have no therapeutic value.
Priority review
Priority review is a program of the United States Food and Drug Administration (FDA) to expedite the review process for drugs that are expected to have a particularly great impact on the treatment of a disease.
See Alirocumab and Priority review
Proteolysis
Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids.
See Alirocumab and Proteolysis
Recombinant DNA
Recombinant DNA (rDNA) molecules are DNA molecules formed by laboratory methods of genetic recombination (such as molecular cloning) that bring together genetic material from multiple sources, creating sequences that would not otherwise be found in the genome.
See Alirocumab and Recombinant DNA
Regeneron Pharmaceuticals
Regeneron Pharmaceuticals, Inc. is an American biotechnology company headquartered in Westchester County, New York.
See Alirocumab and Regeneron Pharmaceuticals
Sanofi
Sanofi S.A. is a French multinational pharmaceutical and healthcare company headquartered in Paris, France.
Statin
Statins (or HMG-CoA reductase inhibitors) are a class of medications that reduce illness and mortality in people who are at high risk of cardiovascular disease.
Subcutaneous administration
Subcutaneous administration is the insertion of medications beneath the skin either by injection or infusion.
See Alirocumab and Subcutaneous administration
The New England Journal of Medicine
The New England Journal of Medicine (NEJM) is a weekly medical journal published by the Massachusetts Medical Society.
See Alirocumab and The New England Journal of Medicine
Therapy
A therapy or medical treatment is the attempted remediation of a health problem, usually following a medical diagnosis.
See also
PCSK9 inhibitors
References
[1] https://en.wikipedia.org/wiki/Alirocumab
Also known as C6472H9996N1736O2032S42, Praluent, REGN727, SAR236553.