Asfotase alfa, the Glossary

Table of Contents

1. 31 relations: Active site, Alexion Pharmaceuticals, Alkaline phosphatase, ALPL, Amino acid, Aspartic acid, Bioavailability, Biological half-life, Biomineralization, Breakthrough therapy, Chinese hamster ovary cell, Cytochrome P450, Disulfide, Enzyme replacement therapy, Erythema, European Medicines Agency, European Union, Food and Drug Administration, Fragment crystallizable region, Glycoprotein, Health Canada, Hematoma, Hypophosphatasia, Immunoglobulin G, Indication (medicine), Orphan drug, Peptide, Prenatal development, Protein production, Small molecule, Subcutaneous administration.

Active site

In biology and biochemistry, the active site is the region of an enzyme where substrate molecules bind and undergo a chemical reaction.

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Alexion Pharmaceuticals

Alexion Pharmaceuticals, a subsidiary of AstraZeneca, is a pharmaceutical company headquartered in Boston, Massachusetts that specializes in orphan drugs to treat rare diseases.

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Alkaline phosphatase

The enzyme alkaline phosphatase (ALP, alkaline phenyl phosphatase) is a phosphatase with the physiological role of dephosphorylating compounds.

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ALPL

Alkaline phosphatase, tissue-nonspecific isozyme is an enzyme that in humans is encoded by the ALPL gene.

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Amino acid

Amino acids are organic compounds that contain both amino and carboxylic acid functional groups.

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Aspartic acid

Aspartic acid (symbol Asp or D; the ionic form is known as aspartate), is an α-amino acid that is used in the biosynthesis of proteins.

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Bioavailability

In pharmacology, bioavailability is a subcategory of absorption and is the fraction (%) of an administered drug that reaches the systemic circulation.

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Biological half-life

Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (Cmax) to half of Cmax in the blood plasma.

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Biomineralization

Biomineralization, also written biomineralisation, is the process by which living organisms produce minerals, often resulting in hardened or stiffened mineralized tissues.

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Breakthrough therapy

Breakthrough therapy is a United States Food and Drug Administration designation that expedites drug development that was created by Congress under Section 902 of the 9 July 2012 Food and Drug Administration Safety and Innovation Act.

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Chinese hamster ovary cell

Chinese hamster ovary (CHO) cells are a family of immortalized cell lines derived from epithelial cells of the ovary of the Chinese hamster, often used in biological and medical research and commercially in the production of recombinant therapeutic proteins.

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Cytochrome P450

Cytochromes P450 (P450s or CYPs) are a superfamily of enzymes containing heme as a cofactor that mostly, but not exclusively, function as monooxygenases.

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Disulfide

In chemistry, a disulfide (or disulphide in British English) is a compound containing a functional group or the anion.

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Enzyme replacement therapy

Enzyme replacement therapy (ERT) is a medical treatment which replaces an enzyme that is deficient or absent in the body.

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Erythema

Erythema is redness of the skin or mucous membranes, caused by hyperemia (increased blood flow) in superficial capillaries.

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European Medicines Agency

The European Medicines Agency (EMA) is an agency of the European Union (EU) in charge of the evaluation and supervision of pharmaceutical products.

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European Union

The European Union (EU) is a supranational political and economic union of member states that are located primarily in Europe.

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Food and Drug Administration

The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services.

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Fragment crystallizable region

The fragment crystallizable region (Fc region) is the tail region of an antibody that interacts with cell surface receptors called Fc receptors and some proteins of the complement system.

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Glycoprotein

Glycoproteins are proteins which contain oligosaccharide (sugar) chains covalently attached to amino acid side-chains.

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Health Canada

Health Canada (HC; Santé Canada, SC)Health Canada is the applied title under the Federal Identity Program; the legal title is Department of Health.

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Hematoma

A hematoma, also spelled haematoma, or blood suffusion is a localized bleeding outside of blood vessels, due to either disease or trauma including injury or surgery and may involve blood continuing to seep from broken capillaries.

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Hypophosphatasia

Hypophosphatasia (also called deficiency of alkaline phosphatase, phosphoethanolaminuria, or Rathbun's syndrome; sometimes abbreviated HPP) is a rare, and sometimes fatal, inherited metabolic bone disease.

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Immunoglobulin G

Immunoglobulin G (IgG) is a type of antibody.

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Indication (medicine)

In medicine, an indication is a valid reason to use a certain test, medication, procedure, or surgery.

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Orphan drug

An orphan drug is a pharmaceutical agent that is developed to treat certain rare medical conditions. Asfotase alfa and orphan drug are orphan drugs.

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Peptide

Peptides are short chains of amino acids linked by peptide bonds.

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Prenatal development

Prenatal development involves the development of the embryo and of the fetus during a viviparous animal's gestation.

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Protein production

Protein production is the biotechnological process of generating a specific protein.

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Small molecule

In molecular biology and pharmacology, a small molecule or micromolecule is a low molecular weight (≤ 1000 daltons) organic compound that may regulate a biological process, with a size on the order of 1 nm.

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Subcutaneous administration

Subcutaneous administration is the insertion of medications beneath the skin either by injection or infusion.

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References

[1] https://en.wikipedia.org/wiki/Asfotase_alfa

Also known as Strensiq.