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BRCA1, the Glossary

Breast cancer type 1 susceptibility protein is a protein that in humans is encoded by the BRCA1 gene.^[1]

164 relations: ABL (gene), Acetaldehyde, AKT1, Allele, Alpha helix, Androgen receptor, Apoptosis, Ashkenazi Jews, Association for Molecular Pathology v. Myriad Genetics, Inc., Ataxia telangiectasia and Rad3 related, ATF1, ATM serine/threonine kinase, BACH1, BARD1, Base pair, Beta sheet, Biological patent, BRCA mutation, BRCA1, BRCA2, BRCC3, BRCT domain, BRE (gene), Breast, Breast cancer, Breast cancer classification, BRIP1, C-terminus, Cancer, Caretaker gene, Cell cycle, CHEK2, Chelation, Chromosome, Chromosome 17, CLSPN, Cofactor of BRCA1, Comparative genomic hybridization, CREB-binding protein, CSNK2B, CSTF2, Cyclin-dependent kinase 2, Cysteine, DNA, DNA damage (naturally occurring), DNA methylation, DNA mismatch repair, DNA repair, DNA replication, Double-strand break repair model, ... Expand index (114 more) »
Tumor markers
Tumor suppressor genes

ABL (gene)

Tyrosine-protein kinase ABL1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene (previous symbol ABL) located on chromosome 9.

See BRCA1 and ABL (gene)

Acetaldehyde

Acetaldehyde (IUPAC systematic name ethanal) is an organic chemical compound with the formula CH3 CHO, sometimes abbreviated as MeCHO.

See BRCA1 and Acetaldehyde

AKT1

RAC(Rho family)-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene.

See BRCA1 and AKT1

Allele

An allele, or allelomorph, is a variant of the sequence of nucleotides at a particular location, or locus, on a DNA molecule.

See BRCA1 and Allele

Alpha helix

An alpha helix (or α-helix) is a sequence of amino acids in a protein that are twisted into a coil (a helix).

See BRCA1 and Alpha helix

The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone, in the cytoplasm and then translocating into the nucleus.

See BRCA1 and Androgen receptor

Apoptosis

Apoptosis (from falling off) is a form of programmed cell death that occurs in multicellular organisms and in some eukaryotic, single-celled microorganisms such as yeast.

See BRCA1 and Apoptosis

Ashkenazi Jews

Ashkenazi Jews (translit,; Ashkenazishe Yidn), also known as Ashkenazic Jews or Ashkenazim, constitute a Jewish diaspora population that emerged in the Holy Roman Empire around the end of the first millennium CE. They traditionally spoke Yiddish and largely migrated towards northern and eastern Europe during the late Middle Ages due to persecution.

See BRCA1 and Ashkenazi Jews

Association for Molecular Pathology v. Myriad Genetics, Inc.

Association for Molecular Pathology v. Myriad Genetics, Inc., 569 U.S. 576 (2013), was a Supreme Court case, which decided that "a naturally occurring DNA segment is a product of nature and not patent eligible merely because it has been isolated.” However, as a "bizarre conciliatory prize" the Court allowed patenting of complementary DNA, which contains exactly the same protein-coding base pair sequence as the natural DNA, albeit with introns removed.

See BRCA1 and Association for Molecular Pathology v. Myriad Genetics, Inc.

Serine/threonine-protein kinase ATR, also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein 1 (FRP1), is an enzyme that, in humans, is encoded by the ATR gene.

See BRCA1 and Ataxia telangiectasia and Rad3 related

ATF1

Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.

See BRCA1 and ATF1

ATM serine/threonine kinase

ATM serine/threonine kinase or Ataxia-telangiectasia mutated, symbol ATM, is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks (canonical pathway), oxidative stress, topoisomerase cleavage complexes, splicing intermediates, R-loops and in some cases by single-strand DNA breaks.

See BRCA1 and ATM serine/threonine kinase

BACH1

Transcription regulator protein BACH1 is a protein that in humans is encoded by the BACH1 gene.

See BRCA1 and BACH1

BARD1

BRCA1-associated RING domain protein 1 is a protein that in humans is encoded by the BARD1 gene.

See BRCA1 and BARD1

Base pair

A base pair (bp) is a fundamental unit of double-stranded nucleic acids consisting of two nucleobases bound to each other by hydrogen bonds.

See BRCA1 and Base pair

Beta sheet

The beta sheet (β-sheet, also β-pleated sheet) is a common motif of the regular protein secondary structure.

See BRCA1 and Beta sheet

Biological patent

A biological patent is a patent on an invention in the field of biology that by law allows the patent holder to exclude others from making, using, selling, or importing the protected invention for a limited period of time.

See BRCA1 and Biological patent

BRCA mutation

A BRCA mutation is a mutation in either of the BRCA1 and BRCA2 genes, which are tumour suppressor genes. BRCA1 and BRCA mutation are breast cancer.

See BRCA1 and BRCA mutation

BRCA1

Breast cancer type 1 susceptibility protein is a protein that in humans is encoded by the BRCA1 gene. BRCA1 and BRCA1 are breast cancer, DNA repair, genes on human chromosome 17, tumor markers and tumor suppressor genes.

See BRCA1 and BRCA1

BRCA2

BRCA2 and BRCA2 are human genes and their protein products, respectively. BRCA1 and BRCA2 are breast cancer, DNA repair, tumor markers and tumor suppressor genes.

See BRCA1 and BRCA2

BRCC3

Lys-63-specific deubiquitinase BRCC36 is an enzyme that in humans is encoded by the BRCC3 gene.

See BRCA1 and BRCC3

BRCT domain

BRCA1 C Terminus (BRCT) domain is a family of evolutionarily related proteins.

See BRCA1 and BRCT domain

BRE (gene)

BRCA1-A complex subunit BRE is a protein that in humans is encoded by the BRE gene.

See BRCA1 and BRE (gene)

Breast

The breast is one of two prominences located on the upper ventral region of the torso among humans and other primates.

See BRCA1 and Breast

Breast cancer

Breast cancer is a cancer that develops from breast tissue.

See BRCA1 and Breast cancer

Breast cancer classification

Breast cancer classification divides breast cancer into categories according to different schemes criteria and serving a different purpose. BRCA1 and breast cancer classification are breast cancer.

See BRCA1 and Breast cancer classification

BRIP1

Fanconi anemia group J protein is a protein that in humans is encoded by the BRCA1-interacting protein 1 (BRIP1) gene. BRCA1 and BRIP1 are genes on human chromosome 17.

See BRCA1 and BRIP1

C-terminus

The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, carboxy tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).

See BRCA1 and C-terminus

Cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

See BRCA1 and Cancer

Caretaker gene

Caretaker genes encode products that stabilize the genome.

See BRCA1 and Caretaker gene

Cell cycle

The cell cycle, or cell-division cycle, is the sequential series of events that take place in a cell that causes it to divide into two daughter cells.

See BRCA1 and Cell cycle

CHEK2

CHEK2 (Checkpoint kinase 2) is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase. BRCA1 and CHEK2 are tumor suppressor genes.

See BRCA1 and CHEK2

Chelation

Chelation is a type of bonding of ions and the molecules to metal ions.

See BRCA1 and Chelation

Chromosome

A chromosome is a package of DNA with part or all of the genetic material of an organism.

See BRCA1 and Chromosome

Chromosome 17

Chromosome 17 is one of the 23 pairs of chromosomes in humans. BRCA1 and chromosome 17 are genes on human chromosome 17.

See BRCA1 and Chromosome 17

CLSPN

Claspin is a protein that in humans is encoded by the CLSPN gene.

See BRCA1 and CLSPN

Cofactor of BRCA1

Cofactor of BRCA1, also known as COBRA1, is a human gene that encodes NELF-B.

See BRCA1 and Cofactor of BRCA1

Comparative genomic hybridization

Comparative genomic hybridization (CGH) is a molecular cytogenetic method for analysing copy number variations (CNVs) relative to ploidy level in the DNA of a test sample compared to a reference sample, without the need for culturing cells.

See BRCA1 and Comparative genomic hybridization

CREB-binding protein

CREB-binding protein, also known as CREBBP or CBP or KAT3A, (where CREB is cAMP response element-binding protein) is a coactivator encoded by the CREBBP gene in humans, located on chromosome 16p13.3.

See BRCA1 and CREB-binding protein

CSNK2B

Casein kinase II subunit beta is a protein that in humans is encoded by the CSNK2B gene.

See BRCA1 and CSNK2B

CSTF2

Cleavage stimulation factor 64 kDa subunit is a protein that in humans is encoded by the CSTF2 gene.

See BRCA1 and CSTF2

Cyclin-dependent kinase 2

Cyclin-dependent kinase 2, also known as cell division protein kinase 2, or Cdk2, is an enzyme that in humans is encoded by the CDK2 gene.

See BRCA1 and Cyclin-dependent kinase 2

Cysteine

Cysteine (symbol Cys or C) is a semiessential proteinogenic amino acid with the formula.

See BRCA1 and Cysteine

DNA

Deoxyribonucleic acid (DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix.

See BRCA1 and DNA

DNA damage (naturally occurring)

DNA damage is an alteration in the chemical structure of DNA, such as a break in a strand of DNA, a nucleobase missing from the backbone of DNA, or a chemically changed base such as 8-OHdG. BRCA1 and DNA damage (naturally occurring) are DNA repair.

See BRCA1 and DNA damage (naturally occurring)

DNA methylation

DNA methylation is a biological process by which methyl groups are added to the DNA molecule.

See BRCA1 and DNA methylation

DNA mismatch repair

DNA mismatch repair (MMR) is a system for recognizing and repairing erroneous insertion, deletion, and mis-incorporation of bases that can arise during DNA replication and recombination, as well as repairing some forms of DNA damage. BRCA1 and DNA mismatch repair are DNA repair.

See BRCA1 and DNA mismatch repair

DNA repair

DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome.

See BRCA1 and DNA repair

DNA replication

In molecular biology, DNA replication is the biological process of producing two identical replicas of DNA from one original DNA molecule.

See BRCA1 and DNA replication

Double-strand break repair model

A double-strand break repair model refers to the various models of pathways that cells undertake to repair double strand-breaks (DSB). BRCA1 and double-strand break repair model are DNA repair.

See BRCA1 and Double-strand break repair model

Dysplasia

Dysplasia is any of various types of abnormal growth or development of cells (microscopic scale) or organs (macroscopic scale), and the abnormal histology or anatomical structure(s) resulting from such growth.

See BRCA1 and Dysplasia

ELK4

ETS domain-containing protein Elk-4 is a protein that in humans is encoded by the ELK4 gene.

See BRCA1 and ELK4

EP300

Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 (where E1A.

See BRCA1 and EP300

Epigenetics

In biology, epigenetics is the study of heritable traits, or a stable change of cell function, that happen without changes to the DNA sequence.

See BRCA1 and Epigenetics

Estrogen receptor alpha

Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor (mainly found as a chromatin-binding protein) that is activated by the sex hormone estrogen.

See BRCA1 and Estrogen receptor alpha

Fallopian tube

The fallopian tubes, also known as uterine tubes, oviducts or salpinges (salpinx), are paired tubes in the human female body that stretch from the ovaries to the uterus.

See BRCA1 and Fallopian tube

FANCA

Fanconi anaemia, complementation group A, also known as FAA, FACA and FANCA, is a protein which in humans is encoded by the FANCA gene.

See BRCA1 and FANCA

FANCD2

Fanconi anemia group D2 protein is a protein that in humans is encoded by the FANCD2 gene.

See BRCA1 and FANCD2

Fanconi anemia

Fanconi anemia (FA) is a rare, autosomal recessive, genetic disease resulting in impaired response to DNA damage in the FA/BRCA pathway.

See BRCA1 and Fanconi anemia

Federal Court of Australia

The Federal Court of Australia is an Australian superior court which has jurisdiction to deal with most civil disputes governed by federal law (with the exception of family law matters), along with some summary (less serious) and indictable (more serious) criminal matters.

See BRCA1 and Federal Court of Australia

FHL2

Four and a half LIM domains protein 2 also known as FHL-2 is a protein that in humans is encoded by the FHL2 gene.

See BRCA1 and FHL2

Formaldehyde

Formaldehyde (systematic name methanal) is an organic compound with the chemical formula and structure, more precisely.

See BRCA1 and Formaldehyde

Gene

In biology, the word gene has two meanings.

See BRCA1 and Gene

Genetic testing

Genetic testing, also known as DNA testing, is used to identify changes in DNA sequence or chromosome structure.

See BRCA1 and Genetic testing

Genome

In the fields of molecular biology and genetics, a genome is all the genetic information of an organism.

See BRCA1 and Genome

Germline mutation

A germline mutation, or germinal mutation, is any detectable variation within germ cells (cells that, when fully developed, become sperm and ova).

See BRCA1 and Germline mutation

H2AFX

H2A histone family member X (usually abbreviated as H2AX) is a type of histone protein from the H2A family encoded by the H2AFX gene. BRCA1 and H2AFX are DNA repair.

See BRCA1 and H2AFX

Hereditary breast–ovarian cancer syndrome

Hereditary breast–ovarian cancer syndromes (HBOC) are cancer syndromes that produce higher than normal levels of breast cancer, ovarian cancer and additional cancers in genetically related families (either one individual had both, or several individuals in the pedigree had one or the other disease). BRCA1 and Hereditary breast–ovarian cancer syndrome are breast cancer.

See BRCA1 and Hereditary breast–ovarian cancer syndrome

High Court of Australia

The High Court of Australia is the apex court of the Australian legal system.

See BRCA1 and High Court of Australia

Histidine

Histidine (symbol His or H) is an essential amino acid that is used in the biosynthesis of proteins.

See BRCA1 and Histidine

Histone deacetylase

Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups (O.

See BRCA1 and Histone deacetylase

Homology directed repair

Homology-directed repair (HDR) is a mechanism in cells to repair double-strand DNA lesions. BRCA1 and Homology directed repair are DNA repair.

See BRCA1 and Homology directed repair

In vitro

In vitro (meaning in glass, or in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context.

See BRCA1 and In vitro

In vivo

Studies that are in vivo (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism.

See BRCA1 and In vivo

Invasive lobular carcinoma

Invasive lobular carcinoma (ILC) is breast cancer arising from the lobules of the mammary glands. BRCA1 and Invasive lobular carcinoma are breast cancer.

See BRCA1 and Invasive lobular carcinoma

Invertebrate

Invertebrates is an umbrella term describing animals that neither develop nor retain a vertebral column (commonly known as a spine or backbone), which evolved from the notochord.

See BRCA1 and Invertebrate

Ionizing radiation

Ionizing radiation (US, ionising radiation in the UK), including nuclear radiation, consists of subatomic particles or electromagnetic waves that have sufficient energy to ionize atoms or molecules by detaching electrons from them.

See BRCA1 and Ionizing radiation

JUNB

Transcription factor jun-B is a protein that, in humans, is encoded by the JUNB gene.

See BRCA1 and JUNB

JunD

Transcription factor JunD is a protein that in humans is encoded by the JUND gene.

See BRCA1 and JunD

LMO4

LIM domain transcription factor LMO4 is a protein that in humans is encoded by the LMO4 gene.

See BRCA1 and LMO4

MAP3K3

Mitogen-activated protein kinase kinase kinase 3 is an enzyme that in humans is encoded by the MAP3K3 gene, which is located on the long arm of chromosome 17 (17q23.3). BRCA1 and MAP3K3 are genes on human chromosome 17.

See BRCA1 and MAP3K3

Mary-Claire King

Mary-Claire King (born February 27, 1946) is an American geneticist.

See BRCA1 and Mary-Claire King

MED17

Mediator of RNA polymerase II transcription subunit 17 is an enzyme that in humans is encoded by the MED17 gene.

See BRCA1 and MED17

MED21

Mediator of RNA polymerase II transcription subunit 21 is an enzyme that in humans is encoded by the MED21 gene.

See BRCA1 and MED21

Meiosis

Meiosis ((since it is a reductional division) is a special type of cell division of germ cells in sexually-reproducing organisms that produces the gametes, the sperm or egg cells. It involves two rounds of division that ultimately result in four cells, each with only one copy of each chromosome (haploid).

See BRCA1 and Meiosis

Methylation

Methylation, in the chemical sciences, is the addition of a methyl group on a substrate, or the substitution of an atom (or group) by a methyl group.

See BRCA1 and Methylation

MicroRNA

MicroRNA (miRNA) are small, single-stranded, non-coding RNA molecules containing 21 to 23 nucleotides.

See BRCA1 and MicroRNA

Mir-17 microRNA precursor family

The miR-17 microRNA precursor family are a group of related small non-coding RNA genes called microRNAs that regulate gene expression.

See BRCA1 and Mir-17 microRNA precursor family

Mir-30 microRNA precursor

miR-30 microRNA precursor is a small non-coding RNA that regulates gene expression.

See BRCA1 and Mir-30 microRNA precursor

MIR146A

MicroRNA 146a is a small non-coding RNA that in humans is encoded by the MIR146A gene.

See BRCA1 and MIR146A

Missense mutation

In genetics, a missense mutation is a point mutation in which a single nucleotide change results in a codon that codes for a different amino acid.

See BRCA1 and Missense mutation

MRE11A

Double-strand break repair protein MRE11 is an enzyme that in humans is encoded by the MRE11 gene.

See BRCA1 and MRE11A

MRN complex

The MRN complex (MRX complex in yeast) is a protein complex consisting of Mre11, Rad50 and Nbs1 (also known as Nibrin in humans and as Xrs2 in yeast).

See BRCA1 and MRN complex

MSH2

DNA mismatch repair protein Msh2 also known as MutS homolog 2 or MSH2 is a protein that in humans is encoded by the MSH2 gene, which is located on chromosome 2. BRCA1 and MSH2 are DNA repair.

See BRCA1 and MSH2

MSH3

DNA mismatch repair protein, MutS Homolog 3 (MSH3) is a human homologue of the bacterial mismatch repair protein MutS that participates in the mismatch repair (MMR) system.

See BRCA1 and MSH3

MSH6

MSH6 or mutS homolog 6 is a gene that codes for DNA mismatch repair protein Msh6 in the budding yeast Saccharomyces cerevisiae.

See BRCA1 and MSH6

Muller's morphs

Hermann J. Muller (1890–1967), who was a 1946 Nobel Prize winner, coined the terms amorph, hypomorph, hypermorph, antimorph and neomorph to classify mutations based on their behaviour in various genetic situations, as well as gene interaction between themselves.

See BRCA1 and Muller's morphs

Multiplex ligation-dependent probe amplification

Multiplex ligation-dependent probe amplification (MLPA) is a variation of the multiplex polymerase chain reaction that permits amplification of multiple targets with only a single primer pair.

See BRCA1 and Multiplex ligation-dependent probe amplification

Mutation

In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA.

See BRCA1 and Mutation

Myc

Myc is a family of regulator genes and proto-oncogenes that code for transcription factors.

See BRCA1 and Myc

Myriad Genetics

Myriad Genetics, Inc. is an American genetic testing and precision medicine company based in Salt Lake City, Utah, United States.

See BRCA1 and Myriad Genetics

N-myc-interactor

N-myc-interactor also known as N-myc and STAT interactor is a protein that in humans is encoded by the NMI gene.

See BRCA1 and N-myc-interactor

Negative elongation factor

In molecular biology, the NELF (negative elongation factor) is a four-subunit protein complex (NELF-A, NELF-B, NELF-C/NELF-D, and NELF-E) that negatively impacts transcription by RNA polymerase II (Pol II) by pausing about 20-60 nucleotides downstream from the transcription start site (TSS).

See BRCA1 and Negative elongation factor

Nibrin

Nibrin, also known as NBN or NBS1, is a protein which in humans is encoded by the NBN gene.

See BRCA1 and Nibrin

Non-homologous end joining

Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. BRCA1 and Non-homologous end joining are DNA repair.

See BRCA1 and Non-homologous end joining

NPM1

Nucleophosmin (NPM), also known as nucleolar phosphoprotein B23 or numatrin, is a protein that in humans is encoded by the NPM1 gene.

See BRCA1 and NPM1

Nuclear export signal

A nuclear export signal (NES) is a short target peptide containing 4 hydrophobic residues in a protein that targets it for export from the cell nucleus to the cytoplasm through the nuclear pore complex using nuclear transport.

See BRCA1 and Nuclear export signal

Nuclear localization sequence

A nuclear localization signal or sequence (NLS) is an amino acid sequence that 'tags' a protein for import into the cell nucleus by nuclear transport.

See BRCA1 and Nuclear localization sequence

Nuclear receptor coactivator 2

The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene.

See BRCA1 and Nuclear receptor coactivator 2

NUFIP1

Nuclear fragile X mental retardation-interacting protein 1 is a protein that in humans is encoded by the NUFIP1 gene.

See BRCA1 and NUFIP1

Ovarian cancer

Ovarian cancer is a cancerous tumor of an ovary.

See BRCA1 and Ovarian cancer

P53

p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. BRCA1 and p53 are genes on human chromosome 17 and tumor suppressor genes.

See BRCA1 and P53

PALB2

Partner and localizer of BRCA2, also known as PALB2 or FANCN, is a protein which in humans is encoded by the PALB2 gene.

See BRCA1 and PALB2

Penetrance

Penetrance in genetics is the proportion of individuals carrying a particular variant (or allele) of a gene (genotype) that also expresses an associated trait (phenotype).

See BRCA1 and Penetrance

POLR2A

DNA-directed RNA polymerase II subunit RPB1, also known as RPB1, is an enzyme that is encoded by the POLR2A gene in humans. BRCA1 and POLR2A are genes on human chromosome 17.

See BRCA1 and POLR2A

Poly (ADP-ribose) polymerase

Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed cell death. BRCA1 and poly (ADP-ribose) polymerase are DNA repair.

See BRCA1 and Poly (ADP-ribose) polymerase

PPP1CA

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit is an enzyme that in humans is encoded by the PPP1CA gene.

See BRCA1 and PPP1CA

Progesterone receptor

The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells.

See BRCA1 and Progesterone receptor

In genetics, a promoter is a sequence of DNA to which proteins bind to initiate transcription of a single RNA transcript from the DNA downstream of the promoter.

See BRCA1 and Promoter (genetics)

Prophylactic surgery

Prophylactic surgery (also known as preventive surgery or risk-reducing surgery), is a form of surgery whose purpose is to minimize or prevent the risk of developing cancer in an organ or gland that has yet to develop cancer and is known to be at high risk of developing cancer.

See BRCA1 and Prophylactic surgery

Prostate cancer

Prostate cancer is the uncontrolled growth of cells in the prostate, a gland in the male reproductive system below the bladder.

See BRCA1 and Prostate cancer

Protein

Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues.

See BRCA1 and Protein

Protein dimer

In biochemistry, a protein dimer is a macromolecular complex or multimer formed by two protein monomers, or single proteins, which are usually non-covalently bound.

See BRCA1 and Protein dimer

Protein–protein interaction

Protein–protein interactions (PPIs) are physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by interactions that include electrostatic forces, hydrogen bonding and the hydrophobic effect.

See BRCA1 and Protein–protein interaction

Rad50

DNA repair protein RAD50, also known as RAD50, is a protein that in humans is encoded by the RAD50 gene.

See BRCA1 and Rad50

RAD51

DNA repair protein RAD51 homolog 1 is a protein encoded by the gene RAD51. BRCA1 and RAD51 are DNA repair.

See BRCA1 and RAD51

RBBP4

Histone-binding protein RBBP4 (also known as RbAp48, or NURF55) is a protein that in humans is encoded by the RBBP4 gene.

See BRCA1 and RBBP4

RBBP7

Histone-binding protein RBBP7 is a protein that in humans is encoded by the RBBP7 gene.

See BRCA1 and RBBP7

RBBP8

Retinoblastoma-binding protein 8 is a protein that in humans is encoded by the RBBP8 gene.

See BRCA1 and RBBP8

Real-time polymerase chain reaction

A real-time polymerase chain reaction (real-time PCR, or qPCR when used quantitatively) is a laboratory technique of molecular biology based on the polymerase chain reaction (PCR).

See BRCA1 and Real-time polymerase chain reaction

RELA

Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene.

See BRCA1 and RELA

Retinoblastoma protein

The retinoblastoma protein (protein name abbreviated Rb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. BRCA1 and retinoblastoma protein are tumor suppressor genes.

See BRCA1 and Retinoblastoma protein

Retinoblastoma-like protein 1

Retinoblastoma-like 1 (p107), also known as RBL1, is a protein that in humans is encoded by the RBL1 gene.

See BRCA1 and Retinoblastoma-like protein 1

Retinoblastoma-like protein 2

Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene.

See BRCA1 and Retinoblastoma-like protein 2

RING finger domain

In molecular biology, a RING (short for Really Interesting New Gene) finger domain is a protein structural domain of zinc finger type which contains a C3HC4 amino acid motif which binds two zinc cations (seven cysteines and one histidine arranged non-consecutively).

See BRCA1 and RING finger domain

RNA Helicase A

ATP-dependent RNA helicase A (RHA; also known as DHX9, LKP, and NDHI) is an enzyme that in humans is encoded by the DHX9 gene.

See BRCA1 and RNA Helicase A

RNA polymerase II

RNA polymerase II (RNAP II and Pol II) is a multiprotein complex that transcribes DNA into precursors of messenger RNA (mRNA) and most small nuclear RNA (snRNA) and microRNA.

See BRCA1 and RNA polymerase II

Sequence homology

Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life.

See BRCA1 and Sequence homology

Signal transduction

Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events.

See BRCA1 and Signal transduction

Sister chromatids

A sister chromatid refers to the identical copies (chromatids) formed by the DNA replication of a chromosome, with both copies joined together by a common centromere.

See BRCA1 and Sister chromatids

SMARCA4

Transcription activator BRG1 also known as ATP-dependent chromatin remodeler SMARCA4 is a protein that in humans is encoded by the SMARCA4 gene.

See BRCA1 and SMARCA4

SMARCB1

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 is a protein that in humans is encoded by the SMARCB1 gene. BRCA1 and SMARCB1 are tumor suppressor genes.

See BRCA1 and SMARCB1

STAT1

Signal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene.

See BRCA1 and STAT1

Supreme Court of the United States

The Supreme Court of the United States (SCOTUS) is the highest court in the federal judiciary of the United States.

See BRCA1 and Supreme Court of the United States

Tandem repeat

In genetics, tandem repeats occur in DNA when a pattern of one or more nucleotides is repeated and the repetitions are directly adjacent to each other, e.g. ATTCG ATTCG ATTCG, in which the sequence ATTCG is repeated three times.

See BRCA1 and Tandem repeat

The Guardian

The Guardian is a British daily newspaper.

See BRCA1 and The Guardian

The New York Times

The New York Times (NYT) is an American daily newspaper based in New York City.

See BRCA1 and The New York Times

The Sydney Morning Herald

The Sydney Morning Herald (SMH) is a daily tabloid newspaper published in Sydney, Australia, and owned by Nine.

See BRCA1 and The Sydney Morning Herald

Three prime untranslated region

In molecular genetics, the three prime untranslated region (3′-UTR) is the section of messenger RNA (mRNA) that immediately follows the translation termination codon.

See BRCA1 and Three prime untranslated region

TOPBP1

DNA topoisomerase 2-binding protein 1 (TOPBP1) is a scaffold protein that in humans is encoded by the TOPBP1 gene.

See BRCA1 and TOPBP1

Transcription factor Jun

Transcription factor Jun is a protein that in humans is encoded by the JUN gene.

See BRCA1 and Transcription factor Jun

Transcriptional regulation

In molecular biology and genetics, transcriptional regulation is the means by which a cell regulates the conversion of DNA to RNA (transcription), thereby orchestrating gene activity.

See BRCA1 and Transcriptional regulation

Triple-negative breast cancer

Triple-negative breast cancer (TNBC) is any breast cancer that either lacks or shows low levels of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) overexpression and/or gene amplification (i.e. the tumor is negative on all three tests giving the name triple-negative). BRCA1 and triple-negative breast cancer are breast cancer.

See BRCA1 and Triple-negative breast cancer

References

[1] https://en.wikipedia.org/wiki/BRCA1

Also known as BRCA gene, BRCA1 (gene), BRCA1 Cancer, BRCA1 mutation, BRCA1 protein, Brca1 gene, Breast cancer 1, Breast cancer gene, Genes, brca1.

, Dysplasia, ELK4, EP300, Epigenetics, Estrogen receptor alpha, Fallopian tube, FANCA, FANCD2, Fanconi anemia, Federal Court of Australia, FHL2, Formaldehyde, Gene, Genetic testing, Genome, Germline mutation, H2AFX, Hereditary breast–ovarian cancer syndrome, High Court of Australia, Histidine, Histone deacetylase, Homology directed repair, In vitro, In vivo, Invasive lobular carcinoma, Invertebrate, Ionizing radiation, JUNB, JunD, LMO4, MAP3K3, Mary-Claire King, MED17, MED21, Meiosis, Methylation, MicroRNA, Mir-17 microRNA precursor family, Mir-30 microRNA precursor, MIR146A, Missense mutation, MRE11A, MRN complex, MSH2, MSH3, MSH6, Muller's morphs, Multiplex ligation-dependent probe amplification, Mutation, Myc, Myriad Genetics, N-myc-interactor, Negative elongation factor, Nibrin, Non-homologous end joining, NPM1, Nuclear export signal, Nuclear localization sequence, Nuclear receptor coactivator 2, NUFIP1, Ovarian cancer, P53, PALB2, Penetrance, POLR2A, Poly (ADP-ribose) polymerase, PPP1CA, Progesterone receptor, Promoter (genetics), Prophylactic surgery, Prostate cancer, Protein, Protein dimer, Protein–protein interaction, Rad50, RAD51, RBBP4, RBBP7, RBBP8, Real-time polymerase chain reaction, RELA, Retinoblastoma protein, Retinoblastoma-like protein 1, Retinoblastoma-like protein 2, RING finger domain, RNA Helicase A, RNA polymerase II, Sequence homology, Signal transduction, Sister chromatids, SMARCA4, SMARCB1, STAT1, Supreme Court of the United States, Tandem repeat, The Guardian, The New York Times, The Sydney Morning Herald, Three prime untranslated region, TOPBP1, Transcription factor Jun, Transcriptional regulation, Triple-negative breast cancer, Tumor suppressor gene, UBE2D1, Ubiquitin, University of California, Berkeley, USF2, Valosin-containing protein, Vertebrate, XIST, Zinc finger, ZNF350, 60S ribosomal protein L31.

BRCA1, the Glossary

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