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CANDLE syndrome, the Glossary

Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome is an autosomal recessive disorder that presents itself via various autoinflammatory responses throughout the body, multiple types of skin lesions, and recurrent long-term fever symptoms.^[1]

43 relations: American Society for Clinical Investigation, Apoptosis, Autoimmune hemolytic anemia, BioMed Central, Contracture, Diabetes, Dominance (genetics), Elsevier, Endocrine Society, European Journal of Pediatrics, Facies (medical), Febrile neutrophilic dermatosis, Fever, Hepatosplenomegaly, Hypertriglyceridemia, Interferon, Interleukin-1 family, Journal of Clinical Investigation, Journal of Dermatology, Journal of the American Academy of Dermatology, Lipodystrophy, Lippincott Williams & Wilkins, Lymphadenopathy, Microdontia, Nail clubbing, Nakajo syndrome, Osteopenia, Oxford University Press, Pericarditis, Phenotype, POMP, Proteasome, PSMA3, PSMB4, PSMB8, PSMB9, Redox, Rheumatology (journal), Skin condition, Springer Science+Business Media, The Journal of Clinical Endocrinology and Metabolism, Tohoku University, Zygosity.
Conditions of the subcutaneous fat
Fever

American Society for Clinical Investigation

The American Society for Clinical Investigation (ASCI), established in 1908, is one of the oldest and most respected medical honor societies in the United States.

See CANDLE syndrome and American Society for Clinical Investigation

Apoptosis

Apoptosis (from falling off) is a form of programmed cell death that occurs in multicellular organisms and in some eukaryotic, single-celled microorganisms such as yeast.

See CANDLE syndrome and Apoptosis

Autoimmune hemolytic anemia

Autoimmune hemolytic anemia (AIHA) is an autoimmune disorder which occurs when antibodies directed against the person's own red blood cells (RBCs) cause them to burst (lyse), leading to an insufficient number of oxygen-carrying red blood cells in circulation (anemia).

See CANDLE syndrome and Autoimmune hemolytic anemia

BioMed Central

BioMed Central (BMC) is a United Kingdom-based, for-profit scientific open access publisher that produces over 250 scientific journals.

See CANDLE syndrome and BioMed Central

Contracture

In pathology, a contracture is a shortening of muscles, tendons, skin, and nearby soft tissues that causes the joints to shorten and become very stiff, preventing normal movement.

See CANDLE syndrome and Contracture

Diabetes

Diabetes mellitus, often known simply as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels.

See CANDLE syndrome and Diabetes

Dominance (genetics)

In genetics, dominance is the phenomenon of one variant (allele) of a gene on a chromosome masking or overriding the effect of a different variant of the same gene on the other copy of the chromosome.

See CANDLE syndrome and Dominance (genetics)

Elsevier

Elsevier is a Dutch academic publishing company specializing in scientific, technical, and medical content.

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Endocrine Society

The Endocrine Society is a professional, international medical organization in the field of endocrinology and metabolism, founded in 1916 as The Association for the Study of Internal Secretions.

See CANDLE syndrome and Endocrine Society

European Journal of Pediatrics

The European Journal of Pediatrics is a monthly peer-reviewed medical journal covering pediatrics.

See CANDLE syndrome and European Journal of Pediatrics

Facies (medical)

In medical contexts, a facies is a distinctive facial expression or appearance associated with a specific medical condition.

See CANDLE syndrome and Facies (medical)

Febrile neutrophilic dermatosis

Sweet syndrome (SS), or acute febrile neutrophilic dermatosis, is a skin disease characterized by the sudden onset of fever, an elevated white blood cell count, and tender, red, well-demarcated papules and plaques that show dense infiltrates by neutrophil granulocytes on histologic examination.

See CANDLE syndrome and Febrile neutrophilic dermatosis

Fever

Fever or pyrexia in humans is a body temperature above the normal range due to an increase in the body's temperature set point in the hypothalamus.

See CANDLE syndrome and Fever

Hepatosplenomegaly

Hepatosplenomegaly (commonly abbreviated HSM) is the simultaneous enlargement of both the liver (hepatomegaly) and the spleen (splenomegaly).

See CANDLE syndrome and Hepatosplenomegaly

Hypertriglyceridemia

Hypertriglyceridemia is the presence of high amounts of triglycerides in the blood.

See CANDLE syndrome and Hypertriglyceridemia

Interferon

Interferons (IFNs) are a group of signaling proteins made and released by host cells in response to the presence of several viruses.

See CANDLE syndrome and Interferon

Interleukin-1 family

The Interleukin-1 family (IL-1 family) is a group of 11 cytokines that plays a central role in the regulation of immune and inflammatory responses to infections or sterile insults.

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Journal of Clinical Investigation

The Journal of Clinical Investigation (JCI) is a twice-monthly peer-reviewed medical journal covering biomedical research.

See CANDLE syndrome and Journal of Clinical Investigation

Journal of Dermatology

The Journal of Dermatology is a peer-reviewed medical journal covering dermatology published by the Japanese Dermatological Association (日本皮膚科学会 Nihon Hifuka Gakkai) and the Asian Dermatological Association.

See CANDLE syndrome and Journal of Dermatology

Journal of the American Academy of Dermatology

The Journal of the American Academy of Dermatology, sometimes abbreviated JAAD, is a monthly peer-reviewed medical journal covering dermatology.

See CANDLE syndrome and Journal of the American Academy of Dermatology

Lipodystrophy

Lipodystrophy syndromes are a group of genetic or acquired disorders in which the body is unable to produce and maintain healthy fat tissue. CANDLE syndrome and Lipodystrophy are conditions of the subcutaneous fat.

See CANDLE syndrome and Lipodystrophy

Lippincott Williams & Wilkins

Lippincott Williams & Wilkins (LWW) is an American imprint of the American Dutch publishing conglomerate Wolters Kluwer.

See CANDLE syndrome and Lippincott Williams & Wilkins

Lymphadenopathy

Lymphadenopathy or adenopathy is a disease of the lymph nodes, in which they are abnormal in size or consistency.

See CANDLE syndrome and Lymphadenopathy

Microdontia

Microdontia is a condition in which one or more teeth appear smaller than normal.

See CANDLE syndrome and Microdontia

Nail clubbing

Nail clubbing, also known as digital clubbing or clubbing, is a deformity of the finger or toe nails associated with a number of diseases, anomalies and defects; some congenital.

See CANDLE syndrome and Nail clubbing

Nakajo syndrome

Nakajo syndrome, also called nodular erythema with digital changes, is a rare autosomal recessive congenital disorder first reported in 1939 by A. Nakajo in the offspring of consanguineous (blood relative) parents. CANDLE syndrome and Nakajo syndrome are autosomal recessive disorders and congenital disorders.

See CANDLE syndrome and Nakajo syndrome

Osteopenia

Osteopenia, known as "low bone mass" or "low bone density", is a condition in which bone mineral density is low.

See CANDLE syndrome and Osteopenia

Oxford University Press

Oxford University Press (OUP) is the publishing house of the University of Oxford.

See CANDLE syndrome and Oxford University Press

Pericarditis

Pericarditis is inflammation of the pericardium, the fibrous sac surrounding the heart.

See CANDLE syndrome and Pericarditis

Phenotype

In genetics, the phenotype is the set of observable characteristics or traits of an organism.

See CANDLE syndrome and Phenotype

POMP

Proteasome maturation protein is a protein that in humans is encoded by the POMP gene.

See CANDLE syndrome and POMP

Proteasome

Proteasomes are protein complexes which degrade ubiquitin-tagged proteins by proteolysis, a chemical reaction that breaks peptide bonds.

See CANDLE syndrome and Proteasome

PSMA3

Proteasome subunit alpha type-3 also known as macropain subunit C8 and proteasome component C8 is a protein that in humans is encoded by the PSMA3 gene.

See CANDLE syndrome and PSMA3

PSMB4

Proteasome subunit beta type-4 also known as 20S proteasome subunit beta-7 (based on systematic nomenclature) is a protein that in humans is encoded by the PSMB4 gene.

See CANDLE syndrome and PSMB4

PSMB8

Proteasome subunit beta type-8 as known as 20S proteasome subunit beta-5i is a protein that in humans is encoded by the PSMB8 gene.

See CANDLE syndrome and PSMB8

PSMB9

Proteasome subunit beta type-9 as known as 20S proteasome subunit beta-1i is a protein that in humans is encoded by the PSMB9 gene.

See CANDLE syndrome and PSMB9

Redox

Redox (reduction–oxidation or oxidation–reduction) is a type of chemical reaction in which the oxidation states of the reactants change.

See CANDLE syndrome and Redox

Rheumatology (journal)

Rheumatology is a monthly peer-reviewed medical journal published by Oxford University Press.

See CANDLE syndrome and Rheumatology (journal)

Skin condition

A skin condition, also known as cutaneous condition, is any medical condition that affects the integumentary system—the organ system that encloses the body and includes skin, nails, and related muscle and glands.

See CANDLE syndrome and Skin condition

Springer Science+Business Media, commonly known as Springer, is a German multinational publishing company of books, e-books and peer-reviewed journals in science, humanities, technical and medical (STM) publishing.

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The Journal of Clinical Endocrinology and Metabolism is a peer-reviewed medical journal in the field of endocrinology and metabolism.

See CANDLE syndrome and The Journal of Clinical Endocrinology and Metabolism

Tohoku University

is a public research university in Sendai, Miyagi, Japan.

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Zygosity

Zygosity (the noun, zygote, is from the Greek "yoked," from "yoke") is the degree to which both copies of a chromosome or gene have the same genetic sequence.

See CANDLE syndrome and Zygosity

References

[1] https://en.wikipedia.org/wiki/CANDLE_syndrome

Also known as Chronic Atypical Neutrophilic Dermatosis, Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and Elevated Temperature.

CANDLE syndrome, the Glossary

Table of Contents

See also

Conditions of the subcutaneous fat

Fever

References