Caspase 3, the Glossary
Caspase-3 is a caspase protein that interacts with caspase-8 and caspase-9.[1]
Table of Contents
59 relations: Adenosine triphosphate, Alpha helix, Alzheimer's disease, Andrew Halayko, APAF1, Apoptosis, Aspartic acid, Beta sheet, Bird, Brain, Carbonyl group, Caspase, Caspase 10, Caspase 6, Caspase 7, Caspase 8, Caspase-9, CFLAR, Chromatin, Cysteine, Cytochrome c, DNA, Enzyme, Enzyme inhibitor, Glutamic acid, Glycylpeptide N-tetradecanoyltransferase 2, Granzyme B, GroEL, HCLS1, Histidine, Hydrogen bond, Hydrolysis, Imidazole, In vitro, In vivo, Lissamphibia, Lizard, Mammal, MEROPS, Mitochondrion, Myocardial infarction, Netrin receptor DCC, NFE2L2, PAC-1, Peptide bond, PH, Protein, Protein–protein interaction, Sequence homology, Stem cell, ... Expand index (9 more) »
Adenosine triphosphate
Adenosine triphosphate (ATP) is a nucleotide that provides energy to drive and support many processes in living cells, such as muscle contraction, nerve impulse propagation, and chemical synthesis.
See Caspase 3 and Adenosine triphosphate
Alpha helix
An alpha helix (or α-helix) is a sequence of amino acids in a protein that are twisted into a coil (a helix).
Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disease that usually starts slowly and progressively worsens, and is the cause of 60–70% of cases of dementia.
See Caspase 3 and Alzheimer's disease
Andrew Halayko
Andrew John Halayko is Professor of Physiology and Pathophysiology, and a Tier 1 Canada Research Chair in Lung Pathobiology and Treatment at the University of Manitoba.
See Caspase 3 and Andrew Halayko
APAF1
Apoptotic protease activating factor 1, also known as APAF1, is a human homolog of C. elegans CED-4 gene.
Apoptosis
Apoptosis (from falling off) is a form of programmed cell death that occurs in multicellular organisms and in some eukaryotic, single-celled microorganisms such as yeast.
Aspartic acid
Aspartic acid (symbol Asp or D; the ionic form is known as aspartate), is an α-amino acid that is used in the biosynthesis of proteins.
See Caspase 3 and Aspartic acid
Beta sheet
The beta sheet (β-sheet, also β-pleated sheet) is a common motif of the regular protein secondary structure.
Bird
Birds are a group of warm-blooded vertebrates constituting the class Aves, characterised by feathers, toothless beaked jaws, the laying of hard-shelled eggs, a high metabolic rate, a four-chambered heart, and a strong yet lightweight skeleton.
Brain
The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals.
Carbonyl group
For organic chemistry, a carbonyl group is a functional group with the formula, composed of a carbon atom double-bonded to an oxygen atom, and it is divalent at the C atom.
See Caspase 3 and Carbonyl group
Caspase
Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death. Caspase 3 and Caspase are eC 3.4.22.
Caspase 10
Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene.
Caspase 6
Caspase-6 is an enzyme that in humans is encoded by the CASP6 gene. Caspase 3 and Caspase 6 are eC 3.4.22 and genes on human chromosome 4.
Caspase 7
Caspase-7, apoptosis-related cysteine peptidase, also known as CASP7, is a human protein encoded by the CASP7 gene. Caspase 3 and Caspase 7 are eC 3.4.22.
Caspase 8
Caspase-8 is a caspase protein, encoded by the CASP8 gene. Caspase 3 and caspase 8 are eC 3.4.22.
Caspase-9
Caspase-9 is an enzyme that in humans is encoded by the CASP9 gene. Caspase 3 and Caspase-9 are eC 3.4.22.
CFLAR
CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene.
Chromatin
Chromatin is a complex of DNA and protein found in eukaryotic cells.
Cysteine
Cysteine (symbol Cys or C) is a semiessential proteinogenic amino acid with the formula.
Cytochrome c
The cytochrome complex, or cyt c, is a small hemeprotein found loosely associated with the inner membrane of the mitochondrion where it plays a critical role in cellular respiration.
See Caspase 3 and Cytochrome c
DNA
Deoxyribonucleic acid (DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix.
Enzyme
Enzymes are proteins that act as biological catalysts by accelerating chemical reactions.
Enzyme inhibitor
An enzyme inhibitor is a molecule that binds to an enzyme and blocks its activity.
See Caspase 3 and Enzyme inhibitor
Glutamic acid
Glutamic acid (symbol Glu or E; the anionic form is known as glutamate) is an α-amino acid that is used by almost all living beings in the biosynthesis of proteins.
See Caspase 3 and Glutamic acid
Glycylpeptide N-tetradecanoyltransferase 2
Glycylpeptide N-tetradecanoyltransferase 2 known also as N-myristoyltransferase, is an enzyme (EC: 2.3.1.97) that in humans is encoded by the NMT2 gene.
See Caspase 3 and Glycylpeptide N-tetradecanoyltransferase 2
Granzyme B
Granzyme B (GrB) is one of the serine protease granzymes most commonly found in the granules of natural killer cells (NK cells) and cytotoxic T cells.
GroEL
GroEL is a protein which belongs to the chaperonin family of molecular chaperones, and is found in many bacteria.
HCLS1
Hematopoietic lineage cell-specific protein is a protein that in humans is encoded by the HCLS1 gene.
Histidine
Histidine (symbol His or H) is an essential amino acid that is used in the biosynthesis of proteins.
Hydrogen bond
In chemistry, a hydrogen bond (or H-bond) is primarily an electrostatic force of attraction between a hydrogen (H) atom which is covalently bonded to a more electronegative "donor" atom or group (Dn), and another electronegative atom bearing a lone pair of electrons—the hydrogen bond acceptor (Ac).
See Caspase 3 and Hydrogen bond
Hydrolysis
Hydrolysis is any chemical reaction in which a molecule of water breaks one or more chemical bonds.
Imidazole
Imidazole (ImH) is an organic compound with the formula C3N2H4.
In vitro
In vitro (meaning in glass, or in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context.
In vivo
Studies that are in vivo (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism.
Lissamphibia
The Lissamphibia (from Greek λισσός (lissós, "smooth") + ἀμφίβια (amphíbia), meaning "smooth amphibians") is a group of tetrapods that includes all modern amphibians.
See Caspase 3 and Lissamphibia
Lizard
Lizard is the common name used for all squamate reptiles other than snakes (and to a lesser extent amphisbaenians), encompassing over 7,000 species, ranging across all continents except Antarctica, as well as most oceanic island chains.
Mammal
A mammal is a vertebrate animal of the class Mammalia.
MEROPS
MEROPS is an online database for peptidases (also known as proteases, proteinases and proteolytic enzymes) and their inhibitors.
Mitochondrion
A mitochondrion is an organelle found in the cells of most eukaryotes, such as animals, plants and fungi.
See Caspase 3 and Mitochondrion
Myocardial infarction
A myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops in one of the coronary arteries of the heart, causing infarction (tissue death) to the heart muscle.
See Caspase 3 and Myocardial infarction
Netrin receptor DCC
Netrin receptor DCC, also known as DCC, or colorectal cancer suppressor is a protein which in humans is encoded by the DCC gene.
See Caspase 3 and Netrin receptor DCC
NFE2L2
Nuclear factor erythroid 2-related factor 2 (NRF2), also known as nuclear factor erythroid-derived 2-like 2, is a transcription factor that in humans is encoded by the NFE2L2 gene.
PAC-1
PAC-1 (first procaspase activating compound) is a synthesized chemical compound that selectively induces apoptosis, in cancerous cells.
Peptide bond
In organic chemistry, a peptide bond is an amide type of covalent chemical bond linking two consecutive alpha-amino acids from C1 (carbon number one) of one alpha-amino acid and N2 (nitrogen number two) of another, along a peptide or protein chain.
See Caspase 3 and Peptide bond
PH
In chemistry, pH, also referred to as acidity or basicity, historically denotes "potential of hydrogen" (or "power of hydrogen").
See Caspase 3 and PH
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues.
Protein–protein interaction
Protein–protein interactions (PPIs) are physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by interactions that include electrostatic forces, hydrogen bonding and the hydrophobic effect.
See Caspase 3 and Protein–protein interaction
Sequence homology
Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life.
See Caspase 3 and Sequence homology
Stem cell
In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can change into various types of cells and proliferate indefinitely to produce more of the same stem cell.
Substrate (chemistry)
In chemistry, the term substrate is highly context-dependent.
See Caspase 3 and Substrate (chemistry)
Survivin
Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene.
T cell
T cells are one of the important types of white blood cells of the immune system and play a central role in the adaptive immune response.
Teleost
Teleostei (Greek teleios "complete" + osteon "bone"), members of which are known as teleosts, is, by far, the largest infraclass in the class Actinopterygii, the ray-finned fishes, and contains 96% of all extant species of fish.
The Proteolysis Map
The Proteolysis MAP (PMAP) was an integrated web resource focused on proteases. Caspase 3 and The Proteolysis Map are eC 3.4.22.
See Caspase 3 and The Proteolysis Map
TRAF3
TNF receptor-associated factor (TRAF3) is a protein that in humans is encoded by the TRAF3 gene.
Transition state
In chemistry, the transition state of a chemical reaction is a particular configuration along the reaction coordinate.
See Caspase 3 and Transition state
XIAP
X-linked inhibitor of apoptosis protein (XIAP), also known as inhibitor of apoptosis protein 3 (IAP3) and baculoviral IAP repeat-containing protein 4 (BIRC4), is a protein that stops apoptotic cell death.
Zymogen
In biochemistry, a zymogen, also called a proenzyme, is an inactive precursor of an enzyme.
References
[1] https://en.wikipedia.org/wiki/Caspase_3
Also known as CASP3, CASP3 (gene), Caspase-3, Caspase-3 p17, EC 3.4.22.56.
, Substrate (chemistry), Survivin, T cell, Teleost, The Proteolysis Map, TRAF3, Transition state, XIAP, Zymogen.