Clomethiazole, the Glossary
Clomethiazole (also called chlormethiazole) is a sedative and hypnotic originally developed by Hoffmann-La Roche in the 1930s.[1]
Table of Contents
39 relations: Alcohol (drug), Allosteric regulation, Anticonvulsant, AstraZeneca, Barbiturate, Benzodiazepine, Carbamazepine, CYP2A6, CYP2B6, CYP2E1, CYP3A4, Diazepam, Diário Oficial da União, Drug of last resort, Drug overdose, Drug tolerance, Ethanedisulfonic acid, Flumazenil, Free base, GABA, GABAA receptor, Germany, Hypnotic, Insomnia, Keith Moon, Muscle relaxant, Neurotransmitter, Parkinson's disease, Physical dependence, Picrotoxin, Psychomotor agitation, Quantitative structure–activity relationship, Receptor (biochemistry), Roche, Sedative, The Who, Therapeutic index, Thiamine, United Kingdom.
Alcohol (drug)
Alcohol, sometimes referred to by the chemical name ethanol, is one of the most widely used and abused psychoactive drugs in the world and falls under the depressant category. Clomethiazole and Alcohol (drug) are GABAA receptor positive allosteric modulators, Hypnotics and sedatives.
See Clomethiazole and Alcohol (drug)
Allosteric regulation
In the fields of biochemistry and pharmacology an allosteric regulator (or allosteric modulator) is a substance that binds to a site on an enzyme or receptor distinct from the active site, resulting in a conformational change that alters the protein's activity, either enhancing or inhibiting its function.
See Clomethiazole and Allosteric regulation
Anticonvulsant
Anticonvulsants (also known as antiepileptic drugs, antiseizure drugs, or anti-seizure medications (ASM)) are a diverse group of pharmacological agents used in the treatment of epileptic seizures.
See Clomethiazole and Anticonvulsant
AstraZeneca
AstraZeneca plc (AZ) is a British-Swedish multinational pharmaceutical and biotechnology company with its headquarters at the Cambridge Biomedical Campus in Cambridge, England.
See Clomethiazole and AstraZeneca
Barbiturate
Barbiturates are a class of depressant drugs that are chemically derived from barbituric acid. Clomethiazole and Barbiturate are Glycine receptor agonists and Hypnotics.
See Clomethiazole and Barbiturate
Benzodiazepine
Benzodiazepines (BZD, BDZ, BZs), colloquially called "benzos", are a class of depressant drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring. Clomethiazole and Benzodiazepine are Hypnotics and sedatives.
See Clomethiazole and Benzodiazepine
Carbamazepine
Carbamazepine, sold under the brand name Tegretol among others, is an anticonvulsant medication used in the treatment of epilepsy and neuropathic pain. Clomethiazole and Carbamazepine are GABAA receptor positive allosteric modulators.
See Clomethiazole and Carbamazepine
CYP2A6
Cytochrome P450 2A6 (abbreviated CYP2A6) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body.
CYP2B6
Cytochrome P450 2B6 is an enzyme that in humans is encoded by the CYP2B6 gene.
CYP2E1
Cytochrome P450 2E1 (abbreviated CYP2E1) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body.
CYP3A4
Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine, which in humans is encoded by CYP3A4 gene.
Diazepam
Diazepam, sold under the brand name Valium among others, is a medicine of the benzodiazepine family that acts as an anxiolytic.
See Clomethiazole and Diazepam
Diário Oficial da União
The Diário Oficial da União (literally Official Diary of the Union), abbreviated DOU, is the official journal of the federal government of Brazil.
See Clomethiazole and Diário Oficial da União
Drug of last resort
A drug of last resort (DoLR), also known as a heroic dose, is a pharmaceutical drug which is tried after all other drug options have failed to produce an adequate response in the patient.
See Clomethiazole and Drug of last resort
Drug overdose
A drug overdose (overdose or OD) is the ingestion or application of a drug or other substance in quantities much greater than are recommended.
See Clomethiazole and Drug overdose
Drug tolerance
Drug tolerance or drug insensitivity is a pharmacological concept describing subjects' reduced reaction to a drug following its repeated use.
See Clomethiazole and Drug tolerance
Ethanedisulfonic acid
Ethanedisulfonic acid is a diprotic sulfonic acid, with pKa values of -1.46 and -2.06, making it a very strong acid.
See Clomethiazole and Ethanedisulfonic acid
Flumazenil
Flumazenil (also known as flumazepil, code name Ro 15-1788) is a selective GABAA receptor antagonist administered via injection, otic insertion, or intranasally.
See Clomethiazole and Flumazenil
Free base
Free base (freebase, free-base) is a descriptor for the neutral form of an amine commonly used in reference to illicit drugs.
See Clomethiazole and Free base
GABA
GABA (gamma Aminobutyric acid, γ-Aminobutyric acid) is the chief inhibitory neurotransmitter in the developmentally mature mammalian central nervous system. Clomethiazole and GABA are GABAA receptor positive allosteric modulators and Glycine receptor agonists.
GABAA receptor
The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel.
See Clomethiazole and GABAA receptor
Germany
Germany, officially the Federal Republic of Germany (FRG), is a country in Central Europe.
Hypnotic
Hypnotic (from Greek Hypnos, sleep), or soporific drugs, commonly known as sleeping pills, are a class of (and umbrella term for) psychoactive drugs whose primary function is to induce sleep (or surgical anesthesiaWhen used in anesthesia to produce and maintain unconsciousness, "sleep" is metaphorical as there are no regular sleep stages or cyclical natural states; patients rarely recover from anesthesia feeling refreshed and with renewed energy. Clomethiazole and Hypnotic are Hypnotics.
See Clomethiazole and Hypnotic
Insomnia
Insomnia, also known as sleeplessness, is a sleep disorder where people have trouble sleeping.
See Clomethiazole and Insomnia
Keith Moon
Keith John Moon (23 August 1946 – 7 September 1978) was an English musician who was the drummer for the rock band the Who.
See Clomethiazole and Keith Moon
Muscle relaxant
A muscle relaxant is a drug that affects skeletal muscle function and decreases the muscle tone.
See Clomethiazole and Muscle relaxant
Neurotransmitter
A neurotransmitter is a signaling molecule secreted by a neuron to affect another cell across a synapse.
See Clomethiazole and Neurotransmitter
Parkinson's disease
Parkinson's disease (PD), or simply Parkinson's, is a long-term neurodegenerative disease of mainly the central nervous system that affects both the motor and non-motor systems of the body.
See Clomethiazole and Parkinson's disease
Physical dependence
Physical dependence is a physical condition caused by chronic use of a tolerance-forming drug, in which abrupt or gradual drug withdrawal causes unpleasant physical symptoms.
See Clomethiazole and Physical dependence
Picrotoxin
Picrotoxin, also known as cocculin, is a poisonous crystalline plant compound.
See Clomethiazole and Picrotoxin
Psychomotor agitation
Psychomotor agitation is a symptom in various disorders and health conditions.
See Clomethiazole and Psychomotor agitation
Quantitative structure–activity relationship
Quantitative structure–activity relationship models (QSAR models) are regression or classification models used in the chemical and biological sciences and engineering.
See Clomethiazole and Quantitative structure–activity relationship
Receptor (biochemistry)
In biochemistry and pharmacology, receptors are chemical structures, composed of protein, that receive and transduce signals that may be integrated into biological systems.
See Clomethiazole and Receptor (biochemistry)
Roche
F.
Sedative
A sedative or tranquilliser is a substance that induces sedation by reducing irritability or excitement. Clomethiazole and sedative are sedatives.
See Clomethiazole and Sedative
The Who
The Who are an English rock band formed in London in 1964.
Therapeutic index
The therapeutic index (TI; also referred to as therapeutic ratio) is a quantitative measurement of the relative safety of a drug.
See Clomethiazole and Therapeutic index
Thiamine
Thiamine, also known as thiamin and vitamin B1, is a vitamin, an essential micronutrient for humans and animals. Clomethiazole and thiamine are Thiazoles.
See Clomethiazole and Thiamine
United Kingdom
The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain, is a country in Northwestern Europe, off the coast of the continental mainland.
See Clomethiazole and United Kingdom
References
[1] https://en.wikipedia.org/wiki/Clomethiazole
Also known as ATC code N05CM02, ATCvet code QN05CM02, C6H8ClNS, Chlormethiazole, Chlormethiazole edisylate, Distraneurin, Heminevrin, Nevrin.